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Search Results for " triglyceride "

Targets Recommended: Lipase

61

抑制剂 & 化合物

21

天然产物

15

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1875	Atglistatin	Lipase	Metabolism
	Atglistatin 是脂肪甘油三酯脂酶的选择性抑制剂(IC50:0.7 μM)，在体外具有抑制脂解的功能。
T10004	Palmitodiolein Triglyceride POO,1,2-Dioleoyl-3-palmitoylglycerol,Glycerol dioleate palmitate	Others	Others
	Palmitodiolein is a triacylglycerol existed in vegetable oils.
T84385	1,2,3-Tri-γ-Linolenoyl Glycerol γ-Linolenic Acid Triglyceride,γ-Linolenin,Tri-γ-linolenoate	Others	Others
	1,2,3-Tri-γ-linolenoyl glycerol, a polyunsaturated triacylglycerol featuring γ-linolenoyl side chains at the C-1, C-2, and C-3 positions, occurs in multiple plant species such as blackcurrant, redcurrant, and borage.
T85100	1,2,3-Tri-13(E)-Docosenoyl Glycerol Tridocosenoyl Glycerol,Tribrassidin,Tri-13(E)-Docosenoin,TG(22:1/22:1/22:1),Brassidic Acid Triglyceride,Glycerol Tridocosenoate	Others	Others
	1,2,3-Tri-13(E)-docosenoyl glycerol, a triacylglycerol featuring 13(E)-docosenoic acid at the \(sn-1\), \(sn-2\), and \(sn-3\) positions, transiently elevates heart triglyceride levels in weanling rats when administered as 15% of a calcium-deficient diet, with levels returning to baseline after 28 days.
T27478	GSK3987	Liver X Receptor	Metabolism
	GSK3987 是广谱LXRα/β激动剂，EC50分别为 50 nM 和 40 nM。GSK3987增加 ABCA1 和 SREBP-1c 蛋白的表达，诱导细胞甘油三酯的积累和胆固醇流出。
T10035	10,12-Tricosadiynoic acid TDA,TCDA	Acyltransferase	Metabolism
	10,12-Tricosadiynoic acid 是一种口服有效的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂，具有高特异性，选择性，高亲和力的特点。10,12-Tricosadiynoic acid 可改善线粒体脂质和 ROS 代谢，在高脂饮食或肥胖引起的代谢性疾病中有研究的价值。
T27719	KD-026 SLx 4090,SLx4090,KD026,SLx-4090	CETP	Metabolism
	KD-026 (SLx 4090) 是具有口服活性的、肠细胞特异性的微粒体甘油三酯转移蛋白 (MTP)抑制剂，IC50为 8.0 nM。KD-026 (SLx 4090) 在糖尿病2型中有研究的价值。
TQ0115	NB-598	Antifungal	Microbiology/Virology
	NB-598 是一种鲨烯环氧化酶竞争性抑制剂，可以阻碍甘油三酯的生物合成。
T2545	Lomitapide Mesylate 甲磺酸洛美他派,BMS-201038 mesylate,AEGR-733 mesylate	CETP	Metabolism
	Lomitapide Mesylate (BMS-201038 mesylate) 是一种高效MTP 蛋白抑制剂，其体外IC50值为8 nM。
T0730	Triacetin Glycerol triacetate,三醋酸甘油酯,1,2,3-Triacetoxypropane,Glyceryl triacetate,Glycerin triacetate,三醋精	Endogenous Metabolite; Antifungal	Metabolism; Microbiology/Virology
	Triacetin (Glyceryl triacetate) 是是甘油和乙酸的三酯，用作抗真菌剂。
T24263	KLH45 KLH-45,KLH 45	Phosphatase	Metabolism
	KLH45 是一种有效的选择性痉挛性截瘫相关甘油三酯水解酶 DDHD2 抑制剂 (IC50 = 1.3 nM)。
T14933	Cetaben	Others	Others
	Cetaben 是不依赖 PPARα 的过氧化物酶体增殖物。它可有效降低胆固醇和甘油三酸酯的浓度，是一种非纤维化降血脂药。
T30506	BMS-212122 UNII-0Z473OO6GB,BMS212122,BMS 212122	CETP	Metabolism
	BMS-212122 (UNII-0Z473OO6GB) 是一种有效的微粒体甘油三酯转移蛋白(MTP )抑制剂，在动物实验中显示出降血脂作用。BMS-212122 显著减少动脉粥样硬化斑块中的脂质含量和单核细胞衍生(CD68+)细胞。
T15006	Dirlotapide CP742033,Slentrol	Others; CETP	Metabolism; Others
	Dirlotapide (CP742033) 是一种肠道选择性微粒体甘油三酯转移蛋白(MTP)抑制剂。它可以减轻糖尿病狗的体重。Dirlotapide 以剂量依赖性方式减少食物摄入量，可能是通过增加肽YY 释放到循环中。
T35258	YM 16638 YM 638,YM-16638,YM16638	LTR	Immunology/Inflammation
	YM 16638 是一种具有口服活性的白三烯（LT）拮抗剂，具有降低甘油三酯和增加过氧化物酶体的作用，可用于研究抗原诱导过敏性绵羊早期和晚期气道反应。
T9186	Ervogastat PF-06865571	Transferase	Metabolism
	Ervogastat (PF-06865571) 是一种有效且耐受性良好的二酰基甘油酰基转移酶 2 抑制剂。 Ervogastat 可降低非酒精性脂肪性肝炎 (NASH) 中的脂肪变性和肝脏甘油三酯水平。
T31992	Granotapide	CETP	Metabolism
	Granotapide 是一种微粒体甘油三酯转移蛋白（MTP）抑制剂，治疗和而预防动脉硬化，冠状动脉疾病，代谢综合征，肥胖，糖尿病，糖尿病前期和高血压。
T6267	Lomitapide AEGR-733,洛美他派,BMS-201038	CETP	Metabolism
	Lomitapide (AEGR-733) 是一种高效的微粒体甘油三酯转移蛋白(MTP)抑制剂，体内试验的IC50值为8 nM。
T11016	DGAT-1 inhibitor 2	Transferase	Metabolism
	DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。
T73499	NG-497 NG497	Lipase	Metabolism
	NG-497 是一种具有选择性的小分子人类的脂肪甘油三酯脂肪酶 (ATGL) 抑制剂，可以靶向人类 ATGL 的酶促活性 patatin 样结构域。NG-497在活性位点附近的疏水腔内结合ATGL。NG-497以剂量依赖性和可逆的方式消除人脂肪细胞中的脂肪分解。NG-497 可用于研究癌症。
T72322	R 59-022 hydrochloride DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience
	R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。
T1415	Gemfibrozil 吉非罗齐,CI-719,Jezil,Decrelip,Lopid	P450; Adrenergic Receptor; PPAR	DNA Damage/DNA Repair; GPCR/G Protein; Metabolism; Neuroscience
	Gemfibrozil (CI-719) 是一种PPAR-α激活剂，可作为降脂药。它也是P450非选择性抑制剂，对 CYP2C9、2C19、2C8 和 1A2 的Ki 值分别为 5.8、24、69 和 82 μM。
T10504	Implitapide Racemate	Others	Others
	Implitapide Racemate is the racemate of Implitapide. Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T16158	PF-02575799	Adenosine Receptor	GPCR/G Protein; Neuroscience
	PF-02575799 is an inhibitor of microsomal triglyceride transfer protein (MTP) (IC50: 0.77±0.29 nM).
T38666	CP-346086 dihydrate	Others	Others
	CP-346086 dihydrate is a potent and orally active inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM for both human and rodent MTP. This compound effectively lowers plasma cholesterol and triglyceride levels in vivo.
T13418	CP-319340(free base)	Others	Others
	CP-319340 free base is a inhibitor of microsomal triglyceride transfer protein (MTP) .
T24223	JTT 130 JTT-130,JTT130	Others	Others
	JTT 130 is an agent of hypolipidemic. It inhibits microsomal triglyceride transfer protein.
T26661	AS1708727	Others	Others
	AS1708727 is a Foxo1 inhibitor, exerting anti-hypertriglyceridemic and anti-diabetic effects by improving triglyceride and blood glucose metabolism at the gene expression level.
T15570	Implitapide 英普他派,AEGR 427	CETP	Metabolism
	Implitapide is an inhibitor of microsomal triglyceride transfer protein (MTP).
T19105	2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol	Others	Others
	2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol is a triglyceride.
T85090	1,2,3-Tritricosanoyl Glycerol Tritricosanoin,Glycerol Tritricosanoate,TG(23:0/23:0/23:0)	Others	Others
	1,2,3-Tritricosanoyl glycerol, a triacylglycerol containing tricosanoic acid at the sn-1, sn-2, and sn-3 positions, serves as an internal standard for the quantification of fatty acids within the triglyceride component of human aortic endothelial cells (HAECs) cultured in media supplemented with stearic and/or oleic acid.
T29448	50F10 50 F 10,50-F-10	Others	Others
	50F10 is a stabilizer for the active LPL dimer. It can act by preventing angptl4- and heat-induced inactivation of LPL and reducing postprandial triglyceride levels.
T68245	PA-082	Others	Others
	PA-082 is a Novel partial agonist of peroxisome proliferator-activated receptor-γ (PPARγ), recruiting PPARγ-coactivator-1α, preventing triglyceride accumulation, and potentiating insulin signaling in vitro.
T68588	CP-10447	Others	Others
	CP-10447 is an inhibitor apolipoprotein B (apoB) and triglyceride secretion in human hepatoma cells (HepG2) by inhibiting MTP activity and stimulating the early ER degradation of apoB. It is useful tool for further study of the mechanisms of apoB secretion and triglyceride-rich lipoprotein assembly.
T27228	E-3030 free acid E-3030,E3030,E 3030	Others	Others
	E-3030 free acid is a peroxisome proliferator-activated receptor (PPAR) agonist. E-3030 decreased blood glucose, triglyceride, non-esterified fatty acids, and insulin levels and increased blood adiponectin levels. Triglyceride- and non-high-density lipopr
T35005	Usistapide R-256918,JNJ-16269110,JNJ16269110,R256918,JNJ 16269110,R 256918	Others	Others
	UsISpide(JNJ-16269110 R256918) is an inhibitor of microsomal triglyceride transfer protein (MTTP) under development for the treatment of obesity and type 2 diabetes.
T40898	DMHCA	Others	Others
	DMHCA, a potent, selective LXR agonist, specifically activates the LXR pathway's cholesterol efflux arm, avoiding triglyceride synthesis stimulation. This compound exhibits anti-inflammatory properties and is utilized in researching cholesterol homeostasis and diabetes.
T28196	NS-220 LS-191458,NS 220	Others	Others
	NS-220, a selective agonist of peroxisome proliferator-activated receptor alpha, potently decreases plasma triglyceride and glucose levels and modifies lipoprotein profiles in KK-Ay mice.
T68375	KD026-metabolite	Others	Others
	KD026-metabolite, is a metabolite of KD-026. KD026, also known as SLx-4090, is a microsomal triglyceride transfer protein (MTTP) inhibitor potentially for the treatment of type 2 diabetes.
T84645	1-Palmitoyl-2-oleoyl-3-linoleoyl-rac-glycerol POL	Others	Others
	POL, a prevalent triglyceride component in various seed and vegetable oils such as olive, sesame, soybean, canola, corn, and hazelnut, is standardly utilized in the USP analysis of sesame oil for pharmaceutical applications.
T39303	CP-346086	Others	Others
	CP-346086 is a highly potent and orally bioavailable inhibitor of microsomal triglyceride transfer protein (MTP), exhibiting an IC50 value of 2.0 nM against both human and rodent MTP. This compound effectively reduces plasma levels of cholesterol and triglycerides when administered in vivo.
T29730	AGR-540 AGR540	Others	Others
	AGR-540 is a prodrug of AGR-529. AGR-540 has been shown to return plasma triglyceride concentrations to normal levels in mouse models. This effect may be attributed to an interaction of the molecule with A1 purinergic receptors of adipose tissue.
T83275	6,9,12,15-Hexadecatetraenoic acid-ethyl ester	Others	Others
	6,9,12,15-Hexadecatetraenoic acid-ethyl ester 为口服活性的多不饱和脂肪酸。该化合物摄入后可减少小鼠血浆中甘油三酯含量。
T85144	1,2-Dioleoyl-3-linoleoyl-rac-glycerol OOL,TG(18:1(9Z)/18:1(9Z)/18:2(9Z,12Z)),TG(18:1/18:1/18:2),TG(54:4)	Others	Others
	1,2-Dioleoyl-3-linoleoyl-rac-glycerol (OOL) is a triglyceride featuring oleic acid at the sn-1 and sn-2 positions and linoleic acid at the sn-3 position. This compound is prevalent in several seed and vegetable oils, such as those from pumpkin seeds, olives, and sesame.
T85047	2-Myristyldipalmitin TG(16:0/14:0/16:0),1,3-Palmitin-2-Myristin	Others	Others
	2-Myristyldipalmitin (PMP) 是一种棕榈酸甘油三酯，具有成为威尔逊氏病 (WD) 脂质标记物的潜力。
T40058	IQZ23 IQZ23	Others	Others
	IQZ23 is a chemical compound that effectively inhibits adipocyte differentiation by activating the AMPK pathway. It demonstrates high efficacy in reducing triglyceride levels (EC50=0.033 μM) in 3T3-L1 adipocytes. Given its properties, IQZ23 holds potential for research related to obesity and metabolic disorders.
T85229	1,3-Dipalmitoyl-2-Docosahexaenoyl Glycerol TG(16:0/22:6/16:0),1,3-Palmitin-2-Docoahexaenoin,16:0/22:6/16:0-TG	Others	Others
	1,3-Dipalmitoyl-2-docosahexaenoyl glycerol, a triacylglycerol, features palmitic acid at the sn-1 and sn-3 positions and docosahexaenoic acid at the sn-2 position. Its dietary administration (30 g/kg) has been shown to decrease hepatic triglyceride and cholesterol levels in mice.
T37579	GW 1929 hydrochloride	Others	Others
	Highly selective orally active peroxisome proliferator-activated receptor (PPAR)γ agonist (pEC50 values are 8.05, < 4 and < 4 for human PPARγ, PPARα and PPARδ receptors respectively). Decreases glucose, fatty acid and triglyceride levels following oral administration in vivo. Brown et al (1999) A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-γ reverses the diabetic phenotype of the Zucker diabetic fatty rat. Diabetes 48 1415 PMID:10389847 \|Nugent et al (2001) Pote...
T35636	SHS4121705	Others	Others
	SHS4121705 is an orally bioavailable mitochondrial uncoupler.1It increases oxygen consumption rate in L6 rat myoblast cells with an EC50value of 4.3 μM. SHS4121705 (25 mg/kg per day in the diet) reduces hepatic steatosis, liver triglyceride levels, and plasma alanine aminotransferase (ALT) levels in Stelic animal model (STAM) mice, a model of non-alcoholic steatohepatitis (NASH). 1.Salamoun, J.M., Garcia, C.J., Hargett, S.R., et al.6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol derivatives as effic...
T79764	PF-07202954	Acyltransferase	Metabolism
	PF-07202954为一种弱碱性DGAT2抑制剂，其对人类DGAT2的IC50值为10 nM。在西方饮食喂养的大鼠模型中，PF-07202954能有效降低肝脏内的甘油三酯含量。

化合物

Cat.No: T1875

Target: Lipase

Cat.No: T10004

Synonym: Triglyceride POO,1,2-Dioleoyl-3-palmitoylglycerol,Glycerol dioleate palmitate

Target: Others

1,2,3-Tri-γ-Linolenoyl Glycerol

Cat.No: T84385

Synonym: γ-Linolenic Acid Triglyceride,γ-Linolenin,Tri-γ-linolenoate

Target: Others

1,2,3-Tri-13(E)-Docosenoyl Glycerol

Cat.No: T85100

Synonym: Tridocosenoyl Glycerol,Tribrassidin,Tri-13(E)-Docosenoin,TG(22:1/22:1/22:1),Brassidic Acid Triglyceride,Glycerol Tridocosenoate

Target: Others

Cat.No: T27478

Target: Liver X Receptor

10,12-Tricosadiynoic acid

Cat.No: T10035

Synonym: TDA,TCDA

Target: Acyltransferase

Cat.No: T27719

Synonym: SLx 4090,SLx4090,KD026,SLx-4090

Target: CETP

Cat.No: TQ0115

Target: Antifungal

Lomitapide Mesylate

Cat.No: T2545

Synonym: 甲磺酸洛美他派,BMS-201038 mesylate,AEGR-733 mesylate

Target: CETP

Cat.No: T0730

Synonym: Glycerol triacetate,三醋酸甘油酯,1,2,3-Triacetoxypropane,Glyceryl triacetate,Glycerin triacetate,三醋精

Target: Endogenous Metabolite, Antifungal

Cat.No: T24263

Synonym: KLH-45,KLH 45

Target: Phosphatase

Cat.No: T14933

Target: Others

Cat.No: T30506

Synonym: UNII-0Z473OO6GB,BMS212122,BMS 212122

Target: CETP

Cat.No: T15006

Synonym: CP742033,Slentrol

Target: Others, CETP

Cat.No: T35258

Synonym: YM 638,YM-16638,YM16638

Target: LTR

Cat.No: T9186

Synonym: PF-06865571

Target: Transferase

Cat.No: T31992

Target: CETP

Cat.No: T6267

Synonym: AEGR-733,洛美他派,BMS-201038

Target: CETP

DGAT-1 inhibitor 2

Cat.No: T11016

Target: Transferase

Cat.No: T73499

Synonym: NG497

Target: Lipase

R 59-022 hydrochloride

Cat.No: T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

Cat.No: T1415

Synonym: 吉非罗齐,CI-719,Jezil,Decrelip,Lopid

Target: P450, Adrenergic Receptor, PPAR

Implitapide Racemate

Cat.No: T10504

Target: Others

Cat.No: T16158

Target: Adenosine Receptor

CP-346086 dihydrate

Cat.No: T38666

Target: Others

CP-319340(free base)

Cat.No: T13418

Target: Others

Cat.No: T24223

Synonym: JTT-130,JTT130

Target: Others

Cat.No: T26661

Target: Others

Cat.No: T15570

Synonym: 英普他派,AEGR 427

Target: CETP

2-γ-Linolenoyl-1,3-dilinoleoyl-sn-glycerol

Cat.No: T19105

Target: Others

1,2,3-Tritricosanoyl Glycerol

Cat.No: T85090

Synonym: Tritricosanoin,Glycerol Tritricosanoate,TG(23:0/23:0/23:0)

Target: Others

Cat.No: T29448

Synonym: 50 F 10,50-F-10

Target: Others

Cat.No: T68245

Target: Others

Cat.No: T68588

Target: Others

E-3030 free acid

Cat.No: T27228

Synonym: E-3030,E3030,E 3030

Target: Others

Cat.No: T35005

Synonym: R-256918,JNJ-16269110,JNJ16269110,R256918,JNJ 16269110,R 256918

Target: Others

Cat.No: T40898

Target: Others

Cat.No: T28196

Synonym: LS-191458,NS 220

Target: Others

KD026-metabolite

Cat.No: T68375

Target: Others

1-Palmitoyl-2-oleoyl-3-linoleoyl-rac-glycerol

Cat.No: T84645

Synonym: POL

Target: Others

Cat.No: T39303

Target: Others

Cat.No: T29730

Synonym: AGR540

Target: Others

6,9,12,15-Hexadecatetraenoic acid-ethyl ester

Cat.No: T83275

Target: Others

1,2-Dioleoyl-3-linoleoyl-rac-glycerol

Cat.No: T85144

Synonym: OOL,TG(18:1(9Z)/18:1(9Z)/18:2(9Z,12Z)),TG(18:1/18:1/18:2),TG(54:4)

Target: Others

2-Myristyldipalmitin

Cat.No: T85047

Synonym: TG(16:0/14:0/16:0),1,3-Palmitin-2-Myristin

Target: Others

Cat.No: T40058

Synonym: IQZ23

Target: Others

1,3-Dipalmitoyl-2-Docosahexaenoyl Glycerol

Cat.No: T85229

Synonym: TG(16:0/22:6/16:0),1,3-Palmitin-2-Docoahexaenoin,16:0/22:6/16:0-TG

Target: Others

GW 1929 hydrochloride

Cat.No: T37579

Target: Others

Cat.No: T35636

Target: Others

Cat.No: T79764

Target: Acyltransferase

Cat. No.	Product Name	Target	Signaling Pathways
T14862	Caprylic/Capric Triglyceride	Others	Others
	Caprylic/Capric Triglyceride 是一种从分离的植物油中提取的甘油三酯和酯，以及从椰子油和棕榈仁油中提取的脂肪酸。它具有良好的氧化稳定性，可用作食品添加剂及用于化妆品。
TWO2727	Propane-1,2,3-triyl tripalmitate Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯	Others; Endogenous Metabolite	Metabolism; Others
	Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。
T19676	Tributyrin NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯	Apoptosis	Apoptosis
	Tributyrin (Glyceryl tributyrate) 是一种中性短链脂肪酸甘油三酯，是一种稳定且吸收迅速的丁酸前药。它通过生物膜扩散并被细胞内脂肪酶代谢，在体内将有效的丁酸直接释放到细胞中，有抗增殖、促凋亡和诱导分化作用。
T5544	2-Furoic acid Furan-2-carboxylic acid,糠酸	Anti-infection; ATP Citrate Lyase; Endogenous Metabolite; Acyltransferase	Metabolism; Microbiology/Virology
	2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid 能够降低血清中胆固醇和甘油三酯的水平，具有抗血脂作用。
T8272	Trierucin	Others; Endogenous Metabolite	Metabolism; Others
	Trierucin 是一种从种子油中提取的三芥酸甘油三酯。
TN2197	Secoisolariciresinol	TNF	Apoptosis
	Secoisolariciresinol 是一种属于苯丙素类的木脂素。
T3220	Euphorbiasteroid Euphobiasteroid,Euphorbia factor L1,千金子甾醇	Others; AMPK	Chromatin/Epigenetic; Others; PI3K/Akt/mTOR signaling
	Euphorbiasteroid (Euphobiasteroid) 是续随子中的一种三环二萜，可抑制酪氨酸酶活性，增强AMPK 的磷酸化。它通过减少细胞内甘油三酯的积累来降低 3T3-L1 细胞的分化，具有抗癌、抗病毒、抗肥胖及多重耐药调节作用。
T5242	Triarachidin Triarachin,1,2,3-Trieicosanoyl Glycerol,Glycerol Trieicosanoate,三花生精	Others; Endogenous Metabolite	Metabolism; Others
	Triarachidin (1,2,3-Trieicosanoyl Glycerol) 是内源性代谢产物的一种。
T3921	Punicalagin 安石榴甙,安石榴苷	SARS-CoV; HBV	Microbiology/Virology
	Punicalagin 是一种在石榴中发现的主要鞣花单宁，是可逆且非竞争性的 3CLpro 抑制剂。Punicalagin 具有抗氧化、抗炎和抗肿瘤活性。
TCS1772	Dehydroabietic acid Dehydroabietate,脱氢松香酸	Antifection	Microbiology/Virology
	Dehydroabietic acid (Dehydroabietate) 是 EBV-EA 活化抑制剂。它是食物衍生化合物，可通过降低血浆葡萄糖、胰岛素水平、血浆甘油三酯 (TG) 和肝 TG 水平来治疗肥胖相关疾病。它的衍生物在动物模型中表现出抗分泌和抗胃蛋白酶作用。
TN5137	Tetramethylkaempferol	transporter; PPAR	DNA Damage/DNA Repair; Metabolism
	Tetramethylkaempferol 是一种 PPARγ 激动剂，它可以通过增加脂联素的水平来提高胰岛素敏感性，脂联素是一种与脂肪组织中胰岛素敏感性相关的重要脂肪细胞因子。它可以浓度依赖性地增强甘油三酯的积累，甘油三酯是脂肪生成的标志物。
TN3884	Dodoviscin I	transporter	Metabolism
	Dodoviscin I can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
T81013	tert-OMe-byakangelicin
	tert-OMe-byakangelicin 是一种香豆素，能够增强肾上腺素诱导的脂肪细胞中的脂肪溶解作用，同时抑制胰岛素在脂肪细胞中刺激的甘油三酯生成。
TN3885	Dodoviscin J	transporter	Metabolism
	Dodoviscin J can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
TN3883	Dodoviscin H	transporter	Metabolism
	Dodoviscin H can promote adipocyte differentiation as characterized by increased triglyceride levels in 3T3L1 cells.
T10044	13-Oxo-9E,11E-octadecadienoic acid	PPAR	DNA Damage/DNA Repair; Metabolism
	13-Oxo-9E,11E-octadecadienoic acid, a potent PPARα activator derived from tomato juice and an isomer of 9-oxo-ODA, exhibits the ability to decrease plasma and hepatic triglyceride levels in obese diabetic mice[1].
T81222	Salvifaricin
	Salvifaricin是一种口服活性的二萜类化合物，可从墨西哥鼠尾草和西班牙鼠尾草中提取。Salvifaricin能显著降低空腹血糖以及血清甘油三酯(TG)水平，表现出抗糖尿病的效果。
TN3882	Dodoviscin A	cAMP; Tyrosinase; transporter	GPCR/G Protein; Metabolism; Proteases/Proteasome
	Dodoviscin A may be a new promising pigmentation-altering agent for cosmetic and therapeutic applications, it can inhibit melanin biosynthesis induced by 3-isobutyl-1-methylxanthine and PD98059.Dodoviscin A can promote adipocyte differentiation as charact
T60692	Masoprocol	Others	Others
	Masoprocol (meso-Nordihydroguaiaretic acid) 是口服有效的脂氧合酶 (lipoxygenase) 抑制剂。Masoprocol 具有出抗高血糖活性，可用于 II 型糖尿病的研究。 Masoprocol 可降低体内肝甘油三酯和葡萄糖浓度。
TN3112	5-Heneicosylresorcinol	NADPH-oxidase; Antifection	Immunology/Inflammation; Microbiology/Virology
	5-Heneicosylresorcinol 对 RBL-2H3 细胞中 β-己糖胺酶的释放具有抑制作用，它还可以防止 3T3-L1 细胞中甘油三酯的积累。它对红线虫、秀丽隐杆线虫和松材线虫具有杀线虫活性，ED50 值分别为 80、30 和 180 ug/mL。
T36563	(E)-Guggulsterone	Others	Others
	Bile acids are essential for solubilization and transport of dietary lipids, are the major products of cholesterol catabolism, and are physiological ligands for farnesoid X receptor (FXR), a nuclear receptor that regulates genes involved in lipid metabolism.1They are also inherently cytotoxic, as physiological imbalance contributes to increased oxidative stress.2,3Bile acid-controlled signaling pathways are promising novel targets to treat such metabolic diseases as obesity, type II diabetes, hy...

天然产物

Caprylic/Capric Triglyceride

Cat.No: T14862

Target: Others

Propane-1,2,3-triyl tripalmitate

Cat.No: TWO2727

Synonym: Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯

Target: Others, Endogenous Metabolite

Cat.No: T19676

Synonym: NSC661583,NSC 661583,NSC-661583,甘油三丁酸酯

Target: Apoptosis

Cat.No: T5544

Synonym: Furan-2-carboxylic acid,糠酸

Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase

Cat.No: T8272

Target: Others, Endogenous Metabolite

Secoisolariciresinol

Cat.No: TN2197

Target: TNF

Euphorbiasteroid

Cat.No: T3220

Synonym: Euphobiasteroid,Euphorbia factor L1,千金子甾醇

Target: Others, AMPK

Cat.No: T5242

Synonym: Triarachin,1,2,3-Trieicosanoyl Glycerol,Glycerol Trieicosanoate,三花生精

Target: Others, Endogenous Metabolite

Cat.No: T3921

Synonym: 安石榴甙,安石榴苷

Target: SARS-CoV, HBV

Dehydroabietic acid

Cat.No: TCS1772

Synonym: Dehydroabietate,脱氢松香酸

Target: Antifection

Tetramethylkaempferol

Cat.No: TN5137

Target: transporter, PPAR

Cat.No: TN3884

Target: transporter

tert-OMe-byakangelicin

Cat.No: T81013

Cat.No: TN3885

Target: transporter

Cat.No: TN3883

Target: transporter

13-Oxo-9E,11E-octadecadienoic acid

Cat.No: T10044

Target: PPAR

Cat.No: T81222

Cat.No: TN3882

Target: cAMP, Tyrosinase, transporter

Cat.No: T60692

Target: Others

5-Heneicosylresorcinol

Cat.No: TN3112

Target: NADPH-oxidase, Antifection

(E)-Guggulsterone

Cat.No: T36563

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01850	PNPLA2 Protein, Human, Recombinant (His & SUMO) Transport-secretion protein 2,Patatin-like phospholipase dom...	Human	E. coli
	PNPLA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 71.3 kDa and the accession number is Q96AD5.
TMPH-01612	LSR Protein, Human, Recombinant (His) Lipolysis-stimulated lipoprotein receptor,Angulin-1,LSR	Human	E. coli
	Probable role in the clearance of triglyceride-rich lipoprotein from blood. Binds chylomicrons, LDL and VLDL in presence of free fatty acids and allows their subsequent uptake in the cells.
TMPH-00491	PNLIPRP1 Protein, Canine, Recombinant (His) Inactive pancreatic lipase-related protein 1,PNLIPRP1	Canine	P. pastoris (Yeast)
	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Canine, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 51.7 kDa and the accession number is P06857.
TMPH-00492	PNLIPRP1 Protein, Canine, Recombinant (His & SUMO) Inactive pancreatic lipase-related protein 1,PNLIPRP1	Canine	E. coli
	May function as inhibitor of dietary triglyceride digestion. Lacks detectable lipase activity towards triglycerides, diglycerides, phosphatidylcholine, galactolipids or cholesterol esters (in vitro). PNLIPRP1 Protein, Canine, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 65.7 kDa and the accession number is P06857.
TMPH-02509	ANGPTL8 Protein, Mouse, Recombinant (E. coli, His) Angiopoietin-like protein 8,Lipasin,Gm6484,Refeeding-induced...	Mouse	E. coli
	Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3.
TMPK-00764	Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc) Apolipoprotein A-II(1-76),Apolipoprotein A-II,Apo-AII,APOA2,...	Human	HEK293 Cells
	APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.1 kDa and the accession number is P02652.
TMPK-00795	Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc) APOA2,Apolipoprotein A-II(1-76),Apolipoprotein A-II,Apolipop...	Mouse	HEK293 Cells
	APOA2 is a protein implicated in triglyceride, fatty acid and glucose metabolism. In pigs, the APOA2 gene is located on pig chromosome 4 (SSC4) in a QTL region affecting fatty acid composition, fatness and growth traits. Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 36.2 kDa and the accession number is P09813.
TMPK-01087	Apolipoprotein A-V/APOA5 Protein, Mouse, Recombinant (His) ApoA-V,Apolipoprotein A-V,Rap3,Apoa5,Apo-AV,Apolipoprotein A...	Mouse	E. coli
	APOA5 is probably the gene with the strongest effect on triglyceride (TG) metabolism. APOA5 is almost exclusively expressed in the liver, and its product apoAV has a very low circulating concentration. New physiological roles of apoAV have been recently elucidated, such as control of chylomicron production in the intestine and TG accumulation in adipose tissue.The key role of APOA5 in TG metabolism has been largely shown through genetic studies in association with either severe or moderate hyper...
TMPJ-01459	FGF-21 Protein, Cynomolgus, Recombinant (His) Fibroblast Growth Factor 21,FGF-21,FGF21	Cynomolgus	HEK293 Cells
	Fibroblast Growth Factor 21 (FGF21) is a growth factor that belongs to the FGF family. FGF family proteins play a central role during prenatal development and postnatal growth and regeneration of mamy tissues, by promoting cellular proliferation and differentiation. FGF21 is a potent activator of glucose uptake on adipocytes, protects animal from diet-induced obesity when overexpression in transgenic mice, and lower blood glucose and triglyceride levels when therapeutically adiministered to diab...
TMPH-02510	ANGPTL8 Protein, Mouse, Recombinant (His) Rifl,Refeeding-induced fat and liver protein,Betatrophin,Ang...	Mouse	P. pastoris (Yeast)
	Hormone that acts as a blood lipid regulator by regulating serum triglyceride levels. May be involved in the metabolic transition between fasting and refeeding: required to direct fatty acids to adipose tissue for storage in the fed state. According to a report, may act by promoting ANGPTL3 cleavage. According to another study, not required for cleavage of ANGPTL3. ANGPTL8 Protein, Mouse, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 22.5 kDa and the...
TMPJ-01196	ANGPTL8 Protein, Human, Recombinant (hFc) βtrophin,Angiopoietin-like protein 8,Lipasin,Angptl8,Betatro...	Human	HEK293 Cells
	The protein specifically promotes pancreatic beta cell proliferation and beta cell mass expansion, thereby improving glucose tolerance. It promotes pancreatic beta cell proliferation without insulin resistance. Also it acts as a blood lipid regulator by regulating serum triglyceride levels and possibly by promoting ANGPTL3 cleavage. It interacts with ANGPTL3. It predominantly expressed in liver and also expressed in adipose tissues. The ability of the protein to induce pancreatic beta cell proli...
TMPJ-00601	Apolipoprotein C-II/APOC2 Protein, Human, Recombinant (His) Apolipoprotein C2,Apolipoprotein C-II,APC2 and APOC2	Human	E. coli
	APOC2 activates the lipoprotein lipase in capillaries, which hydrolyzes triglycerides and thus provides free fatty acids for cells. APOC2 is component of the very low density lipoprotein (VLDL) fraction in plasma. It is also an activator of several triacylglycerol lipases. The association of APOC2 with plasma chylomicrons, VLDL, and HDL is reversible, a function of the secretion and catabolism of triglyceride-rich lipoproteins, and changes rapidly. Defects in APOC2 are the cause of hyperlipoprot...
TMPY-03222	PNLIP Protein, Human, Recombinant (His) PL,pancreatic lipase,PTL,PNLIPD	Human	HEK293 Cells
	PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which a...
TMPJ-00286	ANGPTL3 Protein, Human, Recombinant (hFc) ANGPTL3,ANGPT5,Angiopoietin-related protein 3,ANG-5,Angiopoi...	Human	HEK293 Cells
	Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits ...
TMPY-03353	CEL Protein, Mouse, Recombinant (His) 1810036E18Rik,carboxyl ester lipase,BAL	Mouse	Baculovirus Insect Cells
	CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations in CEL c...

重组蛋白

PNPLA2 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01850

Species: Human

Expression System: E. coli

LSR Protein, Human, Recombinant (His)

Cat.No: TMPH-01612

Species: Human

Expression System: E. coli

PNLIPRP1 Protein, Canine, Recombinant (His)

Cat.No: TMPH-00491

Species: Canine

Expression System: P. pastoris (Yeast)

PNLIPRP1 Protein, Canine, Recombinant (His & SUMO)

Cat.No: TMPH-00492

Species: Canine

Expression System: E. coli

ANGPTL8 Protein, Mouse, Recombinant (E. coli, His)

Cat.No: TMPH-02509

Species: Mouse

Expression System: E. coli

Apolipoprotein A-II/APOA2 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-00764

Species: Human

Expression System: HEK293 Cells

Apolipoprotein A-II/APOA2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00795

Species: Mouse

Expression System: HEK293 Cells

Apolipoprotein A-V/APOA5 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01087

Species: Mouse

Expression System: E. coli

FGF-21 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPJ-01459

Species: Cynomolgus

Expression System: HEK293 Cells

ANGPTL8 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02510

Species: Mouse

Expression System: P. pastoris (Yeast)

ANGPTL8 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-01196

Species: Human

Expression System: HEK293 Cells

Apolipoprotein C-II/APOC2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00601

Species: Human

Expression System: E. coli

PNLIP Protein, Human, Recombinant (His)

Cat.No: TMPY-03222

Species: Human

Expression System: HEK293 Cells

ANGPTL3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00286

Species: Human

Expression System: HEK293 Cells

CEL Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03353

Species: Mouse

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
T71306	Gemfibrozil-d6
	Gemfibrozil-d6 is intended for use as an internal standard for the quantification of gemfibrozil by GC- or LC-MS. Gemfibrozil is a peroxisome proliferator-activated reporter α and PPARγ agonist. In vivo, gemfibrozil reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif l...
T71305	Clofibric Acid-d4
	Clofibric acid-d4 is intended for use as an internal standard for the quantification of clofibric acid by GC- or LC-MS. Clofibric acid is a peroxisome proliferator-activated receptor α (PPARα) agonist (EC50 = 50 µM in a transactivation assay) and the active metabolite of clofibrate. It is formed from clofibrate by tissue and serum esterases. Dietary administration of clofibric acid (0.067-0.22%) reduces serum cholesterol, phospholipid, and triglyceride levels in rats. It decreases glutamate oxal...

同位素标记化合物

Cat.No: T71306

Clofibric Acid-d4

Cat.No: T71305

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