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Search Results for " inflammation disease "

Targets Recommended: Prostaglandin Receptor

58

抑制剂 & 化合物

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天然产物

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化合物库

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重组蛋白

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同位素标记化合物

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Cat. No.	Product Name
L6710	中药抗炎分子库		1246 compounds
	1246 种具有抗炎活性或靶向炎症相关靶点的中药单体集合，是药物开发、药理研究的有效工具；
L6600	胃肠炎天然产物库		219 compounds
	219 种胃肠炎相关的生物活性小分子化合物的特有集合，用于高通量、高内涵筛选；
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；

化合物库

中药抗炎分子库

Cat.No: L6710

Compounds: 1246

胃肠炎天然产物库

Cat.No: L6600

Compounds: 219

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

Cat. No.	Product Name	Target	Signaling Pathways
T9622	MF-766	Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation
	MF-766 是高效的、具有口服活性的EP4选择性拮抗剂，Ki 为 0.23 nM。它在功能检测中表现为一种完整的拮抗剂，其 IC50为 1.4 nM (在 10% HS 存在时变成 1.8 nM)。它具有用于癌症和炎症疾病研究的价值。
T5310	TR-14035 MDK-1191	Integrin	Cytoskeletal Signaling
	TR-14035 (MDK-1191) 是一种具有口服活性的 α4β7/α4β1整合素双重抑制剂，对 α4β7和 α4β1作用的 IC50值分别为 7 和 87 nM，可用于炎症和自体免疫疾病的研究。
T6593	ML324	Histone Demethylase; Others; HSV	Chromatin/Epigenetic; Microbiology/Virology; Others
	ML324 是 jumonji 组蛋白去甲基化酶的特异性抑制剂，IC50值为920 nM。
T7644	DPN Diarylpropionitrile,2,3-双(4-羟苯基)丙腈	Apoptosis; Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Autophagy	Apoptosis; Autophagy; Endocrinology/Hormones
	DPN (Diarylpropionitrile) 是一种非甾体雌激素受体 ERβ选择性配体，其 EC50值为 0.85 nM。DPN 在许多神经系统疾病具有神经保护作用。
T6561	Laquinimod LAQ,ABR-215062,拉喹莫德	Apoptosis; Others; NF-κB	Apoptosis; NF-κB; Others
	Laquinimod (LAQ) 是一种免疫调节剂，可预防中枢神经系统的神经变性和炎症。
T1090	Perphenazine Perphenazin,Etaperazine,Trilafon,奋乃静	CaMK; Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Perphenazine (Trilafon) 是吩噻嗪衍生物和多巴胺拮抗剂，具有止吐和抗精神病特性。它能够抑制5-HT2A 受体，α1A 肾上腺素能受体，多巴胺D2、D3、D2L 受体，以及组胺H1受体，对应的Ki 值分别为5.6、10、0.765、0.13、3.4 和 8 nM。
T4583	PFI-2 hydrochloride (R)-PFI-2 hydrochloride,PFI-2 HCl	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 hydrochloride ((R)-PFI-2 hydrochloride) 是一种有效的、高度选择性的、具有细胞活性的 SETD7 甲基转移酶抑制剂，IC50值为2nM，活性是 (S)-PFI-2 的 500 倍。
T9999	Sirtuin modulator 2 N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide	Others; Sirtuin	Chromatin/Epigenetic; DNA Damage/DNA Repair; Others
	Sirtuin modulator 2 (N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide) 具有抗糖尿病、抗炎和抗肿瘤活性。
T0487	Metoprolol tartrate 酒石酸美托洛尔,CGP 2175E	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	Metoprolol tartrate 是一种心脏选择性β1肾上腺素阻断剂。
T1987	PFI-2 PFI2,PFI 2,(R)-PFI-2	Histone Methyltransferase	Chromatin/Epigenetic
	PFI-2 是一种有效、特异性和细胞活性的赖氨酸甲基转移酶 SETD7 抑制剂，Ki 和 IC50值分别为 0.33 和 2 nM。
T12850	Dilmapimod SB-681323,GW 681323,度马莫得	p38 MAPK; Autophagy	Autophagy; MAPK
	Dilmapimod (SB-681323) 是一种 p38 MAPK 的强效抑制剂，可抑制慢性阻塞性肺疾病的炎症。
T17289	ZED-1227 ZED-101,TAK-227	Others; Glutaminase	Others; Proteases/Proteasome
	ZED-1227 (TAK-227) 是一种具有口服活性、选择性和高效性的转谷氨酰胺酶 2 (TG2) 抑制剂，具有抗癌活性，能阻塞炎症诱导的 TG2 表达和激活，可用于治疗乳糜泻。
T11179	Elubrixin SB-656933	IL Receptor; CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	Elubrixin (SB-656933) 是一种有效和特异性的 CXCR2 和 IL-8 受体拮抗剂。 Elubrixin 可用于炎症性疾病的研究，例如炎症性肠病和气道炎症。
T78525	IRG1-IN-1	Others	Others
	IRG1-IN-1为衣康酸衍生物，具有抑制免疫反应基因1(IRG1)活性的能力，适用于癌症、炎症及自身免疫性疾病的研究领域。
T72031	BI 1015550	PDE	Metabolism
	BI 1015550 是一种具有口服活性的PDE4B 抑制剂，IC50值为 7.2 nM。BI 1015550 具有良好的安全性，在炎症、过敏疾病、肺纤维化和慢性阻塞性肺疾病 (COPD) 中有潜在应用。
T38715	MSDC-0602K MSDC-0602K,Azemiglitazone potassium	PPAR	DNA Damage/DNA Repair; Metabolism
	MSDC-0602K (Azemiglitazone potassium) (Azemiglitazone potassium) is a PPARγ-sparing thiazolidinedione (Ps-TZD) compound that binds to PPARγ with an IC50 of 18.25 μM. It also modulates the mitochondrial pyruvate carrier (MPC). This compound, MSDC-0602K, has potential applications in researching fatty liver conditions, including dysfunctional lipid metabolism, inflammation, and insulin resistance. MSDC-0602K acts as an insulin sensitizer, improving insulinemia and fatty liver disease in mice both ...
T24997	ABT-510 acetate ABT 510 acetate	Apoptosis	Apoptosis
	ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂，是一种凝血酶原类似物，具有抗炎抗癌和抗血管生成活性，能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应，可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。
T111959	IFB-088 acetate	Others	Others
	IFB-088 acetate 是一种苄基胍衍生物，可用于治疗与PPP1R15A 途径相关并与蛋白质错误折叠应激相关的疾病和癌症，如tau 病、突触核蛋白病、多谷氨酰胺和多丙氨酸疾病、白质营养不良、囊性纤维化、多发性硬化症、溶酶体储存障碍、淀粉样变性疾病、炎症、代谢障碍、心血管疾病、骨质疏松症、神经系统创伤等等。
T73695	Canakinumab ACZ 885,Ilaris	IL Receptor	Immunology/Inflammation
	Canakinumab (ACZ885) 是一种重组人靶向 IL-1β 单克隆抗体。Canakinumab 显示出对人类和绒猴 IL-1β 具有抑制作用， IC50 值为分别为 43.6 和 40.8 pM。Canakinumab 具有抗炎活性，通过中和 IL-1β 信号来抑制与自身免疫性疾病相关的炎症。Canakinumab 可用于治疗痛风和冠状动脉疾病。
T26917	BTT-3033 BTT3033,BTT 3033	Apoptosis; Integrin	Apoptosis; Cytoskeletal Signaling
	BTT-3033 是一种具有口服活性和高效性的 α2β1 (EC50: 130 nM) 抑制剂，EC50 值为 130 nM。 BTT-3033 对α2I domain 有亲和力，对血小板与 collagen Ⅰ 结合和细胞增殖有抑制作用。BTT-3033 诱导细胞凋亡，可用于研究前列腺癌、炎症和心血管疾病。
T2171	SEW2871 SEW2871	S1P Receptor; LPL Receptor	GPCR/G Protein
	SEW 2871 是一种可口服的高选择性 S1P1激动剂，EC50为 13.8 nM。它减少血液中的淋巴细胞数量，可用于糖尿病、阿尔茨海默氏病、肝纤维化和炎症相关研究。它激活 ERK、Akt 和 Rac 信号通路，并诱导 S1P1 内在化和再循环。
T60522	Letosteine Viscotiol	Others	Others
	Letosteine (Viscotiol) 是具有口服活性、有效且安全的祛痰剂，可用于研究急性或慢性呼吸道疾病，如支气管肺炎。Letosteine 能够溶解支气管粘液并减轻呼吸道炎症症状，从而实现恢复肺部气体交换和自然防御机制。
T13604	CDDO-dhTFEA	Others; NF-κB; Nrf2	Immunology/Inflammation; NF-κB; Others
	CDDO-dhTFEA 是合成的齐墩果烷三萜化合物，可有效激活Nrf2并抑制促炎转录因子NF-κB。它可以恢复高血压 (MAP)，提高 Nrf2 及其靶基因的表达，抑制 NF-κB 的活化和转化生长因子-β 途径，并减少慢性肾病 (CKD) 大鼠的肾小球硬化，间质纤维化和炎症。
T10865	Cot inhibitor-1	TNF; MAPK	Apoptosis; MAPK
	Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生，其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路，特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性，可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。
T21967	MEG hemisulfate Mercaptoethylguanidine hemisulfate	NOS	Immunology/Inflammation
	MEG hemisulfate (Mercaptoethylguanidine hemisulfate) 是一种有效和选择性的诱导型 NO 合酶 (iNOS) 的抑制剂，在组织匀浆中抑制 iNOS，ecNOS 和 bNOS 的 EC50 值分别为 11.5，110 和 60 μM。MEG hemisulfate 也有效的过氧亚硝酸盐清除剂，可抑制过氧亚硝酸盐诱导的氧化过程。MEG hemisulfate 在许多炎症实验模型中具有保护作用，包括缺血/再灌注损伤，牙周炎，失血性休克，炎性肠病以及内毒素和败血性休克。
TP2309	Neurotensin TFA NEUROTENSIN TFA,Neurotensin TFA (39379-15-2 free base),神经加压素	Others	Others
	Neurotensin TFA (39379-15-2 free base) 是一种内源性 13 个氨基酸的神经肽，具有显着的阿片类非依赖性镇痛作用。它在大脑中充当神经递质，在肠道中充当激素，也充当神经调节剂。由于它与多种神经递质系统如多巴胺能、血清素能、谷氨酸能、GABA 能和胆碱能系统。它具有作为人体代谢物、有丝分裂原、神经递质和创伤的作用。
T28878	Sul-121 HCl Sul-121 Hydrochloride	Others	Others
	Sul-121 has anti-oxidative capacity. In experimental chronic obstructive pulmonary disease (COPD) models, Sul-121 HCl inhibits airway inflammation and hyperresponsiveness (AHR) prospectively through inhibition of oxidative stress.
T63818	Omesdafexor	Others	Others
	Omesdafexor 是 FXR 激动剂，能够用于研究肝病或代谢性炎症引起的疾病。
T32156	Indimilast	Others	Others
	Indimilast is used to inhibit phosphodiesterase IV that regulates lung inflammation and causes bronchiectasis by increasing intracellular cyclic adenosine 3', 5'-monophosphate in airway smooth muscle and inflammatory cells. Potential to treat chronic obst
T60457	COX-2-IN-11	Others	Others
	COX-2-IN-11 (compound 7b2) 是COX-2的有效的选择性抑制剂。COX-2-IN-11 在炎症性疾病的研究方面具有潜力。
T61804	GSK-3β inhibitor 6	Others	Others
	GSK-3β inhibitor 6 is a highly potent inhibitor of GSK-3β, with an IC50 value of 24.4 μM. It demonstrates significant enhancement of hepatocyte glucose uptake (38%). This compound holds great potential for studying various diseases including diabetes, inflammation, cancer, Alzheimer's disease, and bipolar disorder [1].
T62029	ML261	Others	Others
	ML261 是肝脂滴形成的抑制剂，IC50值为 69.7 nM。ML261 在非酒精性脂肪性肝病 (NAFLD) 和炎症中具有研究价值。
T73262	C5aR-IN-3	Others	Others
	C5aR-IN-3 是一种有效的 C5aR 抑制剂。C5a 水平升高与自身免疫性疾病和炎症性疾病等疾病有关。C5aR-IN-3 具有研究炎症性疾病的潜力。
T73335	P2X7-IN-2	Others	Others
	P2X7-IN-2 是P2X7受体抑制剂。P2X7-IN-2 抑制 IL-Iβ 的释放，IC50值为 0.01 nM。P2X7-IN-2 可用于自身免疫病，炎症以及心血管疾病的研究。
T41121	Elubrixin tosylate SB-656933 tosylate,Elubrixin tosylate	Others	Others
	Elubrixin tosylate (SB-656933 tosylate) is a high-potency, selective, competitive, and reversible CXCR2 antagonist, as well as an antagonist of the IL-8 receptor. It effectively inhibits upregulation of neutrophil CD11b (with an IC50 of 260.7 nM) and shape change (with an IC50 of 310.5 nM). This compound holds promise for the study of inflammatory diseases, including inflammatory bowel disease and airway inflammation.
T76056	Glepaglutide
	Glepaglutide (ZP1848)，一种长效的 GLP-2 类似物，是一种有效的GLP-2R 激动剂。Glepaglutide 可减少粪便排出量并增加肠道吸收。Glepaglutide 可减轻小肠炎症。Glepaglutide 可用于炎症性肠病 (IBD) 和克罗恩病的研究。
T76057	Glepaglutide acetate
	Glepaglutide (ZP1848) acetate，一种长效的 GLP-2 类似物，是一种有效的GLP-2R 激动剂。Glepaglutide acetate 可减少粪便排出量并增加肠道吸收。Glepaglutide acetate 可减轻小肠炎症。Glepaglutide acetate 可用于炎症性肠病 (IBD) 和克罗恩病的研究。
T61130	SSTR4 agonist 3	Others	Others
	SSTR4 agonist 3 is a potent compound that activates the SSTR4 receptor. The SSTR4 receptor is highly expressed in the hippocampus and neocortex, which are regions associated with memory, learning, and Alzheimer's disease pathology. SSTR4 agonists demonstrate strong efficacy in rodent models of pain, both acute and chronic, by reducing peripheral nociception and inflammation. Considering its potential application in pain research, SSTR4 agonist 3 is of interest[1].
T75254	P2X7-IN-2 TFA	Others	Others
	P2X7-IN-2 TFA（化合物58）为P2X7受体抑制剂，以IC50为0.01 nM抑制IL-Iβ释放，适用于自身免疫病、炎症及心血管疾病研究。
T76947	Ziltivekimab
	Ziltivekimab (COR-001) 是一种人源化抗IL-6单克隆抗体，具有降低血清CRP的效能，并展现出抗炎活性。该化合物在CKD相关的慢性全身性炎症及心血管疾病研究中有潜在应用。
T26447	A 78773 A78773,A-78773	Others	Others
	A 78773 is a potent, selective, direct, and reversible 5-lipoxygenase inhibitor. It has activity in a variety of purified cells and in more complex biological systems such as whole blood, lung fragments, and tracheal tissues. A 78773 acts against inflamma
T85255	1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-Phosphocholine,PC(16:0/20:4),PAPC	Others	Others
	1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid found in biological membranes, featuring palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively. PAPC undergoes oxidation in vivo, producing derivatives that play roles in chronic inflammation and vascular disease. Additionally, PAPC has been utilized in the investigation of oxidized phospholipid signaling mechanisms. Notably, PAPC levels are diminished in isolated human multiple myeloma ce...
T80599	Dectrekumab QAX576
	Dectrekumab (QAX576) 是针对IL-13的人源化单克隆抗体。它能显著降低嗜酸性粒细胞性食管炎 (EoE) 患者上皮内的嗜酸性粒细胞数量，并改善食管疾病相关的转录失调情况，适用于免疫炎症研究。
T78552	PB118	Others	Others
	PB118是一种新型组蛋白去乙酰化酶 6（HDAC6）抑制剂，具备穿越血脑屏障的能力，可用于AD治疗。PB118 对 HDAC6 的 IC50 为 5.6 nM。
T80771	WRR139	Others	Others
	WRR139为肽乙烯基砜类化合物，涉及诸如炎症与癌症等病症的生物学路径。该化合物同时作用于胞质酶N-聚糖酶1（NGLY1）与Nrf1，表现为抑制剂身份。WRR139可提升Carfilzomib对癌细胞的细胞毒效应。
T62937	MAGLi 432	Others	Others
	MAGLi 432 是一种有效的、高度选择性的、非共价的、可逆的 (MAGL) 抑制剂。MAGLi 432 能够高亲和力的结合 MAGL 活性位点，其 IC50 值为 4.2 nM (human enzyme) 和 3.1 nM (mouse enzyme)。MAGLi 432 能够用于研究慢性炎症、多发性硬化症、血脑屏障功能障碍、阿尔茨海默病和帕金森病等神经系统疾病。
T73470	PF-184	Others	Others
	PF-184 是一种有效的、选择性的 IKK-2抑制剂 (IC50: 37 nM)，选择性优于 rhIKK-1、IKKi，及 30 多种酪氨酸和丝氨酸/苏氨酸激酶。PF-184 可用于炎症研究，如哮喘和慢性阻塞性肺疾病。
T38305	tetranor-PGAM	Others	Others
	Prostaglandin E2 (PGE2), one of the most widely investigated PGs, can be used as a biomarker of inflammation, disease state, or therapeutic effectiveness. However due to its rapid metabolism, direct measurement of PGE2 in biological samples is difficult. The major urinary metabolite of PGE2, tetranor-PGEM, serves as an indirect marker of PGE2 biosynthesis. Though like PGE2, tetranor-PGEM is also chemically unstable. tetranor-PGAM is a dehydration product of tetranor-PGEM and can be measured as a...
T72889	FXR agonist 4	Others	Others
	FXR agonist4，一种法尼酯X受体(FXR)激动剂，具有1.05 μM的EC50值。该化合物在DIO小鼠模型中有效地改善了高脂血症、肝脏脂肪变性、胰岛素抵抗以及肝脏炎症，因此可用于非酒精性脂肪性肝病(NAFLD)的研究。
T82663	CU06-1004 Sac-1004	Others	Others
	CU06-1004 (Sac-1004) 是一种口服活性的内皮功能障碍阻滞剂。它通过降低过度的渗透性和炎症来改善内皮功能障碍，有效抑制了包括糖尿病视网膜病变、中风、癌症和炎症性肠病在内的多种动物模型中的血管渗漏和炎症。此外，CU06-1004 对CDAA 诱导的 NASH 模型的小鼠也具有改善作用，并能够提升心脏功能。

化合物

Cat.No: T9622

Target: Prostaglandin Receptor

Cat.No: T5310

Synonym: MDK-1191

Target: Integrin

Cat.No: T6593

Target: Histone Demethylase, Others, HSV

Cat.No: T7644

Synonym: Diarylpropionitrile,2,3-双(4-羟苯基)丙腈

Target: Apoptosis, Estrogen Receptor/ERR, Estrogen/progestogen Receptor, Autophagy

Cat.No: T6561

Synonym: LAQ,ABR-215062,拉喹莫德

Target: Apoptosis, Others, NF-κB

Cat.No: T1090

Synonym: Perphenazin,Etaperazine,Trilafon,奋乃静

Target: CaMK, Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Histamine Receptor

PFI-2 hydrochloride

Cat.No: T4583

Synonym: (R)-PFI-2 hydrochloride,PFI-2 HCl

Target: Histone Methyltransferase

Sirtuin modulator 2

Cat.No: T9999

Synonym: N-(3-(imidazo[2,1-b]thiazol-6-yl)phenyl)-2-methoxybenzamide

Target: Others, Sirtuin

Metoprolol tartrate

Cat.No: T0487

Synonym: 酒石酸美托洛尔,CGP 2175E

Target: Adrenergic Receptor

Cat.No: T1987

Synonym: PFI2,PFI 2,(R)-PFI-2

Target: Histone Methyltransferase

Cat.No: T12850

Synonym: SB-681323,GW 681323,度马莫得

Target: p38 MAPK, Autophagy

Cat.No: T17289

Synonym: ZED-101,TAK-227

Target: Others, Glutaminase

Cat.No: T11179

Synonym: SB-656933

Target: IL Receptor, CXCR

Cat.No: T78525

Target: Others

Cat.No: T72031

Target: PDE

Cat.No: T38715

Synonym: MSDC-0602K,Azemiglitazone potassium

Target: PPAR

ABT-510 acetate

Cat.No: T24997

Synonym: ABT 510 acetate

Target: Apoptosis

IFB-088 acetate

Cat.No: T111959

Target: Others

Cat.No: T73695

Synonym: ACZ 885,Ilaris

Target: IL Receptor

Cat.No: T26917

Synonym: BTT3033,BTT 3033

Target: Apoptosis, Integrin

Cat.No: T2171

Synonym: SEW2871

Target: S1P Receptor, LPL Receptor

Cat.No: T60522

Synonym: Viscotiol

Target: Others

Cat.No: T13604

Target: Others, NF-κB, Nrf2

Cot inhibitor-1

Cat.No: T10865

Target: TNF, MAPK

MEG hemisulfate

Cat.No: T21967

Synonym: Mercaptoethylguanidine hemisulfate

Target: NOS

Neurotensin TFA

Cat.No: TP2309

Synonym: NEUROTENSIN TFA,Neurotensin TFA (39379-15-2 free base),神经加压素

Target: Others

Cat.No: T28878

Synonym: Sul-121 Hydrochloride

Target: Others

Cat.No: T63818

Target: Others

Cat.No: T32156

Target: Others

Cat.No: T60457

Target: Others

GSK-3β inhibitor 6

Cat.No: T61804

Target: Others

Cat.No: T62029

Target: Others

Cat.No: T73262

Target: Others

Cat.No: T73335

Target: Others

Elubrixin tosylate

Cat.No: T41121

Synonym: SB-656933 tosylate,Elubrixin tosylate

Target: Others

Cat.No: T76056

Glepaglutide acetate

Cat.No: T76057

SSTR4 agonist 3

Cat.No: T61130

Target: Others

Cat.No: T75254

Target: Others

Cat.No: T76947

Cat.No: T26447

Synonym: A78773,A-78773

Target: Others

1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-PC

Cat.No: T85255

Synonym: 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-Phosphocholine,PC(16:0/20:4),PAPC

Target: Others

Cat.No: T80599

Synonym: QAX576

Cat.No: T78552

Target: Others

Cat.No: T80771

Target: Others

Cat.No: T62937

Target: Others

Cat.No: T73470

Target: Others

Cat.No: T38305

Target: Others

Cat.No: T72889

Target: Others

Cat.No: T82663

Synonym: Sac-1004

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T6S0117	Avicularin Fenicularin,扁蓄苷	ERK	MAPK
	Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中，它通过抑制 ERK 信号通路产生抗炎活性。
TN1355	Acanthoside B 无梗五加苷 B,刺五加提取物	Immunology/Inflammation related	Immunology/Inflammation
	Acanthoside B 是一种具有抗炎和抗遗忘作用的木脂素。 Acanthoside B 可用于关于阿尔茨海默病和肺部炎症的研究。
TMS2180	Zeaxanthin Anchovyxanthin,All-Trans-Zeaxanthin,玉米	Antioxidant; Endogenous Metabolite	Metabolism; oxidation-reduction
	Zeaxanthin (All-Trans-Zeaxanthin) 是食物获得类胡萝卜素，存在于眼睛的黄斑部，具有抗氧化活性。
TN5171	Tricetin	Apoptosis; Others; Nrf2	Apoptosis; Immunology/Inflammation; Others
	Tricetin 是一种从石榴中分离出的类黄酮。Tricetin 是 Keap1-Nrf2 蛋白相互作用（PPI）的强效竞争性抑制剂，通过激活 Nrf2/HO-1 信号通路和阻止线粒体依赖性细胞凋亡通路，保护帕金森病患免受 6-OHDA 诱导的神经毒性的影响。Tricetin 通过 Akt/GSK-1β途径抑制鼻咽癌的迁移和指示性蛋白酶早老素-1（PS-1）表达。Tricetin 抑制由Egr-1介导的氧化LDL 诱导的内皮炎症，保护大鼠软骨细胞免受IL-1β诱导的炎症和细胞凋亡。
TN3500	beta-Amyrone β-Amyron,β-香树脂酮	COX; AChR; PPAR; Antifection	DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience
	beta-Amyrone (β-Amyron) 对基孔肯雅病毒复制具有抗真菌活性，EC50 为 86 uM。 beta-Amyrone 通过抑制 COX-2 的表达而具有抗炎活性。 beta-Amyrone 表现出抗α-葡萄糖苷酶抑制活性和中等 AChE 活性。 β-Amyrone 可用于炎症、感染和肥胖等疾病的研究。
T7984	2-Hydroxyflavanone	Others	Others
	2-Hydroxyflavanone 是一种天然存在的黄酮类化合物，存在于许多植物和水果中。它具有抗氧化、抗炎和抗肿瘤的活性，可以清除自由基，减少炎症，并抑制肿瘤细胞的生长，还具有治疗糖尿病、肥胖症、心血管疾病和神经系统疾病等多种疾病的潜力。
T6S1487	Ginsenoside Rg5 人参皂苷Rg5,人参皂甙 Rg5	NF-κB; COX; IGF-1R	Immunology/Inflammation; Neuroscience; NF-κB; Tyrosine Kinase/Adaptors
	Ginsenoside Rg5 是红参的主要成分，可阻断IGF-1与其受体的结合，IC50约为90 nM。它还通过抑制NF-κB p65的 DNA 结合活性来抑制COX-2的 mRNA 表达。它可促进血管生成和改善高血压，具有抗炎和治疗阿尔茨海默病的潜力。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN1378	α-Viniferin ALPHA-VINIFERIN,Alpha-葡萄素	P450; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	α-Viniferin 也称为2-芳基苯并呋喃类黄酮，是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性

天然产物

Cat.No: T6S0117

Synonym: Fenicularin,扁蓄苷

Target: ERK

Cat.No: TN1355

Synonym: 无梗五加苷 B,刺五加提取物

Target: Immunology/Inflammation related

Cat.No: TMS2180

Synonym: Anchovyxanthin,All-Trans-Zeaxanthin,玉米

Target: Antioxidant, Endogenous Metabolite

Cat.No: TN5171

Target: Apoptosis, Others, Nrf2

Cat.No: TN3500

Synonym: β-Amyron,β-香树脂酮

Target: COX, AChR, PPAR, Antifection

2-Hydroxyflavanone

Cat.No: T7984

Target: Others

Ginsenoside Rg5

Cat.No: T6S1487

Synonym: 人参皂苷Rg5,人参皂甙 Rg5

Target: NF-κB, COX, IGF-1R

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Cat.No: TN1378

Synonym: ALPHA-VINIFERIN,Alpha-葡萄素

Target: P450, NO Synthase, Prostaglandin Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01246	GDF-15 Protein, Mouse, Recombinant (His) MIC1,Placental TGF-beta,Placental TGF-β,PTGF-beta,PTGFBPTGF-...	Mouse	E. coli
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec...
TMPY-00672	Azurocidin/CAP37 Protein, Human, Recombinant (His) AZU,NAZC,azurocidin 1,hHBP,AZAMP,HUMAZUR,CAP37,HBP,AZU1	Human	HEK293 Cells
	Azurocidin (AZU1), also known as heparin-binding protein (HBP) or cationic antimicrobial protein 37 (CAP37), is an azurophil granule antibiotic protein, with monocyte chemotactic and antibacterial activity. The Azurophil granules, specialized lysosomes of the neutrophil, contain at least 10 proteins implicated in the killing of microorganisms. Azurocidin is a member of the serine protease family that includes Cathepsin G, neutrophil elastase (NE), and proteinase 3 (PR3), however, Azurocidin is n...
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His) growth arrest-specific 6,Gas-6	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPK-00665	GDF-15 Protein, Cynomolgus, Recombinant (His) PTGFBPTGF-beta,PTGFBPTGF-β,MIC-1,NAG-1,MIC1,PTGF-beta,PTGF-β...	Cynomolgus	E. coli
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus...
TMPK-00663	GDF-15 Protein, Cynomolgus, Recombinant (hFc) PTGF-β,GDF-15,NAG-1,PTGF-beta,PDF,PTGFBPTGF-beta,GDF15,Place...	Cynomolgus	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Cynomolgus...
TMPK-01244	GDF-15 Protein, Mouse, Recombinant (hFc) PTGFBPTGF-beta,PTGFB,PLAB,NAG-1,Placental TGF-β,RG-1,GDF15,G...	Mouse	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein, Mouse, Rec...
TMPK-01245	GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated RG-1,GDF15,Placental TGF-beta,GDF-15,PTGFBPTGF-beta,NAG-1,PT...	Mouse	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00197	GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated Placental TGF-β,GDF15,RG-1,MIC-1,PTGFB,PTGF-beta,PDF,PTGF-β,...	Human	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00664	GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated Placental TGF-beta,PTGFBPTGF-β,PLAB,MIC-1,GDF15,NAG-1,RG-1,P...	Cynomolgus	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPK-00198	GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated MIC-1,PTGFBPTGF-β,GDF15,PTGF-β,GDF-15,PTGF-beta,Placental TG...	Human	HEK293 Cells
	Growth and differentiation factor 15 (GDF15) is an inflammation-associated hormone with poorly defined biology. Here, we investigated the role of GDF15 in bacterial and viral infections. Inflammation induced GDF15, and that GDF15 was necessary for surviving both bacterial and viral infections, as well as sepsis. The protective effects of GDF15 were largely independent of pathogen control or the magnitude of inflammatory response, suggesting a role in disease tolerance. GDF-15 Protein (Primary Am...
TMPJ-01414	GDF-15 Protein, Mouse, Recombinant (His & Flag) Growth Differentiation Factor 15, Macrophage inhibitory cyto...	Mouse	HEK293 Cells
	Growth Differentiation Factor 15 (GDF-15), also called Macrophage Inhibitory Cytokine 1 (MIC-1), is a divergent member of the TGF-beta superfamily. GDF15 can be secreted by a wide variety of cell types in response to a broad range of stressors. GDF-15 expression is dramatically upregulated during acute brain injury, cancer, cardiovascular disease, and inflammation, suggesting its potential value as a disease biomarker. GDF15 was shown to inhibit proliferation of primitive hematopoietic progenito...
TMPH-02659	FPR2 Protein, Mouse, Recombinant (GST & His & Myc) Fpr2,Formyl peptide receptor 2,Formylpeptide receptor-relate...	Mouse	E. coli
	High affinity receptor for N-formyl-methionyl peptides (FMLP), which are powerful neutrophil chemotactic factors. Stimulates chemotaxis in immune cells to site of infection or tissue damage upon recognition of several ligands, such as FMLP, or ligand involved in cell damage, disease or inflammation. Receptor for the chemokine-like protein FAM19A5, mediating FAM19A5-stimulated macrophage chemotaxis and the inhibitory effect on TNFSF11/RANKL-induced osteoclast differentiation. FPR2 Protein, Mouse,...
TMPY-00319	GIP Protein, Human, Recombinant (hFc) gastric inhibitory polypeptide,GIP	Human	HEK293 Cells
	Glucose-dependent insulinotropic polypeptide (GIP) is an incretin that plays an important role in fat accumulation. GIP is involved in fat accumulation and insulin resistance with aging. Glucose-dependent insulinotropic polypeptide (GIP) is an intestinal hormone with a broad range of physiological actions. Elevated concentrations of the incretin hormone GIP are found in patients with atherosclerotic cardiovascular disease, while GIP treatment attenuates atherosclerotic plaque inflammation in mi...
TMPJ-00213	IL-10R beta/IL-10RB Protein, Human, Recombinant (hFc) Cytokine receptor family 2 member 4,Interleukin-10 receptor ...	Human	HEK293 Cells
	Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal...
TMPY-03172	Argininosuccinate lyase Protein, Human, Recombinant (His & GST) ASAL,argininosuccinate lyase,ASL	Human	Baculovirus Insect Cells
	The recycling of citrulline by argininosuccinate synthase 1 (ASS1) and argininosuccinate lyase (ASL) is crucial to maintain arginine availability and nitric oxide (NO) production. Nitric oxide (NO) plays an established role in numerous physiological and pathological processes, but the specific cellular sources of NO in disease pathogenesis remain unclear, preventing the implementation of NO-related therapy. Argininosuccinate lyase (ASL) is the only enzyme able to produce arginine, the substrate ...
TMPJ-00379	AOC3 Protein, Human, Recombinant (hFc) SSAO,AOC3,Membrane primary amine oxidase,Copper amine oxidas...	Human	HEK293 Cells
	Membrane primary amine oxidase(AOC3), also known as vascular adhesion protein (VAP-1) and HPAO, this protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family. VAP-1 is a type 1 membrane-bound glycoprotein that has a distal adhesion domain and an enzymatically active amine oxidase site outside of the membrane, VAP-1 has adhesive properties, functional monoamine oxidase activity, and possibly plays a role in glucose handling, leukocyte trafficking, and migration during inflam...
TMPY-00493	IL-19 Protein, Human, Recombinant (His) interleukin 19,Interleukin-19,IL-10C,NG.1,ZMDA1,MDA1	Human	Baculovirus Insect Cells
	The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e...
TMPJ-01304	C1QTNF1 Protein, Human, Recombinant (His) C1QTNF1,G Protein-Coupled Receptor-Interacting Protein,CTRP1...	Human	HEK293 Cells
	C1QTNF1 is a secreted protein，contains 1 C1q domain and 1 collagen-like domain. C1qTNF proteins constitute a highly conserved family of Acrp30/Adiponectin paralogs that share a modular organization comprising an N-terminal signal peptide, a short variable region, a collagenous domain and a C-terminal globular domain. C1qTNF proteins are predicted to have trimeric structures that assemble into hexameric and higher order molecular forms. C1QTNF1 is a novel adipokine, providing a significant framew...
TMPY-01033	IL-32 Protein, Human, Recombinant (isoform alpha, His) IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform...	Human	HEK293 Cells
	IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,...
TMPJ-00298	CD36 Protein, Human, Recombinant (aa 27-432, His) LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome Memb...	Human	HEK293 Cells
	Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio...
TMPJ-00299	LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) LIMP II,Lysosome membrane protein II,SCARB2,85 kDa lysosomal...	Mouse	HEK293 Cells
	Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc...
TMPY-01771	Latexin Protein, Mouse, Recombinant (His) latexin	Mouse	E. coli
	Latexin, also known as endogenous carboxypeptidase inhibitor, tissue carboxypeptidase inhibitor, TCI, ECI, and LXN, is a cytoplasm protein that belongs to the protease inhibitor I47 (latexin) family. It is highly expressed in the heart, prostate, ovary, kidney, pancreas, and colon. Latexin / LXN is the only known endogenous specific inhibitor of zinc-dependent metallocarboxypeptidases (MCPs) present in mammalians so far. Latexin is originally identified as a molecular marker for the regional spe...
TMPH-01502	Humanin Protein, Human, Recombinant (GST) Humanin,Humanin mitochondrial,MT-RNR2	Human	E. coli
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation....
TMPH-01503	Humanin Protein, Human, Recombinant (hFc) MT-RNR2,Humanin,Humanin mitochondrial	Human	HEK293 Cells
	Plays a role as a neuroprotective factor. Protects against neuronal cell death induced by multiple different familial Alzheimer disease genes and amyloid-beta proteins in Alzheimer disease. Mediates its neuroprotective effect by interacting with a receptor complex composed of IL6ST/GP130, IL27RA/WSX1 and CNTFR. Also acts as a ligand for G-protein coupled receptors FPR2/FPRL1 and FPR3/FPRL2. Inhibits amyloid-beta protein 40 fibril formation. Also inhibits amyloid-beta protein 42 fibril formation....

重组蛋白

GDF-15 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01246

Species: Mouse

Expression System: E. coli

Azurocidin/CAP37 Protein, Human, Recombinant (His)

Cat.No: TMPY-00672

Species: Human

Expression System: HEK293 Cells

GAS6 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00665

Species: Cynomolgus

Expression System: E. coli

GDF-15 Protein, Cynomolgus, Recombinant (hFc)

Cat.No: TMPK-00663

Species: Cynomolgus

Expression System: HEK293 Cells

GDF-15 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-01244

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated

Cat.No: TMPK-01245

Species: Mouse

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (H202D, hFc), Biotinylated

Cat.No: TMPK-00197

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Cynomolgus, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00664

Species: Cynomolgus

Expression System: HEK293 Cells

GDF-15 Protein (Primary Amine Labeling), Human, Recombinant (hFc), Biotinylated

Cat.No: TMPK-00198

Species: Human

Expression System: HEK293 Cells

GDF-15 Protein, Mouse, Recombinant (His & Flag)

Cat.No: TMPJ-01414

Species: Mouse

Expression System: HEK293 Cells

FPR2 Protein, Mouse, Recombinant (GST & His & Myc)

Cat.No: TMPH-02659

Species: Mouse

Expression System: E. coli

GIP Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00319

Species: Human

Expression System: HEK293 Cells

IL-10R beta/IL-10RB Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00213

Species: Human

Expression System: HEK293 Cells

Argininosuccinate lyase Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03172

Species: Human

Expression System: Baculovirus Insect Cells

AOC3 Protein, Human, Recombinant (hFc)

Cat.No: TMPJ-00379

Species: Human

Expression System: HEK293 Cells

IL-19 Protein, Human, Recombinant (His)

Cat.No: TMPY-00493

Species: Human

Expression System: Baculovirus Insect Cells

C1QTNF1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01304

Species: Human

Expression System: HEK293 Cells

IL-32 Protein, Human, Recombinant (isoform alpha, His)

Cat.No: TMPY-01033

Species: Human

Expression System: HEK293 Cells

CD36 Protein, Human, Recombinant (aa 27-432, His)

Cat.No: TMPJ-00298

Species: Human

Expression System: HEK293 Cells

LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00299

Species: Mouse

Expression System: HEK293 Cells

Latexin Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01771

Species: Mouse

Expression System: E. coli

Humanin Protein, Human, Recombinant (GST)

Cat.No: TMPH-01502

Species: Human

Expression System: E. coli

Humanin Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01503

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
T69966	Roxadustat-d5
	Roxadustat-d5 is intended for use as an internal standard for the quantification of roxadustat by GC- or LC-MS. Roxadustat is an inhibitor of hypoxia-inducible factor prolyl hydroxylase (HIF-PH; IC50s = 1.4, 1.26, and 1.32 µM for HIF-PH1, HIF-PH2, and HIF-PH3, respectively). It is selective for HIF-PH over other 2-oxoglutarate-dependent dioxygenases, including lysine-specific demethylase 5A (KDM5A), KDM5B, -5C, -5D, and -6B (IC50s = >100 µM for all). Roxadustat (10-200 µM) stabilizes HIF-1α and ...

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Cat.No: T69966

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