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Search Results for " rn1 "

Targets Recommended: Histone Demethylase MAO

15

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T21652	RN-1 dihydrochloride	Histone Demethylase; MAO	Chromatin/Epigenetic; Metabolism; Neuroscience
	RN-1 dihydrochloride 是血脑屏障通透性的、不可逆的赖氨酸特异性脱甲基酶 1 (LSD1) 选择性抑制剂，IC50为 70 nM，对 LSD1 的选择性高于 MAO-A 和 MAO-B，IC50分别为 0.51 μM 和 2.785 μM。
T9528	ARN19702	Others	Others
	ARN19702 是一种选择性，具有口服活性的，可逆的，可透过血脑屏障的 N-乙酰乙醇胺酸酰胺酶 (NAAA) 抑制剂，对人 NAAA 的 IC50为 230 nM。ARN19702 具有广泛的镇痛作用。
T21658	ARN14974	Others	Others
	ARN14974 是一种有效的全身活性的胞内酸性神经酰胺酶抑制剂 (IC50=79 nM)，是一种苯并恶唑酮甲酰胺化合物。
TQ0015	PRN1371	c-Fms; FGFR; CSF-1R	Angiogenesis; Tyrosine Kinase/Adaptors
	PRN1371 是一种高效的、选择性的FGFR1-4和CSF1R 抑制剂，对FGFR1，FGFR2，FGFR3，FGFR4 和 CSF1R 的IC50值分别为 0.6，1.3，4.1，19.3 和 8.1 nM。
T30137	ARN14686	Others	Others
	ARN14686 is an activity-based affinity probe for the detection of N-acylethanolamine acid amidase (NAAA) using click chemistry.
TMAZ-0076P	Anti-LRRN1 Monoclonal Antibody-PE
	Anti-LRRN1 Monoclonal Antibody-PE is a biotin-conjugated humanized rabbit antibody targeting LRRN1. Anti-LRRN1 Monoclonal Antibody-PE can be used FACS.
TMAZ-0076B	Anti-LRRN1 Monoclonal Antibody-Biotin
	Anti-LRRN1 Monoclonal Antibody-Biotin is a biotin-conjugated humanized rabbit antibody targeting LRRN1. Anti-LRRN1 Monoclonal Antibody-Biotin can be used FACS.
TMAZ-0076A5	Anti-LRRN1 Monoclonal Antibody-AF555
	Anti-LRRN1 Monoclonal Antibody-AF555 is a biotin-conjugated humanized rabbit antibody targeting LRRN1. Anti-LRRN1 Monoclonal Antibody-AF555 can be used FACS.
TMAZ-0076A4	Anti-LRRN1 Monoclonal Antibody-AF488
	Anti-LRRN1 Monoclonal Antibody-AF488 is a biotin-conjugated humanized rabbit antibody targeting LRRN1. Anti-LRRN1 Monoclonal Antibody-AF488 can be used FACS.
TMAZ-0076A6	Anti-LRRN1 Monoclonal Antibody-AF647
	Anti-LRRN1 Monoclonal Antibody-AF647 is a biotin-conjugated humanized rabbit antibody targeting LRRN1. Anti-LRRN1 Monoclonal Antibody-AF647 can be used FACS.
T61256	ARN1468	Others	Others
	ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1].
TMAZ-0076A	Anti-LRRN1 Monoclonal Antibody-APC
	Anti-LRRN1 Monoclonal Antibody-APC is a biotin-conjugated humanized rabbit antibody targeting LRRN1. Anti-LRRN1 Monoclonal Antibody-APC can be used FACS.
T14321	ARN19874	Others	Others
	ARN19874 is a selective, reversible uncompetitive N-acylphosphatidylethanolamine phospholipase D (NAPE-PLD) activity inhibitor. With an IC50 of ~34 μM[1].
T39859	ARN19689	Others	Others
	ARN19689 is an effective inhibitor of human NAAA, demonstrating high potency in the low nanomolar range (IC 50 = 0.042 μM). The compound acts through a non-covalent mechanism, highlighting its ability to interact with the enzyme for inhibition.
T36468	ARN14988	Others	Others
	ARN14988 is a potent inhibitor of acid ceramidase (IC50 = 12.8 nM for the human enzyme). It inhibits acid ceramidase activity and increases levels of C16 dihydro ceramide and C16 ceramide in A375, G361, M14, MeWo, MNT-1, and SK-MEL-28 melanoma cells. ARN14988 also reduces growth of A375 and G361 melanoma cells (EC50s = 41.8 and 67.7 μM, respectively).

化合物

RN-1 dihydrochloride

Cat.No: T21652

Target: Histone Demethylase, MAO

Cat.No: T9528

Target: Others

Cat.No: T21658

Target: Others

Cat.No: TQ0015

Target: c-Fms, FGFR, CSF-1R

Cat.No: T30137

Target: Others

Anti-LRRN1 Monoclonal Antibody-PE

Cat.No: TMAZ-0076P

Anti-LRRN1 Monoclonal Antibody-Biotin

Cat.No: TMAZ-0076B

Anti-LRRN1 Monoclonal Antibody-AF555

Cat.No: TMAZ-0076A5

Anti-LRRN1 Monoclonal Antibody-AF488

Cat.No: TMAZ-0076A4

Anti-LRRN1 Monoclonal Antibody-AF647

Cat.No: TMAZ-0076A6

Cat.No: T61256

Target: Others

Anti-LRRN1 Monoclonal Antibody-APC

Cat.No: TMAZ-0076A

Cat.No: T14321

Target: Others

Cat.No: T39859

Target: Others

Cat.No: T36468

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01030	LRRN1 Protein, Mouse, Recombinant (His) Neuronal leucine-rich repeat protein 1,LRN...	Mouse	HEK293 Cells
	Lrrn1 is required for the formation of MHB--loss of function leads to a loss of the morphological constriction and loss of Fgf8. Cells overexpressing Lrrn1 violate the boundary and result in a loss of cell restriction between midbrain and hindbrain compartments. Lrrn1 also regulates the glycosyltransferase Lunatic Fringe, a modulator of Notch signalling, maintaining its expression in midbrain cells which is instrumental in MHB boundary formation.
TMPY-03654	NRN1L Protein, Human, Recombinant (mFc) neuritin 1-like,NRN1L,UNQ2446	Human	HEK293 Cells
	NRN1L Protein, Human, Recombinant (mFc) is expressed in HEK293 mammalian cells with mFc tag. The predicted molecular weight is 76.4 kDa and the accession number is Q496H8.
TMPY-02579	NRN1 Protein, Human, Recombinant (His) NRN,dJ380B8.2,MGC44811,neuritin <...	Human	Baculovirus Insect Cells
	Neuritin 1 (NRN1) is a member of the neuritin family. Neuritin is a glycosylphosphatidylinositol-anchored protein induced by neural activity. It is expressed in postmitotic-differentiating neurons of the developing nervous system and a population of small-diameter neurons in the dorsal root ganglia and was anterogradely and retrogradely transported. Neuritin message is induced by neuronal activity and by the activity-regulated neurotrophins BDNF, nerve growth factor (NGF), and NT-3. Purified rec...
TMPJ-01148	NRN1L Protein, Human, Recombinant (His) NRN1L,UNQ2446/PRO5725,Neuritin-like protei...	Human	HEK293 Cells
	Neuritin-like protein belongs to the neuritin family. Neuritin is a GPI-anchored protein that promotes neurite outgrowth and branching of neuritic processes in primary hippocampal and cortical cells. Neuritin expression also enhances the development of motor neuron axon arbors by promoting neuromuscular synaptogenesis and by stimulating the addition of new axon branches. Neuritin is induced by neuronal activity and by the neurotrophins, BDNF and NT3. NRN1L contains a consensus cleavage signal fo...

重组蛋白

LRRN1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01030

Species: Mouse

Expression System: HEK293 Cells

NRN1L Protein, Human, Recombinant (mFc)

Cat.No: TMPY-03654

Species: Human

Expression System: HEK293 Cells

NRN1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02579

Species: Human

Expression System: Baculovirus Insect Cells

NRN1L Protein, Human, Recombinant (His)

Cat.No: TMPJ-01148

Species: Human

Expression System: HEK293 Cells

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