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Search Results for " hypothermia "

Targets Recommended: Adrenergic Receptor

抑制剂 & 化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T13016	SR59230A	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	SR59230A 是可透过血脑屏障的、选择性的 β3-肾上腺素能受体拮抗剂，对 β3，β1 和 β2 受体的 IC50分别为 40、408 和 648 nM。
T29206	ZCZ011 ZCZ 011,ZCZ-011	Others	Others
	ZCZ011 is a positive allosteric modulator of the cannabinoid CB1 receptor. ZCZ011 is brain penetrant, increased the potency of orthosteric agonists in mouse behavioral assays indicative of cannabimimetic activity, including antinociception, hypothermia, c
T84955	2-Aminotetralin 2-AT	Others	Others
	2-Aminotetralin acts as a neuromodulatory agent by inhibiting serotonin (5-HT) and norepinephrine reuptake in the rat brain at a dose of 39.4 mg/kg. It triggers hypothermia in rats through intracisternal or intraperitoneal injection, while the implantation of crystals in the hypothalamus' medial preoptic area leads to hyperthermia. Additionally, it mimics (+)-amphetamine in a two-lever drug discrimination test among rats in a dose-dependent manner.
T72395	CB1 inverse agonist 2	Others	Others
	CB1inverse agonist 2 是一种口服有效的大麻素受体 CB1反向激动剂。CB1inverse agonist 2 在小鼠模型中，能有效抑制 CP55940 导致的体温失温和厌食情况。
T28845	SR142948A HCl SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride	Others	Others
	SR 142948A is a non-peptide antagonist of neurotensin receptor. SR 142948A affects the expression of c-Fos and has properties of antipsychotic agent. SR 142948A blocks hypothermia and analgesia induced by neurotensin. It blocks the increase in the concent
T38007	Noladin ether	Others	Others
	Noladin ether 是一种选择性的大麻素 CB1 受体激动剂（Ki=21.2 nM）。Noladin ether 可导致体温过低、肠道不动和轻度的缓解疼痛作用。
T84941	(±)-N-desmethyl Venlafaxine hydrochloride Wy 45494	Others	Others
	(±)-N-desmethyl Venlafaxine, a minor active metabolite of venlafaxine, serves as a selective norepinephrine and serotonin reuptake inhibitor (SNRI). Generated through the metabolization by the cytochrome P450 (CYP) isoform CYP3A4, it exhibits reuptake inhibition of norepinephrine and serotonin in rat synaptosome preparations, demonstrated by IC50 values of 4.7 and 1.6 µM, respectively. Clinically, it has been shown to counteract reserpine-induced hypothermia in mice, displaying efficacy at a min...
T38138	ACEA 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide	Others	Others
	Arachidonoyl 2-chloroethylamide (ACEA) is a potent and selective cannabinoid (CB) receptor 1 agonist with Ki values of 1.4 and >2,000 nM for CB1 and CB2 receptors, respectively. In whole animal experiments, ACEA induces hypothermia in mice with the same efficacy as arachidonoyl ethanolamide , in spite of its higher affinity for the CB1 receptor. These data have been interpreted to indicate that ACEA may be a substrate for fatty acid amide hydrolase (FAAH), and thus only transiently available in ...
T73677	SR 142948 dihydrochloride	Others	Others
	SR 142948 dihydrochloride是一种口服活性高、选择性强的非肽类神经降压素受体(NT)拮抗剂，其在h-NTR1-CHO细胞、HT-29细胞和成年大鼠脑中IC50分别为1.19 nM、0.32 nM、3.96 nM。在HT-29细胞中，该化合物能够有效拮抗NT诱导的肌醇单磷酸盐形成，IC50为3.9 nM。此外，SR 142948 dihydrochloride在体内能够阻断NT诱导的体温下降、镇痛和转向行为，且具有良好的血脑屏障通透性，适用于精神疾病研究。

化合物

SR59230A

Cat.No: T13016

Synonym:

Target: Adrenergic Receptor

ZCZ011

Cat.No: T29206

Synonym: ZCZ 011,ZCZ-011

CB1 inverse agonist 2

Synonym: SR142948A,SR 142948A,SR-142948A,SR142948A hydrochloride

(±)-N-desmethyl Venlafaxine hydrochloride

Cat.No: T84941

Synonym: Wy 45494

Target: Others

ACEA

Cat.No: T38138

Synonym: 2'-chloro-AEA,Arachidonoyl 2'-Chloroethylamide

Target: Others

SR 142948 dihydrochloride

Cat.No: T73677

Synonym:

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T82407	Feruloyl tyramine
	Feruloyl tyramine 为一酰胺类化合物，可从大麻籽乙醇提取物中分离。在小鼠侧脑室注射该化合物，可引发体温降低及运动协调障碍。

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