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Search Results for " tumor microenvironment "

Targets Recommended: COX

29

抑制剂 & 化合物

1

天然产物

2

化合物库

6

重组蛋白

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Cat. No.	Product Name
L2520	糖代谢化合物库		702 compounds
	702 种糖代谢相关的化合物，可用于高通量和高内涵筛选；
L8500	HIF-1化合物库		1336 compounds
	1336 个HIF-1相关小分子的独特集合，可用于缺血性疾病、癌症等相关领域的药物开发和药理研究；

化合物库

糖代谢化合物库

Cat.No: L2520

Compounds: 702

HIF-1化合物库

Cat.No: L8500

Compounds: 1336

Cat. No.	Product Name	Target	Signaling Pathways
T6540	Ibuprofen Lysine 布洛芬赖氨酸盐,Neoprofen	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen Lysine (Neoprofen) 是一种非甾体抗炎药。
T1394	Ibuprofen Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil	COX	Immunology/Inflammation; Neuroscience
	Ibuprofen (Advil) 是一种丙酸衍生物和非甾体抗炎药 (NSAID)，具有抗炎、镇痛和解热作用。它是COX-1和COX-2的抑制剂，IC50值分别为 13 和 370 μM，导致前列腺素和血栓素前体的形成减少。
T35343	MTI-31 MTI-31,LXI-15029	mTOR	PI3K/Akt/mTOR signaling
	MTI-31 (LXI-15029) 是口服有效的，高度选择性的mTORC1和mTORC2抑制剂，对 mTOR 的Kd 为 0.20 nM，IC50为 39 nM。MTI-31可用于乳腺癌的研究。
T12516	Polyinosinic-polycytidylic acid sodium 双链聚肌胞,Poly(I:C) sodium	Apoptosis; Others; TLR	Apoptosis; Immunology/Inflammation; Others
	Polyinosinic-polycytidylic acid sodium (Poly(I:C) sodium) 是双链 RNA 的合成类似物，是TLR3和视黄酸诱导型基因 I 受体激动剂。它可以用作疫苗佐剂，直接触发癌细胞发生凋亡，还增强先天性和适应性免疫反应，并改变肿瘤的微环境。
T3633	Crenigacestat LY3039478	Gamma-secretase	Neuroscience; Proteases/Proteasome; Stem Cells
	Crenigacestat (LY3039478) 是一种口服具有活性的Notch 和γ-secretase 的抑制剂，其在多种肿瘤细胞中的IC50为 ∼1nM。
T17731	CL2A-SN-38 CL2A SN 38,CL2A-SN38	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	CL2A-SN-38 由CL2A链接子和抗癌化合物SN-38 组成，可在肿瘤细胞内和肿瘤微环境中递送活性活性分子，通常会与抗体制成具有生物活性的抗体偶联活性分子 (ADC)。
T78277	ATG-031
	ATG-031 是一种高亲和力的人源化抗 CD24 单克隆抗体，在体外和体内显示出抗肿瘤活性。ATG-031 阻断TME中的CD24-Siglec10轴。ATG-031 可用于研究非霍奇金淋巴瘤和调节肿瘤微环境。
T31825	Fluoromisonidazole
	Fluoromisonidazole, a Radiation-Sensitizing Agent, can be used for imaging tumor hypoxia: imaging the microenvironment for personalized cancer therapy.
T22725	DiMNF	Others	Others
	DiMNF is a selective aryl hydrocarbon receptor (AHR) modulator. It also suppresses the expression of CD55 and CD46 induced by IL-1β in an inflammatory tumor cell microenvironment.
T82268	Gotistobart BNT 316,ONC-392
	Gotistobart (ONC-392)为一种人源化抗CTLA-4抗体，旨在通过选择性消耗肿瘤微环境中的调节性T细胞(Treg)，以增强免疫疗效。
T78250	Selicrelumab
	Selicrelumab是一种针对CD40的抗体激动剂，能够诱导肿瘤微环境的改变，适用于胰腺癌及肿瘤新辅助治疗的研究。
T40099	ALV2	Others	Others
	ALV2 is a potent and selective Helios degrader compound that binds to the CRBN protein, exhibiting an IC50 value of 0.57 μM. Helios, a zinc-finger transcription factor, plays a crucial role in preserving a stable T reg cell phenotype within the inflammatory tumor microenvironment.
T10713	CCR4 antagonist 2	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	CCR4 antagonist 2 (Compound 31) is a novel potent, orally bioavailable small molecule antagonists of CC chemokine receptor 4 (CCR4) that inhibits Treg trafficking into the Tumor Microenvironment without suppressing the number of Treg in healthy tissues. CCR4 antagonist 2 (Compound 31) exhibits IC50 values of Ca2+flux and (chemotaxis) CTX are 40 nM and 70 nM, respectively.
T69648	Inupadenant HCl	Others	Others
	Inupadenant, also known as EOS-850, is a highly selective small molecule antagonist of the adenosine A2a receptor, in the adenosine triphosphate adenosine pathway, a key driver of immunosuppression in the tumor microenvironment across a broad range of tumors.
T74507	IDO1-IN-20	Others	Others
	IDO1-IN-20是一种催化色氨酸氧化代谢的酶，能在肿瘤微环境中对肿瘤进行免疫抑制。
T78521	Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE	Others; Drug-Linker Conjugates for ADC	Antibody-drug Conjugate/ADC Related; Others
	Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE（化合物S6）作为抗肿瘤微环境特异性活化的抗癌剂，已被证实能够抑制小鼠肿瘤生长。
T74975	Zn-DPA-maytansinoid conjugate 1	Others	Others
	Zn-DPA-maytansinoid conjugate 1 为一种靶向小分子免疫检查点的类美坦素偶联物。其能持续诱导肿瘤生长消退，并激活肿瘤微环境（TME），转化为“炎热肿瘤”。
T13538	AlbA-DCA	ROS	Immunology/Inflammation
	AlbA-DCA is a conjugate formed by the attachment of Albiziabioside A to a dichloroacetate acid subunit. It can induce a marked increase in intracellular ROS and alleviate the accumulation of lactic acid in the tumor microenvironment, and also selectively
T79199	F-CRI1	STING	Immunology/Inflammation
	F-CRI1为高效STING激动剂，Kd值达40.62 nM。该化合物通过18F标记成为放射性探针，适用于肿瘤微环境中STING可视化的研究。
T79205	PD-1/PD-L1-IN-34	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-34（化合物(1S,2S)-A25）能有效地抑制PD-1/PD-L1相互作用，其IC50值为0.029 μM，表现出对PD-L1的选择性结合亲和力，KD值为0.1554 μM。该化合物通过激活免疫微环境来抑制肿瘤生长。
T76983	Tengonermin
	Tengonermin (ARENEGYR) 是一种血管靶向剂，由与CNGRCG 肽结合的人肿瘤坏死因子-α (TNF-α) 组成。Tengonermin 通过改变肿瘤微环境来增加肿瘤内化疗的渗透和 T 细胞浸润。
T77189	Sudubrilimab
	Sudubrilimab (HS636) 是一种针对 PDL1的 Ig G1-kappa 单克隆抗体。Sudubrilimab 在重链的 C 末端与 TGF-β1受体 Ⅱ 胞外域 (TGFBR2-ECD) 融合，可在免疫抑制性肿瘤微环境中隔离 PD-1/PD-L1通路和 TGF-β 生物活性。
T35587	Ganglioside GD1a mixture (sodium salt) Ganglioside B1	Others	Others
	Ganglioside GD1a is a sialic acid-containing glycosphingolipid found in brain, erythrocytes, bone marrow, testis, spleen, and liver. [1] It can be shed from the surface of tumor cells into the microenvironment where it influences tumor-host cell interactions to promote tumor cell proliferation, invasion, and metastasis. Ganglioside GD1a (20 μM) also increases endothelial cell proliferation. Furthermore, ganglioside GD1a has been shown to act as a functional coreceptor for toll-like receptor 2 (T...
T36900	PD-1/PD-L1-IN-NP19 PD-1/PD-L1-IN-NP19	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-NP19 是 PD-1/PD-L1 的抑制剂，抑制人类 PD-1/PD-L1 相互作用的 IC50 值为 12.5 nM。PD-1/PD-L1-IN-NP19 可以激活肿瘤的免疫微环境，这可能有助于其抗肿瘤作用。
T77090	Mitazalimab
	Mitazalimab（ADC-1013; JNJ-64457107）是一种FcγR依赖性CD40激动剂，以肿瘤导向活性为特征。该化合物通过激活抗原呈递细胞（如树突状细胞[DC]），启动肿瘤反应性T细胞，进而诱导肿瘤特异性T细胞浸润并杀死肿瘤，有效重塑肿瘤浸润性骨髓微环境。
T72668	PD-1/PD-L1-IN-26	PD-1/PD-L1	Apoptosis; Cell Cycle/Checkpoint; Immunology/Inflammation
	PD-1/PD-L1-IN-26 (Compound II-14) 是一种高效的 PD-1/PD-L1 抑制剂，IC50 为 0.0380 μM。该化合物能够激活肿瘤免疫微环境，通过促进 CD4+ T 细胞向肿瘤组织的浸润。PD-1/PD-L1-IN-26 展示了在癌症治疗研究中的应用潜力。
T76255	Certepetide
	Certepetide (CEND-1)，即双功能环肽（a.k.a. iRGD），是一种具有穿透肿瘤功能的多肽。通过与α-V整联蛋白（alphav-integrins）的RGD motif相互作用，以及激活神经纤毛蛋白1（NRP-1），Certepetide能够将实体瘤微环境转化成临时的活性分子通道，从而在肿瘤中累积。该化合物在胰腺癌和其他实体瘤的研究中具有应用潜力。
T74052	Polyinosinic-polycytidylic acid potassium	Others	Others
	Polyinosinic-polycytidylic acid potassium (Poly(I:C) potassium) 是双链 RNA 的合成类似物，是一种TLR3和视黄酸诱导型基因 I 受体 (RIG-I 和MDA5) 的激动剂。Polyinosinic-polycytidylic acid potassium 可以用作疫苗佐剂，以增强先天性和适应性免疫反应，并改变肿瘤的微环境，还可以直接触发癌细胞发生凋亡 (Apoptosis)。
T83877	2-(cyclohexylmethyl)-Plumbagin	Others	Others
	2-(cyclohexylmethyl)-Plumbagin是naphthoquinone plumbagin的衍生物。在模拟胰腺癌肿瘤微环境的营养匮乏条件下，与营养丰富条件下的PANC-1细胞相比，对PANC-1人类胰腺癌细胞表现出选择性的细胞毒性，50%优选细胞毒性值(PC50s)分别为0.11和47.2 µM。1 µM浓度下，还可诱导PANC-1细胞发生凋亡。此外，2-(cyclohexylmethyl)-Plumbagin在营养匮乏条件下，而非营养丰富条件下，选择性降低PANC-1细胞中Akt和哺乳动物雷帕霉素靶蛋白(mTOR)的磷酸化。在以每周五次、每次50和250 µg/动物剂量给药的MiaPaCa-2胰腺癌小鼠异种移植模型中，能减少肿瘤体积和重量。

化合物

Ibuprofen Lysine

Cat.No: T6540

Synonym: 布洛芬赖氨酸盐,Neoprofen

Target: COX

Cat.No: T1394

Synonym: Brufen,(±)-Ibuprofe,布洛芬,Motrin,Advil

Target: COX

Cat.No: T35343

Synonym: MTI-31,LXI-15029

Target: mTOR

Polyinosinic-polycytidylic acid sodium

Cat.No: T12516

Synonym: 双链聚肌胞,Poly(I:C) sodium

Target: Apoptosis, Others, TLR

Cat.No: T3633

Synonym: LY3039478

Target: Gamma-secretase

Cat.No: T17731

Synonym: CL2A SN 38,CL2A-SN38

Target: Others, Drug-Linker Conjugates for ADC

Cat.No: T78277

Fluoromisonidazole

Cat.No: T31825

Cat.No: T22725

Target: Others

Cat.No: T82268

Synonym: BNT 316,ONC-392

Cat.No: T78250

Cat.No: T40099

Target: Others

CCR4 antagonist 2

Cat.No: T10713

Target: Calcium Channel

Inupadenant HCl

Cat.No: T69648

Target: Others

Cat.No: T74507

Target: Others

Mc-Alanyl-Alanyl-Asparagine-PAB-MMAE

Cat.No: T78521

Target: Others, Drug-Linker Conjugates for ADC

Zn-DPA-maytansinoid conjugate 1

Cat.No: T74975

Target: Others

Cat.No: T13538

Target: ROS

Cat.No: T79199

Target: STING

PD-1/PD-L1-IN-34

Cat.No: T79205

Target: PD-1/PD-L1

Cat.No: T76983

Cat.No: T77189

Ganglioside GD1a mixture (sodium salt)

Cat.No: T35587

Synonym: Ganglioside B1

Target: Others

PD-1/PD-L1-IN-NP19

Cat.No: T36900

Synonym: PD-1/PD-L1-IN-NP19

Target: PD-1/PD-L1

Cat.No: T77090

PD-1/PD-L1-IN-26

Cat.No: T72668

Target: PD-1/PD-L1

Cat.No: T76255

Polyinosinic-polycytidylic acid potassium

Cat.No: T74052

Target: Others

2-(cyclohexylmethyl)-Plumbagin

Cat.No: T83877

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3604	Sodium dichloroacetate Sodium Dichloroacetate,DCA,bichloroacetic acid,二氯乙酸钠,Sodium dichloroacetate (DCA),二氯醋酸酯	Apoptosis; Dehydrogenase; Reactive Oxygen Species; PDK	Apoptosis; Immunology/Inflammation; Metabolism; NF-κB; PI3K/Akt/mTOR signaling
	Sodium dichloroacetate (DCA) 是一种肿瘤细胞线粒体中的代谢调节剂，一种丙酮酸脱氢酶激酶 (PDK) 抑制剂。Sodium dichloroacetate 具有抗肿瘤活性，可以降低肿瘤微环境中的乳酸，增加活性氧的产生并促进肿瘤细胞凋亡。

天然产物

Sodium dichloroacetate

Cat.No: T3604

Synonym: Sodium Dichloroacetate,DCA,bichloroacetic acid,二氯乙酸钠,Sodium dichloroacetate (DCA),二氯醋酸酯

Target: Apoptosis, Dehydrogenase, Reactive Oxygen Species, PDK

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01381	CSPG4/MCSP Protein, Cynomolgus, Recombinant (His) MCSPG,CSPG4,MCSP,NG2	Cynomolgus	HEK293 Cells
	The chondroitin sulfate proteoglycan-4 (CSPG4) is a cell surface proteoglycan overexpressed in a huge range of human and canine neoplastic lesions by tumor cells, tumor microenvironment and cancer initiating cells. CSPG4 plays a central role in the oncogenic pathways required for malignant progression and metastatization.
TMPK-00188	JAM-A Protein, Mouse, Recombinant (His) F11R,JCAM1,PAM-1,PAM-1KAT,JAM-1,JAM,JCAM,JAM-A,KAT,F11 recep...	Mouse	HEK293 Cells
	junctional adhesion molecule A (JAM-A), a cell adhesion molecule, is highly elevated in human GBM cancer stem cells and predicts poor patient prognosis. While JAM-A is also highly expressed in other cells in the tumor microenvironment, specifically microglia and macrophages,JAM-A functions to suppress pathogenic microglial activation in the female tumor microenvironment, highlighting an emerging role for sex differences in the GBM microenvironment and suggesting that sex differences extend beyon...
TMPK-00732	WISP1/CCN4 Protein, Mouse, Recombinant (His) ELM-1,WISP1tc,WISP1c,CCN4,WISP-1,WISP1i	Mouse	HEK293 Cells
	The interplay between glioma stem cells (GSCs) and the tumor microenvironment plays crucial roles in promoting malignant growth of glioblastoma (GBM), the most lethal brain tumor. WISP1 is preferentially expressed and secreted by GSCs. Silencing WISP1 markedly disrupts GSC maintenance, reduces tumor-supportive TAMs (M2), and potently inhibits GBM growth. WISP1 signals through Integrin α6β1-Akt to maintain GSCs by an autocrine mechanism and M2 TAMs through a paracrine manner.
TMPK-00518	CD44 Protein, Cynomolgus, Recombinant (His) CDw44,IN,MIC4,CD44,ECMR-III,CSPG8,HCELL,HUTCH-I,MC56,MDU2,Ep...	Cynomolgus	HEK293 Cells
	CD44 is a hyaluronan binding cell surface signal transducing receptor that influences motility, cell survival and proliferation as well as the formation of tumor microenvironment. CD44 contains two variable regions encoded by variable exons. Alternative splicing, which is often deregulated in cancer, can produce various isoforms of CD44 with properties that may have different tissue specific effects and therefore even diverse effects on cancer progression
TMPK-00710	Claudin-4 Protein-VLP, Human, Recombinant Claudin4,CLDN4,Claudin-4,CPETR1,CPE-R,WBSCR8,CPE R	Human	HEK293 Cells
	Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs in...
TMPH-02524	Arginase-1/ARG1 Protein, Mouse, Recombinant (His) Arginase-1,Type I arginase,Liver-type arginase,Arg1	Mouse	P. pastoris (Yeast)
	Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys.; Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available i...

重组蛋白

CSPG4/MCSP Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-01381

Species: Cynomolgus

Expression System: HEK293 Cells

JAM-A Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00188

Species: Mouse

Expression System: HEK293 Cells

WISP1/CCN4 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00732

Species: Mouse

Expression System: HEK293 Cells

CD44 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00518

Species: Cynomolgus

Expression System: HEK293 Cells

Claudin-4 Protein-VLP, Human, Recombinant

Cat.No: TMPK-00710

Species: Human

Expression System: HEK293 Cells

Arginase-1/ARG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02524

Species: Mouse

Expression System: P. pastoris (Yeast)

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