98
51
2
108
12
Cat. No. | Product Name | ||
---|---|---|---|
L8400 | 血液病分子库 | 514 compounds | |
514 种造血系统疾病相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2520 | 糖代谢化合物库 | 702 compounds | |
702 种糖代谢相关的化合物,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12499 |
PKR-IN-2
|
PKM | Metabolism |
PKR-IN-2 是丙酮酸激酶PKR 亚型的激活剂,可用于 PKR 功能相关疾病的研究,包括癌症、糖尿病、肥胖、自身免疫性疾病、良性前列腺增生等。 | |||
T41160 |
Lalistat 2
|
Lipase | Metabolism |
Lalistat 2 是一种溶酶体酸性脂肪酶的特异性抑制剂,IC50 为 152 nM,对人胰脂肪酶或牛乳脂蛋白脂肪酶没有抑制作用(高达 10 μM)。 | |||
T4223 |
Mitapivat
PKR-IN-1 |
PKM | Metabolism |
Mitapivat (PKR-IN-1) 是口服具有活性的变构丙酮酸激酶 (pyruvate kinase) 激活剂,其AC50=20 nM。它在广泛的 PKLR 基因型中增加酶活性、蛋白质稳定性和 ATP 水平。它有潜在的恢复 PK 缺乏的糖酵解途径活性的作用。 | |||
T1536 |
Promestriene
3-propyl ethyl,舒经劳,17B-methyl estradiol,Promestriano |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Promestriene (3-propyl ethyl) 是局部有效的雌激素,是合成的雌二醇二乙醚。它对阴道萎缩有作用,但吸收量小。 | |||
T29856 |
Aleplasinin
PAZ 417,PAZ417,PAZ-417 |
PAI-1 | Metabolism |
Aleplasinin (PAZ 417) 是纤溶酶原激活物抑制剂 1 (PAI-1) 的选择性和口服活性抑制剂,是纤溶系统的关键负调节剂。 Aleplasinin 可用于阿尔茨海默病研究。 | |||
T4505 |
Ferrous Bisglycinate
Bisglycine iron(II) salt,Iron(II) bisglycinate,甘氨酸亚铁 |
Estrogen/progestogen Receptor | Endocrinology/Hormones |
Ferrous Bisglycinate (Bisglycine iron(II) salt) 是口服具有活力的铁强化剂剂补充剂。它可用于研究缺铁性贫血。 | |||
T13692 |
Ferric maltol
Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate,麦芽酚铁 |
Others | Others |
Ferric maltol (Iron(III) 2-methyl-4-oxo-4H-pyran-3-olate) 是一种具有口服活性的单一铁离子 (Fe3+) 复合物,可用于研究炎症性肠病缺铁性贫血。 | |||
T7313 |
Enclomiphene citrate
恩氯米芬柠檬酸盐,Enclomifene citrate,(E)-Clomiphene citrate,trans-Clomiphene citrate |
Estrogen Receptor/ERR | Endocrinology/Hormones |
Enclomiphene citrate (trans-Clomiphene citrate) 是口服具有活力的 oestrogen receptor 拮抗剂,具有抗雌激素活性。 | |||
T13396 |
Zinc Protoporphyrin
Zinc Protoporphyrin-9,锌原卟啉,ZnPP,Zn(II)-protoporphyrin IX |
Apoptosis; Reactive Oxygen Species; Endogenous Metabolite | Apoptosis; Immunology/Inflammation; Metabolism; NF-κB |
Zinc Protoporphyrin (Zn(II)-protoporphyrin IX) 是一种具有口服活性的,竞争性血红素加氧酶-1 抑制剂,显著减弱间苯三酚对 H2O2 的保护作用,具有抗癌活性。它用于评估人群铁状态与血红蛋白浓度的组合,也可用作个体孕妇和儿童缺铁的筛查标志物。 | |||
T3036 |
Dydrogesterone
|
Progesterone Receptor | Others |
Dydrogesterone 是一种口服有效的孕激素,可作用于孕酮缺乏相关疾病。 | |||
T8132 |
Iron sucrose
Iron saccharate,蔗糖铁,Sucroferric oxyhydroxide |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
Iron sucrose (Sucroferric oxyhydroxide) 是一种静脉注射铁制剂,也是一种促氧化剂,可用于研究缺铁性贫血。 | |||
T61144 |
Hepcidin antagonist-1
|
Others | Others |
Hepcidin antagonist-1 是一种铁调素拮抗剂。Hepcidin antagonist-1 可用于研究像缺铁疾病和贫血类的代谢紊乱。 | |||
T20093 |
p-Phenylenediamine, N,N'-diphenyl-
NSC 761,NSC 5761,Flexamine G,NSC-5761,N,N'-二苯基-1,4-苯二胺,DPPD |
Others | Others |
p-Phenylenediamine, N,N'-diphenyl- (NSC-761) 是一种生物活性化学品。它已被用于预防羔羊维生素 E 缺乏症。 | |||
T4552 |
Fursultiamine
Diteftin,呋喃硫胺,Judolor,Alinamin F |
Others | Others |
Fursultiamine (Alinamin F) 是维生素 B1衍生物,具有抗伤害和抗肿瘤作用。它可用于研究维生素 B1缺乏病、骨关节炎和癌症。 | |||
T17176 |
Salicyl-AMS
|
Antibacterial | Microbiology/Virology |
Salicyl-AMS 是一种分支杆菌生长素生物合成抑制剂,能在体外缺铁的情况下抑制分枝杆菌的生长。 | |||
T5963 |
Menadione bisulfite sodium
Sodium menadione bisulfite,亚硫酸氢钠甲萘醌,Menadione sodium bisulfite,Vitamin K3 sodium bisulfite |
Others | Others |
Menadione bisulfite sodium (Vitamin K3 sodium bisulfite) 是可以诱导急性氧化应激的试剂,可用作植物防御活化剂,具有抵抗病菌的作用。 | |||
T4994 |
Tocofersolan
Vitamin E-TPGS,Tocophersolan,TPGS,D-α-Tocopherol polyethylene glycol 1000 succinate,托可索仑,维生素E聚乙二醇琥珀酸酯 |
Others | Others |
Tocofersolan (TPGS) 是合成的 α-生育酚的聚乙二醇衍生物。 | |||
T20506 |
Maleuric acid
N-Carbamoylmaleamic acid,AI3 32778,AI3-32778,AI332778 |
Others | Others |
Maleuric acid (N-Carbamoylmaleamic acid) 可抗有丝分裂,可与放射自显影技术结合起来用于生物研究。Maleuric acid 可用于改善动植物的生长和繁殖力以及治疗乳清酸缺乏症。 | |||
T10393 |
AT-007
|
Reductase | Endocrinology/Hormones; Metabolism |
AT-007 是口服有效的,中枢神经系统渗透性醛糖还原酶的高效抑制剂, IC50为 100 pM。在 GALT 缺失大鼠中,它降低了有毒的半乳糖醇水平并预防了疾病并发症。 | |||
T13219 |
TTA-Q6
|
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
TTA-Q6 是一种选择性 T 型 Ca2+ 通道拮抗剂,具有潜在的抗肿瘤和免疫调节活性,可抑制肿瘤细胞摄取细胞外钙离子,诱导细胞内钙缺乏和内质网(ER)应激,用于治疗神经系统疾病。 | |||
T77194L |
D-Ribose 5-phosphate disodium dihydrate
|
Endogenous Metabolite | Metabolism |
D-Ribose 5-phosphate disodium dihydrate 参与磷酸戊糖途径,是磷酸戊糖途径的中间产物,可用于研究由核黄素缺乏引起的眼部疾病和内分泌与代谢疾病。 | |||
T13730 |
Hydroxocobalamin acetate
|
Others | Others |
Hydroxocobalamin acetate 是可注射的天然维生素 B12,其不良反应特征良好,可用于研究维生素 B12 缺乏症 (包括恶性贫血) 。 | |||
T4512 |
Magnesium glycinate
magnesium 2-aminoacetate,Magnesium diglycinate,甘氨酸镁 |
Others | Others |
Magnesium glycinate (magnesium 2-aminoacetate) 是一种营养补充剂,是甘氨酸的镁盐,具有良好的理化性质和生物活性。Magnesium 是人体必需的矿物质,参与能量代谢过程,协助维持正常的肌肉功能,对人体起着至关重要的作用。 | |||
T37192 |
4-Methylumbelliferyl-α-D-Galactopyranoside
4MU-α-Gal |
Others | Others |
4-Methylumbelliferyl-α-D-Galactopyranoside (4MU-α-Gal) (4-MU-α-Gal)是α-半乳糖苷酶的荧光底物。除了用于表征新的α-半乳糖苷酶外,4-MU-α-Gal 还用于评估与法布里病相关的α-半乳糖糖苷酶活性的缺乏。 | |||
T77599 |
Methyl retinoate
Retinoic acid, methyl ester |
Others | Others |
Methyl retinoate (Retinoic acid, methyl ester) 在体内实验中会诱导给部位发生无菌炎症,会使血液中白细胞数量增加,而红细胞和Hb含量减少。Methyl retinoate 可促进自发性白血病的产生。Methyl retinoate 可用于治疗因维生素A缺乏而产生的胃肥大和溃疡。 | |||
T31859 |
Fosdenopterin
|
Others | Others |
Fosdenopterin is a molybdenum cofactor deficiency. | |||
T1182L |
Levocarnitine propionate
L-Propionylcarnitine,ST261,ST 261,Propionyl-L-carnitine,ST-261 |
||
Propionylcarnitine is present in high abundance in the urine of patients with Methylmalonyl-CoA mutase (MUT) deficiency. | |||
T31851 |
Formiminoglutamic acid
NSC-334078,NSC334078,NSC 334078 |
Others | Others |
Formiminoglutamic acid is used to indicate folic acid deficiency and megaloblastic anemia of pregnancy with the measurement in the urine after oral administration of histidine. | |||
T32193 |
Iron sorbitex
Jectofer,Yectofer,Iron Sorbitol,HSDB 1967,Astra 1572 |
Others | Others |
Iron Sorbitex is used for the treatment of Iron Sorbitex deficiency anemia in patients with chronic kidney disease. Iron Sorbitex can be used as an Iron Sorbitex replacement product used for the treatment of Iron Sorbitex deficiency anemia in patients wit | |||
T73783 |
D-Ribofuranose
|
Others | Others |
D-Ribofuranose (D-Ribose) 是一种在脑脊液中发现的内源性代谢物,用于磷酸 5 核糖异构酶缺乏症和中链酰基 CoA 脱氢酶缺乏症的研究。 | |||
T69677 |
Mitapivat sulfate anhydrous
|
Others | Others |
Mitapivat sulfate anhydrous is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency. | |||
T34316 |
Rhizoferrin
|
Others | Others |
Rhizoferrin 是一种来自真菌Rhizopus microsporus var.rhizopodiformis 的新型铁载体,可用于研究植物缺铁引起的萎黄病。 | |||
T69865 |
Mitapivat sulfate
|
Others | Others |
Mitapivat sulfate, also known as AG-348 sulfate hydrate, is an allosteric activator of Pyruvate Kinase (PK) that may be useful in the treatment of Pyruvate Kinase Deficiency. | |||
T61512 |
FT3967385
|
Others | Others |
FT3967385 is a newly developed compound that functions as a USP30 inhibitor, emulating the genetic deficiency of USP30. This inhibition serves as a catalyst for the amplification of mitochondrial ubiquitylation through the PINK1-PARKIN pathway. | |||
T73734 |
Acetoacetic acid
|
Others | Others |
Acetoacetic acid是一种存在于脑脊液中的内源代谢物,主要应用于脑膜炎、妊娠、3-羟基-3-甲基戊二酰辅酶A裂解酶缺乏症、子痫前期/子痫、2型糖尿病、1型葡萄糖转运蛋白缺乏综合征及琥珀酰辅酶A:3-氧酸辅酶A转移酶缺乏症的研究中。 | |||
T76121 |
Phosphoglucomutase
|
Endogenous Metabolite | Metabolism |
Phosphoglucomutase可促进弓形虫的囊肿发育。缺乏 Phosphoglucomutase 会引发代谢疾病。 | |||
T15709 |
Lapaquistat acetate
TAK-475 |
Others | Others |
Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholester | |||
T72973 |
Octotiamine
硫辛酸硫胺,TATD |
Others | Others |
Octotiamine (TATD),一种维生素B1类似物,成为维生素复合物的组成部分,主要用于研究维生素B1缺乏症。 | |||
T36947 |
Pyrithiamine (hydrobromide)
|
Others | Others |
Pyrithiamine is the pyridine analog of thiamine that prevents growth of organisms that require intact thiamine. [1] It inhibits the growth of bacterial and fungal species at a pyrithiamine:thiamine ratio of 10:1 in growth media and induces symptoms of thiamine deficiency in mice at a dietary ratio of 3:1. These effects are reversible with addition of sufficient thiamine in all species. Pyrithiamine inhibits the formation of cocarboxylase from thiamine in chicken blood in a dose-dependent manner.... | |||
T36842 |
Isobutyryl Coenzyme A (sodium salt)
|
Others | Others |
Isobutyryl coenzyme A (isobutyryl-CoA) is a short-chain branched acyl CoA. Isobutyryl-CoA is a substrate for isobutyryl-CoA dehydrogenase (IBDH) in the catabolism of valine and an intermediate in the synthesis of isobutyryl-L-carnitine , which accumulates in IBDH deficiency. | |||
T73754 |
Pristanic acid
|
Others | Others |
Pristanic acid,一种血液中的内源代谢物,用于研究α甲基酰基辅酶A消旋酶缺乏症和齐薇格综合征。 | |||
T63728 |
RAD51-IN-7
|
Others | Others |
RAD51-IN-7 是 RAD51 的有效抑制剂。其中 RAD51 是一种真核生物基因。RAD51-IN-7 对线粒体缺陷病症表现出研究潜力。 | |||
T35665 |
Pregnanetriol
|
Others | Others |
Pregnanetriol is a metabolite of 17α-hydroxyprogesterone .1,2It is formed from 17α-hydroxyprogesterone by reduction of the C-20 ketone.2Urinary levels of pregnanetriol are elevated in patients with 21-hydroxylase deficiency and congenital adrenal hyperplasia.3,4 1.Kamrath, C., Hartmann, M.F., Boettcher, C., et al.Diagnosis of 21-hydroxylase deficiency by urinary metabolite ratios using gas chromatography-mass spectrometry analysis: Reference values for neonates and infantsJ. Steroid Biochem. Mol... | |||
T82294 |
GLUT1-IN-3
|
Others | Others |
GLUT1-IN-3 (Compd 4b) 是针对1型葡萄糖转运蛋白缺乏综合症相关疾病研究的化合物,具有有效抑制癫痫发作的作用。 | |||
T64308 |
Fosdenopterin hydrobromide dihydrate
|
Others | Others |
Fosdenopterin (Precursor Z) hydrobromide dehydrate 是一种合成的环吡喃蝶呤单磷酸盐 (cPMP),能够用于A 型钼辅因子缺乏症 (MoCD) 的研究。 | |||
T73790 |
3-Hydroxysebacic acid
|
Others | Others |
3-Hydroxysebacic acid 是存在于尿中的内源代谢物,可用于研究中链酰基钴 A 脱氢酶缺乏症。 | |||
T61669 |
BChE-IN-4
|
Others | Others |
BChE-IN-4 is a highly potent inhibitor of the enzyme butyrylcholinesterase, capable of crossing the blood-brain barrier. It effectively reduces learning and memory impairments resulting from a deficiency in cholinergic activity in a mouse model. BChE-IN-4 holds promise for further investigation in the field of Alzheimer's disease research [1]. | |||
T15691 |
L-Alanosine
NSC-153353,丙氨菌素 |
Others | Others |
L-Alanosine inhibits adenylosuccinate synthetase. L-Alanosine is an antibiotic from Streptomyces alanosinicus with antineoplastic activity. L-Alanosine blocks the common de novo purine biosynthesis pathway and, thereby, inhibit tumor cells with MTAP defic | |||
T63892 |
RAD51-IN-5
|
Others | Others |
RAD51-IN-5 是 RAD51 有效的抑制剂。其中 RAD51 是一种真核生物基因。RAD51-IN-5 对线粒体缺陷病症表现出研究潜力。 | |||
T25496 |
Hexaglutamate folate
Pteglu6 |
Others | Others |
Hexaglutamate folate is a naturally occurring form of folic acid. The bioavailability of dietary folate may be limited by the need for the glutamate moieties to be deconjugated before absorption. Folate deficiency in humans results in anemia, neural tube |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T0613 |
3-Hydroxyisovaleric acid
β-羟基异戊酸,Beta-Hydroxyisovaleric acid |
Others; Endogenous Metabolite | Metabolism; Others |
3-Hydroxyisovaleric acid (Beta-Hydroxyisovaleric acid) 是尿液中排泄的内源性代谢产物 ,可作为生物素缺乏的早期和敏感指标。 | |||
T0062 |
Folic acid
Folate,Vitamin B9,Pteroylglutamic acid,Vitamin M,叶酸,Folacin |
DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Folic acid (Vitamin B9) 是维生素B9,是合成DNA/RNA,新细胞产生和维持的必要成分。 | |||
T4734 |
Suberic acid
Octanedioic acid,1,8-Octanedioic acid,辛二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Suberic acid (1,8-Octanedioic acid) 被发现和肉毒碱-甲酰基-丙氨酸转位酶缺乏(丙二醇-羧基酶缺乏症)有关。 | |||
T3S0507 |
Homovanillic acid
Homovaniuic acid,Vanilacetic acid,高香草酸,Vanillacetic acid |
Others; Endogenous Metabolite | Metabolism; Others |
Homovanillic acid (Vanillacetic acid) 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
T19581 |
Tiglyl carnitine
|
Endogenous Metabolite | Metabolism |
Tiglyl carnitine 与肺癌和肉碱和甘氨酸对3-酮硫解酶缺乏症有关 。 | |||
T4851 |
Methyl acetylacetate
Methyl acetoacetate,乙酰乙酸甲酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Methyl acetylacetate (Methyl acetoacetate) 是内源性代谢产物的一种。 | |||
TQ0024 |
3-Hydroxyglutaric acid
|
Endogenous Metabolite | Metabolism |
3-Hydroxyglutaric acid 是一种戊二酸的衍生物。 | |||
T4766 |
3-Methylglutaric acid
|
Endogenous Metabolite | Metabolism |
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。 | |||
T4817 |
Methylmalonic acid
NSC 25201,MMA,Isosuccinic acid,甲基丙二酸,Methylpropanedioic acid,Methylmalonate |
Others; Dehydrogenase; Endogenous Metabolite | Metabolism; Others |
Methylmalonic acid 是癌症患者缺乏维生素 B-12的指标。Methylmalonic acid 是竞争性琥珀酸脱氢酶抑制剂。 | |||
TWP2911 |
Thymidine
beta-胸苷,5-Methyldeoxyuridine,Deoxyribothymidine,DThyd,NSC 21548,Thymidin |
Others; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
Thymidine (DThyd) 是一种细胞同步剂,是脱氧核糖核酸的特殊前体。它可在 DNA 复制前在 G1/S 边界阻滞细胞,是DNA 合成抑制因子。 | |||
T5279 |
Ethylmalonic acid
alpha-Carboxybutyrate,2-Ethylmalonic acid,乙基丙二酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ethylmalonic acid 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。 | |||
TN1704 |
Glycyrrhetic acid 3-O-β-D-glucuronide
Glycyrrhetic acid 3-O-mono-beta-D-glucuronide,单葡萄糖醛酸甘草次酸 |
Others | Others |
Glycyrrhetic acid 3-O-mono-beta-D-glucuronide 是从甘草中分离出的甘草酸 3-O-β-D-葡萄糖醛酸,是甘草甜素的重要衍生物。它具有抗过敏活性,可作为甜味剂。 | |||
T19608 |
Zinc sulfate heptahydrate
|
Others | Others |
Zinc sulfate heptahydrate 是七水合形式的硫酸锌,是一种膳食补充剂,可用于锌缺乏症和预防高危人群的锌缺乏症。 | |||
T1709 |
2'-Deoxyinosine
Guanine deoxyriboside,Deoxyinosine,2'-脱氧肌苷 |
Others; Endogenous Metabolite | Metabolism; Others |
2'-Deoxyinosine (Guanine deoxyriboside) 具有 抑制人癌细胞株生长的活性,并发现其与嘌呤核苷磷酸化酶缺乏有关。 | |||
T4586 |
(Rac)-Arnebin 1
β,β-二甲基丙烯酰阿卡宁,beta, beta-dimethylacrylshikonin |
Others | Others |
(Rac)-Arnebin 1 (beta, beta-dimethylacrylshikonin) 具有抗肿瘤作用,是β,β-Dimethylacrylalkannin 和 β,β-Dimethylacrylshikonin 的消旋体。β,β-Dimethylacrylalkannin 和 β,β-Dimethylacrylshikonin 是分离自紫草属植物中的萘醌类化合物。 | |||
T4804 |
Pyruvic acid
BTS,Pyroracemic acid,α-Ketopropionic acid,2-Oxopropionic acid,Acetylformic acid,丙酮酸,NSC 179 |
Others; Endogenous Metabolite | Metabolism; Others |
Pyruvic acid (Acetylformic acid) 是碳水化合物,是蛋白质和脂肪代谢的中间产物。 | |||
T37177 |
Norcholic Acid
|
Others | Others |
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,4 | |||
T17048 |
Tetradecanoylcarnitine
L-Myristoylcarnitine,Myristoyl-L-(-)-carnitine |
Endogenous Metabolite | Metabolism |
Tetradecanoylcarnitine (L-Myristoylcarnitine) 是一种酰基肉碱,参与长链脂肪酸的β-氧化,是极长链酰辅酶A脱氢酶缺乏症的一种潜在标记物。 | |||
T4880 |
L-Dihydroorotic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Dihydroorotic acid 是一种能够通过二氢乳清酶,能够逆水解产生的无环 L-脲基琥珀酸。 | |||
T4894 |
L-Arabinitol
贝他米松-21-丙酸酯,L-(-)-Arabitol |
Endogenous Metabolite | Metabolism |
L-Arabinitol (L-(-)-Arabitol) 是一种红薯、蛾豆、鹿莓等食品的潜在生物标志物,与阿尔茨海默病和 5-磷酸核糖异构酶缺乏症有关。 | |||
TN1957 |
Mulberrofuran Q
MulberrofuranQ |
||
Mulberrofuran Q是一种有活性的化合物,可抑制12-羟基-5,8,10-十七碳三烯酸(HHT)和血栓烷B2(环加氧酶产物)的形成 ,可保护神经细胞免受缺氧-缺糖(OGD)诱导的氧化应激的影响。 | |||
T5515 |
Hemin
氯化血红素,Hemin chloride |
Mitophagy; Ferroptosis; Autophagy | Apoptosis; Autophagy |
Hemin (Hemin chloride) 是一种含有氯的含铁卟啉,一种血红素加氧酶 (HO)-1 诱导剂。Hemin 对卟啉病具有治疗活性,可以减少患者的血红素缺乏,从而通过生物化学反馈抑制 δ-氨基乙酰丙酸合成酶的活性。 | |||
T7094 |
Levomefolic Acid
L-5-甲基四氢叶酸,5-MTHF,5-甲基四氢叶酸 |
Reactive Oxygen Species; Endogenous Metabolite | Immunology/Inflammation; Metabolism; NF-κB |
Levomefolic Acid (5-MTHF) 是一种具有口服活性、可穿过血脑屏障的天然活性叶酸,是广泛使用的叶酸食品补充剂。 | |||
T5076 |
L-Allothreonine
L-别苏氨酸,L-allo-Threonine |
Others; Endogenous Metabolite | Metabolism; Others |
L-Allothreonine (L-allo-Threonine) 是内源性代谢产物的一种。 | |||
T4887 |
3-Amino-2-methylpropanoic acid
DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine |
Endogenous Metabolite | Metabolism |
3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物,是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。 | |||
T5291 |
Malonic acid
Carboxyacetic Acid,1,3-Propanedioic Acid,丙二酸,Propanedioic Acid |
Others | Others |
Malonic acid (propanedioic acid) 是竞争性抑制剂的典型例子:它作用于呼吸电子传递链中的琥珀酸脱氢酶(复合物 II)。发现丙二酸与丙二酰辅酶A 脱羧酶缺乏有关,这是一种先天性代谢错误。 | |||
T4901 |
5'-Guanylic acid disodium salt
Guanosine 5'-monophosphate disodium salt,5'-鸟苷酸二钠,鸟苷钠5'-单磷酸,GMP-5 |
Others; Endogenous Metabolite | Metabolism; Others |
5'-Guanylic acid disodium salt (GMP-5) 由鸟嘌呤,核糖和磷酸组成,是信使 RNA 中的一种核苷酸单体。 鸟苷衍生物参与细胞内信号转导,并已鉴定存在于端粒,核糖体 DNA,免疫球蛋白重链转换区和原癌基因的控制区中的重复基因组序列中。 | |||
T4856 |
Acetyl-L-lysine
N-乙酰-L-赖氨酸,Nα-Acetyl-L-lysine,(2S)-2-Acetamido-6-aminohexanoic acid |
Endogenous Metabolite | Metabolism |
Acetyl-L-lysine (Nα-Acetyl-L-lysine) 是一种 N-乙酰化氨基酸。它是人类尿液中的一种正常成分,在正常样本中的浓度太小,无法进行常规检测;然而,在一名氨基酰化酶I缺乏症患者的尿液中发现其水平升高。 | |||
T3O2749 |
L-Leucine
(S)-Leucine,Leu,L-亮氨酸,亮氨酸 |
mTOR | PI3K/Akt/mTOR signaling |
L-Leucine ((S)-Leucine) 是必需的支链氨基酸,能够激活 mTOR 信号通路。 | |||
T4858 |
4-Hydroxyphenylpyruvic acid
4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid |
Endogenous Metabolite | Metabolism |
4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物,是一种酶抑制剂。 | |||
T0934 |
Nicotinamide
Nicotinic acid amide,Vitamin B3,Niacinamide,烟酰胺,Vitamin PP |
Sirtuin; Endogenous Metabolite | Chromatin/Epigenetic; DNA Damage/DNA Repair; Metabolism |
Nicotinamide 是维生素 B3 的吡啶核苷形式,可作为烟酰胺腺嘌呤二核苷酸或 NAD+ 的前体,可通过膳食摄入来补充,能预防或治疗黑舌病和糙皮病。 | |||
T3578 |
Pyridoxal phosphate
PLP,PAL-P,磷酸吡哆醛,pyridoxal 5'-phosphate,Pyridoxyl phosphate,Pyridoxal 5′-phosphate,Vitamin B6 phosphate |
Reverse Transcriptase; Endogenous Metabolite | Metabolism; Microbiology/Virology |
Pyridoxal phosphate (Vitamin B6 phosphate) 是维生素 B6 的活性形式,可抑制逆转录酶活性,用于研究迟发性运动障碍症。 | |||
T1040 |
Vitamin B12
Cyanocobalamin,Cobalamin,维生素B12 |
Endogenous Metabolite | Metabolism |
Vitamin B12 (Cobalamin) 是一种维生素,在维持血流形成和脑、神经系统正常功能等方面发挥关键作用。 | |||
T5215 |
N-(3-Phenylpropionyl)glycine
N-(3-苯基丙酰基)甘氨酸,Phenylpropionylglycine |
Others | Others |
N-(3-Phenylpropionyl)glycine (Phenylpropionylglycine) 是一种酰基甘氨酸。酰基甘氨酸通常是脂肪酸的次要代谢物。 | |||
T5267 |
N-Acetyl-L-glutamic acid
Ac-L-Glu-OH,N-乙酰-L-谷氨酰胺,N-Acetylglutamic acid |
Others; Endogenous Metabolite | Metabolism; Others |
N-Acetyl-L-glutamic acid (Ac-L-Glu-OH) 是一种 N-Acyl-L-氨基酸,是动物细胞培养基的组成成分,是一种酿酒酵母和人类的代谢物。 | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T4919 |
Ureidopropionic acid
Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid |
Endogenous Metabolite | Metabolism |
Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说,它是二氢尿嘧啶的分解产物,由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。 | |||
T4838 |
(S)-Malic acid
L-(-)-Malic acid,(S)-(-)-HYDROXYSUCCINIC ACID,(S)-2-Hydroxysuccinic acid,L-苹果酸 |
Others; Endogenous Metabolite | Metabolism; Others |
(S)-Malic acid ((S)-2-Hydroxysuccinic acid) 是天然存在的二羧酸,是水果酸甜味的来源,常用作食品添加剂。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 | |||
T19346 |
5'-Guanylic acid
鸟苷酸,5'-guanosine monophosphate,5'-GMP |
Endogenous Metabolite | Metabolism |
5'-Guanylic acid (5'-guanosine monophosphate) 与几种代谢紊乱有关,包括腺苷脱氨酶缺乏症、 aica-核糖体途径、腺嘌呤磷酸转移酶缺乏症 (aprt) 以及 2-羟基葡糖酸盐途径。 | |||
T39460 |
Mead acid
5,8,11-Eicosatrienoic acid |
Others | Others |
Mead acid, also known as 5,8,11-Eicosatrienoic acid, is an unsaturated fatty acid belonging to the Omega-9 series. It serves as an indicator of deficiency in essential fatty acids. | |||
T13731 |
Hydroxocobalamin monohydrochloride
Vitamin B12a monohydrochloride,盐酸羟钴胺 |
Others | Others |
Hydroxocobalamin monohydrochloride is an injectable naturally occurring form of vitamin B12. It is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia. | |||
T37977 |
Succinyladenosine
|
Others | Others |
Succinyladenosine is a biochemical marker of adenylosuccinase (ASL) deficiency. It is formed through the dephosphorylation of intracellular adenylosuccinic acid (S-AMP) by cytosolic 5-nucleotidase [1]. | |||
T40381 |
2,8-Dihydroxyadenine
|
Others | Others |
2,8-Dihydroxyadenine, an endogenous metabolite, can induce the generation of urinary crystals and nephrolithiasis. Moreover, 2,8-Dihydroxyadenine serves as a diagnostic tool for detecting adenine phosphoribosyltransferase (APRT) deficiency. | |||
T73775 |
Dopamine 3-O-sulfate
|
Others | Others |
Dopamine 3-O-sulfate,一种主要存在于血浆中的化合物,可作为芳香族氨基酸脱羧酶(AADC)缺乏症的生物标志物。 | |||
T78466 |
Erythronic acid potassium
|
Endogenous Metabolite | Metabolism |
Erythronic acid potassium为糖类内源性代谢物,关键作用于高尿酸血症发病及改善过程,并与转醛缩酶缺乏症相关的线粒体功能障碍有关,常用于代谢性疾病研究。 | |||
T36472 |
Tetrahydro-11-deoxy Cortisol
|
Others | Others |
Tetrahydro-11-deoxy cortisol (THS) is the primary urinary metabolite of 11-deoxycortisol. Urinary excretion of THS is elevated in patients with 11β-hydroxylase deficiency, a condition resulting from mutations in the cytochrome P450 (CYP) isoform CYP11B1. Urinary levels of THS are also elevated in patients with adrenocortical carcinoma (ACC) and adrenocortical adenoma (ACA) but are higher in patients with ACC compared to ACA. | |||
TN3472 | Axillaridine A | Others | Others |
Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and | |||
T78476 |
Hydroxocobalamin
Vitamin B12a |
Endogenous Metabolite | Metabolism |
Hydroxocobalamin(Vitamin B12a)为可注射型天然维生素B12,不良反应特性良好,适用于治疗维生素B12缺乏症(包括恶性贫血)的膳食补充。 | |||
TN4334 |
Isotaxiresinol
|
TNF | Apoptosis |
Isotaxiresinol prevents d-GalN/LPS-induced hepatic injury by inhibiting hepatocyte apoptosis through the blocking of TNF-alpha and IFN-gamma production by activated macrophages and direct inhibition of the apoptosis induced by TNF-alpha. Isotaxiresinol ma | |||
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Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-00331 |
Simian immunodeficiency virus (SIV) (isolate SIVmac251v31523ru28) gp120 Protein (His)
SIV-GP12 |
SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate SIVmac251v31523ru28) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 54.6 kDa and the accession number is D7PU90. | |||
TMPY-00336 |
Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein (His)
SIV-GP12 |
SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate 216.94.A2) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is E2EXP2. | |||
TMPY-00328 |
Simian immunodeficiency virus (SIV) (isolate F236) gp120 Protein (His)
SIV-GP12 |
SIV | HEK293 Cells |
Simian immunodeficiency virus (SIV) (isolate F236) gp120 Protein (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 59.8 kDa and the accession number is P12492. | |||
TMPH-03509 |
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO)
Protein Vpx,X ORF protein,vpx,Viral protein X |
SIV | E. coli |
Simian immunodeficiency virus (SIV) (isolate PBj14/BCL-3) Vpx Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 28.9 kDa and the accession number is P19508. | |||
TMPY-01101 |
Coagulation factor X/F10 Protein, Human, Recombinant (His)
FXA,FX,coagulation factor X,coagulation factor 10 |
Human | Baculovirus Insect Cells |
Coagulation factor X, also known as FX, F10, Eponym Stuart-Prower factor, and thrombokinase, is an enzyme of the coagulation cascade. It is one of the vitamin K-dependent serine proteases, and plays a crucial role in the coagulation cascade and blood clotting, as the first enzyme in the common pathway of thrombus formation. Factor X deficiency is one of the rarest of the inherited coagulation disorders. FX deficiency among the most severe of the rare coagulation defects, typically including hema... | |||
TMPY-02185 |
Coagulation factor XIII B/F13B Protein, Human, Recombinant (His)
Coagulation factor 13,coagulation factor XIII, B polypeptide... |
Human | HEK293 Cells |
Coagulation factor XIII B chain, also known as Fibrin-stabilizing factor B subunit, Protein-glutamine gamma-glutamyltransferase B chain, Transglutaminase B chain and F13B, is a secreted protein which contains 1 Sushi ( CCP / SCR ) domains. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have en... | |||
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPY-03425 |
Tau Protein, Human, Recombinant (His)
PPND,FTDP-17,MTBT1,DDPAC,MAPTL,MTBT2,microtubule-associated ... |
Human | E. coli |
MAPT (microtubule-associated protein tau) can produce tau proteins. Tau proteins are proteins that stabilize microtubules. They are abundant in neurons of the central nervous system and are less common elsewhere, but are also expressed at very low levels in CNS astrocytes and oligodendrocytes. When tau proteins are defective, and no longer stabilize microtubules properly, they can result in dementias such as Alzheimer's disease. Tau protein is a highly soluble microtubule-associated protein (MAP... | |||
TMPY-02801 |
PHGDH Protein, Human, Recombinant (His)
phosphoglycerate dehydrogenase,HEL-S-113,3PGDH,NLS1,PHGDHD,P... |
Human | E. coli |
PHGDH is a member of the D-isomer specific 2-hydroxyacid dehydrogenase family. This new family consists of D-isomer-stereospecific enzymes. The conserved residues in this family appear to be the residues involved in the substrate binding and the catalytic reaction, and thus to be targets for site-directed mutagenesis. A number of NAD-dependent 2-hydroxyacid dehydrogenases which seem to be specific for the D-isomer of their substrate have been shown to be functionally and structurally related. PH... | |||
TMPY-02707 |
PAH Protein, Human, Recombinant (415 Asn/Asp, His)
phenylalanine hydroxylase,PH,PKU1,PKU |
Human | Baculovirus Insect Cells |
PAH (phenylalanine hydroxylase), also known as PH, belongs to the biopterin-dependent aromatic amino acid hydroxylase family. It contains 1 ACT domain, N-terminal region of PAH is thought to contain allosteric binding sites for phenylalanine and to constitute an "inhibitory" domain that regulates the activity of a catalytic domain in the C-terminal portion of the molecule. In humans, PAH is expressed both in the liver and the kidney, and there is some indication that it may be differentially reg... | |||
TMPY-00828 |
Iduronate 2 sulfatase/IDS Protein, Human, Recombinant (His)
MPS2,IDS,SIDS,iduronate 2-sulfatase |
Human | HEK293 Cells |
Iduronate 2-Sulfatase, also known as IDS, is a member of the highly conserved sulfatase family of enzymes that catalyze the hydrolysis of O- and N-sulfate esters from a variety of substrates. The human Iduronate 2-Sulfatase/IDS consists of a signal peptide, a propeptide, and a mature chain that may be further processed into two chains. Among the identified 18 human sulfatases, Iduronate 2-Sulfatase/IDS is required for the lysosomal degradation of the glycosaminoglycans (GAG), heparan sulfate, an... | |||
TMPY-04483 |
IRAK4 Protein, Human, Recombinant (His)
IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas... |
Human | Baculovirus Insect Cells |
Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ... | |||
TMPY-02686 |
PON3 Protein, Human, Recombinant (S50N, His)
paraoxonase 3 |
Human | Baculovirus Insect Cells |
PON3 was enriched in the mitochondria-associated membrane fraction of hepatocytes. PON3 deficiency resulted in impaired mitochondrial respiration, increased mitochondrial superoxide levels, and increased hepatic expression of inflammatory genes. PON3 deficiency did not influence atherosclerosis development on an apolipoprotein E null hyperlipidemic background, but it did lead to a significant 60% increase in atherosclerotic lesion size in Pon3KO mice on the C57BL/6J background when fed a cholate... | |||
TMPJ-00505 |
Serpin A1 Protein, Human, Recombinant (aa 25-418, His)
Alpha-1-Antiproteinase,α-1-Antiproteinase,SERPINA1,Serpin A1... |
Human | HEK293 Cells |
Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants re... | |||
TMPY-04073 |
MRPL44 Protein, Human, Recombinant (His)
mitochondrial ribosomal protein L44,COXPD16,L44MT,MRP-L44 |
Human | Baculovirus Insect Cells |
MRPL44 (Mitochondrial Ribosomal Protein L44) is a Protein Coding gene. MRPL44 encodes a protein in the large subunit of the mitochondrial ribosome and is suggested to locate near the tunnel exit of the yeast mitochondrial ribosome. It belongs to the mitochondrion-specific ribosomal protein mL44 subfamily. In the patient fibroblasts, decreased MRPL44 affected assembly of the large ribosomal subunit and stability of 16S rRNA leading to complex IV deficiency. It may have a function in the assembly/... | |||
TMPJ-00997 |
GALK1 Protein, Human, Recombinant (His)
Galactokinase,Galactose Kinase,GALK1,GALK |
Human | E. coli |
Galactokinase belongs to the GHMP kinase family and GalK subfamily. Galactokinase is more important to the galactose metabolism pathway. It modifies galactose to create a similar molecule called Galactose-1-Phosphate.Thus, a series of additional steps converts Galactose-1-Phosphate to another simple sugar Glucose, which is the main energy source for most cells. Galactokinase deficiency results in Galactosemia II, an autosomal recessive deficiency characterized by congenital cataracts during infa... | |||
TMPY-03332 |
PRTFDC1 Protein, Human, Recombinant (His)
HHGP,PRTFDC1,phosphoribosyl transferase domain containing 1 |
Human | E. coli |
PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a sever... | |||
TMPY-01635 |
PCSK1 Protein, Human, Recombinant (His)
proprotein convertase subtilisin/kexin type 1,SPC3,PC1,BMIQ1... |
Human | HEK293 Cells |
Neuroendocrine convertase 1, also known as Prohormone convertase 1, Proprotein convertase 1, PCSK1 and NEC1, is an enzyme which belongs to the peptidase S8 family and Furin subfamily. PCSK1 is an enzyme that performs the proteolytic cleavage of prohormones to their intermediate (or sometimes completely cleaved) forms. It is present only in neuroendocrine cells such as brain, pituitary and adrenal, and most often cleaves after a pair of basic residues within prohormones but can occasionally cleav... | |||
TMPY-04464 |
GALK1 Protein, Human, Recombinant (His & GST)
galactokinase 1,HEL-S-19,GALK,GK1 |
Human | Baculovirus Insect Cells |
Galactokinase, also known as Galactose kinase, GALK and GALK1, is a protein which belongs to theGHMP kinase family and GalK subfamily. Galactokinase / GALK1 is a major enzyme for galactose metabolism. Galactokinase (GALK) deficiency is an autosomal recessive disorder characterized by elevation of blood galactose concentration and diminished galactose-1-phosphate, leading to the production of galactitol. Defects in GALK1 are the cause of galactosemia II ( GALCT2 ) which II is an autosomal ... | |||
TMPH-02197 |
TXNDC5 Protein, Human, Recombinant
Endoplasmic reticulum resident protein 46,TXNDC5,Thioredoxin... |
Human | E. coli |
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. TXNDC5 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 36.2 kDa and the accession number is Q8NBS9. | |||
TMPK-00050 |
Leptin Protein, Mouse, Recombinant (hFc)
LEP,Obesity factor,Leptin,LEPD,Obese protein,OBS,OB |
Mouse | HEK293 Cells |
Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. | |||
TMPY-03452 |
PTS Protein, Human, Recombinant (His)
PTPS,PTS,6-pyruvoyltetrahydropterin synthase |
Human | E. coli |
PTS(6-pyruvoyltetrahydropterin synthase) belongs to the PTPS family. It catalyzes the elimination of inorganic triphosphate from dihydroneopterin triphosphate, which is the second and irreversible step in the biosynthesis of tetrahydrobiopterin from GTP. Tetrahydrobiopterin, also known as BH(4), is an essential cofactor and regulator of various enzyme activities, including enzymes involved in serotonin biosynthesis and NO synthase activity. Mutations in this gene result in hyperphenylalaninemia.... | |||
TMPH-02196 |
TXNDC5 Protein, Human, Recombinant (GST)
Thioredoxin-like protein p46,Endoplasmic reticulum resident ... |
Human | E. coli |
Possesses thioredoxin activity. Has been shown to reduce insulin disulfide bonds. Also complements protein disulfide-isomerase deficiency in yeast. TXNDC5 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 63.2 kDa and the accession number is Q8NBS9. | |||
TMPY-05067 |
Fibrinogen Gamma Chain Protein, Mouse, Recombinant
3010002H13Rik,fibrinogen γ chain,fibrinogen gamma chain,Fibr... |
Mouse | P. pastoris (Yeast) |
Loss of function mutations in FGG have been associated with fibrinogen deficiency. FGG mRNA was expressed abnormally in HCC and elevated plasma fibrinogen may serve as a useful predictor of clinical progression of HCC patients. Fibrinogen Gamma Chain Protein, Mouse, Recombinant is expressed in yeast. The predicted molecular weight is 30.5 kDa and the accession number is Q3UEM7. | |||
TMPY-04732 |
Fibrinogen Gamma Chain Protein, Human, Recombinant
fibrinogen gamma chain,fibrinogen γ chain,Fibrinogen γ Chain |
Human | P. pastoris (Yeast) |
Loss of function mutations in FGG have been associated with fibrinogen deficiency. FGG mRNA was expressed abnormally in HCC and elevated plasma fibrinogen may serve as a useful predictor of clinical progression of HCC patients. Fibrinogen Gamma Chain Protein, Human, Recombinant is expressed in yeast. The predicted molecular weight is 32.2 kDa and the accession number is P02679-1. | |||
TMPJ-00535 |
F13A Protein, Human, Recombinant (His)
F13A1,Coagulation Factor XIII A Chain,Transglutaminase A Cha... |
Human | HEK293 Cells |
Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is composed of just 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium io... | |||
TMPY-03985 |
Adenosine Deaminase Protein, Human, Recombinant (His)
ADA1,adenosine deaminase,ADA |
Human | Baculovirus Insect Cells |
Adenosine Desaminase (ADA) deficiency, is a purine metabolic disorder that cause severe combined immunodeficiency (SCID) due to the accumulation of toxic metabolites that primarily affects development, differentiation and function of T and B lymphocytes. Adenosine deaminase is a polymorphic enzyme that has an important role in immune functions and in the regulation of intracellular and extracellular concentrations of adenosine and adenosine receptor activity. ADA activity might be considered as... | |||
TMPY-00368 |
ALR Protein, Human, Recombinant (His)
HPO,ERV1,HERV1,ALR,HSS,HPO2,growth factor, augmenter of live... |
Human | HEK293 Cells |
Alterations in GFER gene have been associated with progressive mitochondrial myopathy, congenital cataracts, hearing loss, developmental delay, lactic acidosis and respiratory chain deficiency in 3 siblings born to consanguineous Moroccan parents by homozygosity mapping and candidate gene approach. Using homozygosity mapping, we discovered that a mutation in the GFER gene causes an infantile mitochondrial disorder. | |||
TMPJ-01034 |
TIM Protein, Human, Recombinant (His)
TPI1,TPI,Triose-Phosphate Isomerase,Triosephosphate Isomeras... |
Human | E. coli |
Triose-phosphate isomerase, also named Triose-phosphate isomerase, TPI and TIM, is an enzyme that catalyzes the reversible interconversion of the triose phosphate isomers dihydroxyacetone phosphate and D-glyceraldehyde 3-phosphate. TPI has been found in nearly every organism searched for the enzyme, including animals such as mammals and insects as well as in fungi, plants, and bacteria. However, some bacteria that do not perform glycolysis, like ureaplasmas, lack TPI. TPI plays an important role... | |||
TMPY-01480 |
LTC4S Protein, Human, Recombinant (His)
LTC4S,MGC33147,leukotriene C4 synthase |
Human | Baculovirus Insect Cells |
Leukotriene C4 synthase, also known as LTC4 synthase, Leukotriene-C(4) synthase, and LTC4S, is a multi-pass membrane protein that belongs to the MAPEG family. LTC4S is detected in the lung, platelets, and the myelogenous leukemia cell line KG-1 (at protein level). LTC4S activity is present in eosinophils, basophils, mast cells, certain phagocytic mononuclear cells, endothelial cells, vascular smooth muscle cells, and platelets. LTC4S is essential for the production of cysteinyl leukotrienes (Cys... | |||
TMPY-01117 |
MRAP Protein, Human, Recombinant (hFc)
FALP,FGD2,melanocortin 2 receptor accessory protein,GCCD2,B2... |
Human | HEK293 Cells |
MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain, has a unique structure, an antiparallel homodimer. MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) rece... | |||
TMPJ-01302 |
ACAT2 Protein, Human, Recombinant (His)
ACTL,Acetyl-CoA transferase-like protein,Acetyl-CoA acetyltr... |
Human | E. coli |
ACAT2 is a cytoplasmic enzyme which belongs to the thiolase family. ACAT2 takes part in lipid metabolism, lipoprotein assembly, catalyzing cholesterol esterification in mammalian cells. It is responsible for the synthesis of cholesteryl esters which are part of lipoproteins containing apoB. ACAT2 deficiency contributes to severe mental retardation and hypotonus. | |||
TMPJ-00540 |
PEPD Protein, Human, Recombinant
PRD,Imidodipeptidase,PEPD,PeptidaseD,Prolinedipeptidase,Xaa-... |
Human | E. coli |
PEPD belongs to the peptidase M24B family of Eukaryotic-type prolidase subfamily. PEPD is a cytosolic dipeptidase that hydrolyzes dipeptides with proline or hydroxyproline at the carboxy terminus. It is important in collagen metabolism because of the high levels of imino acids. Defects in PEPD are a cause of prolidase deficiency which is an autosomal recessive disorder associated with iminodipeptiduria. | |||
TMPY-04557 |
PHKG1 Protein, Human, Recombinant (GST)
phosphorylase kinase, γ 1 (muscle),phosphorylase kinase, gam... |
Human | Baculovirus Insect Cells |
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. PHKG1 is the catalytic member of a 16 subunit protein kinase complex that contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. Muscle glycogenosis caused by phosphorylase kinase (Phk) deficiency may lead to exercise intolerance, ... | |||
TMPJ-00932 |
PBLD Protein, Human, Recombinant (His)
MAWBP,MAWD-Binding Protein,PBLD,MAWDBP,Unknown Protein 32 Fr... |
Human | E. coli |
Phenazine Biosynthesis-Like Domain-Containing protein (PBLD) belongs to the phenazine biosynthesis-like protein (PhzF) family, which is expressed in most tissues. PBLD takes part in the MAPK signaling pathway, and is involved in multiple basic cellular functions. The expression of PBLD can be increased in several disease processes, including insulin resistance, folate deficiency and hypotension. | |||
TMPJ-00816 |
FBPase1 Protein, Human, Recombinant (His)
D-fructose-1,FBP,6-bisphosphate 1-phosphohydrolase 1,FBPase ... |
Human | HEK293 Cells |
Fructose-1,6-bisphosphatase 1(FBP1) is a homotetramer protein and belongs to the FBPase class 1 family. It involves in carbohydrate biosynthesis; gluconeogenesis pathway. FBP1 is a gluconeogenesis regulatory protein which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBP1 deficiency is associated with hypoglycemia and metabolic acidosis. FBP1 regulates mouse endogenous glucose production. FBP1 coupled with phosphofructokinase (PFK) takes p... | |||
TMPK-01170 |
Hepcidin/HAMP Protein, Mouse, Recombinant (GST)
Hamp1,LEAP-1,PLTR,HFE2B,LEAP1,Hepc1,Hepc |
Mouse | E. coli |
Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis. | |||
TMPJ-01002 |
SGSH Protein, Human, Recombinant (His)
SGSH,N-Sulphoglucosamine Sulphohydrolase,Sulfoglucosamine Su... |
Human | HEK293 Cells |
N-Sulphoglucosamine Sulphohydrolase (SGSH) is an important member of the sulfatase family which is involved in the degradation of heparin sulfate. SGSH binds one calcium ion per subunit as a cofactor. SGSH catalyzes N-sulfo-D-glucosamine and H2O to D-glucosamine and sulfate. SGSH deficiency is result in mucopolysaccharidosis type 3A (MPS3A), a recessive lysosomal storage disease characterized by neurological dysfunction but relatively mild somatic manifestations. | |||
TMPY-04555 |
GRK5 Protein, Human, Recombinant (His)
G protein-coupled receptor kinase 5,GPRK5 |
Human | Baculovirus Insect Cells |
G protein-coupled receptor kinase 5, also known as G protein-coupled receptor kinase GRK5 and GRK5, is a member of the protein kinase superfamily, AGC Ser/Thr protein kinase family, and GPRK subfamily. GRKs specifically phosphorylate agonist-occupied G protein-coupled receptors at the inner surface of the plasma membrane (PM), leading to receptor desensitization. GRKs utilize a variety of mechanisms to bind tightly, and sometimes reversibly, to cellular membranes. GRKs play an important role in ... | |||
TMPJ-01111 |
TSTA3 Protein, Human, Recombinant (His)
GDP-L-Fucose Synthase,Short-Chain Dehydrogenase/Reductase Fa... |
Human | E. coli |
GDP-L-Fucose Synthase is a NADP(H)-binding protein. It catalyzes the two-step epimerase and the reductase reactions in GDP-D-mannose metabolism, converting GDP-4-keto-6-D-dexoymannose to GDP-L-fucose. GDP-L-Fucose is the substrate of several fucosyltransferase, involving the expression of mamy glycoconjugates, including blood group ABH antigens and development adhesion antigens. Mutations in the TSTA3 gene may cause leukocyte adhesion deficiency type II. | |||
TMPK-01137 |
FAM3D Protein, Human, Recombinant (hFc)
OIT1,EF7,FAM3D |
Human | HEK293 Cells |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t... | |||
TMPY-03989 |
PFDN1 Protein, Human, Recombinant (His)
PDF,PFD1,prefoldin subunit 1 |
Human | E. coli |
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ... | |||
TMPY-00452 |
SBDS Protein, Mouse, Recombinant (His)
4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s... |
Mouse | E. coli |
The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His ta... | |||
TMPJ-00084 |
RBP4 Protein, Human, Recombinant
Retinol-Binding Protein 4,Plasma Retinol-Binding Protein,PRB... |
Human | E. coli |
Retinol Binding Protein 4 (RBP4) is a member of the Lipocalin family and in the blood. RBP4 is the specific vector for retinol. RBP4 is expressed and secreted by adipose tissue, and is associated with insulin resistance. RBP4 delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin to prevents its loss by filtration through the kidney glomeruli. Defects in RBP4 cause retinol-binding protein deficiency and can cause night vi... | |||
TMPK-01161 |
LAMP5 Protein, Mouse, Recombinant (hFc)
C20orf103,BADLAMP,dJ1119D9.3,LAMP-5,UNC-43,BAD-LAMP |
Mouse | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Mouse, Recombinant (hFc) is expressed in H... | |||
TMPK-01234 |
LAMP5 Protein, Human, Recombinant (His)
BAD-LAMP,BADLAMP,C20orf103,UNC-43,dJ1119D9.3,LAMP-5 |
Human | HEK293 Cells |
Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. LAMP5 deficiency led to a larger intensity-dependent increase of wave I, II and V peak amplitude of auditory brainstem response. LAMP5 plays a pivotal role in sensorimotor processing in the brainstem and spinal cord. LAMP5 Protein, Human, Recombinant (His) is expressed in H... | |||
TMPK-00449 |
HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated
E4ICD,ALS19,ErbB4,4ICD,HER4,p180erbB4,MGC138404 |
Human | HEK293 Cells |
Her4, a member of the EGF receptor family, plays a variety of roles in physiological and pathological states. Genetic studies have indicated a link between Her4 and type 2 diabetes and obesity. Her4 may play an important role in glucose homeostasis and lipogenesis. Her4 deficiency-related obesity and adipose tissue inflammation may contribute to the development of MetS. HER4/ERBB4 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The... | |||
TMPJ-00855 |
GLUL Protein, Human, Recombinant (His)
GLUL,GS,Glutamine Synthetase,Glutamate-Ammonia Ligase,GLNS,G... |
Human | E. coli |
Glutamine Synthetase reglutes intracellular concentration of glutamate. Glutamine Synthetase catalyzes the synthesis of glutamine from glutamate and ammonia. Glutamine is an important source of energy and that takes part in cell prolifetation, inhibition of apoptosis, and cell signaling. Glutamine Synthetase is expressed during early fetal stages, and has a role in maintaining body PH by removing ammonia from circulation. Mutations in the GLUL gene are related to congenital glutamine deficiency. | |||
TMPY-02046 |
PFDN1 Protein, Mouse, Recombinant (His)
AU044714,AA408327,2700086I23Rik,prefoldin subunit 1 |
Mouse | E. coli |
PFDN1 expression positively correlated with tumor size and tumor invasion. The inhibitory effect of PFDN1 on tumor cell growth and motility was partially due to G2/M cell cycle blockage and cytoskeletal deficiency. PFDN1 was involved in the progression of CRC, and provide new insights into PFDN1 as a potential therapeutic target for colorectal cancer (CRC) treatment. PFDN1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is ... | |||
TMPJ-00800 |
BPGM Protein, Human, Recombinant (His)
3-Diphosphoglycerate Mutase,2,DPGM,Bisphosphoglycerate Mutas... |
Human | E. coli |
Bisphosphoglycerate Mutase (BPGM) is a member of the Phosphoglycerate Mutase family and BPG-Dependent PGAM subfamily. BPGM is a multifunctional enzyme. BPGM catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. It also has phosphoglycerate phosphomutase activity. BPGM plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Deficiency of BPGM increases the affinity of cells... | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0265 |
Homovanillic Acid-13C-d3
|
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Homovanillic Acid-13C-d3 是 Homovanillic Acid 的 13C 和氘代化合物。Homovanillic Acid 的 CAS 号为 306-08-1。Homovanillic acid 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
TMID-0057 |
(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid
|
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(4-Hydroxy-3-methoxyphenyl)acetic-2,2-d2 Acid 是 (4-Hydroxy-3-methoxyphenyl)acetic Acid 的氘代化合物。(4-Hydroxy-3-methoxyphenyl)acetic Acid 的 CAS 号为 306-08-1。Homovanillic acid 是一种多巴胺代谢物,它与乳糜泻、生长激素缺乏、芳香族氨基酸脱羧酶缺乏症以及脂联素还原酶缺乏症相关。 | |||
TMID-0097 |
Ethyl-d5-malonic Acid
|
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Ethyl-d5-malonic Acid 是 Ethyl-malonic Acid 的氘代化合物。Ethyl-malonic Acid 的 CAS 号为 601-75-2。Ethylmalonic acid 是潜在有毒物质,非致癌性,与神经性厌食和甲氧基脱羧酶缺乏症有关。 | |||
TMIH-0206 |
Dydrogesterone-d6
|
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Dydrogesterone-d6 是 Dydrogesterone 的氘代化合物。Dydrogesterone 的 CAS 号为 152-62-5。Dydrogesterone 是一种口服有效的孕激素,可作用于孕酮缺乏相关疾病。 | |||
TMIH-0037 |
2-Methylpropanedioic acid-d3
methyl-d3-malonic acid |
||
2-Methylpropanedioic acid-d3 是 2-Methylpropanedioic acid 的氘代化合物。2-Methylpropanedioic acid 的 CAS 号为 516-05-2。Methylmalonic acid 是癌症患者缺乏维生素 B-12的指标。 | |||
TMIH-0191 |
dimethyl 2-(methyl-d3)malonate
|
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dimethyl 2-(methyl-d3)malonate 是 dimethyl 2-(methyl)malonate 的氘代化合物。dimethyl 2-(methyl)malonate 的 CAS 号为 516-05-2。Methylmalonic acid 是癌症患者缺乏维生素 B-12的指标。 | |||
TMIJ-0375 |
Levomefolic Acid-13C-d3
|
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Levomefolic Acid-13C-d3 是 Levomefolic Acid 的 13C 和氘代化合物。Levomefolic Acid 的 CAS 号为 31690-09-2。Levomefolic acid是一种具有口服活性、可穿过血脑屏障的天然活性叶酸,是广泛使用的叶酸食品补充剂。 | |||
T35698 |
Octanoic Acid-13C
|
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Octanoic acid-13C is intended for use as an internal standard for the quantification of octanoic acid by GC- or LC-MS. Octanoic acid is a medium-chain saturated fatty acid. It has been found in Teleme cheeses made from goat, ovine, or bovine milk.1 Octanoic acid is active against the bacteria S. mutans, S. gordonii, F. nucleatum, and P. gingivalis (IC80s = <125, <125, 1,403, and 2,294 μM, respectively).2 Levels of octanoic acid are increased in the plasma of patients with medium-chain acyl-CoA d... | |||
T36059 |
Dichlorphenamide-13C6
Dichlorphenamide-13C6 |
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Dichlorphenamide-13C6is intended for use as an internal standard for the quantification of dichlorphenamide by GC- or LC-MS. Dichlorphenamide is a sulfonamide and an orally bioavailable carbonic anhydrase (CA) inhibitor (Kis = 1.20, 38, 50, and 50 nM for the human CA isoforms CAI, CAII, CAIX, and CAXII, respectively).1It lowers intraocular pressure in rabbits when 50 μl of a 10% solution is applied topically to the eye.2Dichlorphenamide rescues the potassium deficiency and prevents insulin-induc... | |||
TMIJ-0081 |
L-Leucine-d10
|
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L-Leucine-d10 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸,能够激活mTOR信号通路。 | |||
TMIJ-0374 |
L-Leucine-d3
|
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L-Leucine-d3 是 L-Leucine 的氘代化合物。L-Leucine 的 CAS 号为 61-90-5。L-Leucine 是必需的支链氨基酸,能够激活mTOR信号通路。 | |||
T36055 |
Nitisinone-13C6
Nitisinone-13C6 |
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Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F... |