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Search Results for " nicotinamide mononucleotide "

Targets Recommended: NAMPT

2

抑制剂 & 化合物

1

天然产物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T12854	SBI-797812	NAMPT	Metabolism
	SBI-797812 是在结构上类似于活性位点定向的 NAMPT 抑制剂的化合物，能够阻断这些抑制剂与 NAMPT 的结合。它将 NAMPT 反应平衡转向 NMN 形成，提高 NAMPT 对 ATP 的亲和力，稳定 His247 处的磷酸化 NAMPT，增加焦磷酸盐副产物的消耗，并通过 NAD+钝化反馈抑制。
T13907	Sulfo-ara-F-NMN CZ-48	Others	Others
	Sulfo-ara-F-NMN 是一种具有细胞渗透性的烟酰胺单核苷酸 (NMN) 的类似物。Sulfo-ara-F-NMN 对激活 SARM1具有选择性，对 CD38具有抑制作用， IC50 约为 10 μM。Sulfo-ara-F-NMN 对具有更高的环化酶活性 CZ-48或 NMN 的激活会引起 SARM1的构象变化，导致 cADPR 的产生、NAD 的消耗和非凋亡细胞死亡。

化合物

Cat.No: T12854

Target: NAMPT

Sulfo-ara-F-NMN

Cat.No: T13907

Synonym: CZ-48

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4721	β-Nicotinamide mononucleotide NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸	Others; Endogenous Metabolite	Metabolism; Others
	β-nicotinamide mononucleotide 是烟酰胺磷酸核糖转移酶 (NAMPT) 反应的产物。β-nicotinamide mononucleotide的作用包括其在细胞生化功能、心脏保护、糖尿病、肥胖相关并发症和阿尔茨海默病中的作用。

天然产物

β-Nicotinamide mononucleotide

Cat.No: T4721

Synonym: NMN,β-NM,β烟酰胺单核苷酸,烟酰胺单核苷酸

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02811	NRK1 Protein, Mouse, Recombinant (His) Ribosylnicotinamide kinase 1,Nmrk1,Ribosylnicotinic...	Mouse	E. coli
	Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN).
TMPY-02577	NAMPT Protein, Human, Recombinant (His & GST) VISFATIN,PBEF,PBEF1,1110035O14Rik,VF,nicotinamide p...	Human	Baculovirus Insect Cells
	Nicotinamide phosphoribosyltransferase (NAMPT), also known as pre-B-cell colony-enhancing factor 1 (PBEF1) or visfatin, is an enzyme belonging to the family of glycosyltransferases, to be specific, the pentosyltransferases. This enzyme participates in nicotinate and nicotinamide metabolism. This enzyme catalyzes the condensation of nicotinamide with 5- phosphoribosyl-1- pyrophosphate to yield nicotinamide mononucleotide, one step in the biosynthesis of nicotinamide adenine dinucleotide. NAMPT is...
TMPY-03406	NMNAT1 Protein, Human, Recombinant (His) PNAT1,LCA9,nicotinamide nucleotide adenylyltransfer...	Human	Baculovirus Insect Cells
	NMNAT, also known as NMNAT1, is a member of the Nicotinamide-nucleotide adenylyltransferases. It is widely expressed with high levels in skeletal muscle, heart, liver, and kidney. NMNAT appears to have the ability to protect against axonal degeneration following mechanical or toxic insults. The coenzyme NAD and its derivatives are involved in hundreds of metabolic redox reactions and are utilized in protein ADP-ribosylation, histone deacetylation, and in some Ca(2+) signaling pathways. NMNAT enz...
TMPH-00673	NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His) NAD-capped RNA hydrolase NudC,nudC,NADH pyrophosphatase	E. coli	E. coli
	mRNA decapping enzyme that specifically removes the nicotinamide adenine dinucleotide (NAD) cap from a subset of mRNAs by hydrolyzing the diphosphate linkage to produce nicotinamide mononucleotide (NMN) and 5' monophosphate mRNA. The NAD-cap is present at the 5'-end of some mRNAs and stabilizes RNA against 5'-processing. Has preference for mRNAs with a 5'-end purine. Catalyzes the hydrolysis of a broad range of dinucleotide pyrophosphates. NADH pyrophosphatase Protein, E. coli O157:H7, Recombina...

重组蛋白

NRK1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02811

Species: Mouse

Expression System: E. coli

NAMPT Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-02577

Species: Human

Expression System: Baculovirus Insect Cells

NMNAT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03406

Species: Human

Expression System: Baculovirus Insect Cells

NADH pyrophosphatase Protein, E. coli O157:H7, Recombinant (His)

Cat.No: TMPH-00673

Species: E. coli

Expression System: E. coli

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