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Search Results for " epilepsy "

Targets Recommended: Neuropeptide Y Receptor

94

抑制剂 & 化合物

9

天然产物

3

化合物库

7

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L2300	离子通道库		931 compounds
	931 种与离子通道相关的生物活性小分子化合物的特有集合，用于离子通道相关的疾病和药物研究，可用于高通量筛选和高内涵筛选；
L7400	钠通道分子库		118 compounds
	118 种钠通道相关化合物的独特集合，可用于高通量筛选和高内涵筛选；
L6140	糖类及苷类化合物库		595 compounds
	595 种糖类或苷类的化合物，可用于高通量筛选和高内涵筛选；

化合物库

离子通道库

Cat.No: L2300

Compounds: 931

钠通道分子库

Cat.No: L7400

Compounds: 118

糖类及苷类化合物库

Cat.No: L6140

Compounds: 595

Cat. No.	Product Name	Target	Signaling Pathways
T8963	CYM2503	Neuropeptide Y Receptor	GPCR/G Protein; Neuroscience
	CYM2503 是 GAL2 受体的正变构调节剂 (PAM)，可在体外增强甘丙肽诱导的 IP1 产生。它对受体的正构甘丙肽结合位点没有亲和力（通过其无法置换碘化甘丙肽或自行诱导 IP1 积累来衡量）。
T4664	ML 297 ML297	Potassium Channel	Membrane transporter/Ion channel
	ML 297 是选择性的 GIRK1/2激活剂，EC50为 0.16 μM。ML 297 在癫痫病的研究中具有价值。
T0786	Clidinium bromide 克利溴铵,Ro 2-3773	AChR	Neuroscience
	Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂，可通过减少胃酸和减慢肠道速度，缓解痉挛和腹部疼痛的症状。
T8944	TTA-A2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	TTA-A2 是一种选择性 T 型钙通道拮抗剂，是一种有效的抗惊厥药，可减少孕烷 X 受体的激活。它对 Cav3.1 (a1G) 和 Cav3.2 (a1H) 通道在 -80 mV 和- 100 mV 保持电位上具有同样的作用，IC50 值分别为 89 和 92 nM。它可用于多种人类神经系统疾病的研究，包括睡眠障碍和癫痫。
T0680	Lamotrigine LTG,BW430C,拉莫三嗪	5-HT Receptor; Sodium Channel; Autophagy	Autophagy; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Lamotrigine (BW430C) 是一种抗癫痫剂和情绪稳定剂，可研究癫痫、局灶性癫痫等。。它选择性地阻断电压门控钠离子通道，稳定突触前神经元膜，抑制谷氨酸释放。
T8937	Soticlestat TAK-935,OV935	P450	Metabolism
	Soticlestat (OV935) 是一种首创的、口服有活性的胆固醇 24-羟化酶 (cholesterol 24-hydroxylase, CH24H) 选择性抑制剂。它可用于研究癫痫综合征。
T4979	Procyclidine hydrochloride (±)-Procyclidine hydrochlorid,丙环定盐酸盐	NMDAR; iGluR	Membrane transporter/Ion channel; Neuroscience
	Procyclidine hydrochloride ((±)-Procyclidine hydrochlorid) 是具有NMDA 拮抗剂特性的抗胆碱能试剂。
T0024	Primidone Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360	GABA Receptor; Sodium Channel; GluR; AChR	Membrane transporter/Ion channel; Neuroscience
	Primidone (NCI-C56360) 是一种强效抗惊厥试剂。它是神经元性电压门控钠通道阻滞剂，在癫痫、原发性震颤和精神疾病的研究中具有价值。
T0028	Gamibetal 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Gamibetal (4-Amino-3-hydroxybutyric Acid) 是 γ-氨基-β-羟基丁酸，对癫痫具有潜在的研究价值。
T3217	PF-CBP1 hydrochloride PF-CBP1 HCl	Epigenetic Reader Domain; Histone Acetyltransferase	Chromatin/Epigenetic
	PF-CBP1 hydrochloride (PF-CBP1 HCl) 是 CREB 结合蛋白溴结构域的一种高选择性抑制剂，抑制 CREBBP 和 EP300溴结构域的 IC50分别为 125 和 363 nM。它降低 LPS 诱导的巨噬细胞中炎症因子的表达，也可下调皮质神经元 RGS4 的表达，可用于癫痫和帕金森病等神经疾病的研究。
T0267	Zonisamide AD 810,唑尼沙胺,CI 912	Calcium Channel; Sodium Channel; Carbonic Anhydrase	Membrane transporter/Ion channel; Metabolism
	Zonisamide (AD 810) 是锌酶碳酸酐酶 (carbonic anhydrase) 的有效抑制剂，对人类线粒体同工酶 hCA II 和 hCA V 作用的 Ki 值分别为 35.2 nM 和 20.6 nM。Zonisamide 具有抗癫痫活性，在癫痫、癫痫发作和帕金森病的研究中具有价值。
T7806	Licarbazepine 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平	Others	Others
	Licarbazepine (10,11-hydroxy-10,11 Dihydrocarbamezer) 是一种有效的电压门控钠通道阻滞剂，具有抗惊厥和稳定情绪的功效。
T1602	Valproic acid sodium salt 丙戊酸钠,Sodium Valproate	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic acid sodium salt (Sodium Valproate) 是一种HDAC 抑制剂，可抑制HDAC1的活性，诱导HDAC2的降解。它激活Notch1信号并抑制小细胞肺癌细胞的增殖。它可研究癫痫、偏头痛和双相情感障碍等。
T6474	Divalproex Sodium Valproate semisodium,Epival,双丙戊酸钠	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	Divalproex Sodium (Valproate semisodium) 结合并抑制 γ-氨基丁酸 (GABA) 转氨酶，其抗惊厥活性可通过增加 GABA 脑浓度和抑制分解 GABA 或阻止 GABA 再摄取到神经胶质和神经末梢的酶来发挥。它也是一种 HDAC 抑制剂。由丙戊酸钠和丙戊酸组成，具有抗惊厥和抗癫痫活性。 Divalproex 还可以通过抑制电压敏感的钠通道来抑制重复的神经元放电。
T68112	Nafimidone	Others	Others
	Nafimidone 在大鼠杏仁核癫痫模型中显示出抗惊厥活性，可用于治疗慢性顽固性癫痫病。
T31614	Elpetrigine JZP-4,JZP4,GW-273293,JZP 4,GW 273293,GW273293	Sodium Channel	Membrane transporter/Ion channel
	Elpetrigine (GW273293) 是一种潜在的钠通道阻滞剂，具有抗癫痫活性，可用于研究癫痫。
T27252	ELB-139 ELB139,ELB 139	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	ELB-139 是一种 GABAA receptor 激动剂，可用于研究抑郁症和癫痫。
TNU0685	Dipropofol 4,4-Bis(2,6-di-isopropylphenol)	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Dipropofol (4,4-Bis(2,6-di-isopropylphenol)) is a small molecule GABAA receptor agonist that can be used to study epilepsy.
T23301	(S)-(+)-Niguldipine hydrochloride	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	(S)-(+)-Niguldipine hydrochloride 是一种选择性 α1A-AR 拮抗剂，可用于研究抑郁症和癫痫。
T22808	GR 46611 3-[3-[2-二甲基氨基乙基]-1H-吲哚-5-基]-N-[4-甲氧基苄基]丙烯酰胺	5-HT Receptor	GPCR/G Protein; Neuroscience
	GR 46611 是一种选择性 5-HT1B 和 5-HT1D 受体激动剂，可用于治疗癫痫的研究。
T8594	Pheneturide 2-PHENYLBUTYRYLUREA,S-46,Benuride,苯丁酰脲	Others	Others
	Pheneturide (Benuride) 是Phenobarbita l 脱羧后的产物，可阻止精神运动性癫痫发作。
T25813	Milenperone R 34009,R-34009,R34009	Others	Others
	Milenperone (R 34009) 是一种新型抗侵袭化合物，可用于控制癫痫和酗酒患者行为障碍。
T31860	Fosdevirine GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	Fosdevirine (GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T8604	Fenaclon Fenaclonum	Others	Others
	Fenaclon (Fenaclonum) 是一种抗惊厥药。它适用于治疗癫痫。
T23072	NNC 05-2090 hydrochloride	Transaminase	Metabolism
	NNC 05-2090 hydrochloride 是一种 betaine/GABA transporter (BGT-1) 抑制剂，IC50 值为 10.6 μM。NNC 05-2090 hydrochloride 可用于研究癫痫和神经疾病。
T16427	Padsevonil UCB-0942,UCB1415943-000	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Padsevonil (UCB-0942) 是一种潜在的 GABA A受体正变构调节剂，具有抗癫痫活性，可用于治疗癫痫。
T60796	Cholesterol 24-hydroxylase-IN-1	P450	Metabolism
	Cholesterol 24-hydroxylase-IN-1 是一种能透过血脑屏障且具有口服活性、选择性和高效性的的胆固醇24-羟化酶(CH24H or CYP46A1)抑制剂。Cholesterol 24-hydroxylase-IN-1 可用于研究癫痫类的神经系统疾病。
T22638	CBiPES hydrochloride CBiPES HCl	GluR	Neuroscience
	CBiPES hydrochloride(CBiPES HCl) 是一种高效的 mGlu2 受体正变构调节剂，EC50值为 92.8 nM。CBiPES hydrochloride 可阻断 WT 和 mGlu（3）受体的作用。CBiPES hydrochloride 可用于研究像癫痫和帕金森综合征类的神经系统疾病。
T77596	Soretolide D2916,D-2916	Others	Others
	Soretolide (D2916) 是一种用于治疗癫痫的小分子化合物。
T24167	Inflachromene ICM	Others	Others
	Inflachromene(ICM) 是一种 HMGB1 和 HMGB 表达抑制剂，具有抗炎活性。Inflachromene 通过抑制 HMGB1 易位来减轻小鼠癫痫模型的癫痫发作严重程度，通过 HMGB1/2 调节的 TLR4-NF-κB 通路抑制内膜增生，通过调节 Beclin 1 活性来抑制自噬。Inflachromene 可用于研究癫痫。
TD1228	ETHOTOIN	Others	Others
	Ethotoin (Peganone) 是一种用于癫痫研究的，具有口服活性的抗惊厥剂。Ethotoin 是一种海因类化合物，与苯妥英相似。
T31592	E6801 E 6801,E-6801	5-HT Receptor	GPCR/G Protein; Neuroscience
	E6801是一种新型选择性5-HT6受体激动剂，具有广泛的生物活性。E6801可用于研究痴呆、帕金森病、抑郁症、肥胖症癫痫，焦虑等多种疾病。
T67954	Endixaprine SR 41378	Others	Others
	Endixaprine (SR 41378) 是一种小分子化合物，可用于治疗神经系统疾病，可能用于研究焦虑症和癫痫。
T39630	Zandatrigine NBI-921352,XEN901	Sodium Channel	Membrane transporter/Ion channel
	Zandatrigine (NBI-921352) 是钠通道蛋白 8 型亚基 α 的阻断剂，可用于癫痫治疗的神经系统病理学研究。
T0355	Valpromide Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide	Epoxide Hydrolase; HSV	Metabolism; Microbiology/Virology
	Valpromide (Dipropylacetamide) 是丙戊酸的羧酰胺衍生物，用于治疗癫痫和一些情感障碍。
T7612	ICA 110381	Potassium Channel	Membrane transporter/Ion channel
	ICA 110381 是一种KCNQ2/Q3钾通道开放剂，有潜力用于癫痫的研究。ICA 110381 是KCNQ2/Q3激动剂 (EC50=0.38 μM) 以及KCNQ1拮抗剂 (IC50=15 μM)。
T0598	Iminostilbene 亚氨基芪,Dibenzazepine	Others	Others
	Iminostilbene (Dibenzazepine) 是 carbamazepine 的化学前体，主要用于治疗癫痫和神经性疼痛。
T12758L	Ro 25-6981 Maleate Ro-25-6981 Maleate,Ro 256981 Maleate	NMDAR	Neuroscience
	Ro 25-6981 Maleate 是一种具有选择性的 NR2B 亚基特异性 NMDA 受体拮抗剂，具有抗惊厥抗抑郁活性，可用于研究帕金森和癫痫等神经系统疾病。
T73586	Anticonvulsant agent 2	Others	Others
	Anticonvulsant agent 2 是一种有效的口服活性抗惊厥剂，在耐药性癫痫模型中显示出抗癫痫活性。
T72170	NaV1.2/1.6 channel blocker-1	Sodium Channel	Membrane transporter/Ion channel
	NaV1.2/1.6 channel blocker-1 是一种有效的 NaV1.2/1.6 channel 阻滞剂，对 rNaV1.6 和 hNaV1.2 有抑制作用。NaV1.2/1.6 channel blocker-1 可用于研究全身性癫痫和运动障碍。
T34609	Selurampanel BGG-492,BGG 492,BGG492	iGluR	Membrane transporter/Ion channel; Neuroscience
	Selurampanel (BGG492) 是一种具有口服活性和选择性的竞争性 AMPA 谷氨酸受体拮抗剂，是一种喹唑啉二酮磺酰胺。Selurampanel 可用于研究癫痫、偏头痛和耳鸣。
T22655	CGS 20625	Others	Others
	CGS 20625 是一种具有口服活性、特异性和高效性的中枢苯二氮卓受体的部分激动剂，具有抗焦虑和抗惊厥活性。CGS 20625 对 [3H]-氟硝西泮与中枢苯二氮卓受体的结合有抑制作用，可用于研究焦虑症和癫痫等神经系统疾病。
T27405	GAT211 AZ4,GAT-211,AZ 4,GAT 211,AZ-4	cAMP; Cannabinoid Receptor; Arrestin	GPCR/G Protein
	GAT211 (AZ-4) 是一种具有选择性和高效性的大麻素 1 受体 (CB1R) 正变构调节剂 (PAM)，对 cAMP 和 β-arrestin2 具有较高的亲和力。GAT211 具有降眼压和抗精神病的作用，可用于研究癫痫。
T61745	hCAI/II-IN-6	Carbonic Anhydrase	Metabolism
	hCAI/II-IN-6 是一种具有选择性和口服活性的human carbonic anhydrase(CA) 抑制剂。hCAI/II-IN-6对 hCA I，hCA II，hCA VII 和 hCA XII 有抑制作用，Ki 值分别为 220，4.9，6.5 和＞50000 nM。hCAI/II-IN-6 在体内显示抗惊厥活性。hCAI/II-IN-6 可以用于研究癫痫。
T31860L	(Iso)-Fosdevirine (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761	HIV Protease	Microbiology/Virology; Proteases/Proteasome
	(Iso)-Fosdevirine ( (Iso)-GSK2248761) 是一种具有选择性和高效性的非核苷类逆转录酶 (NNRTI) 抑制剂，具有抗 HIV 活性，可用于研究迟发性癫痫等神经系统相关疾病。
T60351	Acetazolamide sodium OT-302 sodium	Carbonic Anhydrase	Metabolism
	Acetazolamide sodium (OT-302 sodium) 是一种高效的碳酸酐酶 (CA)IX抑制剂，具有利尿、抗淋球菌和降压活性，可用于癫痫、青光眼、水肿和高原反应等适应症。
T3562	Valrocemide TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺	Others	Others
	Valrocemide (TV1901) 是有前景的抗癫痫候选药物，具有广泛的抗惊厥特性。
T16489	Darigabat CVL-865,PF-6372865,PF-06372865	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Darigabat (PF-06372865) 是一种可穿过血脑屏障且具有口服活性和选择性的 GABAA 受体调节剂，具有抗焦虑活性，对 α2、α1 PAM、α2 PAM 的 Ki 值分别为 2.9 nM、21 nM、134 nM。Darigabat 可用于研究焦虑症和癫痫。
T17197	UCL 2077	Others	Others
	UCL 2077 是癫痫相关 KCNQ 通道的亚型选择性阻滞剂，也是一种选择性慢后超极化通道阻滞剂，在培养的海马神经元中 IC50 为 500 nM，对 Ca2+ 通道、动作电位、输入电阻的影响小，以及超极化后的介质。
T20025	Imipramine HSDB 3100,Melipramine,HSDB3100,Dimipressin,HSDB-3100	Apoptosis	Apoptosis
	Imipramine (Dimipressin) 是一种具有口服活性的 Fascin1 抑制剂，具有抗抑郁和抗肿瘤活性。Imipramine 抑制 5-羟色胺转运体（IC50：32 nM），诱导细胞凋亡，诱导 U-87MG 胶质瘤细胞自噬。Imipramine 具有神经保护和免疫调节活性，抑制TNBC细胞的侵袭和迁移，可用于研究乳腺癌和癫痫。

化合物

Cat.No: T8963

Target: Neuropeptide Y Receptor

Cat.No: T4664

Synonym: ML297

Target: Potassium Channel

Clidinium bromide

Cat.No: T0786

Synonym: 克利溴铵,Ro 2-3773

Target: AChR

Cat.No: T8944

Target: Calcium Channel

Cat.No: T0680

Synonym: LTG,BW430C,拉莫三嗪

Target: 5-HT Receptor, Sodium Channel, Autophagy

Cat.No: T8937

Synonym: TAK-935,OV935

Target: P450

Procyclidine hydrochloride

Cat.No: T4979

Synonym: (±)-Procyclidine hydrochlorid,丙环定盐酸盐

Target: NMDAR, iGluR

Cat.No: T0024

Synonym: Primaclone,Mysoline,去氧苯比妥,扑米酮,NCI-C56360

Target: GABA Receptor, Sodium Channel, GluR, AChR

Cat.No: T0028

Synonym: 3-Hydroxy-GABA,4-氨基-3-羟基丁酸,4-Amino-3-hydroxybutyric Acid

Target: HIV Protease

PF-CBP1 hydrochloride

Cat.No: T3217

Synonym: PF-CBP1 HCl

Target: Epigenetic Reader Domain, Histone Acetyltransferase

Cat.No: T0267

Synonym: AD 810,唑尼沙胺,CI 912

Target: Calcium Channel, Sodium Channel, Carbonic Anhydrase

Cat.No: T7806

Synonym: 10,11-hydroxy-10,11 Dihydrocarbamezer,10,11-二氢-10-羟基卡马西平

Target: Others

Valproic acid sodium salt

Cat.No: T1602

Synonym: 丙戊酸钠,Sodium Valproate

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, HDAC, Autophagy

Divalproex Sodium

Cat.No: T6474

Synonym: Valproate semisodium,Epival,双丙戊酸钠

Target: HDAC

Cat.No: T68112

Target: Others

Cat.No: T31614

Synonym: JZP-4,JZP4,GW-273293,JZP 4,GW 273293,GW273293

Target: Sodium Channel

Cat.No: T27252

Synonym: ELB139,ELB 139

Target: GABA Receptor

Cat.No: TNU0685

Synonym: 4,4-Bis(2,6-di-isopropylphenol)

Target: GABA Receptor

(S)-(+)-Niguldipine hydrochloride

Cat.No: T23301

Target: Adrenergic Receptor

Cat.No: T22808

Synonym: 3-[3-[2-二甲基氨基乙基]-1H-吲哚-5-基]-N-[4-甲氧基苄基]丙烯酰胺

Target: 5-HT Receptor

Cat.No: T8594

Synonym: 2-PHENYLBUTYRYLUREA,S-46,Benuride,苯丁酰脲

Target: Others

Cat.No: T25813

Synonym: R 34009,R-34009,R34009

Target: Others

Cat.No: T31860

Synonym: GSK-2248761A,IDX 899,GSK 2248761A,GSK 2248761,GSK-2248761,IDX-12899,GSK2248761,FDV,GSK2248761A

Target: HIV Protease

Cat.No: T8604

Synonym: Fenaclonum

Target: Others

NNC 05-2090 hydrochloride

Cat.No: T23072

Target: Transaminase

Cat.No: T16427

Synonym: UCB-0942,UCB1415943-000

Target: GABA Receptor

Cholesterol 24-hydroxylase-IN-1

Cat.No: T60796

Target: P450

CBiPES hydrochloride

Cat.No: T22638

Synonym: CBiPES HCl

Target: GluR

Cat.No: T77596

Synonym: D2916,D-2916

Target: Others

Cat.No: T24167

Synonym: ICM

Target: Others

Cat.No: TD1228

Target: Others

Cat.No: T31592

Synonym: E 6801,E-6801

Target: 5-HT Receptor

Cat.No: T67954

Synonym: SR 41378

Target: Others

Cat.No: T39630

Synonym: NBI-921352,XEN901

Target: Sodium Channel

Cat.No: T0355

Synonym: Depamide,Valpramide,丙戊酰胺,Dipropylacetamide,2-propylpentanamide

Target: Epoxide Hydrolase, HSV

Cat.No: T7612

Target: Potassium Channel

Cat.No: T0598

Synonym: 亚氨基芪,Dibenzazepine

Target: Others

Ro 25-6981 Maleate

Cat.No: T12758L

Synonym: Ro-25-6981 Maleate,Ro 256981 Maleate

Target: NMDAR

Anticonvulsant agent 2

Cat.No: T73586

Target: Others

NaV1.2/1.6 channel blocker-1

Cat.No: T72170

Target: Sodium Channel

Cat.No: T34609

Synonym: BGG-492,BGG 492,BGG492

Target: iGluR

Cat.No: T22655

Target: Others

Cat.No: T27405

Synonym: AZ4,GAT-211,AZ 4,GAT 211,AZ-4

Target: cAMP, Cannabinoid Receptor, Arrestin

Cat.No: T61745

Target: Carbonic Anhydrase

(Iso)-Fosdevirine

Cat.No: T31860L

Synonym: (Iso)-Fosdevirine（Iso-1018450-26-4）,(Iso)-GSK2248761

Target: HIV Protease

Acetazolamide sodium

Cat.No: T60351

Synonym: OT-302 sodium

Target: Carbonic Anhydrase

Cat.No: T3562

Synonym: TV1901,N-丙戊酰基甘氨酰胺,N-Valproylglycinamide,丙戊塞胺

Target: Others

Cat.No: T16489

Synonym: CVL-865,PF-6372865,PF-06372865

Target: GABA Receptor

Cat.No: T17197

Target: Others

Cat.No: T20025

Synonym: HSDB 3100,Melipramine,HSDB3100,Dimipressin,HSDB-3100

Target: Apoptosis

Cat. No.	Product Name	Target	Signaling Pathways
T7064	Valproic Acid Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid	Mitophagy; Gamma-secretase; HIV Protease; GABA Receptor; Sodium Channel; HDAC; Autophagy	Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience; Proteases/Proteasome; Stem Cells
	Valproic Acid (2-Propylpentanoic Acid) 是一种 HDAC 抑制剂，可抑制 HDAC1 活性，诱导 HDAC2 降解，具有口服活性。Valproic Acid 可以用于癫痫和躁郁症的研究。
TN2865	(E)-3,4,5-Trimethoxycinnamic acid O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid	Others	Others
	(E)-3,4,5-Trimethoxycinnamic acid (O-Methylsinapic acid) 是一种来自羌活根和根茎的天然产物。
T0804	Pilocarpine Hydrochloride NSC 5746 HCl,盐酸毛果芸香碱,Pilocarpine HCl,(+)-Pilocarpine hydrochloride	AChR	Neuroscience
	Pilocarpine Hydrochloride (NSC 5746 HCl) 是一种 M3 型毒蕈碱乙酰胆碱受体激动剂，用于制作癫痫实验模型
T4S1519	Pseudoginsenoside RT5 拟人参皂苷RT5	Others	Others
	Pseudoginsenoside RT5 分离于 Panax quinquefolium 中。它通过促进神经生长和提高认知能力，具有抗癫痫、抗抑郁活性，还具有抗菌、抗肿瘤、抗疟疾等活性。
T8162	Cannabidivarin Cannabidivarin,GWP-42006,GWP42006,GWP 42006	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Cannabidivarin (GWP42006) 是一种非拟精神病药大麻素。它具有缓解多种神经系统疾病 (包括癫痫和自闭症谱系障碍) 的研究潜力。
T5786	TETRAHYDROPIPERINE 四氢胡椒碱,Cosmoperine	P450; TRP/TRPV Channel	Membrane transporter/Ion channel; Metabolism
	Tetrahydropiperine (Cosmoperine) 是胡椒碱的环己基类似物，也是一种天然芳基戊酰胺，从Piper longum 分离得到。它对细胞色素 P450 (CYP) 同工型 CYP1A1/芳基烃羟化酶 (AHH；IC50=23 µM)具有抑制作用。
T5739	Paederosidic acid 鸡屎藤苷酸,异戊二酸紫草酸	Apoptosis; BCL	Apoptosis
	Paederosidic acid 是从鸡矢藤分离出的一种天然产物，通过诱导线粒体介导的凋亡抑制肺癌细胞，具有显着的抗肿瘤、抗惊厥和镇静作用。
T4120	N-Methylsarcosine N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,N,N-二甲基甘氨酸,DMG	Endogenous Metabolite	Metabolism
	N-Methylsarcosine (Dimethylglycine) 被用作运动性能增强剂和免疫兴奋剂。它也被用于治疗自闭症、癫痫和线粒体疾病。它也被用作慢性阻塞性肺疾病(COPD)患者蛋白质降解的生物标志物。此外，它被用作鉴定、区分和表征氨基酸甲基转移酶的底物。它在甘氨酸基离子液体和乳化剂的发展中起着重要的作用。
T75494	Shinjulactone M	Others	Others
	Shinjulactone M 是一种从 Ailanthus 中分离出来的一种苦木苦味素类化合物。Ailanthus 可用作退热药 (抗疟) 和驱虫药，用于慢性支气管炎、癫痫和哮喘的研究。

天然产物

Cat.No: T7064

Synonym: Sodium valproate,2-Propylpentanoic Acid,丙戊酸,VPA,Depakine,2-Propylvaleric Acid

Target: Mitophagy, Gamma-secretase, HIV Protease, GABA Receptor, Sodium Channel, HDAC, Autophagy

(E)-3,4,5-Trimethoxycinnamic acid

Cat.No: TN2865

Synonym: O-Methylsinapic acid,3,4,5-三甲氧基肉桂酸,3,4,5-Trimethoxy-trans-cinnamic acid,3,4,5-Trimethoxyphenylacrylic acid

Target: Others

Pilocarpine Hydrochloride

Cat.No: T0804

Synonym: NSC 5746 HCl,盐酸毛果芸香碱,Pilocarpine HCl,(+)-Pilocarpine hydrochloride

Target: AChR

Pseudoginsenoside RT5

Cat.No: T4S1519

Synonym: 拟人参皂苷RT5

Target: Others

Cat.No: T8162

Synonym: Cannabidivarin,GWP-42006,GWP42006,GWP 42006

Target: GABA Receptor

TETRAHYDROPIPERINE

Cat.No: T5786

Synonym: 四氢胡椒碱,Cosmoperine

Target: P450, TRP/TRPV Channel

Paederosidic acid

Cat.No: T5739

Synonym: 鸡屎藤苷酸,异戊二酸紫草酸

Target: Apoptosis, BCL

N-Methylsarcosine

Cat.No: T4120

Synonym: N,N-Dimethylglycine,N,N-Dimethylaminoacetic acid,Dimethylglycine,N,N-二甲基甘氨酸,DMG

Target: Endogenous Metabolite

Shinjulactone M

Cat.No: T75494

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-01174	Cystatin B Protein, Mouse, Recombinant (His) PME,CST6cystatin B (liver thiol proteinase inhibitor)10STFBc...	Mouse	E. coli
	Cystatin B, also called stefin B or liver thiol proteinase inhibitor, is a member of family 1 of the cystatin superfamily. Like Cystatin A, it is an intracellular inhibitor regulating the activities of cysteine proteases of the papain family such as cathepsins B, H and L. Defects in Cystatin-B / CSTB are the cause of progressive myoclonic epilepsy type 1 (EPM1) which is an autosomal recessive disorder characterized by severe, stimulus-sensitive myoclonus and tonic-clonic seizures.
TMPJ-00007	NPY Protein, Human, Recombinant (His) Pro-Neuropeptide Y,Neuropeptide Y,NPY,C-Flanking Peptide of ...	Human	HEK293 Cells
	Pro-Neuropeptide Y (NPY) is a member of the NPY family. NPY is a secreted protein and is one of the most abundant peptides in the nervous system. It also can be found in some chromaffin cells of the adrenal medulla. NPY can be cleaved into Neuropeptide Y and C-flanking peptide of NPY chain, which regulates energy usage, and it is involved in learning, memory processing, and epilepsy. NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone. In addition, NPY i...
TMPY-04473	ADK Protein, Human, Recombinant (His & GST) adenosine kinase,AK	Human	Baculovirus Insect Cells
	Adenosine kinase(ADK) belongs to the family of transferases. Adenosine kinase (ADK) is the key enzyme in adenosine metabolism and catalyzes ATP and adenosine into two products: ADP and AMP. Two isoforms of the enzyme adenosine kinase (ADK), which differ at their N-terminal ends, are found in mammalian cells. It has been shown that the two ADK isoforms differ only in their first exons and the promoter regions; hence they arise via differential splicing of their first exons with the other exons co...
TMPJ-00298	CD36 Protein, Human, Recombinant (aa 27-432, His) LGP85,Scavenger Receptor Class B Member 2,CD36,Lysosome Memb...	Human	HEK293 Cells
	Scavenger Receptor Class B Member 2 (SCARB2) is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junction obstructio...
TMPY-01695	CASPR2 Protein, Mouse, Recombinant (His) 5430425M22Rik,Caspr2,contactin associated protein-like 2,mKI...	Mouse	HEK293 Cells
	CNTNAP2/CASPR2 is a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. CNTNAP2/CASPR2 is localized at the juxtaparanodes of myelinated axons, and media...
TMPJ-00299	LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc) LIMP II,Lysosome membrane protein II,SCARB2,85 kDa lysosomal...	Mouse	HEK293 Cells
	Lysosome membrane protein II (LIMPII)，also known as SCARB2, is a type III multi-pass membrane glycoprotein that is located primarily in limiting membranes of lysosomes and endosomes on all tissues and cell types so far examined. Earlier studies in mice and rat suggested that this protein may participate in membrane transportation and the reorganization of endosomal/lysosomal compartment. The protein deficiency in mice was reported to impair cell membrane transport processes and cause pelvic junc...
TMPY-02090	Cystatin B Protein, Human, Recombinant (His) PME,EPM1A,STFB,ULD,cystatin B (stefin B),EPM1,CST6	Human	E. coli
	Cystatin-B, also known as CPI-B, Liver thiol proteinase inhibitor, Stefin-B, CSTB and CST6, is a cytoplasm and nucleus protein which belongs to thecystatin family. Cystatin-B / CSTB is an intracellular thiol proteinase inhibitor. Tightly binding reversible inhibitor of cathepsins L, H and B. Cystatin-B / CSTB is able to form a dimer stabilized by noncovalent forces, inhibiting papain and cathepsins l, h and b. Cystatin-B / CSTB is also thought to play a role in protecting against the prot...

重组蛋白

Cystatin B Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01174

Species: Mouse

Expression System: E. coli

NPY Protein, Human, Recombinant (His)

Cat.No: TMPJ-00007

Species: Human

Expression System: HEK293 Cells

ADK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04473

Species: Human

Expression System: Baculovirus Insect Cells

CD36 Protein, Human, Recombinant (aa 27-432, His)

Cat.No: TMPJ-00298

Species: Human

Expression System: HEK293 Cells

CASPR2 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01695

Species: Mouse

Expression System: HEK293 Cells

LIMPII/SR-B2 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00299

Species: Mouse

Expression System: HEK293 Cells

Cystatin B Protein, Human, Recombinant (His)

Cat.No: TMPY-02090

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0266	Pilocarpine-d3 HCl
	Pilocarpine-d3 HCl 是 Pilocarpine HCl 的氘代化合物。Pilocarpine HCl 的 CAS 号为 54-71-7。Pilocarpine Hydrochloride 是一种 M3 型毒蕈碱乙酰胆碱受体激动剂，用于制作癫痫实验模型
T37847	Zonisamide-13C2,15N Zonisamide-13C2,15N
	Zonisamide-13C2,15N is intended for use as an internal standard for the quantification of zonisamide by GC- or LC-MS. Zonisamide is an antiepileptic agent.1 It selectively inhibits the repeated firing of sodium channels (IC50 = 2 μg/ml) in mouse embryo spinal cord neurons and inhibits spontaneous channel firing when used at concentrations greater than 10 μg/ml.2 In rat cerebral cortex neurons, zonisamide (1-1,000 μM) inhibits T-type calcium channels with a maximum reduction of 60% of the calcium...

同位素标记化合物

Pilocarpine-d3 HCl

Cat.No: TMIJ-0266

Zonisamide-13C2,15N

Cat.No: T37847

Synonym: Zonisamide-13C2,15N

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