Hydroxocobalamin monohydrochloride is an injectable naturally occurring form of vitamin B12. It is used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.

Hydroxocobalamin monohydrochloride ?is an injectable naturally occurring form of vitamin B12 with a favorable adverse effect profile.Hydroxocobalamin monohydrochloride ?used as a dietary supplement in the treatment of vitamin B12 deficiency including pernicious anemia.

More than 60% of the mice administered 35 mg/kg (0.63 mmol/kg) of NaSH (LD90) survive (at 24 h) when hydroxocobalamin (0.25 mmol/kg) is given after NaSH administration whereas less than 15% of the mice survive without hydroxocobalamin. Hydroxocobalamin (50–100 μM) or cobalt (50–100 μM) also preventes hepatocyte cytotoxicity induced by NaSH (500 μM). Furthermore, adding hydroxocobalamin 60 min later than NaSH still shows some protective activity.Treatment with hydroxocobalamin before or after giving LPS attenuates LPS-induced hypotension and increases in plasma RNI and enhances LPS-induced urinary excretion of RNI.?Hydroxocobalamin (20 mg/kg i.p.) given to Swiss-Webster mice 30 min before giving LPS (16 mg/kg i.p.) decreases the 24-hr mortality of LPS from 80 to 50% and the 36- and 96-hr mortality from 100 to 60% (hydroxocobalamin).