首页工具

登录

搜索结果

Search Results for " lung diseases "

Targets Recommended: Others

22

抑制剂 & 化合物

1

天然产物

4

化合物库

13

重组蛋白

如果没找到您满意的产品或者您对产品有其他要求，可以联系我们专业顾问为您提供针对性的合理建议。 QQ咨询网站留言咨询

Cat. No.	Product Name
L9810	抗纤维化化合物库		1180 compounds
	1180 种潜在的抗纤维化分子，是研究纤维化的有效工具，可以用于高通量筛选和高内涵筛选；
L4300	Wnt/Hedgehog/Notch 通路化合物库		237 compounds
	237 个Wnt & Hedgehog & Notch 靶点相关的生物活性小分子化合物的特有集合，用于相关通路的研究及药物的筛选，可用于高通量、高内涵筛选。
L4600	植物来源化合物库		3048 compounds
	3048 个植物来源天然产物的独特集合，来自277类植物的精心之选；
L3300	组胺&褪黑色素化合物库		153 compounds
	153 种生物活性小分子化合物，用于高通量、高内涵筛选；

化合物库

抗纤维化化合物库

Cat.No: L9810

Compounds: 1180

Wnt/Hedgehog/Notch 通路化合物库

Cat.No: L4300

Compounds: 237

植物来源化合物库

Cat.No: L4600

Compounds: 3048

组胺&褪黑色素化合物库

Cat.No: L3300

Compounds: 153

Cat. No.	Product Name	Target	Signaling Pathways
T8313	HCH6-1	Others	Others
	HCH6-1 是甲酰肽受体 1 的竞争性二肽拮抗剂。它能够抑制 fMLF (FPR1激动剂) 特异性激活的人中性粒细胞的趋化性、超氧阴离子生成和弹性酶释放。动物实验中，它对急性肺损伤具有保护作用，可用于研究 FPR1 参与的炎症性肺部疾病。
T6978	Almitrine mesylate Almitrine dimesylate,甲磺酸阿米三嗪,Almitrine bismethanesulfonate,Almitrine bismesylate	Potassium Channel	Membrane transporter/Ion channel
	Almitrine mesylate (Almitrine dimesylate) 是外周化学感受器激动剂，对Ca2+依赖性的K+通道具有选择性抑制作用。
T9089	FTO-IN-1 UUN44923	Others	Others
	UUN44923 是脂肪及肥胖相关酶(FTO) 抑制剂(IC50<1 μM)。其中FTO-IN-1 (UUN44923) 可用于研究癌症。
T25131	AZD8309 AZD 8309,AZD-8309	Glutathione Peroxidase; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation; Metabolism
	AZD8309 是一种强效的、可口服的趋化因子受体CXCR2的拮抗剂，能够调节中性粒细胞的转运，可显著降低胰腺和肺部的MPO，并降低胰腺内的胰蛋白酶和弹性蛋白酶活性。AZD8309 能够用于研究炎症系列疾病。
T39719	Nrf2 activator-1 Nrf2 activator-1	Nrf2	Immunology/Inflammation
	Nrf2 activator-1 是一种有效的 NF-E2 相关因子 2 (Nrf2) 激活剂。Nrf2 activator-1 可用于研究包括哮喘、急性肺损伤 (ALI)、急性呼吸窘迫综合征 (ARDS) 和肺纤维化等 COPD 和其他呼吸系统疾病。
T63809	Ansornitinib	Others	Others
	Ansornitinib 是口服具有活力的双激酶抑制剂，能够抑制血小板衍生生长因子受体 (PDGFR) 和血管内皮生长因子受体 (VEGFR2)。Ansornitinib 是一种抗纤维化剂，能够用于研究肺部，肝脏，肾脏以及胃肠等纤维化疾病。
T60522	Letosteine Viscotiol	Others	Others
	Letosteine (Viscotiol) 是具有口服活性、有效且安全的祛痰剂，可用于研究急性或慢性呼吸道疾病，如支气管肺炎。Letosteine 能够溶解支气管粘液并减轻呼吸道炎症症状，从而实现恢复肺部气体交换和自然防御机制。
T60437	PNU-282987 free base	5-HT Receptor; AChR	GPCR/G Protein; Neuroscience
	PNU-282987 free base 是一种具有选择性和高效性的 α7 烟碱乙酰胆碱受体 (nAChR) 激动剂，也是5-HT3受体的拮抗剂，具有抗炎活性，对脓毒症诱导的小鼠急性肺损伤有保护作用，可减弱 ILC2s 活化和链格孢菌诱导的气道炎症。PNU-282987 free base 可用于研究神经系统疾病。
T22343	HKB99	Phosphatase	Metabolism
	HKB99 是磷酸甘油酸突变酶 1(PGAM1) 的变构抑制剂，抑制非小细胞肺癌的生长和转移。HKB99 与EGFR抑制剂具有协同作用，可协助EGFR抑制剂杀瘤。HKB99 促进氧化应激，可诱导多种信号通路发生变化。HKB99 可用于研究代谢相关疾病。
T29969	AMG-126737 105RSZ5CNS,AMG 126737,SCHEMBL7986111	Others	Others
	AMG-126737 is an effective human lung mast cell trypsin inhibitor with potential therapeutic effect in lung diseases.
T15354	FTY720 (S)-Phosphate (S)-FTY720 phosphate,(S)-FTY720P	Others	Others
	FTY720 (S)-Phosphate is an S1P receptor 1 (S1PR1) agonist. It is used in the research of acute inflammatory diseases such as acute lung injury.
T70616	ACT-672125	Others	Others
	ACT-672125 is a Potent CXCR3 Antagonist with Therapeutic Potential in Autoimmune Diseases. ACT-672125 showed good physicochemical properties and safety profile. In a proof-of-mechanism model of lung inflammation, ACT-672125 inhibited the recruitment of CXCR3 expressing T cells into the inflamed lung in a dose-dependent manner.
T21074	Dexamethasone acetate Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron	Others	Others
	Dexamethasone acetate is an adrenocortical steroid. It is used in the treatment of many conditions, including rheumatic problems, a number of skin diseases, asthma, severe allergies, chronic obstructive lung disease, brain swelling, croup, and antibiotics
T78091	(S)-FTY720-phosphonate	LPL Receptor	GPCR/G Protein
	FTY720 (S)-Phosphate，作为S1P受体1 (S1PR1) 激动剂，可用于研究急性肺损伤等急性炎症。
T71089	PF-00956980	Others	Others
	PF-00956980 是一种可逆的 pan-JAK 抑制剂，作用于 JAK1、JAK2 和JAK3的IC50值分别是 2.2、23.1 和 59.9 μM，可用于肺部和皮肤炎症性疾病研究。
T76526	Ac-D-DGla-LI-Cha-C
	Ac-D-DGla-LI-Cha-C 是一种有效的HCV 蛋白酶抑制剂肽。Ac-D-DGla-LI-Cha-C 可用于癌症、自身免疫性疾病、纤维化疾病、炎症性疾病、神经退行性疾病、感染性疾病、肺部疾病、心脏和血管疾病以及代谢性疾病的研究。
T63761	ACT-660602	Others	Others
	ACT-660602 是口服具有活力的趋化因子受体 CXCR3 拮抗剂 (IC50: 204 nM)。ACT-660602 能够抑制 T 细胞迁移，并在体内急性肺损伤模型中显示出显著作用。ACT-660602 能够用于研究自身免疫性疾病。
T63169	MIF2-IN-1	Others	Others
	MIF2-IN-1 (compound 5d) 是一种有效的 MIF2 互变异构酶抑制剂 (IC50: 1.0 μM)。MIF2-IN-1 通过 MAPK 通路，阻滞细胞周期，进而抑制非小细胞肺癌细胞的增殖。MIF2-IN-1 具有潜力进行癌症疾病的研究。
T63325	ATX inhibitor 9	Others	Others
	ATX inhibitor 9 是增稠的杂芳基衍生物化合物，也是 ATX 的有效抑制剂。其中 Autotaxin (ATX)，也称为 ENPP2，是一种主要在肺癌细胞、支气管上皮细胞和肺泡巨噬细胞中高度表达的分泌酶。ATX inhibitor 9 对癌症或纤维退行性疾病具有研究潜力。
T63630	Gefitinib dihydrochloride	Others	Others
	Gefitinib dihydrochloride 是有效的、选择性的、口服具有活力的 EGFR 酪氨酸激酶抑制剂 (IC50: 33 nM)。Gefitinib dihydrochloride 能够选择性抑制 EGF 刺激的肿瘤细胞生长，其IC50值为 54 nM，能够阻断 EGF 刺激的肿瘤细胞中EGFR 自磷酸化。Gefitinib dihydrochloride 可以诱导细胞自噬 (autophagy) 和凋亡 (apoptosis)，能够用于进行癌症相关疾病，如肺癌和乳腺癌的研究。
T63183	RET-IN-9	Others	Others
	RET-IN-9 是一种 RET 的有效抑制剂。其中 RET 激酶是一种单通道跨膜受体酪氨酸激酶，在肾脏和肠神经系统的发育以及维持神经、内分泌、造血和男性生殖系统的体内平衡中发挥着重要作用。RET-IN-9 具有潜力进行 RET 相关疾病的研究（包括非小细胞肺癌和甲状腺髓样癌）。
T37631	tetranor-12(S)-HETE	Others	Others
	12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetran...

化合物

Cat.No: T8313

Target: Others

Almitrine mesylate

Cat.No: T6978

Synonym: Almitrine dimesylate,甲磺酸阿米三嗪,Almitrine bismethanesulfonate,Almitrine bismesylate

Target: Potassium Channel

Cat.No: T9089

Synonym: UUN44923

Target: Others

Cat.No: T25131

Synonym: AZD 8309,AZD-8309

Target: Glutathione Peroxidase, CXCR

Nrf2 activator-1

Cat.No: T39719

Synonym: Nrf2 activator-1

Target: Nrf2

Cat.No: T63809

Target: Others

Cat.No: T60522

Synonym: Viscotiol

Target: Others

PNU-282987 free base

Cat.No: T60437

Target: 5-HT Receptor, AChR

Cat.No: T22343

Target: Phosphatase

Cat.No: T29969

Synonym: 105RSZ5CNS,AMG 126737,SCHEMBL7986111

Target: Others

FTY720 (S)-Phosphate

Cat.No: T15354

Synonym: (S)-FTY720 phosphate,(S)-FTY720P

Target: Others

Cat.No: T70616

Target: Others

Dexamethasone acetate

Cat.No: T21074

Synonym: Dexamethasone 21-acetate monohydrate,Decadron-LA,Decadron

Target: Others

(S)-FTY720-phosphonate

Cat.No: T78091

Target: LPL Receptor

Cat.No: T71089

Target: Others

Ac-D-DGla-LI-Cha-C

Cat.No: T76526

Cat.No: T63761

Target: Others

Cat.No: T63169

Target: Others

ATX inhibitor 9

Cat.No: T63325

Target: Others

Gefitinib dihydrochloride

Cat.No: T63630

Target: Others

Cat.No: T63183

Target: Others

tetranor-12(S)-HETE

Cat.No: T37631

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T5S2347	Deoxyshikonin 去氧紫草素,Arnebin 7	Others; HIF/HIF Prolyl-Hydroxylase; Antibacterial	Chromatin/Epigenetic; Metabolism; Microbiology/Virology; Others
	Deoxyshikonin (Arnebin 7) 是从紫草中分离的天然产物，具有抗肿瘤活性，在体外具有促血管生成作用。它和没食子酸十二烷基酯在体内外均与青霉素有显着的协同抗菌活性。

天然产物

Cat.No: T5S2347

Synonym: 去氧紫草素,Arnebin 7

Target: Others, HIF/HIF Prolyl-Hydroxylase, Antibacterial

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase 12	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...
TMPY-02028	RON/CD136 Protein, Human, Recombinant (His) CD136,macrophage stimulating 1 receptor,CDw136,PTK8,RON	Human	HEK293 Cells
	The tyrosine kinase receptor, macrophage-stimulating 1 receptor (MST1R), a c-met-related tyrosine kinase, also known as the Ron receptor or CD136, controls cell survival and motility programs related to invasive growth. As the tyrosine kinase receptor is comprised of an extracellular domain, MST1R protein contains the ligand-binding pocket and an intracellular region where the kinase domain is located. MST1R signaling may be involved in the regulation of macrophage and T-lymphocyte activation in...
TMPK-00096	FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated FGF-10,KGF2	Human	E. coli
	Fibroblast growth factor 10 (FGF10) regulates multiple stages of structural lung morphogenesis, cellular differentiation, and the response to injury. As a driver of lung airway branching morphogenesis, FGF10 signaling defects during development lead to neonatal lung disease. Lung diseases impact patients across the lifespan, from infants in the first minutes of life through the aged population. Congenital abnormalities of lung structure can cause lung disease at birth or make adults more suscept...
TMPK-00867	EMAP-II/AIMP1 Protein, Mouse, Recombinant (His) p43,SCYE1,HLD3,EMAP-II,AIMP1,EMAP-2	Mouse	E. coli
	The potent antiangiogenic and proinflammatory protein Endothelial Monocyte Activating Polypeptide II (EMAP II) has been described as a mediator of pulmonary vascular and alveolar formation and its expression is inversely related to the periods of vascularization and alveolarization in the developing lung. Hence the study of EMAP II could play a vital role in studying and devising appropriate therapeutics for diseases of aberrant lung development, such as BPD.
TMPY-04321	CHRNA5 Protein, Human, Recombinant (His) cholinergic receptor, nicotinic, α5 (neuronal),cholinergic r...	Human	HEK293 Cells
	Genetic variation in the cluster on chromosome 15, encoding the nicotinic acetylcholine receptor subunits (CHRNA5-CHRNA3-CHRNB4), has shown strong associations with tobacco consumption and an additional risk increase in smoking-related diseases such as chronic obstructive pulmonary disease (COPD), peripheral artery disease and lung cancer. CHRNA5 may influence susceptibility to lung cancer among Han smokers. Genetic variation in nicotinic receptor alpha 5 (CHRNA5) has been associated with increa...
TMPJ-01283	UGRP1 Protein, Human, Recombinant Uteroglobin-Related Protein 1,Secretoglobin Family 3A Member...	Human	E. coli
	Uteroglobin-Related Protein 1 (UGRP1) belongs to the secretoglobin family which has been suggested to play a role in lung inflammation and allergic diseases. UGRP1 is a 17 kDa secreted homodimeric protein that shows amino acid sequence similarity with uteroglobin. UGRP1 is expressed predominantly in the lung and low levels of expression are detected in the thyroid. Expression of UGRP1 in lung epithelial cells is enhanced by IL-10 and decreased through the activities of IL-9 and IL-5. UGRP1 inter...
TMPK-01201	BPIFA1/LUNX Protein, Human, Recombinant Lung-specific protein X,BPI fold-containing family ...	Human	E. coli
	Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases.
TMPK-01202	CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated C1QR1,C1q/MBL/SPA receptor,ECSM3,C1qRp,C1qR(p),C1qR,dJ737E23...	Human	HEK293 Cells
	CD93 has been shown critical roles in inflammatory and immune diseases. CD93 silencing increased IL-6 and TSLP, but not IL-33 levels in culture supernatants. HDM-induced asthma mice showed significant airway hyperresponsiveness and inflammation with Th2 cytokine activation, along with decreased CD93 expression in bronchial epithelial cells and lung homogenates but increased serum CD93 levels.
TMPJ-00666	CLIC2 Protein, Human, Recombinant (His) CLIC2,XAP121,Chloride Intracellular Channel Protein 2	Human	E. coli
	Chloride Intracellular Channel Protein 2 (CLIC2) is a critical component of all living cells; it regulatescellular traffic of Chloride ion and it can be inserted into membranes anf form chloride ion channels. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions, channel activity depends on the pH. CLIC2 is involved in regulating membrane potential and organic solute transport. CLIC2 modulates the activity of RYR2 and inhibits Calcium influx. CLIC2 can be d...
TMPY-06810	SFTPB Protein, Human, Recombinant (His) SFTP3,SMDP1,PSP-B,SFTB3,SP-B	Human	CHO Cells
	Pulmonary surfactant-associated protein B, also known as SFTPB and SP-B, contains one saposin A-type domain and three saposin B-type domains. SP-B is produced primarily by alveolar type II cells (AEC2) but also by nonciliated respiratory epithelial cells lining distal portions of the respiratory tract. Its secretion promotes alveolar homeostasis, stabilizing lipid layers and lowering surface tension at the air-liquid interface in the peripheral air spaces. Alveolar SP-B influences surfactant for...
TMPY-02163	PGLYRP1 Protein, Mouse, Recombinant (His) Tnfsf3l,peptidoglycan recognition protein 1,PGRP,Tasg7,Tag7,...	Mouse	HEK293 Cells
	Peptidoglycan recognition protein 1, also known as Peptidoglycan recognition protein short, PGRP-S, PGLYRP1, PGLYRP, PGRP and TNFSF3L, is a secreted protein that belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. PGLYRP1 / PGLYRP is highly expressed in bone marrow. It is weakly expressed in kidney, liver, small intestine, spleen, thymus, peripheral leukocyte, lung, fetal spleen and neutrophils. PGLYRP1 / PGLYRP is a pattern receptor that binds to murein peptidoglycans (PGN) of Gram-posi...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His) IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPJ-01212	ULBP-1 Protein, Mouse, Recombinant (His) RAET1I,ULBP1,NKG2DL1	Mouse	HEK293 Cells
	Mouse ULBP1, also known as RAET1I and NKG2DL1, is a member of the ULBP/RAET1 gene family. ULBP1 plays an important role in immune responses, especially in cancer and infectious diseases, and is well-known to bind to NKG2D together with at least ULBP 2 and 3. These proteins are distantly related to major histocompatibility class I (MHC I) molecules, possessing the alpha 1 and alpha 2 Ig-like domains, but lacking the alpha 3 domain. Unlike MHC Class I, they have no capacity to bind peptide or inte...

重组蛋白

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

RON/CD136 Protein, Human, Recombinant (His)

Cat.No: TMPY-02028

Species: Human

Expression System: HEK293 Cells

FGF-10 Protein (Primary Amine Labeling), Human, Recombinant, Biotinylated

Cat.No: TMPK-00096

Species: Human

Expression System: E. coli

EMAP-II/AIMP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00867

Species: Mouse

Expression System: E. coli

CHRNA5 Protein, Human, Recombinant (His)

Cat.No: TMPY-04321

Species: Human

Expression System: HEK293 Cells

UGRP1 Protein, Human, Recombinant

Cat.No: TMPJ-01283

Species: Human

Expression System: E. coli

BPIFA1/LUNX Protein, Human, Recombinant

Cat.No: TMPK-01201

Species: Human

Expression System: E. coli

CD93/C1qR1 Protein, Human, Recombinant (His&Avi), Biotinylated

Cat.No: TMPK-01202

Species: Human

Expression System: HEK293 Cells

CLIC2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00666

Species: Human

Expression System: E. coli

SFTPB Protein, Human, Recombinant (His)

Cat.No: TMPY-06810

Species: Human

Expression System: CHO Cells

PGLYRP1 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-02163

Species: Mouse

Expression System: HEK293 Cells

IL-32 Protein, Human, Recombinant (isoform alpha, His)

Cat.No: TMPY-01033

Species: Human

Expression System: HEK293 Cells

ULBP-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01212

Species: Mouse

Expression System: HEK293 Cells

我们的所有产品和服务仅用于科学研究，不能被用于人体，我们也不向个人提供产品和服务。

Copyright © 2015-2024 TargetMol Chemicals Inc. All rights reserved. 沪ICP备20019793号-4

沪公网安备 31010602006700号

沪公网安备 31010602006700号

TargetMol Loading

联系我们

电话：

400-820-0310

邮箱：

service@tsbiochem.com

QQ：

2881945090（终端用户）

2885109491（经销商）

经销：

终端：

地址：

上海市静安区江场三路238号8楼