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Targets Recommended: c-Fms CSF-1R

4

抑制剂 & 化合物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T7100	PLX5622 PLX-5622	c-Fms; CSF-1R	Tyrosine Kinase/Adaptors
	PLX5622 是一种选择性的、高效的、能透过血脑屏障的、口服具有活性的 CSF1R 抑制剂 (IC50= 0.016 µM;Ki= 5.9 nM)，具有较好的药理学特性，可用于病程发展前和过程中，扩大的和特异性的小胶质细胞的消除。
T68474	RWJ-58643 HCl	Others	Others
	RWJ 58643 is a reversible beta-tryptase and trypsin inhibitor. Low-dose RWJ-58643 (100 microg) and budesonide (200 microg) significantly reduced symptoms, eosinophils and levels of IL-5 following NAC. However, higher doses of RWJ-58643 (300 and 600 microg) caused a late eosinophilia and preceding increases in IL-5 compared with placebo.
T70527	DAT-230	Others	Others
	DAT-230 is a promising microtubule inhibitor that has great potential for the treatment of fibrosarcoma in vitro and in vivo. DAT-230 exhibited potent anti-proliferative activity against various cancer cells. DAT-230 -treatment in HT-1080 cells resulted in microtubule de-polymerization and G2/M phase arrest preceding apoptosis. Phosphor-cdc2 (thr14/tyr15) reduction, cyclin B1 accumulation and aberrant spindles denoted the cyclin B1-cdc2 complex active and M phase arrest in HT-1080 cells treated ...
T12505	PLX5622 hemifumarate	c-Fms	Tyrosine Kinase/Adaptors
	PLX5622 hemifumarate 是高度选择性的、能透过血脑屏障的、具有口服活性的 CSF1R 抑制剂，IC50值为 0.016 μM，Ki 值为 5.9 nM，可用于病程发展前和过程中，扩大和特异性的小胶质细胞的消除。PLX5622 hemifumarate 具有较理想的药代动力学特性。

化合物

Cat.No: T7100

Synonym: PLX-5622

Target: c-Fms, CSF-1R

Cat.No: T68474

Target: Others

Cat.No: T70527

Target: Others

PLX5622 hemifumarate

Cat.No: T12505

Target: c-Fms

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03269	Prolyl Endopeptidase Protein, Mouse, Recombinant (His) PEP,AI450383,AI047692,D10Wsu136e,prolyl endopeptidase,Pop	Mouse	Baculovirus Insect Cells
	Prolyl endopeptidase, also known as PREP, belongs to a distinct class of serine peptidases. It is a large cytosolic enzyme which was first described in the cytosol of rabbit brain as an oligopeptidase. Prolyl endopeptidase degrades the nonapeptide bradykinin at the Pro-Phe bond. It is involved in the maturation and degradation of peptide hormones and neuropeptides such as alpha-melanocyte-stimulating hormone, luteinizing hormone-releasing hormone (LH-RH), thyrotropin-releasing hormone, angiotens...
TMPJ-00304	ALK-1 Protein, Mouse, Recombinant (hFc) TSR-I,Serine/threonine-protein kinase receptor R3,ALK-1,SKR3...	Mouse	HEK293 Cells
	Activin Receptor-Like Kinase 1 (ALK-1) is a type I cell-surface receptor for the TGF-β superfamily of ligands, which mediates signaling of BMP9 (bone morphogenetic protein) and BMP10. ALK1 signaling is necessary for angiogenesis during embryogenesis, wound healing, and tumor growth. ALK-1 has a high degree of similarity in serine-threonine kinase subdomains, a glycine and serine rich region preceding the kinase-domain, and a C-terminal tail with other activin receptor-like kinase proteins. ALK-1...
TMPY-02300	BIN1 Protein, Human, Recombinant (His) AMPHL,bridging integrator 1,AMPH2,SH3P9	Human	E. coli
	Amphiphysin 2, also named bridging integrator-1 (BIN1) or SH3P9, Amphiphysin2/BIN1 is a crescent-shaped N-BAR protein playing a key role in forming deeply invaginated tubes in muscle T-tubules, has been recently implicated in rare and common diseases affecting different tissues and physiological functions. BIN1 downregulation is linked to cancer progression and also correlates with ventricular cardiomyopathy and arrhythmia preceding heart failure. Increased BIN1 expression is linked to increased...

重组蛋白

Prolyl Endopeptidase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-03269

Species: Mouse

Expression System: Baculovirus Insect Cells

ALK-1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00304

Species: Mouse

Expression System: HEK293 Cells

BIN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02300

Species: Human

Expression System: E. coli

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