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Search Results for " ossification "

Targets Recommended: Others RAR/RXR

抑制剂 & 化合物

天然产物

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T23383	SR11237 SR 11237	Others; RAR/RXR	Metabolism; Others
	SR11237 是一种泛视黄醇 X 受体 (RXR) 激动剂。 SR11237 导致 RXR/RXR 同源二聚体形成并反式激活包含 RXR 反应元件的报告基因。
T1900	LDN-212854 LDN212854,BMP Inhibitor III	ALK; TGF-beta/Smad	Angiogenesis; Stem Cells; Tyrosine Kinase/Adaptors
	LDN-212854 (BMP Inhibitor III) 是一种新型BMP 抑制剂，抑制 ALK2 的IC50=1.3 nM，比对ALK1，ALK3，ALK4和ALK5的抑制性高2，66，1641和7135倍。
T84860	Zilurgisertib fumarate INCB-000928 fumarate, NBU-928 fumarate	Others	Others

T82929	AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG
	AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG 促进骨化作用。该化合物适用于研究成骨缺陷或骨矿物质密度（BMD）降低相关疾病，如骨质疏松症。

化合物

SR11237

Cat.No: T23383

Synonym: SR 11237

Target: Others, RAR/RXR

LDN-212854

Cat.No: T1900

Synonym: LDN212854,BMP Inhibitor III

Target: ALK, TGF-beta/Smad

Zilurgisertib fumarate

Cat.No: T84860

Synonym: INCB-000928 fumarate, NBU-928 fumarate

Target: Others

AVSEHQLLHDKGKSIQDLRRRFFLHHLI-{Aib}-EIHTAYRFGG

Cat.No: T82929

Synonym:

Target:

Cat. No.	Product Name	Target	Signaling Pathways
T12874	Secalciferol (24R)-24,25-Dihydroxyvitamin D3	Others	Others
	Secalciferol is a Vitamin D metabolite,Secalciferol is a possibly anti-inflammatory steroid which is involved in bone ossification.

天然产物

Secalciferol

Cat.No: T12874

Synonym: (24R)-24,25-Dihydroxyvitamin D3

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02552	BMP3 Protein, Mouse, Recombinant (Myc) Bone morphogenetic protein 3,Bmp3,BMP-3	Mouse	E. coli
	Negatively regulates bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification.
TMPH-01528	IHH Protein, Human, Recombinant (His) HHG-2,IHH,Indian hedgehog protein	Human	E. coli
	Intercellular signal essential for a variety of patterning events during development. Binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. Implicated in endochondral ossification: may regulate the balance between growth and ossification of the developing bones. Induces the expression of parathyroid hormone-related protein (PTHRP).
TMPH-02594	MMP-13 Protein, Mouse, Recombinant (His) Matrix metalloproteinase-13,Collagenase 3,Mmp13	Mouse	E. coli
	Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone develop...
TMPH-02277	PTPN11 Protein, Human, Recombinant (T253M & Q257L, His) Protein-tyrosine phosphatase 1D,Tyrosine-protein phosphatase...	Human	E. coli
	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulation of its RhoA binding activity. Dephosphorylates CDC73. Dephosphorylates SOX9 on tyrosine residues, leading to inactivate SOX9 and promote ossification.
TMPH-01015	BMP-3 Protein, Human, Recombinant (His) BMP3A,Bone morphogenetic protein 3A,BMP3,Osteogenin,Bone mor...	Human	E. coli
	Growth factor of the TGF-beta superfamily that plays an essential role in developmental process by inducing and patterning early skeletal formation and by negatively regulating bone density. Antagonizes the ability of certain osteogenic BMPs to induce osteoprogenitor differentitation and ossification. Initiates signaling cascades by associating with type II receptor ACVR2B to activate SMAD2-dependent and SMAD-independent signaling cascades including TAK1 and JNK pathways. BMP-3 Protein, Human, R...
TMPJ-01390	MINPP1 Protein, Human, Recombinant (His) 3,4,5)-Tetrakisphosphate 3-Phosphatase,2,5)P(4) 3-Phosphatas...	Human	HEK293 Cells
	Multiple Inositol Polyphosphate Phosphatase 1/MINPP1 is an enzyme that removes 3-phosphate from inositol phosphate substrates. MINPP1 also converts 2,3 bisphosphoglycerate (2,3-BPG) to 2-phosphoglycerate. MINPP1 is synthesized as a 487 amino acid precursor that contains an 30 amino acid signal peptide and a 457 amino aicd mature chain. MINPP1 is widely expressed with the highest levels found in kidney, liver and placenta. It acts as a phosphoinositide 5- and phosphoinositide 6-phosphatase and re...
TMPY-01817	GDF-10 Protein, Mouse, Recombinant (hFc) growth differentiation factor 10,Bmp3b	Mouse	HEK293 Cells
	BMP-3b / GDF-10 is a member of the bone morphogenetic protein (BMP) family and the TGF-beta superfamily. This group of proteins is characterized by a polybasic proteolytic processing site which is cleaved to produce a mature protein containing seven conserved cysteine residues. The members of this family are regulators of cell growth and differentiation in both embryonic and adult tissues. Studies in mice suggest that the protein encoded by this gene plays a role in skeletal morphogenesis. In th...