DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfidebonds or thioether The bond binds to the antibody. The IC50 of DM4-SM
Azido-PEG3-SS-NHS is a three-unit polyethylene glycol (PEG) linker functionalized with an azide group, a cleavable disulfidebond, and an N-hydroxysuccinimide ester. It is primarily employed in the synthesis of antibody-drug conjugates (ADCs) [1].
CL2A is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker, characterized by its ability to induce a bystander effect. It forms a disulfidebond with an antibody at a cysteine residue. Labetuzumab govitecan utilizes this linker for its drug conjugation[1].
YK-5-252 is a dual action combretastatin A-4 (CA-4) prodrug which releases CA-4 through a disulfidebond cleavage mechanism and contains a near-infrared (NIR) fluorophore.
Thioredoxin reductase peptide, corresponding to residues 53–67 in thioredoxin reductase (TrxR), is used in thioredoxin reductase research. Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfidebond of thioredoxin (Trx) and is essential for cellular redox homeostasis.