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Search Results for " ras/erk activation "

Targets Recommended: Ras

抑制剂 & 化合物

天然产物

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Cat. No.	Product Name	Target	Signaling Pathways
T20759	XRP44X XRP-44-X,XRP 44X,XRP-44X,XRP 44 X	Ras	GPCR/G Protein; MAPK
	XRP44X (XRP 44X) 是Ras 诱导的转录激活的抑制剂，IC50为 10 nM，通过 FGF-2 抑制 Ras-Erk-1/2 通路激活。它抑制Elk3。它还对微管有影响。
T69195	UC-857993	Others	Others
	UC-857993 是一种选择性SOS1-Ras 抑制剂 (Kd=14.7 μM, His6-SOS1cat)，抑制其催化活性。UC-857993 还能抑制ERK 和Ras 激活，抑制小鼠胚胎成纤维细胞 (MEF) 的生长。
T37422	Ras Inhibitory Peptide	Others	Others
	Son of sevenless homolog 1 (Sos1) is a guanine nucleotide exchange factor (GEF) that directs the exchange of Ras-GDP to Ras-GTP by binding to SH3 domains of the growth factor receptor-bound protein 2 (Grb2), leading to the activation of ERK. Ras inhibitory peptide is a synthetic peptide that contains the sequence PVPPR, which corresponds to a region within human Sos1 that interacts with an SH3 domain of Grb2. It specifically blocks the interaction of the GEF with Grb2, preventing an interaction ...
T71163	Pimasertib HCl	Others	Others
	Pimasertib HCl is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. Pimasertib selectively binds to and inhibits the activity of MEK1/2, preventing the activation of MEK1/2-dependent effector proteins and transcription factors, which may result in the inhibition of growth factor-mediated cell signaling and tumor cell proliferation. MEK1/2 (MAP2K1/K2) are dual-specificity threonine/tyrosine kinases that play key roles in the activati...

化合物

XRP44X

Cat.No: T20759

Synonym: XRP-44-X,XRP 44X,XRP-44X,XRP 44 X

Ras Inhibitory Peptide

Cat. No.	Product Name	Target	Signaling Pathways
TN2114	Pseudoginsenoside Rh2 拟人参皂苷RH2,拟人参皂苷 Rh2	ERK; Raf; p53	Apoptosis; MAPK
	Pseudoginsenoside Rh2 has cytotoxicity, it induces mitochondrial apoptosis in A549 cells and is responsible for excessive activation of the Ras/Raf/ERK/p53 pathway. (20Z) -Pseudoginsenoside Rh2 and (20E)-Pseudoginsenoside Rh2 have antioxidative activity.

天然产物

Pseudoginsenoside Rh2

Cat.No: TN2114

Synonym: 拟人参皂苷RH2,拟人参皂苷 Rh2

Target: ERK, Raf, p53

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00376	IL-17RD Protein, Human, Recombinant (hFc) IL17Rhom,IL17RD,IL-17RD,IL-17 RD,IL17RLM,SEF,interleukin 17 ...	Human	HEK293 Cells
	Interleukin-17 receptor D (IL-17 RD), also known as SEF (similar expression to FGFs), is a type I transmembrane protein that is found in both the cytoplasm and plasma membrane. IL-17RD functions as a feedback inhibitor of fibroblast growth factor mediated Ras-MAPK signaling and ERK activation. It may inhibit FGF-induced FGFR1 tyrosine phosphorylation, regulate the nuclear ERK signaling pathway by spatially blocking nuclear translocation of activated ERK By similarity, and mediate JNK activation ...
TMPJ-01125	PEA15 Protein, Human, Recombinant 15 kDa Phosphoprotein Enriched in Astrocytes,PEA15,PED,Astro...	Human	E. coli
	Astrocyticphosphoprotein PEA-15 (PEA15) is a death effector domain (DED)-containing protein. PEA15 is mainly expressed in the central nervous system, principally in astrocytes. Increased PEA15 levels affect tumorigenesis and cancer progression. PEA15 is overexpressed in breast cancers and gliomas as well as in type 2 diabetes. PEA15 blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. PEA15 also inhibits RPS6KA3 activities by holding it in the cytoplasm...
TMPY-04455	PKC iota Protein, Human, Recombinant (GST) PKCI,nPKC-iota,protein kinase C, ι,DXS1179E,nPKC-ι,protein k...	Human	Baculovirus Insect Cells
	Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues includ...