17
1
2
20
Cat. No. | Product Name | ||
---|---|---|---|
L9410 | 共价抑制剂库 | 1920 compounds | |
1920 种小分子的独特集合,包含已发现的共价抑制剂以及包含某些共价反应基团常见弹头的分子,如氯乙酰基,2-氯丙酰基,丙烯酰基,1-丙-2-炔基,1-丁-2-炔基,酮羰基,二硫键等,可以用于共价抑制剂药物研发; | |||
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2568L |
Felypressin acetate
2-(L-Phenylalanine)-8-L-lysinevasopressin,醋酸苯赖加压素,PLV2. H-Cys-Phe-Phe-Gln-Asn-Cys-Pro-Lys-Gly-NH2 (Disulfide bond),PLV 2,PLV-2 |
Vasopressin Receptor | GPCR/G Protein |
Felypressin acetate (PLV-2) 是加压素 1 的激动剂,作用于所有精氨酸加压素受体 1AS。 Felypressin acetate 可用于牙科手术。 | |||
T19925 |
EcDsbB-IN-9
|
Others | Others |
EcDsbB-IN-9 是一种特异性 EcDsbB 抑制剂,靶向革兰氏阴性菌的二硫键形成酶 DsbB。 | |||
T8587 |
EcDsbB-IN-12
4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one |
Others | Others |
EcDsbB-IN-12 (4,5-dichloro-2-[(2-chlorophenyl)methyl]pyridazin-3-one) 靶向二硫键形成酶,是一种新型强效特异性EcDsbB 抑制剂。 | |||
T15076 |
DBCO-S-S-PEG3-biotin
生物素-PEG3-二硫-DBCO |
Others; PROTAC Linker | Others; PROTAC |
DBCO-S-S-PEG3-biotin 是一种属于 PEG 类的 PROTAC linker,可用于 PROTAC 分子的合成。 | |||
TP1604L |
Thioredoxin reductase peptide acetate
Thioredoxin reductase peptide acetate(950890-23-0 free base) |
Others | Others |
Thioredoxin reductase peptide acetate(950890-23-0 free base) 对应于硫氧还蛋白还原酶 (TrxR) 中的 53–67 位残基,用于硫氧还蛋白还原酶研究。哺乳动物硫氧还蛋白还原酶 (TR) 催化硫氧还蛋白 (Trx) 的氧化还原活性二硫键的还原,并且在结构和谷胱甘肽还原酶的作用机制,除了 C 末端的 16 个氨基酸延伸部分含有一个罕见的连位硒硫键。 | |||
T17731L |
CL2A-SN-38 DCA 1279680-68-0(free base)
|
Others | Others |
CL2A-SN-38 DCA 1279680-68-0(free base) 是一种药物-接头偶联物,由有效的 DNA 拓扑异构酶 I 抑制剂 SN-38 和接头 CL2A 组成,用于制造抗体药物偶联物 (ADC)。CL2A-SN-38 由有效的 DNA 拓扑异构酶组成I 抑制剂 SN-38 和接头 CL2A 以制造抗体药物偶联物 (ADC)。 CL2A-SN-38 对一系列人类实体瘤类型提供显着和特异性的抗肿瘤作用。 CL2A 是一种不可切割的复杂 PEG8 和含有三唑的 PABC-肽-mc 接头。 CL2A 可通过 pH 敏感性裂解,产生旁观者效应,并通过二硫键在半胱氨酸残基处结合抗体。 | |||
T38312 |
L-Cysteine-glutathione disulfide
|
Others | Others |
L-Cysteine-glutathione disulfide, a glutathione derivative endogenous to mammalian cells, is comprised of the oxidized form of free glutathione tripeptide linked via a disulfide bond to L-cysteine. It has been shown to protect mice against acetaminophen-induced hepatotoxicity. | |||
T35251 |
YK-5-252
YK 5 252,YK5-252,YK-5252 |
Others | Others |
YK-5-252 is a dual action combretastatin A-4 (CA-4) prodrug which releases CA-4 through a disulfide bond cleavage mechanism and contains a near-infrared (NIR) fluorophore. | |||
T17505 |
Azido-PEG3-SS-NHS
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
Azido-PEG3-SS-NHS is a three-unit polyethylene glycol (PEG) linker functionalized with an azide group, a cleavable disulfide bond, and an N-hydroxysuccinimide ester. It is primarily employed in the synthesis of antibody-drug conjugates (ADCs) [1]. | |||
T11059 |
DM4-SMe
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
DM4-SMe is a cytotoxic part of antibody-drug conjugates (ADCs) and a metabolite of antibody-maytansin conjugates (AMCs) and tubulin inhibitors, which can also be stabilized by disulfide bonds or thioether The bond binds to the antibody. The IC50 of DM4-SM | |||
T84657 |
113-O12B
|
Others | Others |
113-O12B是一种含有二硫键的可电离阳离子类脂质,用于生成用于递送mRNA的脂质纳米颗粒(LNP)。 | |||
T17732 |
CL2A
|
Others; ADC Linker | Antibody-drug Conjugate/ADC Related; Others |
CL2A is a pH-sensitive, cleavable PEG8- and triazole-containing PABC-peptide-mc linker, characterized by its ability to induce a bystander effect. It forms a disulfide bond with an antibody at a cysteine residue. Labetuzumab govitecan utilizes this linker for its drug conjugation[1]. | |||
T84857 |
113-O16B
|
Others | Others |
113-O16B为含有二硫键的可电离阳离子类脂质,已应用于生成携带mRNA的脂质纳米粒子(LNP)。 | |||
TP1604 |
Thioredoxin reductase peptide
|
||
Thioredoxin reductase peptide corresponds to residues 53–67 in thioredoxin reductase (TrxR), used in thioredoxin reductase research.Mammalian thioredoxin reductase (TR) catalyzes the reduction of the redox-active disulfide bond of thioredoxin (Trx) and is | |||
T76480 |
Amylin (1-37) (human)
|
||
Amylin (1-37) (human) (hIAPP (1-37)) 为胰岛β细胞分泌颗粒中的肽类激素,其C端经酰胺化处理,第2和第7个半胱氨酸残基间形成二硫键。 | |||
T80992 |
Thrombospondin (TSP-1)-derived CD36 binding motif
|
||
Thrombospondin (TSP-1)-derived CD36 binding motif 是一种源自基质结合糖蛋白TSP-1的生物活性肽,具备与CD36相互作用的关键结合基序。该肽通过二硫键形成环状结构,与癌症转移、肿瘤粘附和新血管形成等过程相关。研究表明,它能竞争性抑制血小板聚集和肿瘤转移。 | |||
T80255 |
CHRG01
|
||
CHRG01为源自人b-防御素3(hBD3)第54至67个C末端氨基酸,并将所有Cys残基替换为Ser以移除所有二硫键的生物活性肽。与hBD3类似,CHRG01展现出静电依赖性的抗菌性质。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1085L |
Glutathione oxidized
Bi(glutathion-S-yl),Oxidized glutathione,L-谷胱甘肽(氧化型),氧化型谷胱甘肽,L-Glutathione oxidized,Glutathione disulfide,L(-)-Glutathione,GSSG |
Reactive Oxygen Species; Endogenous Metabolite; Glutathione reductase | Immunology/Inflammation; Metabolism; NF-κB; oxidation-reduction |
Glutathione oxidized (L(-)-Glutathione) 是氧化型谷胱甘肽,谷胱甘肽是细胞内一种主要的抗氧化剂和解毒剂。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPY-01104 |
Coagulation factor XI/F11 Protein, Human, Recombinant (His)
coagulation factor 11,coagulation factor XI,FXI |
Human | HEK293 Cells |
Factor XI (plasma thromboplastin antecedent) is a plasma glycoprotein, and a zymogen acting as a serine protease which participates in blood coagulation as a catalyst in the conversion of factor IX to factor IXa in the presence of calcium ions. It is an unusual dimeric protease, with structural features that distinguish it from vitamin K-dependent coagulation proteases. The factor XI is synthesized in the liver as a single polypeptide chain with a molecular weight estimated between 125 ~160 kDa ... | |||
TMPH-01340 |
Filaggrin Protein, Human, Recombinant (His)
Filaggrin,FLG |
Human | P. pastoris (Yeast) |
Aggregates keratin intermediate filaments and promotes disulfide-bond formation among the intermediate filaments during terminal differentiation of mammalian epidermis. Filaggrin Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.8 kDa and the accession number is P20930. | |||
TMPY-02887 |
IFI30 Protein, Human, Recombinant (His)
interferon γ inducible protein 30,IP30,IFI-30,GILT,IP-30,int... |
Human | HEK293 Cells |
IFI30 belongs to the GILT family. This family includes the two characterized human gamma-interferon-inducible lysosomal thiol reductase (GILT) sequences: P13284 and Q9UL08. It also contains several other eukaryotic putative proteins with similarity to GILT. The aligned region contains three conserved cysteine residues. Besides, the two GILT sequences possess a C-X(2)-C motif that is shared by some of the other sequences in the family. This motif is thought to be associated with disulfide bond re... | |||
TMPY-02890 |
ERP27 Protein, Human, Recombinant (mFc)
endoplasmic reticulum protein 27,C12orf46,PDIA8 |
Human | HEK293 Cells |
ERP27 contains 1 thioredoxin domain and is a noncatalytic member of the protein disulfide isomerase family. Protein disulfide isomerases (PDIs) constitute a family of structurally related enzymes which catalyze disulfide bonds formation, reduction, or isomerization of newly synthesized proteins in the lumen of the endoplasmic reticulum (ER). They act also as chaperones, and are, therefore, part of a quality-control system for the correct folding of the proteins in the same subcellular compartmen... | |||
TMPJ-01020 |
GFER Protein, Human, Recombinant (His)
Augmenter of liver regeneration,FAD-linked sulfhydryl oxidas... |
Human | E. coli |
GFER is a hepatotrophic growth factor and flavin-linked sulfhydryl oxidase which belongs to the Erv1/ALR family of proteins. GFER is widely expressed in various human tissues. They are two isoforms of this protein. Isoform 1 could regenerate the redox-active disulfide bonds in CHCHD4/MIA40, a chaperone essential for disulfide bond formation and protein folding in the mitochondrial intermembrane space. The reduced form of CHCHD4/MIA40 forms a transient intermolecular disulfide bridge with GFER/ER... | |||
TMPJ-00902 |
Kell Protein, Human, Recombinant (His)
CD238,KEL,Kell blood group glycoprotein |
Human | HEK293 Cells |
Kell blood group glycoprotein (KEL) is a single-pass type II membrane protein which belongs to the peptidase M13 family. It is expressed in Expressed at high levels in erythrocytes and testis, and, at lower levels, in skeletal muscle, tonsils, lymph node, spleen and appendix. KEL has been shown zinc endopeptidase with endothelin-3-converting enzyme activity. It cleaves EDN1, EDN2 and EDN3, with a marked preference for EDN3. It links via a single disulfide bond to the XK membrane protein that car... | |||
TMPJ-00301 |
Coagulation Factor X Protein, Human, Recombinant (hFc)
Stuart-Prower factor,Stuart factor,Coagulation factor X |
Human | HEK293 Cells |
F10, also known as Coagulation factor X, belongs to the peptidase S1 family that is synthesized as a 488 amino acid (aa) with a signal peptide and a pro region (residues 1‑40). Both the intrinsic and extrinsic pathways activate Factor X to Xa, which consists of light (residues 41‑179) and heavy (residues 235‑488) chains linked by a disulfide bond. Coagulation factor X is initially synthesized in the liver. The two chains are formed from a single-chain precursor by the excision of two Arg residue... | |||
TMPJ-00824 |
Ig lambda constant 2 Protein, Human, Recombinant (His)
Ig λ constant 2 Protein, Human, Recombinant (His),MGC45681,I... |
Human | HEK293 Cells |
Immunoglobulin lambda constant region is constant region of immunoglobulin light chains. Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. IGLC2 is 105 amino acids (aa) in length. I... | |||
TMPY-02768 |
Selenoprotein M Protein, Human, Recombinant (His)
SEPM |
Human | E. coli |
Selenoprotein M is a selenoprotein, which contains a selenocysteine (Sec) residue at its active site. The selenocysteine M is encoded by the UGA codon that normally signals translation termination. The 3' UTR of selenoprotein genes have a common stem-loop structure, the sec insertion sequence (SECIS), that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. This gene is expressed in a variety of tissues, and the protein is localized to the perinuclear structures.... | |||
TMPY-04626 |
Enterokinase/EK Protein, Bovine, Recombinant
EK, Enterokinase, PRSS7, Enteropeptidase, EC 3.4.21.9, Serin... |
Bovine | P. pastoris (Yeast) |
Enterokinase is a member of the trypsin family of serine proteases. The precursor protein is cleaved into two chains which then forms a heterodimer linked by a disulfide bond. The heavy chain anchors enterokinase in the intestinal brush border membrane and the light chain is the catalytic subunit, which initiates conversion activation of a subset of pancreatic proteolytic proenzymes. Enterokinase is the physiological activator of trypsinogen and has a specificity for the sequence (Asp)4-Lys-Ile.... | |||
TMPJ-00056 |
AG-2 Protein, Human, Recombinant (His)
HPC8,AG2,AG-2,hAG-2,Anterior Gradient Protein 2 Homolog,AGR2... |
Human | HEK293 Cells |
Anterior Gradient 2 (AGR2) is an 18-21 kDa member of the PDI family of enzymes. AGR2 is widely expressed in secretory cells, such as small intestine goblet, prostate epithelium, enteroendocrine cells, and multiple carcinoma cell types. AGR2 forms transient disulfide linkages with molecules destined for secretion, possibly aiding protein folding. Expression of AGR2 shows a positive correlation with expression of estrogen receptor in breast carcinoma and a negative correlation with expression of E... | |||
TMPJ-01290 |
Neurturin Protein, Human, Recombinant
Neurturin,NRTN |
Human | E. coli |
Neurturin is a member of the GDNF family of ligands, which include glial cell-derived neurotrophic factor (GDNF), Neurturin, Persephin, and Artemin. Neurturin is expressed in both neuronal and nonneuronal tissues. Similarly to other TGFβ family proteins, Neurturin is synthesized as a precursor protein that is cleaved at the dibasic cleavage site (RXXR) to release the carboxyterminal domain. The carboxy terminal domain of Neurturin contains the characteristic seven conserved cysteine residues nec... | |||
TMPJ-01116 |
HABP2 Protein, Human, Recombinant (His)
Factor seven-activating protease,Factor VII-activating prote... |
Human | HEK293 Cells |
Hyaluronan-binding protein 2(HABP2) is an extracellular serine protease which binds hyaluronic acid. It secreted as an inactive single-chain precursor and is then activated to a heterodimeric form, which consists of a 50 kDa heavy and a 27 kDa light chain linked by a disulfide bond. HABP2 is involved in cell adhesion, it can cleave the alpha-chain at multiple sites and the beta-chain between 'Lys-53' and 'Lys-54' , but not the gamma-chain of fibrinogen. As a result of this, it does not initiate... | |||
TMPH-02249 |
TRIM72 Protein, Human, Recombinant (E. coli, His & Myc)
Mitsugumin-53,Tripartite motif-containing protein 72,TRIM72 |
Human | E. coli |
Muscle-specific protein that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites. Specifically binds phosphatidylserine. Acts as a sensor of oxidation: upon membrane damage, entry of extracellular oxidative environment results in disulfide bond formation and homooligomerization at the injury site. This oligomerization acts as a nucleation site for recruitment of TRIM72-containing vesicles to the injury site, leading to membrane patch fo... | |||
TMPY-01190 |
INHBB Protein, Human, Recombinant (His)
inhibin beta B,INHBB,Inhibin β B Protein,MGC157939,inhibin β... |
Human | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two ß subunits, ßA ßA (activin A), ßB ßB (activin B), or ßA ßB (activin AB). Inhibin is composed of an alpha and one of two ß subunits, ßA (inhibin A) or ßB (inhibin B). Activins are produced in... | |||
TMPY-02211 |
USP5 Protein, Human, Recombinant (His)
ISOT,ubiquitin specific peptidase 5 (isopeptidase T) |
Human | Baculovirus Insect Cells |
Ubiquitin carboxyl-terminal hydrolase 5, also known as Deubiquitinating enzyme 5, Isopeptidase T, Ubiquitin thiolesterase 5, Ubiquitin-specific-processing protease 5, ISOT and USP5, is a member of the peptidase C19 family. USP5 contains 2 UBA domains and one UBP-type zinc finger. The UBP-type zinc finger domain interacts selectively with an unmodified C-terminus of the proximal ubiquitin. Both UBA domains are involved in polyubiquitin recognition. The UBP-type zinc finger domain crystallizes as ... | |||
TMPY-00821 |
HGFA Protein (pro form), Human, Recombinant (His)
MGC138397,HGFA,RP11-529E1.2,肝细胞生长因子,MGC138395 |
Human | HEK293 Cells |
HGF activator (HGFA) is a serum-derived serine protease and belongs to the peptidase family S1.HGFA is responsible for the conversion of hepatocyte growth factor (HGF), from the inactive single-chain precursor to the active heterodimeric form, which is a potent mitogen, motogen, and morphogen for liver cells, epithelial cells, and endothelial cells. HGFA is synthesized and secreted by the liver and circulates in the plasma as an inactive single-chain zymogen in normal states. The zymogen is clea... | |||
TMPY-02839 |
Adrenomedullin Protein, Human, Recombinant (hFc)
AM,PAMP,adrenomedullin |
Human | HEK293 Cells |
Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report... | |||
TMPY-01846 |
Activin A Protein, Mouse, Recombinant (His)
inhibin, β A,inhibin, beta A |
Mouse | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. The activin and inhibin protein complexes are both dimeric in structure, and, in each complex, the two monomers are linked to one another by a single disulfide bond. Activin is composed of two β subunits, βA βA (activin A), βB βB (activin B), or βA βB (activin AB). Inhibin is composed of an alpha and one of two β subunits, βA (inhibin A) or βB (inhibin B). Activins are produced in... | |||
TMPH-03741 |
BoNT/F Protein, Clostridium botulinum, Recombinant (His)
Bontoxilysin-F,BoNT/F,botF,Botulinum neurotoxin type F |
Clostridium botulinum | E. coli |
Botulinum toxin causes flaccid paralysis by inhibiting neurotransmitter (acetylcholine) release from the presynaptic membranes of nerve terminals of the eukaryotic host skeletal and autonomic nervous system, with frequent heart or respiratory failure. Precursor of botulinum neurotoxin F which may have 2 coreceptors; complex polysialylated gangliosides found on neural tissue and specific membrane-anchored proteins found in synaptic vesicles. Receptor proteins are exposed on host presynaptic cell ... |