112
5
46
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T36670 |
JNJ-67856633
|
MALT | Immunology/Inflammation |
JNJ-67856633 是口服有效的、选择性的、变构性的 MALT1 protease 抑制剂。在某些情况下,JNJ-67856633可以导致肿瘤停滞。 | |||
T16040 |
Mepazine
甲哌啶嗪,Pecazine |
Apoptosis; MALT | Apoptosis; Immunology/Inflammation |
Mepazine (Pecazine) 是一种有效的特异性 MALT1 抑制剂。 Mepazine 抑制 GSTMALT1 全长和 GSTMALT1 325-760,IC50 为 0.83 μM 和 0.42 μM。 Mepazine 增强细胞凋亡并影响细胞活力。 | |||
T9216 |
MLT-943
MLT943 |
MALT | Immunology/Inflammation |
ML-943 是选择性的、口服活性的MALT1 protease 抑制剂。它可抑制 PBMC 或全血中 IL-2 的分泌,PBMC 中抑制的IC50值为 0.07~0.09 μM,全血中抑制的IC50值为 0.6~0.8 μM)。它具有抗炎作用,可用于研究 FcgR 介导的炎症。 | |||
T2558 |
Cladribine
2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA |
Apoptosis; Adenosine deaminase | Apoptosis; Metabolism |
Cladribine (2CdA) 是一种嘌呤核苷类似物,是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂,可阻断受损 DNA 的修复。它可抑制 DNA 甲基化,具有抗淋巴瘤活性,可研究血液恶性肿瘤和多发性硬化。 | |||
T2350 |
MALT1 inhibitor MI-2
MALT1 inhibitor,MI 2,MI 2 (MALT1 inhibitor) |
MALT | Immunology/Inflammation |
MI 2 (MALT1 inhibitor) 是一种MALT1抑制剂 (IC50=5.84 μM),对动物无毒性。它能够直接与 MALT1 结合,不可逆地抑制蛋白酶功能,并伴有 NF-κB 报告子活性抑制、c-REL 核定位抑制和 NF-κB 靶基因下调。 | |||
T16551 |
Pladienolide B
|
Apoptosis | Apoptosis |
Pladienolide B 是一种有效的剪接体抑制剂,是从钝顶链霉菌 Mer-12 中分离出的大环内酯类化合物,其作用靶向剪接体的 SF3B1 亚单位。Pladienolide B 通过抑制前 mRNA 剪接发挥抗肿瘤作用,诱导调亡。Pladienolide B 具有抗肿瘤活性,可用于研究白血病和淋巴肿瘤。 | |||
TNU0352 |
1-beta-D-Arabinofuranosylthymine
Thymine 1-β-D-arabinofuranoside,Spongothymidine |
Apoptosis | Apoptosis |
1-beta-D-Arabinofuranosylthymine (Thymine 1-β-D-arabinofuranoside) is a purine nucleoside analog. Purine nucleoside analogs have a broad spectrum of antitumor activity, targeting inert lymphoid malignancies and inducing apoptosis.1-beta-D-Arabinofuranosylthymine's anticancer mechanism is dependent on the inhibition of DNA synthesis.1-beta-D-Arabinofuranosylthymine is a purine nucleoside analog. | |||
T4215 |
TCS-PIM-1-4a
5-[[3-(三氟甲基)苯基]亚甲基]-2,4-噻唑烷二酮,SMI-4a |
Apoptosis; Pim | Apoptosis; Chromatin/Epigenetic; JAK/STAT signaling |
TCS-PIM-1-4a (SMI-4a) 是一种泛-Pim 激酶抑制剂,可通过激活 AMPK 来阻断 mTORC1的活性。它可杀死多种髓样和淋巴样细胞系,IC50值为 0.8 μM 至 40 μM。 | |||
T22922 |
Lenalidomide hemihydrate
|
TNF; Ligand for E3 Ligase; Molecular Glues | Apoptosis; PROTAC |
Lenalidomide hemihydrate 是 Thalidomide 的衍生物,也是具有口服活性免疫调节剂,以分子胶的方式作用。它是泛素 E3 连接酶 cereblon 的配体,通过 CRBN-CRL4 泛素连接酶对两种淋巴转录因子 IKZF1 和 IKZF3 进行选择性泛素化和降解。 | |||
T7084 |
2-Bromo-4'-hydroxyacetophenone
SHP-1 Inhibitor II,PTP Inhibitor I,α-Bromo-4-hydroxyacetophenone,4-Hydroxyphenacyl bromide,2-溴-4'-羟基苯乙酮 |
Phosphatase | Metabolism |
2-Bromo-4'-hydroxyacetophenone(PTP Inhibitor I) 是一种PTP1B 的有效抑制剂,其Ki=42 μM。 | |||
T36944 |
Ara-G
|
Nucleoside Antimetabolite/Analog | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Ara-G 是一种脱氧鸟苷 (GdR) 类似物和核苷类似物,可被 T 淋巴谱系细胞迅速转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸 (araGTP),从而抑制 DNA 合成和对 T 淋巴母细胞的选择性体外毒性细胞系以及来自 T 细胞急性淋巴细胞白血病 (ALL) 患者的新鲜分离的白血病细胞。 | |||
T69228 |
E3P13
|
Others | Others |
E3P13 is a novel lymphoid tyrosine phosphatase (LYP) inhibitor. | |||
T28143 |
ND-2110
ND2110 |
Others | Others |
ND-2110, a selective interleukin-1 receptor-associated kinase 4 inhibitors, is used for the treatment of autoimmune disorders and lymphoid malignancy. | |||
T69242 |
NC1
|
Others | Others |
NC1 is a novel highly active allosteric inhibitor of protein tyrosine phosphatase, non-receptor type 22 (PTPN22) which is a lymphoid-specific tyrosine phosphatase (LYP). | |||
T68411 |
AT-7519M
|
Others | Others |
AT-7519M is a small molecule inhibitor of cyclin-dependent kinases 1, 2, 4, 5, and 9 with in vitro activity against lymphoid malignancies. | |||
T24990 |
8-Deazafolic acid
NSC-173522,NSC173522,NSC 173522 |
Others | Others |
8-Deazafolic acid is a potent folate-dependent bacteria inhibitor, Streptococcus faecium (ATCC 8043) and Lactobacillus casei (ATCC 7469), and to have activity against lymphoid leukemia L1210 in mice. | |||
T36879 |
L-Leucyl-L-Leucine methyl ester hydrobromide
|
Others | Others |
The lysosomotropic dipeptide LLME has selective toxicity for NK cells, CTL, and M phi without adverse effects on a variety of other lymphoid or nonlymphoid cell types. See also E-2080. | |||
T26968 |
CCT036477
CCT 036477,CCT-036477 |
Others | Others |
CCT036477 is a selective inhibitor of wingless-type MMTV integration site family dependent transcription. CCT036477reduces the transcriptional activity of the T-cell factor and lymphoid enhancer factor transcription factor family at the ß-catenin level. | |||
T61698 |
TK4g
|
Others | Others |
TK4g is a potent Janus kinase (JAK) inhibitor, demonstrating IC50 values of 12.61 nM and 15.80 nM against JAK2 and JAK3, respectively. It holds promise for research focused on lymphoid-derived diseases and leukemia cancer [1]. | |||
T11889 | LTV-1 | Others | Others |
LTV-1 has the potential for autoimmunity treatment. LTV-1 is a potent lymphoid tyrosine phosphatase (LYP) inhibitor in T cells with an IC50 of 508 nM. | |||
T75212 |
Confiden
|
Others | Others |
Confiden 为一种嘌呤核苷类似物,广泛抗肿瘤活性,针对惰性淋巴系统恶性肿瘤。其抗癌机制通过抑制DNA合成及诱导细胞凋亡(apoptosis)实现。 | |||
TP1014 |
Z-VRPR-FMK (TFA)
VRPR |
||
Z-VRPR-FMK (TFA) (VRPR) is a tetrapeptide and a selective and irreversible inhibitor of lymphoma translocation protein 1 (MALT1) in mucosa-associated lymphoid tissue. | |||
T75221 |
2’-O-Me-5-I-U-3’-phosphoramidite
|
Others | Others |
2’-O-Me-5-I-U-3’-phosphoramidite 为一种嘌呤核苷类似物,以抗肿瘤活性广泛,主要针对惰性淋巴系统恶性肿瘤。其作用机制主要通过抑制 DNA 合成及诱导细胞凋亡(apoptosis)实现。 | |||
T75188 |
2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium
|
Others | Others |
2’-Deoxy-2’-fluorouridine 5’-monophosphate triethyl ammonium 为嘌呤核苷类似物,主要拥有广泛的抗肿瘤活性,并针对惰性淋巴系统恶性肿瘤。其抗癌作用机制涉及抑制 DNA 合成和诱导细胞凋亡(apoptosis)等过程。 | |||
T75200 |
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine
|
Others | Others |
N4-Acetyl-5’-O-(4,4’-dimethoxytrityl)-5-methyl-2’-deoxycytidine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统的恶性肿瘤。其抗癌机制涉及抑制DNA合成及诱导细胞凋亡(apoptosis)等作用。 | |||
T75056 |
N1-Methyl-2’-beta-C-methyl adenosine
|
Others | Others |
N1-Methyl-2’-beta-C-methyl adenosine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要靶向惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡 (apoptosis) 实现。 | |||
T75201 |
5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite
|
Others | Others |
5’-O-DMTr-5-MedC (Ac)-methyl phosphonamidite 是一种嘌呤核苷类似物,主要具有抗肿瘤活性,并且能够针对惰性淋巴系统中的恶性肿瘤。其抗癌机制包括抑制 DNA 合成以及诱导细胞凋亡 (apoptosis)。 | |||
T75055 |
N1-Methyl-2’-beta-C-methyl inosine
|
Others | Others |
N1-Methyl-2’-beta-C-methyl inosine 是一种嘌呤核苷类似物,主要针对惰性淋巴系统的恶性肿瘤展现出广泛的抗肿瘤活性。其作用机制包括抑制 DNA 合成和诱导细胞凋亡(apoptosis)。 | |||
T75206 |
Rev 2’-O-MOE-C(Bz)-5’-amidite
|
Others | Others |
Rev 2’-O-MOE-C(Bz)-5’-amidite 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统恶性肿瘤。其抗癌机制包括抑制 DNA 合成和诱导细胞凋亡 (apoptosis)。 | |||
T75186 |
5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine
|
Others | Others |
5’-O-Benzoyl-3’-O-(4-methoxybenzyl)-2’-O,4’-C-methyleneuridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统的恶性肿瘤。其作用机制主要通过抑制 DNA 合成和诱导细胞凋亡 (apoptosis) 实现。 | |||
T75204 |
3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridine
|
Others | Others |
3’-O-(4,4’-Dimethoxy trityl)-2’-O-(2-methoxyethyl)-5-methyluridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要用于靶向惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡(apoptosis)实现。 | |||
T75069 |
N6-Methyl-2’-beta-C-ethynyl adenosine
|
Others | Others |
N6-Methyl-2’-beta-C-ethynyl adenosine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成,诱导细胞凋亡 (apoptosis) 等。 | |||
T75191 |
2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate ammonium
|
Others | Others |
2’-O-(2-Methoxyethyl)guanosine 5’-triphosphate (ammonium) 为一种嘌呤核苷类似物,主要针对惰性淋巴系统恶性肿瘤展现出广泛的抗肿瘤活性。其作用机制包括抑制 DNA 合成与诱导细胞凋亡(apoptosis),从而实现其抗癌效果。 | |||
T75075 |
4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide
|
Others | Others |
4-Amino-1-(β-D-ribofuranosyl)-7H-pyrrolo[2.3-d]pyrimidine-5-carboxamide 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统恶性肿瘤。其作用机制包括抑制DNA合成和诱导细胞凋亡(apoptosis)。 | |||
T75220 |
5-Aza-xylo-cytidine
|
Others | Others |
5-Aza-xylo-cytidine为嘌呤核苷类似物,拥有针对惰性淋巴系统恶性肿瘤的广泛抗肿瘤活性。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。 | |||
T75211 |
Confidential-2
|
Others | Others |
Confidential-2 为嘌呤核苷类似物,具广泛抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。其抗癌机制通过抑制 DNA 合成及诱导细胞凋亡(apoptosis)实现。 | |||
T61020 |
TK4b
|
Others | Others |
TK4b 可用于淋巴源性疾病和白血病癌症的研究。TK4b 是一种Janus 激酶(JAK) 抑制剂,其对 JAK3 和 JAK2 的IC50值分别为 18.42 nM 和19.40 nM。 | |||
T75036 |
N1-(2-Methyl)propyl pseudouridine
|
Others | Others |
N1-(2-Methyl)propyl pseudouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要用于靶向惰性淋巴系统恶性肿瘤。其抗癌机制包括抑制 DNA 合成和诱导细胞凋亡(apoptosis)。 | |||
T75066 |
N1-Methylxylo-guanosine
|
Others | Others |
N1-Methylxylo-guanosine 为一种具备广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统恶性肿瘤。其抗癌机制涉及抑制 DNA 合成与诱导细胞凋亡(apoptosis)。 | |||
TNU1041 |
3’-Deoxy-1,2-O-isopropylidene-5-O-(p-toluoyl)-L-arabinofuranose
|
Others | Others |
3’-Deoxy-1,2-O-isopropylidene-5-O-(p-toluoyl)-L-arabinofuranose 是一种嘌呤核苷类似物,通过抑制DNA 合成、诱导细胞凋亡发挥抗肿瘤活性,它可以靶向惰性淋巴系统恶性肿瘤。 | |||
T75054 |
8-Chloro-2’-O-methyl inosine
|
Others | Others |
8-Chloro-2’-O-methyl inosine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,特别是针对惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡(apoptosis)来实现。 | |||
T75198 |
2’-O,4’-C-Methyleneadenosine 5’-monophosphate triethylammonium
|
Others | Others |
2’-O,4’-C-Methyleneadenosine 5’-monophosphate (triethylammonium) 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统的恶性肿瘤。其作用机制涉及抑制 DNA 合成和诱导细胞凋亡(apoptosis)。 | |||
T75038 |
N1-Benzoyl pseudouridine
|
Others | Others |
N1-Benzoyl pseudouridine 是嘌呤核苷类似物,广泛应用于靶向惰性淋巴系统恶性肿瘤的抗肿瘤活性中。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。 | |||
T75215 |
3’-Deoxy-N1-Methyl inosine
|
Others | Others |
3’-Deoxy-N1-Methyl inosine为嘌呤核苷类似物,具备广谱抗肿瘤活性,专门靶向惰性淋巴系统中的恶性肿瘤。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。 | |||
T75073 |
6-Mthoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine
|
Others | Others |
6-Mthoxy-9-beta-D-(2-C-ethynyl-ribofuranosyl) purine 是一种嘌呤核苷类似物。嘌呤核苷类似物具有广泛的抗肿瘤活性,靶向惰性淋巴系统恶性肿瘤。这一过程中的抗癌机制依赖于抑制 DNA 合成,诱导细胞凋亡 (apoptosis) 等。 | |||
T75234 |
2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]uridine
|
Others | Others |
2’-Deoxy-2’-fluoro-N3-[(pyrid-4-yl)methyl]uridine 是一种嘌呤核苷类似物,以其广泛的抗肿瘤活性而闻名,主要针对惰性淋巴系统的恶性肿瘤。其抗癌机制主要通过抑制 DNA 合成和诱导细胞凋亡(apoptosis)实现。 | |||
T75053 |
3’-β-C-Methyl-2-thiouridine
|
Others | Others |
3’-β-C-Methyl-2-thiouridine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要通过抑制DNA合成及诱导细胞凋亡(apoptosis)等机制,靶向惰性淋巴系统恶性肿瘤。 | |||
T75087 |
Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester
|
Others | Others |
Uridine-5-oxo-acetyl-(9-fluorenylmethyl) ester 为一种嘌呤核苷类似物,广泛显示出抗肿瘤活性,并针对惰性淋巴系统恶性肿瘤。其抗癌机制主要通过抑制DNA合成和诱导细胞凋亡(apoptosis)实现。 | |||
T75077 |
2’-β-C-Methyl-3-deazauri dine
|
Others | Others |
2’-β-C-Methyl-3-deazauridine 是嘌呤核苷类似物,广泛应用于靶向惰性淋巴系统恶性肿瘤的抗肿瘤活性中。其主要通过抑制 DNA 合成及诱导细胞凋亡(apoptosis)等机制发挥抗癌作用。 | |||
T75203 |
2-(P-Cyanophenyl methylidene hydrazino) adenosine
|
Others | Others |
2-(P-Cyanophenyl methylidene hydrazino) adenosine 是一种具有广泛抗肿瘤活性的嘌呤核苷类似物,主要针对惰性淋巴系统恶性肿瘤。其抗癌机制包括抑制DNA合成和诱导细胞凋亡(apoptosis)。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T13818 |
Phytohemagglutinin
PHA-M,植物血球凝集素,PHA,植物血凝素 |
Apoptosis | Apoptosis |
Phytohemagglutinin (PHA-M) 是一种普通豆菜豆的主要种子凝集素,聚集在子叶的薄壁细胞中。它是一种 T 细胞激活剂,能够刺激人单核白细胞,可诱导 ChAT mRNA 表达,增强 ACh 合成。 | |||
TNU0052 |
Nebularine
9-(beta-D-Ribofuranosyl)-9H-purine |
Apoptosis | Apoptosis |
Nebularine (9-(beta-D-Ribofuranosyl)-9H-purine),是一种嘌呤核苷类似物,具有广谱的抗肿瘤活性,针对惰性淋巴恶性肿瘤并诱导凋亡。Nebularine的抗癌机制依赖于抑制DNA合成。 | |||
T78491 |
Phytohemagglutinin P
PHA-P |
Others | Others |
Phytohemagglutinin P(PHA-P)是一类植物凝集素,以选择性方式激活血源性或淋巴样单核细胞的有丝分裂。 | |||
TN4799 |
Piptocarphin F
|
Others | Others |
Piptocarphin F shows strong cytotoxic activities against mouse lymphoid tumor cell line P388. It also shows cytotoxic activity (IC50 3.87-12.5 umol/L) against the human leukemic cell line HL-60. | |||
TN4798 |
Piptocarphin A
|
Others | Others |
Piptocarphin A shows strong cytotoxic activity against mouse lymphoid tumor cell line P388 with the IC(50) value of 0.77 microM. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-00272 |
RELT/TNFRSF19L Protein, Human, Recombinant (hFc)
RELT,TNFRSF19L,Receptor expressed in lymphoid tissu... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 19L (TNFRSF19L), also known as Receptor expressed in lymphoid tissues and RELT, is a member of the TNF-receptor superfamily. TNFRSF19L is a single-pass type membrane protein and contains one TNFR-Cys repeat. TNFRSF19L is highly expressed in spleen, lymph node, thymus, peripheral blood leukocytes, bone marrow and fetal liver. It has been shown TNFRSF19L activates the NF-kappaB pathway and selectively binds TNF receptor-associated factor 1 (TRAF1).... | |||
TMPH-01526 |
KMT2E Protein, Human, Recombinant (His & Myc)
Inactive histone-lysine N-methyltransferase 2E,Myeloid/l... |
Human | E. coli |
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r... | |||
TMPH-01242 |
IKZF1 Protein, Human, Recombinant (Avi & His)
DNA-binding protein Ikaros,Ikaros family zinc finger protein... |
Human | E. coli |
IKZF1 Protein, Human, Recombinant (Avi & His) is expressed in E. coli expression system with N-6xHis-Avi tag. The predicted molecular weight is 56.8 kDa and the accession number is Q13422. | |||
TMPH-03283 |
CD39 Protein, Rat, Recombinant (His)
ATP diphosphohydrolase,Entpd1,Nucleoside triphosphate diphos... |
Rat | Baculovirus Insect Cells |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. | |||
TMPH-03284 |
CD39 Protein, Rat, Recombinant (E. coli, His)
Entpd1,ATP-DPH,Ecto-ATP diphosphohydrolase 1,CD39,Ecto-ATPas... |
Rat | E. coli |
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. | |||
TMPJ-00994 |
LTBR Protein, Mouse, Recombinant (hFc)
Tnfcr,Lymphotoxin-beta receptor,Tumor necrosis factor recept... |
Mouse | HEK293 Cells |
It is a single-pass type I membrane protein and contains 4 TNFR-Cys repeats. The protein is a member of the tumor necrosis factor (TNF) family of receptors. It is expressed on the surface of most cell types, including cells of epithelial and myeloid lineages, but not on T and B lymphocytes. The protein is the receptor for the heterotrimeric lymphotoxin containing LTA and LTB, and for TNFS14/LIGHT. It promotes apoptosis via TRAF3 and TRAF5 and may play a role in the development of lymphoid organs... | |||
TMPJ-01470 |
SCF Protein, Human, Recombinant
Mast Cell Growth Factor,c-Kit ligand,KITLG,MGF,Stem Cell Fac... |
Human | E. coli |
Stem Cell Factor (SCF) is a hematopoietic growth factor that exerts its activity at the early stages of hematopoiesis. SCF stimulates the proliferation of myeloid, erythroid, and lymphoid progenitors in bone marrow cultures and has been shown to act synergistically with colony stimulating factors. | |||
TMPJ-00059 |
IL-7 Protein, Human, Recombinant (His)
Interleukin-7,IL7,白细胞介素,IL-7,白介素 |
Human | HEK293 Cells |
Human Interleukin 7 (IL-7) is a potent lymphoid cell growth factor stimulating the proliferation of lymphoid progenitors. IL7 can associate with the hepatocyte growth factor (HGF) to form a hybrid cytokine that functions as a pre-pro-B cell growth-stimulating factor. Human IL7 cDNA encodes a 177 amino acid precursor protein containing a 25 amino acid signal peptide and a 152 amino acid mature protein. Human and mouse IL7 share 65% sequence identity in the mature region and both exhibit cross-spe... | |||
TMPJ-00779 |
TNF alpha Protein, Rabbit, Recombinant
TNF-a,Tumor Necrosis Factor,TNF-α,TNF α,Cachectin,肿瘤坏死因子,Tum... |
Rabbit | E. coli |
Tumor necrosis factor alpha (TNFα) is the prototypic ligand of the TNF superfamily. TNFα forms a homotrimer and functions by activating two types of receptors TNF-R1 (TNF receptor type 1,p55R) and TNF-R2 (TNF receptor type 2,p75R). TNFα is a pleiotropic cytokine that is capable to promote inflammation, to induce apoptotic cell death, and to inhibit tumorigenesis and viral replication. TNFα is a potent lymphoid factor that exerts cytotoxic effects on a wide range of tumor cells and certain other ... | |||
TMPJ-00154 |
IL-15RA Protein, Mouse, Recombinant (hFc, Human Cells)
sIL-15 receptor subunit α,Il15ra,Interleukin-15 receptor sub... |
Mouse | HEK293 Cells |
Mouse interleukin-15 receptor subunit alpha, also known as Il15ra, is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits (Common gamma chain, or gamma c) to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells. Human Il... | |||
TMPJ-00038 |
IL-7 Protein, Mouse, Recombinant (His)
interleukin-7,白介素,IL-7,IL-7 interleukin-7,PBGF,Lymphopoietin... |
Mouse | HEK293 Cells |
Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell... | |||
TMPY-02153 |
TNF beta Protein, Human, Recombinant
LT,TNF β,TNFSF1,肿瘤坏死因子,TNFB,lymphotoxin alpha,lymphotoxin α |
Human | E. coli |
Lymphotoxin-alpha, also known as LT-alpha, TNF-beta, Tumor necrosis factor ligand superfamily member 1, LTA TNFSF1, and TNFB, is a secreted protein that belongs to the tumor necrosis factor family. TNF-beta/TNFSF1/Lymphotoxin alpha is highly inducible, secreted, and exists as a homotrimeric molecule. It is a cytokine that in its homotrimeric form binds to TNFRSF1A / TNFR1, TNFRSF1B / TNFBR, and TNFRSF14 / HVEM. In its heterotrimeric form with LTB, TNF-beta/TNFSF1/Lymphotoxin alpha binds to TNFRS... | |||
TMPY-00828 |
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
MPS2,IDS,SIDS,iduronate 2-sulfatase |
Human | HEK293 Cells |
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, an... | |||
TMPJ-01461 |
IL-15RA & IL-15 Protein, Human, Recombinant (hFc)
IL-15 Receptor α & IL-15 Fusion Protein,Interleukin-15,IL15R... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPJ-01462 |
IL-15RA & IL-15 Protein, Human, Recombinant - PBS Lyophilized (hFc)
IL15,IL15RA&IL15,IL-15,Interleukin-15,IL-15 Receptor α & IL-... |
Human | HEK293 Cells |
IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 ... | |||
TMPK-00631 |
DR3/TNFRSF25 Protein, Mouse, Recombinant (His)
TRAMP,TNFRSF12,WSL1,LARD,DR3,WSL,DDR3,TR3,TNFRSF25,APO3,WSL-... |
Mouse | HEK293 Cells |
TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. | |||
TMPH-00281 |
IL-7 Protein, Bovine, Recombinant (His)
IL7,Interleukin-7 |
Bovine | E. coli |
Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. IL-7 Protein, Bovine, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.3 kDa and the accession number is P26895. | |||
TMPJ-00515 |
HCLS1 Protein, Human, Recombinant (His)
p75,Hematopoietic cell-specific LYN substrate 1,LckBP1,Hemat... |
Human | HEK293 Cells |
Hematopoietic lineage cell-specific protein (HCLS1) is a protein that in humans is encoded by the HCLS1 gene. It is expressed only in tissues and cells of hematopoietic origin. It is substrate of the antigen receptor-coupled tyrosine kinase and plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. It may also be involved in the regulation of gene expression. | |||
TMPK-01169 |
IL-23 P19/IL23A Protein, Mouse, Recombinant (His & Avi), Biotinylated
Interleukin-23 subunit α,Interleukin-23 subunit alpha,IL-23 ... |
Mouse | HEK293 Cells |
The heterodimeric cytokine interleukin-23 (IL-23 or IL23A/IL12B) is produced by dendritic cells and macrophages and promotes the proinflammatory and regenerative activities of T helper 17 (Th17) and innate lymphoid cells. A recent study has reported that IL-23 is also secreted by lung adenoma cells and generates an inflammatory and immune-suppressed stroma. | |||
TMPH-02220 |
SPI1 Protein, Human, Recombinant (His)
Transcription factor PU.1,31 kDa-transforming protein,SPI1 |
Human | E. coli |
Binds to the PU-box, a purine-rich DNA sequence (5'-GAGGAA-3') that can act as a lymphoid-specific enhancer. This protein is a transcriptional activator that may be specifically involved in the differentiation or activation of macrophages or B-cells. Also binds RNA and may modulate pre-mRNA splicing. | |||
TMPK-00234 |
CD84 Protein, Human, Recombinant (His & Avi)
CD84,DKFZp781E2378,Hly9-beta,Hly9-β,CD84 molecule,SLAMF5,LY9... |
Human | HEK293 Cells |
Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells. | |||
TMPY-03394 |
RYBP Protein, Human, Recombinant (His & GST)
DEDAF,RING1 and YY1 binding protein,AAP1,YEAF1 |
Human | Baculovirus Insect Cells |
APAP-1, also known as AAP1 and RYBP, is widely expressed. It is highest expressed in lymphoid tissues and placenta. APAP-1 contains 1 RanBP2-type zinc finger. It may bind to DNA. APAP-1 inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes. It may be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1. APAP-1 also promotes apoptosis. | |||
TMPH-03247 |
Artemin Protein, Rat, Recombinant (His & Myc)
Artemin,Artn |
Rat | E. coli |
Ligand for the GFR-alpha-3-RET receptor complex but can also activate the GFR-alpha-1-RET receptor complex. Supports the survival of sensory and sympathetic peripheral neurons in culture and also supports the survival of dopaminergic neurons of the ventral mid-brain. Strong attractant of gut hematopoietic cells thus promoting the formation Peyer's patch-like structures, a major component of the gut-associated lymphoid tissue. Artemin Protein, Rat, Recombinant (His & Myc) is expressed in E. coli ... | |||
TMPY-02924 |
RGS1 Protein, Human, Recombinant (His)
1R20,IER1,BL34,HEL-S-87,regulator of G-protein signaling 1,I... |
Human | E. coli |
RGS1 (regulator of G-protein signaling 1) has been associated with multiple autoimmune disorders including type I diabetes. RGS1 desensitizes the chemokine receptors CCR7 and CXCR4 that are critical to the localization of T and B cells in lymphoid organs. RGS1 expression may be a prognostic marker for risk stratification and a promising target for the development of a new Multiple myeloma (MM) therapy. The markers in the RGS1 gene might be in linkage disequilibrium with a protective allele that ... | |||
TMPJ-00456 |
APRIL/TNFSF13 Protein, Mouse, Recombinant (hFc)
TRDL-1,TNFSF13,CD256,TALL-2,A proliferation-inducing ligand |
Mouse | HEK293 Cells |
Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. TNFSF13 is a Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA and plays a role in the regulation of tumor cell growth. It expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissu... | |||
TMPJ-00274 |
LTBR Protein, Human, Recombinant (His)
TNFCR,Tumor Necrosis Factor Receptor Superfamily Member 3,Ly... |
Human | HEK293 Cells |
Tumor necrosis factor receptor superfamily member 3, also known as Lymphotoxin-beta receptor,Tumor necrosis factor C receptor,Tumor necrosis factor receptor 2-related protein,Tumor necrosis factor receptor type III,LTBR,TNFCR, TNFR3 and TNFRSF3, is a member of the tumor necrosis factor (TNF) family of receptors. LTBR is a single-pass type I membrane protein and contains four TNFR-Cys repeats. It is expressed on the surface of most cell types, but not on T and B lymphocytes. LTBR and its ligand p... | |||
TMPJ-00192 |
CD32B Protein, Human, Recombinant (His)
FCG2,IgG Fc Receptor II-b,CDw32,Low Affinity Immunoglobulin ... |
Human | HEK293 Cells |
FcγRIIB is a low affinity receptor that recognizes the Fc portion of IgG. The human CD32 group consists of FcγRIIA, FcγRIIB, and FcγRIIC proteins that share 94-99% sequence identity in their extracellular domains but differ substantially in their transmembrane and cytoplasmic domains. FcγRII protein is expressed on cells of both myeloid and lymphoid lineages as well as on cells of non-hematopoietic origin. FcγRIIB has an intrinsic cytoplasmic immunoreceptor tyrosine-based inhibitory motif (ITIM)... | |||
TMPJ-00168 |
HVEM Protein, Mouse, Recombinant (hFc)
Tnfrsf14,Herpesvirus entry mediator,ATAR,Tumor necrosis fact... |
Mouse | HEK293 Cells |
Mouse Protein Tnfrsf14, is a type I transmembrane protein belonging to the TNF receptor superfamily. It is tumor necrosis factor receptor superfamily member 14 and expressed on the surface of T cells during the resting state. Interaction of HVEM with TNF family member LIGHT co-stimulates T cells and promotes inflammation. HVEM also triggers inhibitory signaling cascade in effector T (Teff) cells and regulatory T cells (Tregs) as a ligand of B and T lymphocyte attenuator. Tnfrsf14 is detected in ... | |||
TMPH-03266 |
CHI3L1 Protein, Rat, Recombinant (His)
Chi3l1,Cartilage glycoprotein 39,CGP-39,GP-39,Chitinase-3-li... |
Rat | E. coli |
Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mu... | |||
TMPY-02193 |
GOLPH2/GOLM1 Protein, Human, Recombinant (His)
HEL46,PSEC0257,GOLPH2,bA379P1.3,C9orf155,GP73,golgi membrane... |
Human | HEK293 Cells |
Golgi membrane protein 1, also known as Golgi membrane protein GP73, Golgi phosphoprotein 2, and GOLM1, is a protein that belongs to the GOLM1 / CASC4 family. GOLM1 is widely expressed. It is highly expressed in the colon, prostate, trachea, and stomach. It is expressed at a lower level in testis, muscle, lymphoid tissues, white blood cells, and spleen. It is predominantly expressed by cells of the epithelial lineage. GOLM1 is expressed at a low level in the normal liver. Expression significantl... | |||
TMPY-02387 |
NF-kB p65 Protein, Human, Recombinant (aa 1-306, GST)
NFKB3,p65,v-rel avian reticuloendotheliosis viral oncogene h... |
Human | E. coli |
RELA (v-rel reticuloendotheliosis viral oncogene homolog A), also known as Nuclear factor NF-kappa-B p65 subunit, or Transcription factor p65, is a transcription factor expressed in growth plate chondrocytes where it facilitates chondrogenesis. The v-rel avian reticuloendotheliosis viral oncogene homolog A (RELA) gene encodes the major component of the NF-?B complex. NF-kappaB is a generic name for an evolutionarily conserved transcription-factor system that contributes to the mounting of an eff... | |||
TMPY-04547 |
PBK/TOPK Protein, Human, Recombinant (His)
HEL164,Nori-3,CT84,TOPK,PDZ binding kinase,SPK |
Human | Baculovirus Insect Cells |
PDZ binding kinase (PBK), also known as TOPK (T-LAK cell-originated protein kinase), is a serine/threonine kinase related to the dual specific mitogen-activated protein kinase kinase (MAPKK) family, and has all the characteristic protein kinase subdomains and a C-terminal PDZ-binding T/SXV motif. PBK is expressed in the testis restrictedly expressed in outer cell layer of seminiferous tubules, as well as placenta. PBK may be enrolled in the activation of lymphoid cells and support testicular fun... | |||
TMPY-01246 |
MARCO Protein, Mouse, Recombinant (His)
AI323439,Ly112,macrophage receptor with collagenous structur... |
Mouse | HEK293 Cells |
Macrophage receptor MARCO, also known as Macrophage receptor with collagenous structure and Marco, is a single-pass type II membrane protein. MARCO is a member of the class A scavenger receptor family and is part of the innate antimicrobial immune system. It is expressed in subpopulations of macrophages in the spleen and the medullary cord of lymph nodes. Although it is expressed on subsets of macrophages, it can be upregulated on other macrophages after bacterial infection. The strategic positi... | |||
TMPY-04412 |
Germinal Center Kinase/MAP4K2 Protein, Human, Recombinant (His & GST)
mitogen-activated protein kinase kinase kinase kinase 2,GCK,... |
Human | Baculovirus Insect Cells |
Mitogen-activated protein kinase kinase kinase kinase 2, also known as B lymphocyte serine/threonine-protein kinase, Germinal center kinase, MAPK/ERK kinase kinase kinase 2, MEK kinase kinase 2, Rab8-interacting protein, and MAP4K2, is cytoplasm and peripheral membrane protein that belongs to the protein kinase superfamily, STE Ser/Thr protein kinase family and STE2 subfamily. MAP4K2 contains one CNH domain and one protein kinase domain. Although this kinase is found in many tissues, its express... | |||
TMPJ-01159 |
CD16/FCGR3 Protein, Mouse, Recombinant (His)
IgG Fc receptor III,CD16,FcRIII,Low affinity immunoglobulin ... |
Mouse | HEK293 Cells |
Low affinity immunoglobulin gamma Fc region receptor III (Fc gamma RIII/CD16) is a member of the Ig superfamily. Based on close relationships in their extracellular domains, the Fc gamma Rs have been divided into three classes composing of Fc gamma RI (CD64), Fc gamma RII (CD32), and Fc gamma RIII (CD16). Each group may be encoded by multiple genes and exist in different isoforms depending on species and cell type. Mouse CD16 is a type I transmembrane protein having two extracellular Ig-like dom... | |||
TMPY-02518 |
TCL1A Protein, Human, Recombinant (His)
TCL1,T-cell leukemia/lymphoma 1A |
Human | E. coli |
T-cell leukemia/lymphoma protein 1A (abbreviated for TCL1A) is a member of the TCL1 family. TCL1 protooncogene is expressed in CD3-CD4-CD8-precursor T cells and is extinguished at the CD4+CD8+stage of thymocyte development. In B cells, TCL1 is first expressed in pro-B cells and remains high in naive mantle zone B cells of peripheral lymphoid tissues. The TCL1 protooncogene is overexpressed in many mature B cell lymphomas, especially from AIDS patients. It has been demonstrated that TCL1 is a pow... | |||
TMPY-03435 |
NCKIPSD Protein, Human, Recombinant (GST)
NCK interacting protein with SH3 domain,WASLBP,SPIN90,ORF1,V... |
Human | E. coli |
NCKIPSD is localized exclusively in the cell nucleus. It plays a role in signal transduction and may function in the maintenance of sarcomeres and the assembly of myofibrils into sarcomeres. NCKIPSD also plays an important role in stress fiber formation. NCKIPSD gene is involved in therapy-related leukemia by a chromosomal translocation t(3;11)(p21;q23) that involves this gene and the myeloid/lymphoid leukemia gene. Alternative splicing occurs in this locus and two transcript variants encoding d... | |||
TMPJ-01166 |
IGFBP-7 Protein, Mouse, Recombinant (His)
TAF,IGFBP-rP1,Insulin-like growth factor-binding protein 7,T... |
Mouse | HEK293 Cells |
Insulin-like growth factor-binding protein 7(IGFBP-7) is a secreted glycosylated protein that contains three protein domain modules. IGFBP7 contains an N-terminal IGFBP domain, followed by a Kazal-type serine proteinase inhibitor domain and a C-terminal immunoglobulin-like C2-type domain. Human and mouse IGFBP7 are highly homologous and share 94% aa sequence identity. It is expressed in many normal tissues and in cancer cells. It is abundantly expressed in high endothelial venules (HEVs) of bloo... | |||
TMPY-01674 |
CRTAM Protein, Human, Recombinant (His)
cytotoxic and regulatory T cell molecule,CD355 |
Human | HEK293 Cells |
Cytotoxic and regulatory T-cell molecule, also known as Class-I MHC-restricted T-cell-associated molecule and CRTAM, is a single-pass type I membrane protein which belongs to thenectin family.CRTAM contains oneIg-like C2-type (immunoglobulin-like) domain and oneIg-like V-type (immunoglobulin-like) domain. In the immune system, the expression of CRTAM is restricted to activated class-I MHC-restricted cells, including NKT and CD8 cells. It is strongly expressed in spleen, thymus, small inte... | |||
TMPJ-00395 |
SEMA4D Protein, Mouse, Recombinant (hFc)
Semacl2,Sema J,Semaphorin-C-like 2,Semaj,CD100,Semaphorin-4D... |
Mouse | HEK293 Cells |
SEMA4D is a member of the semaphorin family,contains one Ig-like C2-type domain, one PSI domain and one Sema domain. SEMA4D is strongly expressed in lymphoid tissues, especially in the thymus, as well as in the nervous tissues. However, SEMA4D is expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver. SEMA4D is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. S... | |||
TMPJ-00952 |
SDF-1/CXCL12 Protein, Mouse, Recombinant
Sdf1,C-X-C motif chemokine 12,Thymic lymphoma cell-stimulati... |
Mouse | E. coli |
Mouse Cxcl12 is a secreted and highly conserved protein which belongs to the intercrine alpha (chemokine CxC) family.CXCL12 is widely expressed in various organs including brain, kidney, skeletal muscle, heart, liver, and lymphoid organs. Cxcl12 activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. It also binds to atypical chemokine receptor ACKR3 which activates the beta-arrestin pathway and acts as a scaven... | |||
TMPJ-00055 |
Podoplanin Protein, Mouse, Recombinant (hFc)
T1-alpha,PA2.26 antigen,T1A,Podoplanin,T1-α,Glycoprotein 38,... |
Mouse | HEK293 Cells |
Podoplanin belongs to the podoplanin family, also known as Glycoprotein 38. Podoplanin is synthesized as a 172 amino acid (aa) precursor with a 22 aa signal sequence, a 119 aa extracellular domain (ECD), a 21 aa transmembrane region, and a short, 10 aa cytoplasmic tail. Detected at high levels in lung and brain, at lower levels in kidney, stomach, liver, spleen and esophagus, and not detected in skin and small intestine. Expressed in epithelial cells of choroid plexus, ependyma, glomerulus and ... | |||
TMPY-03968 |
Secretogranin II Protein, Human, Recombinant (His)
EM66,SgII,SN,CHGC,secretogranin II |
Human | HEK293 Cells |
Kit ligand, also known as Hematopoietic growth factor KL, Mast cell growth factor, Steel factor, Stem cell factor, c-Kit ligand, Kitlg and KITL, is a single-pass type I membrane protein that belongs to the SCF family. KITL / kit ligand also belongs to the family of dimeric transmembrane growth factors. The soluble form of KIT ligand is a secreted protein. Mast cells are thought to participate in a variety of immune responses, such as parasite resistance and the allergic reaction. Mast cell devel... | |||
TMPH-02524 |
Arginase-1/ARG1 Protein, Mouse, Recombinant (His)
Arginase-1,Type I arginase,Liver-type arginase,Arg1 |
Mouse | P. pastoris (Yeast) |
Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available i... | |||
TMPJ-00446 |
CD32A Protein, Human, Recombinant (R167, His)
FcRII-a,IGFR2,Low Affinity Immunoglobulin Gamma Fc Region Re... |
Human | HEK293 Cells |
Receptors for the Fc region of IgG (FcγR) are members of the Ig superfamily that function in the activation or inhibition of immune responses. Human FcγRs are divided into three classes designated FcγRI (CD64), FcγRII (CD32), and FcγRIII (CD16), which generate multiple isoforms, are recognized. The activating type receptor either has or associates noncovalently with an accessory subunit that has an immunoreceptor tyrosinebased activation motif (ITAM) in its cytoplasmic domain. FcγRI binds IgG... | |||
TMPH-02690 |
PLA2G10 Protein, Mouse, Recombinant (His & Myc)
Pla2g10,Group X secretory phospholipase A2,Phosphatidylcholi... |
Mouse | E. coli |
Secretory calcium-dependent phospholipase A2 that primarily targets extracellular phospholipids. Hydrolyzes the ester bond of the fatty acyl group attached at sn-2 position of phospholipids with preference for phosphatidylcholines and phosphatidylglycerols over phosphatidylethanolamines. Preferentially releases sn-2 omega-6 and omega-3 polyunsaturated fatty acyl (PUFA) chains over saturated fatty acyls. Contributes to phospholipid remodeling of very low-density lipoprotein (VLDL), low-density li... |