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Targets Recommended: TLR HIV Protease

抑制剂 & 化合物

天然产物

化合物库

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Cat. No.	Product Name
L2610	神经递质受体化合物库	1513 compounds
	1513 种与神经递质受体相关的化合物，用于高通量、高内涵筛选；
L9500	表型筛选靶点鉴定库	1796 compounds
	1796 种靶点明确的已知活性化合物，适合表型筛选；
L6620	抗寄生虫天然产物库	253 compounds
	253 个抗寄生虫相关的天然产物集合，是药物开发、药理研究的有效工具；

化合物库

Cat. No.	Product Name	Target	Signaling Pathways
T38261	Sparstolonin B	TLR; HIV Protease	Immunology/Inflammation; Microbiology/Virology; Proteases/Proteasome
	Sparstolonin B 是一种选择性 TLR2 和 TLR4 拮抗剂，是一种是一种从 Sparganium stoloniferum 和 Scirpus yagara 的块茎中分离出的异香豆素化合物，具有抗 HIV 、抗癌、抗肿瘤和抗炎活性，抑制选择性Toll样受体，抑制游离脂肪酸棕榈酸酯诱导的软骨细胞炎症并减轻肥胖小鼠的创伤后关节炎，抑制脂多糖诱导的 3T3-L1 脂肪细胞炎症，可用于研究验证和乳腺癌。
T37424	CAY10781 CAY10781	Others	Others
	CAY10781 是一种神经纤毛蛋白-1 (NRP-1) 和 VEGF-A.1 之间蛋白质-蛋白质相互作用的抑制剂。当使用浓度为 12.5 μM 时，它可抑制 43% 的相互作用。当以相同浓度使用时，CAY10781 还抑制 VEGF-A 诱导的儿茶酚胺 A 分化 (CAD) 细胞中 VEGFR2 的磷酸化。
T69822	Ritlecitinib tosylate	Others	Others
	Ritlecitinib, also known as PF-06651600, is a potent and selective JAK3 inhibitor. PF-06651600 is a potent and low clearance compound with demonstrated in vivo efficacy. The favorable efficacy and safety profile of this JAK3-specific inhibitor PF-06651600 led to its evaluation in several human clinical studies. JAK3 was among the first of the JAKs targeted for therapeutic intervention due to the strong validation provided by human SCID patients displaying JAK3 deficiencies.
T69612	PSB-KD477	Others	Others
	PSB-KD477 is an Agonist of the Cannabinoid-Activated Orphan G-Protein-Coupled Receptor GPR18. PSB-KD477 displayed significantly higher potency and efficacy than THC, determined in a GPR18-dependent β-arrestin recruitment assay, and were found to be selective versus the CB-sensitive receptors CB1, CB2, and GPR55. Structure-activity relationships were steep, and indole substitution was crucial for biological activity. These first selective agonists, which are structurally distinct from the lipidic...
T36723	Desmethyl Ranolazine	Others	Others
	Desmethyl ranolazine is a metabolite of the antianginal agent ranolazine .1It is formed from ranolazine by the cytochrome P450 (CYP) isoform CYP3A. 1.Wang, Y., Chen, X., Sun, Z., et al.Development and validation of a sensitive LC-MS/MS assay for simultaneous quantitation of ranolazine and its three metabolites in human plasmaJ. Chromatogr. B889-89010-16(2012)
T37403	O-desmethyl Brinzolamide (hydrochloride)	Others	Others
	O-desmethyl Brinzolamide is an active metabolite of the carbonic anhydrase (CA) inhibitor brinzolamide .1,2It inhibits CAII and CAIV (IC50s = 0.136 and 165 nM, respectively).1 1.Huang, Q., Rui, E.Y., Cobbs, M., et al.Design, synthesis, and evaluation of NO-donor containing carbonic anhydrase inhibitors to lower intraocular pressureJ. Med. Chem.58(6)2821-2833(2015) 2.Lo Faro, A.F., Tini, A., Gottardi, M., et al.Development and validation of a fast ultra-high-performance liquid chromatography tand...
T37344	5,6-dimethyl-2-Thiouracil	Others	Others
	5,6-dimethyl-2-Thiouracil is a heterocyclic building block that has been used in the synthesis of anti-HIV-1 pyrimidinones.1 It has also been used as an internal standard for the quantification of thyreostats, including 2-thiouracil, in bovine plasma.2 \|1. Navrotskii, M.B. Synthesis and anti-HIV-1 activity of new 2-[(2-phthalimidoethyl)thio]-4(3H)-pyrimidinone derivatives. Pharm. Chem. J. 39(9), 466-467 (2005).\|2. Schmidt, K.S. In-house validation and factorial effect analysis of a liquid chroma...
T37246	Palonosetron N-oxide	Others	Others
	Palonosetron N-oxide is a metabolite of the serotonin (5-HT) receptor subtype 5-HT3antagonist palonosetron .1It is also a potential impurity in palonosetron preparations.2Palonosetron N-oxide is a degradation product formed by exposure to oxidative stress. 1.Stoltz, R.A., Cyong, J.-C., Shah, A., et al.Pharmacokinetic and safety evaluation of palonosetron, a 5-hydroxytryptamine-3 receptor antagonist, in U.S. and Japanese healthy subjectsJ. Clin. Pharmacol.44(5)520-531(2004) 2.Vishnu Murthy, M., S...

化合物

Sparstolonin B

Cat.No: T38261

Synonym:

Target: TLR, HIV Protease

CAY10781

Cat.No: T37424

Synonym: CAY10781

Target: Others

Ritlecitinib tosylate

O-desmethyl Brinzolamide (hydrochloride)

Cat.No: T37403

Synonym:

Target: Others

5,6-dimethyl-2-Thiouracil

Cat. No.	Product Name	Target	Signaling Pathways
T8067	Methyl Nonadecanoate Nonadecanoic Acid methyl ester,正十九酸甲酯	Others	Others
	Methyl Nonadecanoate (Nonadecanoic Acid methyl ester)是一种内标物，能够用于生物柴油中脂肪酸甲酯含量的测定。

天然产物

Methyl Nonadecanoate

Cat.No: T8067

Synonym: Nonadecanoic Acid methyl ester,正十九酸甲酯

Target: Others

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