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Search Results for " anti-tuberculosis "

Targets Recommended: Antibacterial

67

抑制剂 & 化合物

11

天然产物

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T38359	Dup-721	Antibacterial	Microbiology/Virology
	DuP-721 是广谱的口服有效的抗菌剂，可以抑制多种临床敏感和耐药细菌，特别是结核杆菌M. tuberculosis。
T8694	ML406	Antibacterial; Antibiotic	Microbiology/Virology
	ML406 是一种小分子探针，通过抑制M.tuberculosisBioA(DAPA 合酶) 显示出抗结核活性，IC50为 30 nM。
T22365	Methyl α-D-mannopyranoside 甲基-D-丙噻,Methyl α-D-mannopyranoside	Antibacterial	Microbiology/Virology
	Methyl α-D-mannopyranoside (Methyl α-D-mannopyranoside) 是一种化学合成的中间体，在抗结核吸入治疗中靶向巨噬细胞。
T5400	Q203 IAP6,Telacebec	Antibacterial; Antibiotic	Microbiology/Virology
	Q203 (Telacebec)是一种中氮杂吡啶酰胺。在培养基中抑制结核分枝杆菌H37Rv 活性的MIC50值为2.7 nM。
T3642	TBA-354 TBA 354	Antibacterial; Antibiotic	Microbiology/Virology
	TBA-354 有抗结核作用，对结核分枝杆菌 H37Rv 菌株具有活性。
T110951	Compound F0447-0245	Others	Others
	Antitubercular agent-33 是一种 2-氨基噻唑衍生物，对于结核分枝杆菌 (Mycobacterium tuberculosis,Mtb)显示出有效的抗结核活性。
T11497	Ganfeborole HCl GSK3036656 HCl,GSK656 HCl	Antibacterial	Microbiology/Virology
	Ganfeborole HCl (GSK3036656 HCl) 是一种具有抗结核活性的小分子化合物，是结核分枝杆菌（Mtb）亮氨酰-tRNA 合成酶（LeuRS；IC50：0.2 μM）的抑制剂。
T10329	anti-TB agent 1	Antibiotic	Microbiology/Virology
	anti-TB agent 1是一种有效的口服活性抗结核化合物，对结核分枝杆菌H37Rv、rRMP 和rINH 的MICs＜2nM。
T4531	GSK2200150A	Antibacterial	Microbiology/Virology
	GSK2200150A 是一种通过高通量筛选活动确定的抗结核剂，对 H37Rv 的 MIC 是 0.38 μM。
T2585	Bedaquiline R207910,TMC207,贝达喹啉	Antibacterial; Antibiotic	Microbiology/Virology
	Bedaquiline (R207910) 是一种二芳基喹啉药物，能同时靶向 c-亚基和 ε-亚基，抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。
T6096	Pretomanid (S)-PA 824,PA-824	Antibacterial; Antibiotic	Microbiology/Virology
	Pretomanid ((S)-PA 824) 是一种抗生素，可研究肺部多重耐药性结核病。它对结核病(MTB) 具有亚微摩尔作用活性。它对 MTB 泛敏感和抗 Rifampin 的临床分离株的 MIC 值为 0.015 至 0.25 μg/mL。
T5997	TBAJ-587	Antibacterial; Antibiotic	Microbiology/Virology
	TBAJ-587 是一种抗结核药物，在 MABA 和 LORA 试验中抑制 M.tb 菌株 H37Rv 的生长，MIC90 分别为 0.006 和 <0.02 µg/mL。它对 M. tuberculosis 具有更有效的活性，并且在 TB 动物模型中具有更好的功效。
T12231	NITD-349	Others; Antibacterial	Microbiology/Virology; Others
	NITD-349 是MmpL3的抑制剂，它对毒性结核分枝杆菌 H37Rv 显示出高效的抗分枝杆菌活性，MIC50 为 23 nM。
T4202	Delamanid 迪拉马尼,德拉马尼,OPC-67683	Anti-infection; Antibacterial; Antibiotic	Microbiology/Virology
	Delamanid (OPC-67683) 是一种新的分枝杆菌细胞壁合成抑制剂，可用于耐多药结核病。
T38345	SQ609	Others	Others
	SQ609是从一个双哌啶衍生物库中选取的抗结核潜在药物。SQ609在体外小鼠巨噬细胞中具有显著的抗结核活性。
T9085	JFD01307SC [(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]	Antibacterial	Microbiology/Virology
	JFD01307SC ([(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]) 是一种谷氨酰胺合成酶抑制剂。它是抗结核剂，可作为 L-谷氨酸盐的模拟物，靶向参与谷氨酰胺生物合成的酶。
T62338	IMPDH2-IN-2	Others	Others
	IMPDH2-IN-2 是一种肌苷 5'-单磷酸脱氢酶 (IMPDH) 的有效抑制剂 (Ki,app: 14 μM)，也是一种潜在的抗结核药。IMPDH2-IN-2 具有中等的抗菌效果，在 GAST/Fe 和丰富的 7H9/ADC/Tween 培养基中的 MIC 值分别为 6.3 和 11 μM。
T11449L	Golotimod Gamma-D-glutamyl-L-tryptophan,SCV 07	Antibiotic	Microbiology/Virology
	Golotimod (SCV 07) 是一种具有抗菌活性的二肽，具有免疫调节活性，能显著提高抗结核治疗的疗效，诱导胸腺和脾脏细胞增殖，调节巨噬细胞功能，抑制 STAT3 信号传导。Golotimod 可用于研究复发性生殖器单纯疱疹病毒 2 （HSV-2）感染和口腔黏膜炎。
T23621	Aconiazide Aconiazida	Others	Others
	Aconiazide is a prodrug of anti-tuberculosis.
T11259	FadD32 Inhibitor-1	Others	Others
	FadD32 inhibitor -1 has anti-tuberculosis activity and is an effective FadD32 inhibitor.
T28120	MTC420 MTC-420,MTC 420	Others	Others
	MTC420 is a anti-tuberculosis agent with acceptable anti-tuberculosis activity (Mtb IC50 =525 nM, Mtb Wayne IC50 = 76 nM and MDR Mtb patient isolates IC50 = 140 nM).
T10563	BM635	Others	Others
	BM635 is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T27978	Maritinone	Others	Others
	Maritinone is a novel anti-tuberculosis (anti-TB) agent.
T33683	NITD-304 NITD304	Others	Others
	NITD-304 is an anti-tuberculosis drug candidate for the treatment of multidrug-resistant tuberculosis (MDR-TB), showing effective activity against both MTB drug-sensitive and multidrug-resistant clinical isolates.
T27477	GSK366A	Others	Others
	GSK366A is an anti-TB agent against Mycobacterium bovis BCG and Mycobacterium tuberculosis, targeting MmpL3 and inhibiting EchA6.
T10171	5-Hydroxypyrazine-2-Carboxylic Acid	Others	Others
	5-Hydroxypyrazine-2-Carboxylic Acid is a metabolite of anti-tuberculosis drug pyrazinamide.
T62086	Tuberculosis inhibitor 5	Others	Others
	Tuberculosis inhibitor 5 (Compound 11i) 是一种有效的抗结核剂，无明显细胞毒性。Tuberculosis inhibitor 5 是一种抗分枝杆菌 (antimycobacterial) 联苯类似物。
T39091	Spectinamide 1599	Others	Others
	Spectinamide-1599 is a combination partner for anti-tuberculosis therapy.
T63755	Antitubercular agent-22	Others	Others
	Antitubercular agent-22 (Compound 2) 是有效的抗念珠菌和抗结核剂，能够作用于 Candida albicansMTCC 3017 (MIC: 2.34 μg/ml) 和 M. tuberculosis(H37Rv) (MIC: 2 μg/ml)。
T30604	BTZ-N3 BTZ N3	Others	Others
	BTZ-N3 is an effective and selective anti-tuberculosis drug candidate.
T61303	MmpL3-IN-1	Others	Others
	MmpL3-IN-1, also known as compound 32, is a highly effective inhibitor of Mycobacterial membrane protein large 3 (MmpL3). With an anti-tuberculosis activity exhibiting a minimum inhibitory concentration (MIC) of less than 0.016 μg/mL in M. tuberculosis, MmpL3-IN-1 is a valuable compound for research on drug-resistant tuberculosis [1].
T16419	Oxyphenbutazone	COX	Immunology/Inflammation; Neuroscience
	Oxyphenbutazone is a non-selective COX inhibitor. Oxyphenbutazone is a phenylbutazone derivative. It has an anti-inflammatory effect. Oxyphenbutazone selectively kills non-replicating Mycobaterium tuberculosis.
T63525	Antitubercular agent-23	Others	Others
	Antitubercular agent-23 是有效的抗念珠菌及抗结核剂，能够作用于 Candida albicansMTCC 3017 (MIC: 1.1 μg/ml) 和 M. tuberculosis(H37Rv) (MIC: 1 μg/ml)。
T61520	Antitubercular agent-24	Others	Others
	Antitubercular agent-24 (Compound 1) exhibits anti-tubercular properties against M. tuberculosis H37Rv. It demonstrates an extracellular IC50 of 0.83 μM and an intracellular IC50 of 0.17 μM [1].
T61676	4-Piperidinecarboxamide	Others	Others
	4-Piperidinecarboxamide is a mycobacterial aspartyl-tRNA synthetase (AspS) inhibitor and a potential anti-tuberculosis (TB) agent [1].
T73329	MMV676584	Others	Others
	MMV676584 具有抗结核活性。MMV676584是一种新的真霉菌瘤候选药物。
T40520	Thiophene-2 Thiophene-2,TP2	Others	Others
	Thiophene-2 (TP2) is a targeted inhibitor of polyketide synthase 13 (Pks13), specifically designed to disrupt mycolic acid biosynthesis. By doing so, it effectively induces rapid cell death in mycobacteria. Thiophene-2 demonstrates notable anti-tuberculosis activity and exhibits a minimum inhibitory concentration (MIC) value of 1 μM against Mycobacterium tuberculosis.
T38298	Tuberculosis inhibitor 3	Others	Others
	Tuberculosis inhibitor 3 (compound 2i) displays potent anti-TB activity (MIC < 0.016 μg/mL) against drug-sensitive/resistant MTB strains. Tuberculosis inhibitor 3 (compound 2i) shows acceptable PK profiles with oral bioavailability[1].
T10887	CRS400393	Antibacterial	Microbiology/Virology
	CRS400393 is an effective anti-mycobacterial drug , with MIC of 0.03, 2, and ≤ 0.12 µg/mL against M. abs., M. avium, M. intracellulare, and M. tuberculosis, respectively.
T61149	Antibacterial agent 121	Others	Others
	Antibacterial agent 121 (Compound 10) demonstrates antibacterial properties and exhibits efficacy against mycobacterial strains while also possessing anti-inflammatory activity. This compound finds potential applications in Tuberculosis (TB) research [1].
T10563L2	BM635 mesylate (1493762-74-5 free base) BM635 mesylate	Others	Others
	BM635 mesylate is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T10513	Benzothiohydrazide	Antibacterial	Microbiology/Virology
	Benzothiohydrazide 是异烟肼的类似物，具有抗结核活性，可用于分离真菌和细菌。
T10563L	BM635 hydrochloride (1493762-74-5 free base) BM635 hydrochloride	Others	Others
	BM635 hydrochloride is an MmpL3 inhibitor with outstanding anti-mycobacterial activity (MIC50: 0.12 μM against M. tuberculosis H37Rv).
T78602	Chaetoglobosin C	Others	Others
	Chaetoglobosin C (Compound 4)，源自真菌Chaetomium globosum KMITL-N0802，为一种蒽醌-色酮类化合物，具备抗结核分枝杆菌的活性。
T73441	TBI-166	Others	Others
	TBI-166，一种利米吩嗪类似物，是一种具有口服活性的抗结核药物，不良反应比 riminophenazine 化合物 Clofazimine 小。
T63786	WX-081	Others	Others
	WX-081 是抗结核剂 (anti-tuberculosis)，对 M. tuberculosisH37Rv 表现出明显的抗分枝杆菌效果，并能够作用于药物敏感结核病 (DS-TB) 杆菌 (MIC: 0.083 μg/ml) 和耐多药结核病 (MDR-TB) 菌株 (MIC: 0.11 μg/ml)，对 hERG 通道表现出抑制作用 (IC50: 1.89 μM)。
T72177	Oxyphenbutazone monohydrate 羟布宗一水合物	Others	Others
	Oxyphenbutazone monohydrate 是一种保泰松 (Phenylbutazone) 代谢物，具有抗炎作用。Oxyphenbutazone monohydrate 是一种具有口服活性的非选择性 COX 抑制剂。Oxyphenbutazone monohydrate 能选择性地杀死不复制的结核分枝杆菌 (Mycobaterium tuberculosis)。
T38073	Thiocarlide Isoxyl	Others	Others
	Thiocarlide (isoxyl) is a thiourea derivative that was used in the 1960s to successfully treat tuberculosis (TB). It has considerable antimycobacterial activity in vitro and is effective against multi-drug resistant strains of Mycobacterium tuberculosis in the range of 1-10 &#181g/ml. [1] [2] At concentrations of 10 &#181M, isoxyl inhibits the synthesis of M. bovis during six hours of exposure which is similar to isoniazid (INH) and ethionamide (ETH), two other predominant anti-tuberculosis drug...
T21778	10-DEBC hydrochloride	Others	Others
	10-DEBC hydrochloride 是选择性的Akt 抑制剂，IC50为 1.28 μM。10-DEBC hydrochloride 也是一种新型抗肺结核的化合物。
T61772	PknB-IN-1	Others	Others
	PknB-IN-1 (Compound 2) is an inhibitor of protein kinase B (PknB) with a concentration causing 50% inhibition (IC50) of 14.4 μM. This compound demonstrates anti-mycobacterial activity by effectively suppressing the growth of M. tuberculosis H37Rv strain, with a minimum inhibitory concentration (MIC) of 6.2 μg/mL [1].

化合物

Cat.No: T38359

Target: Antibacterial

Cat.No: T8694

Target: Antibacterial, Antibiotic

Methyl α-D-mannopyranoside

Cat.No: T22365

Synonym: 甲基-D-丙噻,Methyl α-D-mannopyranoside

Target: Antibacterial

Cat.No: T5400

Synonym: IAP6,Telacebec

Target: Antibacterial, Antibiotic

Cat.No: T3642

Synonym: TBA 354

Target: Antibacterial, Antibiotic

Compound F0447-0245

Cat.No: T110951

Target: Others

Ganfeborole HCl

Cat.No: T11497

Synonym: GSK3036656 HCl,GSK656 HCl

Target: Antibacterial

anti-TB agent 1

Cat.No: T10329

Target: Antibiotic

Cat.No: T4531

Target: Antibacterial

Cat.No: T2585

Synonym: R207910,TMC207,贝达喹啉

Target: Antibacterial, Antibiotic

Cat.No: T6096

Synonym: (S)-PA 824,PA-824

Target: Antibacterial, Antibiotic

Cat.No: T5997

Target: Antibacterial, Antibiotic

Cat.No: T12231

Target: Others, Antibacterial

Cat.No: T4202

Synonym: 迪拉马尼,德拉马尼,OPC-67683

Target: Anti-infection, Antibacterial, Antibiotic

Cat.No: T38345

Target: Others

Cat.No: T9085

Synonym: [(1,1-DIOXIDOTETRAHYDROTHIEN-3-YL)AMINO]

Target: Antibacterial

Cat.No: T62338

Target: Others

Cat.No: T11449L

Synonym: Gamma-D-glutamyl-L-tryptophan,SCV 07

Target: Antibiotic

Cat.No: T23621

Synonym: Aconiazida

Target: Others

FadD32 Inhibitor-1

Cat.No: T11259

Target: Others

Cat.No: T28120

Synonym: MTC-420,MTC 420

Target: Others

Cat.No: T10563

Target: Others

Cat.No: T27978

Target: Others

Cat.No: T33683

Synonym: NITD304

Target: Others

Cat.No: T27477

Target: Others

5-Hydroxypyrazine-2-Carboxylic Acid

Cat.No: T10171

Target: Others

Tuberculosis inhibitor 5

Cat.No: T62086

Target: Others

Spectinamide 1599

Cat.No: T39091

Target: Others

Antitubercular agent-22

Cat.No: T63755

Target: Others

Cat.No: T30604

Synonym: BTZ N3

Target: Others

Cat.No: T61303

Target: Others

Oxyphenbutazone

Cat.No: T16419

Target: COX

Antitubercular agent-23

Cat.No: T63525

Target: Others

Antitubercular agent-24

Cat.No: T61520

Target: Others

4-Piperidinecarboxamide

Cat.No: T61676

Target: Others

Cat.No: T73329

Target: Others

Cat.No: T40520

Synonym: Thiophene-2,TP2

Target: Others

Tuberculosis inhibitor 3

Cat.No: T38298

Target: Others

Cat.No: T10887

Target: Antibacterial

Antibacterial agent 121

Cat.No: T61149

Target: Others

BM635 mesylate (1493762-74-5 free base)

Cat.No: T10563L2

Synonym: BM635 mesylate

Target: Others

Benzothiohydrazide

Cat.No: T10513

Target: Antibacterial

BM635 hydrochloride (1493762-74-5 free base)

Cat.No: T10563L

Synonym: BM635 hydrochloride

Target: Others

Chaetoglobosin C

Cat.No: T78602

Target: Others

Cat.No: T73441

Target: Others

Cat.No: T63786

Target: Others

Oxyphenbutazone monohydrate

Cat.No: T72177

Synonym: 羟布宗一水合物

Target: Others

Cat.No: T38073

Synonym: Isoxyl

Target: Others

10-DEBC hydrochloride

Cat.No: T21778

Target: Others

Cat.No: T61772

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3332	Isosteviol 异甜菊醇,(-)-Isosteviol	IL Receptor; Potassium Channel; TNF; NF-κB; Reactive Oxygen Species; COX; Topoisomerase	Apoptosis; DNA Damage/DNA Repair; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience; NF-κB
	Isosteviol ((-)-Isosteviol) 是一种常见的天然甜味剂，属于四环二萜糖苷，是甜菊糖苷通过酸催化水解产生的。它抑制 DNA 聚合酶和 DNA 拓扑异构酶，具有抗菌、抗癌和抗结核作用。
T8298	Vasicine hydrochloride 鸭嘴花碱盐酸盐,Peganine hydrochloride	Antibacterial; Antibiotic	Microbiology/Virology
	Vasicine hydrochloride (Peganine hydrochloride) 是从Justicia adhatoda 中分离得到的一种喹唑啉类生物碱，有抗结核活性。
T67136	1-Hydroxy-2-butanone	Endogenous Metabolite; Antibiotic	Metabolism; Microbiology/Virology
	1-Hydroxy-2-butanone 是可从竹子汁和番茄叶中提取得到的天然产物，具有抗结核活性。
TN1622	Ermanin 堪非醇3,4'-二-O-甲醚	NOS; Influenza Virus; COX; HIV Protease; Antibacterial; Antibiotic	Immunology/Inflammation; Microbiology/Virology; Neuroscience; Proteases/Proteasome
	Ermanin 是一种从 Tanacetum microphyllum 中分离出来的类黄酮。Ermanin抑制血小板聚集，具有抗结核和抗病毒/细菌特性。Ermanin 可抑制 iNOS 和 COX-2 的表达，从而具有抗炎活性。Ermanin 可能具有抗 HIV-1 活性。Ermanin 在较低浓度下可有效地抑制 Dione juno 幼虫。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN5614	Dehydrobruceantin
	Dehydrobruceantin has anti-tuberculosis activity.
TN3674	Clauszoline M	Antifection	Microbiology/Virology
	Clauszoline M shows a significant anti-tuberculosis activity.
TN5648	Porson
	Porson exhibited anti-tubercular activity against Mycobacterium tuberculosis H37Rv in vitro and MICs values of 40.0 μg/mL.
TN1378	α-Viniferin ALPHA-VINIFERIN,Alpha-葡萄素	P450; NO Synthase; Prostaglandin Receptor	GPCR/G Protein; Immunology/Inflammation; Metabolism
	α-Viniferin 也称为2-芳基苯并呋喃类黄酮，是前列腺素H2合成酶抑制剂。具有抗阿尔茨海默病、抗结核、抗肿瘤、抗炎、抗糖尿病等多种药理活性
T72742	(-)-Pinocembrin (-)-乔松素	Others	Others
	(-)-Pinocembrin 对 H37Ra 结核分枝杆菌展示了抗菌活性，无论是休眠还是活跃期，其 IC50 值分别为1.11 mg/mL 和 1.21 mg/mL。作为一种抗增殖剂，(-)-Pinocembrin 对于 THP-1、A549、Panc-1、HeLa 和 MCF7 细胞系，IC50 值范围为 1.88 至 11.00 mg/mL。
T38330	Collinin	Others	Others
	Collinin is a coumarin that has been found in Z. schinifolium and has diverse biological activities.1,2,3,4 It is active against drug-susceptible and -resistant strains of M. tuberculosis (MIC50s = 3.13-6.25 μg/ml).1 Collinin inhibits LPS-induced nitric oxide (NO) production (IC50 = 5.9 μM) and reduces COX-2 protein levels in RAW 264.7 cells.2 It completely inhibits aggregation of isolated rabbit platelets induced by arachidonic acid , collagen, or platelet activating factor (PAF) when used at a...

天然产物

Cat.No: T3332

Synonym: 异甜菊醇,(-)-Isosteviol

Target: IL Receptor, Potassium Channel, TNF, NF-κB, Reactive Oxygen Species, COX, Topoisomerase

Vasicine hydrochloride

Cat.No: T8298

Synonym: 鸭嘴花碱盐酸盐,Peganine hydrochloride

Target: Antibacterial, Antibiotic

1-Hydroxy-2-butanone

Cat.No: T67136

Target: Endogenous Metabolite, Antibiotic

Cat.No: TN1622

Synonym: 堪非醇3,4'-二-O-甲醚

Target: NOS, Influenza Virus, COX, HIV Protease, Antibacterial, Antibiotic

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Dehydrobruceantin

Cat.No: TN5614

Cat.No: TN3674

Target: Antifection

Cat.No: TN5648

Cat.No: TN1378

Synonym: ALPHA-VINIFERIN,Alpha-葡萄素

Target: P450, NO Synthase, Prostaglandin Receptor

(-)-Pinocembrin

Cat.No: T72742

Synonym: (-)-乔松素

Target: Others

Cat.No: T38330

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T11817	Lansoprazole Sulfide D4	Proton pump	Membrane transporter/Ion channel
	Lansoprazole Sulfide D4 is a deuterium labeled Lansoprazole Sulfide. Lansoprazole Sulfide is an orally active anti-TB (Mycobacterium tuberculosis) agent with IC50 values of 0.59 μM intracellularly and 0.46 μM in broth.Lansoprazole Sulfide is an active metabolite of the proton pump inhibitor Lansoprazole.

同位素标记化合物

Lansoprazole Sulfide D4

Cat.No: T11817

Target: Proton pump

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