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Search Results for " transmission "

Targets Recommended: Nucleoside Antimetabolite/Analog Influenza Virus DNA/RNA Synthesis

76

抑制剂 & 化合物

12

天然产物

2

化合物库

25

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name
L9420	外泌体相关化合物库		76 compounds
	76 种外泌体相关的化合物，可以用于高通量和高内涵筛选；
L3700	JAK-STAT 化合物库		252 compounds
	252 个 JAK/STAT 靶点相关的小分子化合物的独特集合，用于高通量、高内涵筛选；

化合物库

外泌体相关化合物库

Cat.No: L9420

Compounds: 76

JAK-STAT 化合物库

Cat.No: L3700

Compounds: 252

Cat. No.	Product Name	Target	Signaling Pathways
T8354	Triazavirin	Nucleoside Antimetabolite/Analog; Influenza Virus; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Triazavirin 是一种核酸的核苷类似物和抗病毒剂，通过抑制病毒 RNA 和 DNA 的合成以及基因组片段的复制而起作用。在流感传播阶段，它可作为保护剂。
T23513	VU10010 VU 10010	AChR	Neuroscience
	VU10010 (VU 10010) 是一种高度选择性的M4mAChR 变构增强剂，EC50为 400 nM。它与 M4mAChR 的变构位点结合，增强与 G 蛋白偶联，增加对乙酰胆碱的亲和力，还会增加卡巴胆碱引起的兴奋性传导抑制。
T1234	5,5-Dimethyloxazolidine-2,4-dione Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	5,5-Dimethyloxazolidine-2,4-dione (Dimethadione) 是抗惊厥药，是 TRIMETHADIONE 的活性代谢物。
T9988	Wnt/β-catenin agonist 3	Wnt/beta-catenin	Cytoskeletal Signaling; Stem Cells
	Wnt/β-catenin agonist 3是一种Wnt/beta-catenin 信号通路激动剂。
TP1559L	Ziconotide Acetate (107452-89-1 free base) 醋酸齐考诺肽,Prialt,Ziconotide Acetate	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Ziconotide Acetate (107452-89-1 free base) (Prialt) 是一种镇痛剂，已用于治疗神经性和非神经性疼痛。 Ziconotide 通过与位于伤害感受通路初级传入神经元末端部分的 N 型钙通道结合起作用，因此通过有效的镇痛作用减少突触传递。
T3280	Clodronate disodium tetrahydrate clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium	IL Receptor; TNF	Apoptosis; Immunology/Inflammation
	Clodronate disodium tetrahydrate (Clastoban) 是一种选择性、高效的，可逆、Cl-竞争性的囊泡核苷酸转运体阻滞剂(IC50:15.6 nM)。是一种双膦酸盐，具有抗骨质疏松、抗炎作用，可用于缓解疼痛的研究。它可抑制神经元释放囊泡 ATP，缓解慢性神经病理性疼痛和炎症性疼痛。
T0924	Benzocaine 苯唑卡因,苯佐卡因	Others; MRP; Sodium Channel	Immunology/Inflammation; Membrane transporter/Ion channel; Others
	Benzocaine 作用电压门控 Na+通道的共同受体，+30 mV 下的 IC50为0.8 mM。
TP1868	Proctolin 直肠肽	Others	Others
	Proctolin 是内源性五肽，也是兴奋性神经调节剂。
T27400L	Ganaplacide phosphate Ganaplacide phosphate (1261113-96-5 Free base)	Others	Others
	Ganaplacide phosphate 对疟原虫症状性无性血期感染具有多阶段抗疟活性，并且能够在动物模型中预防传播和阻断感染。
T16697	Pyronaridine tetraphosphate	Topoisomerase	DNA Damage/DNA Repair
	Pyronaridine tetraphosphate 是一种具有口服活性的、含甘露醇的DNA 拓扑异构酶 2 的抑制剂和红细胞裂殖杀灭剂，具有抗疟活性和抗肿瘤活性。Pyronaridine tetraphosphate 可治疗 P. falciparum 和 Echinococcus granulosus感染，可减轻埃博拉病毒传播。
T7115	Pymetrozine CGA 215944,吡蚜酮	Antibacterial	Microbiology/Virology
	Pymetrozine (CGA 215944)是一种针对Homoptera的喂养抑制剂，能有效防止通过蚜虫Myzus persicae传播cauliflower mosaic caulimovirus。
T22963	McN-A 343	AChR	Neuroscience
	McN-A 343作为选择性M1 muscarinic激动剂, 以其刺激交感神经节中muscarinic传导的能力而闻名。在溃疡性结肠炎的实验模型中，它已被发现能有效减轻炎症和氧化应激。
T0166	Pancuronium dibromide Pancuronium bromide,Pavulon,泮库溴铵	AChR	Neuroscience
	Pancuronium dibromide (Pavulon) 是一种双季基类固醇，是一种神经肌肉松弛剂。它通过与乙酰胆碱竞争 nACh 受体上的结合位点来抑制神经肌肉传递。它还可抑制心脏毒蕈碱受体并具有拟交感神经作用。
T67765	MenA-IN-2	Others	Others
	MenA-IN-2是一种有效的 1,4-二羟基-2-萘甲酸酯异戊二烯转移酶 (MenA) 抑制剂，对 MenA 的 IC50 值为 22 µM，对结核分枝杆菌 (Mtb) 的 GIC50 值为 10 µM。MenA-IN-2 Mtb 的持续传播具有抑制作用。
T13102	TCMDC-135051	Others	Others
	TCMDC-135051 是一种高选择性和有效性的蛋白激酶 PfCLK3 抑制剂，具有低的靶外毒性。TCMDC-135051 可以防止滋养体到裂殖体的转变，破坏转录并减少向蚊子载体的传播。TCMDC-135051 具有抗寄生虫活性 (EC50=320 nM)。
T1065	Baclofen 巴氯芬,Lioresal	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Baclofen (Lioresal) 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物，是可口服的选择性代谢型 GABA-B 受体激动剂，具有高血脑屏障渗透率，用于治疗因脊髓损伤和多发性硬化引起的痉挛。
T8630	Baclofen hydrochloride 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Baclofen hydrochloride (4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride) 是一种 GAMMA-AMINOBUTYRIC ACID 衍生物，是一种特异性 GABA-B 受体激动剂。它用于治疗肌肉痉挛，尤其是由于脊髓损伤引起的肌肉痉挛。其治疗效果来自于脊髓和脊髓上部位的作用，通常是减少兴奋性传递。
T25616	Lanepitant 2HCl LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Lanepitant 2HCl 是一种非肽类神经激肽-1 受体拮抗剂，具有镇痛和抗炎活性。Lanepitant 2HCl 抑制 P 物质与神经激肽-1 受体的结合，抑制神经源性炎症和疼痛传递，可用于研究偏头痛等疼痛性神经病变类疾病。
T50008	2,2-Dimethyl-5-(2,5-xylyloxy)valeramide 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide	Others	Others
	2,2-Dimethyl-5-(2,5-xylyloxy)valeramide (5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide) 是一种苯氧基家族化合物。它已被证明对神经系统具有刺激作用，包括神经元放电率的增加、突触传递的增加和神经递质释放的增加；还被证明对心血管系统有刺激作用，包括提高心率和血压。
T1092	Zolmitriptan 佐米曲普坦,311C90,BW-311C90	5-HT Receptor	GPCR/G Protein; Neuroscience
	Zolmitriptan (311C90) 是一种5-HT1B/1D 受体部分激动剂，可用于偏头痛的研究，对 5-HT1B、5-HT1D、5-HT1F 受体的Ki 分别为 5.01、0.63 和 63.09 nM。
TP2505L	LAH4 acetate KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)	Antibacterial	Microbiology/Virology
	LAH4 acetate 是所设计的两性肽抗生素的α -螺旋结构，能够与DNA 络合，与细胞表面膜结合后被包裹在核内体中，随着pH 值的下降破坏核内体膜。具有强大的抗菌、核酸转染和细胞渗透活性。LAH4 acetate 具有较高的质粒DNA 传递能力。LAH4 acetate 对细菌膜外膜中的阴离子脂具有很强的亲和力。
TP2226	BzATP triethylammonium salt	P2X Receptor	Membrane transporter/Ion channel; Neuroscience
	BzATP triethylammonium salt 是一种 P2X 受体激动剂，对 P2X1、P2X2、P2X3、P2X2/3、P2X4 和 P2X7 均有效 (pEC50=8.74/5.26/7.10/7.50/6.19/6.31/5.33)。BzATP triethylammonium salt 可以诱导细胞死亡并减少突触传递。
T69043	GJH-166	Others	Others
	GJH-166 is an analog of dopamine that has been shown to inhibit adrenergic transmission in canines.
T71952	DDD01035881	Others	Others
	DDD01035881 is a novel transmission blocker of antimalarials, targeting male gametes.
T34458	Ryanodol	Others	Others
	Ryanodol is a complex diterpenoid that modulates intracellular calcium-ion release at ryanodine receptors, ion channels critical for skeletal and cardiac muscle excitation-contraction coupling and synaptic transmission.
T24450	Mephenoxalone Lenetran Lenetran,TAB Lenetranat	Others	Others
	Mephenoxalone is a muscle relaxant and mild anxiolytic. It inhibits neuron transmission and relaxing skeletal muscles by inhibiting the reflex arc.
T26230	Stilbamidine dihydrochloride NSC 35605,NCI 174	Others	Others
	Stilbamidine dihydrochloride is a blocker of neuromuscular transmission and axonal conduction used to study the distribution of the drug in the organs and tissues of rats following intravenous injection.
T69964	Bornaprine	Others	Others
	Bornaprine is an anticholinergic drug used to treat Parkinson's disease due to inhibition of muscarinic or nicotinic transmission.
T69165	Methiothepin methanesulfonate	Others	Others
	Methiothepin methanesulfonate is an inhibitor of HCV infection and cell-to-cell transmission that acts by targeting the HCV E2 glycoprotein.
T31903	Galphimine B	Others	Others
	Galphimine B is a cyclodesiccated triterpenoid from Galphimia Glauca, which can regulate the synaptic transmission of dopaminergic ventral tegmental neurons and has a sedative effect.
TP1471	Ziconotide TFA (107452-89-1 free base) Ziconotide TFA
	Ziconotide TEA acts by binding to N-type calcium channels situated on the terminal part of primary afferent neurons of the nociceptive pathway therefore reducing synaptic transmission with potent antinociceptive effects.
T24839	Stampidine HI-113,HI 113,HI113	Others	Others
	Stampidine can prevent the sexual transmission of HIV-1. It exhibited remarkable subnanomolar to low nanomolar in vitro antiretroviral potency against nucleoside reverse transcriptase inhibitor-resistant primary clinical HIV isolates, non-nucleoside RT-re
T71531	Metamizil hydrochloride	Others	Others
	Metamizil hydrochloride is a cholinolytic agent -- an agent that blocks the transmission of excitation from cholinergic nerve fibers -- and an antagonist of the mediator acetylcholine.
T60950	Pirepemat fumarate	Others	Others
	Pirepemat (IRL752) fumarate 可用于研究帕金森病。Pireemat fumarate 是一种偏向皮质的儿茶酚胺传递剂和认知促进剂。
T6782	Benzocaine hydrochloride Benzocaine HCl,Ethyl p-aminobenzoate hydrochloride,Ethyl 4-aminobenzoate hydrochloride	Sodium Channel	Membrane transporter/Ion channel
	Benzocaine hydrochloride (Ethyl 4-aminobenzoate hydrochloride) 是一种表面麻醉剂，通过阻止脉冲沿神经纤维和神经末梢传递而起作用。
T70075	KDS2010 mesylate	Others	Others
	KDS2010 is a potent, highly selective, and reversible MAO-B inhibitor which shows 12,500-fold selectivity over MAO-A. KDS2010 overcomes the disadvantages of the irreversible MAO-B inhibitor and significantly attenuates increased astrocytic GABA levels and astrogliosis, thereby enhancing synaptic transmission, and rescuing learning and memory impairments in APP/PS1 mice.
T69012	Cinnarizine clofibrate	Others	Others
	Cinnarizine clofibrate is a calcium channel protein inhibitor as well as an antihistamine channel blocker. The compound is a drug derivative of piperazine. Cinnarizine is used for the control of vomiting due to motion sickness. It acts by interfering with the signal transmission between vestibular apparatus of the inner ear and the vomiting centre of the hypothalamus
T62410	Hydroxyethylamine	Others	Others
	Hydroxyethylamine (Compd VII) 是一种 SARS-CoV-2 3CLpro 抑制剂，在传播试验中的IC50为 ~10 μM。Hydroxyethylamine 表现出显著的抗病毒效果。
TD0005	SYBR GREEN II SUPER Green II RNA gel stain 10,000× concentrate in DMSO (Electrophoresis Grade),SUPER Green II （效果同SYBR Green II）RNA染料（10,000× DMSO溶液）（电泳级）
	1) Non-toxicity: belong to flower-stem dye, easy to biodegrade, no carcinogenic toxicity. 2) High sensitivity: at least 100pg ssDNA or RNA can be detected, which is 25 ~ 100 times higher than EB staining. 3) High SIGNal-to-noise ratio: the sample fluorescence signal is strong, while the background signal is low. 4) Simple operation: like EB, the dye does not degrade in the prefabricated gel and electrophoresis process;The dyeing process after electrophoresis takes only 30 minutes without decolor...
TP2077	α-Bungarotoxin
	Neurotoxin that blocks neuromuscular transmission via irreversible inhibition of nicotinic ACh receptors (nAChRs). Prevents opening of nicotinic receptor-associated ion channels and is selective for α7 receptors over α3β4 receptors (IC50 values are 1.6 nM
T68811	Trimetaphan camsilate	Others	Others
	Trimetaphan camsilate is a drug that counteracts cholinergic transmission at the ganglion type of nicotinic receptors of the autonomic ganglia and therefore blocks both the sympathetic nervous system and the parasympathetic nervous system. It acts as a non-depolarizing competitive antagonist at the nicotinic acetylcholine receptor, is short-acting, and is given intravenously.
T81511	Peptide F, bovine
	Peptide F, bovine，是源自牛大脑和肾上腺髓质的前脑啡肽F，与脑啡能系统的疼痛传导过程相关。
T17306	(R)-Baclofen hydrochloride Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐	GABA Receptor	Membrane transporter/Ion channel; Neuroscience
	Arbaclofen hydrochloride, a Gamma-Aminobutyric Acid derivative, is a specific agonist of GABA-B receptors, it is used to treat spasticity, especially that due to spinal cord damage. It acts at spinal and supraspinal sites, generally reduces excitatory tra
T75710	Ziconotide TFA
	Ziconotide TFA (SNX-111 TFA)，一种肽类化合物，作为高效且选择性的N型钙通道拮抗剂，能减少突触传递，适用于慢性疼痛的研究。
T76568	Aminopeptidase N Ligand (CD13) NGR peptide
	AminopeptidaseN Ligand (CD13) NGR peptide 是靶向CD13的多肽，常见于癌症研究中，用作细胞内传递的载体介质。
T68836	ADS-J1	Others	Others
	ADS-J1 is an HIV-1 entry inhibitor that potently inhibits seminal amyloid fibrillization and block fibril-mediated enhancement of viral infection. Semen-derived amyloid fibrils, comprising SEVI (semen-derived enhancer of viral infection) fibrils and SEM1 fibrils, may remarkably enhance HIV-1 sexual transmission and are potential targets for the development of an effective microbicide.
T69627	Dapivirine HCl	Others	Others
	Dapivirine HCl is the salt form of Dapivirine, also known as TMC120, a non-nucleoside inhibitor for HIV reverse transcriptase with IC50 of 24 nM. The HIV-1 replication inhibitor dapivirine (DPV) is one of the most promising drug candidates being used in topical microbicide products for prevention of HIV-1 sexual transmission.
TP1032	Transdermal Peptide TFA (918629-48-8 free base) Transdermal Peptide TFA,TD 1 (peptide) (TFA)
	Transdermal Peptide TFA (TD 1 Peptide TFA) is an 11-amino acid polypeptide that binds to Na+/K+ -atpase beta-subunit (ATP1B1) and interacts with the C terminal of ATP1B1.Transdermal Peptide TFA can enhance the transmission of some large molecules in the s
T80065	Calcicludine	Calcium Channel	Membrane transporter/Ion channel; Metabolism
	Calcicludine是Dendroaspis angusticeps产毒蛋白，针对高电压激活的calcium channel（特别是L型）有抑制作用，IC50为88 nM，影响兴奋性突触传递。
T36783	BPIQ-II (hydrochloride)	Others	Others
	BPIQ-II is a linear imidazoloquinazoline that potently inhibits the tyrosine kinase activity of the epidermal growth factor receptor (EGFR; IC50 = 8 pM). It is selective for EGFR over an assortment of other tyrosine and serine/threonine kinases. Cellular studies indicate that BPIQ-II can enter cells and very selectively shut down EGF-stimulated signal transmission by binding competitively at the ATP site of EGFR.

化合物

Cat.No: T8354

Target: Nucleoside Antimetabolite/Analog, Influenza Virus, DNA/RNA Synthesis

Cat.No: T23513

Synonym: VU 10010

Target: AChR

5,5-Dimethyloxazolidine-2,4-dione

Cat.No: T1234

Synonym: Dimethadion,Dimethadione,二甲双酮,Dimethyloxazolidinedione

Target: Calcium Channel

Wnt/β-catenin agonist 3

Cat.No: T9988

Target: Wnt/beta-catenin

Ziconotide Acetate (107452-89-1 free base)

Cat.No: TP1559L

Synonym: 醋酸齐考诺肽,Prialt,Ziconotide Acetate

Target: Calcium Channel

Clodronate disodium tetrahydrate

Cat.No: T3280

Synonym: clodronic acid disodium tetrahydrate,Disodium clodronate tetrahydrate,Clastoban,氯屈膦酸二钠(四水合物),Clodronate disodium

Target: IL Receptor, TNF

Cat.No: T0924

Synonym: 苯唑卡因,苯佐卡因

Target: Others, MRP, Sodium Channel

Cat.No: TP1868

Synonym: 直肠肽

Target: Others

Ganaplacide phosphate

Cat.No: T27400L

Synonym: Ganaplacide phosphate (1261113-96-5 Free base)

Target: Others

Pyronaridine tetraphosphate

Cat.No: T16697

Target: Topoisomerase

Cat.No: T7115

Synonym: CGA 215944,吡蚜酮

Target: Antibacterial

Cat.No: T22963

Target: AChR

Pancuronium dibromide

Cat.No: T0166

Synonym: Pancuronium bromide,Pavulon,泮库溴铵

Target: AChR

Cat.No: T67765

Target: Others

Cat.No: T13102

Target: Others

Cat.No: T1065

Synonym: 巴氯芬,Lioresal

Target: GABA Receptor

Baclofen hydrochloride

Cat.No: T8630

Synonym: 4-amino-3-(4-chlorophenyl)butanoic acid hydron chloride

Target: GABA Receptor

Lanepitant 2HCl

Cat.No: T25616

Synonym: LY303870 dihydrochloride,LY 303870 dihydrochloride,LY-303870 dihydrochloride,Lanepitant dihydrochloride

Target: Neurokinin receptor

2,2-Dimethyl-5-(2,5-xylyloxy)valeramide

Cat.No: T50008

Synonym: 5-(2,5-二甲基苯氧基)-2,2-二甲基戊酰胺,5-(2,5-dimethylphenoxy)-2,2-dimethylpentanamide

Target: Others

Cat.No: T1092

Synonym: 佐米曲普坦,311C90,BW-311C90

Target: 5-HT Receptor

Cat.No: TP2505L

Synonym: KKALLALALHHLAHLALHLALALKKA acetate,LAH4 acetate(184776-51-0 Free base)

Target: Antibacterial

BzATP triethylammonium salt

Cat.No: TP2226

Target: P2X Receptor

Cat.No: T69043

Target: Others

Cat.No: T71952

Target: Others

Cat.No: T34458

Target: Others

Cat.No: T24450

Synonym: Lenetran Lenetran,TAB Lenetranat

Target: Others

Stilbamidine dihydrochloride

Cat.No: T26230

Synonym: NSC 35605,NCI 174

Target: Others

Cat.No: T69964

Target: Others

Methiothepin methanesulfonate

Cat.No: T69165

Target: Others

Cat.No: T31903

Target: Others

Ziconotide TFA (107452-89-1 free base)

Cat.No: TP1471

Synonym: Ziconotide TFA

Cat.No: T24839

Synonym: HI-113,HI 113,HI113

Target: Others

Metamizil hydrochloride

Cat.No: T71531

Target: Others

Pirepemat fumarate

Cat.No: T60950

Target: Others

Benzocaine hydrochloride

Cat.No: T6782

Synonym: Benzocaine HCl,Ethyl p-aminobenzoate hydrochloride,Ethyl 4-aminobenzoate hydrochloride

Target: Sodium Channel

KDS2010 mesylate

Cat.No: T70075

Target: Others

Cinnarizine clofibrate

Cat.No: T69012

Target: Others

Hydroxyethylamine

Cat.No: T62410

Target: Others

Cat.No: TD0005

Synonym: SUPER Green II RNA gel stain *10,000× concentrate in DMSO* (Electrophoresis Grade),SUPER Green II （效果同SYBR Green II）RNA染料（10,000× DMSO溶液）（电泳级）

α-Bungarotoxin

Cat.No: TP2077

Trimetaphan camsilate

Cat.No: T68811

Target: Others

Peptide F, bovine

Cat.No: T81511

(R)-Baclofen hydrochloride

Cat.No: T17306

Synonym: Arbaclofen hydrochloride,(R)-巴氯芬盐酸盐

Target: GABA Receptor

Cat.No: T75710

Aminopeptidase N Ligand (CD13) NGR peptide

Cat.No: T76568

Cat.No: T68836

Target: Others

Cat.No: T69627

Target: Others

Transdermal Peptide TFA (918629-48-8 free base)

Cat.No: TP1032

Synonym: Transdermal Peptide TFA,TD 1 (peptide) (TFA)

Cat.No: T80065

Target: Calcium Channel

BPIQ-II (hydrochloride)

Cat.No: T36783

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4S0554	Theaflavine-3,3'-digallate TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素	Others	Others
	Theaflavine-3,3'-digallate (theaflavin digallate) 和乳酸一起可以减少单纯疱疹病毒的传播。
T9299	D-Leucine D-亮氨酸,(R)-Leucine	Endogenous Metabolite	Metabolism
	D-Leucine ((R)-Leucine) 具有抗癫痫特性，活性比L-leucine，能够有效终止癫痫发作。在体外，它能够抑制长期点位，但基底突触传递无影响。
TN1202	(-)-α-Pinene 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene	Virus Protease; GABA Receptor; Endogenous Metabolite; Antibacterial	Membrane transporter/Ion channel; Metabolism; Microbiology/Virology; Neuroscience
	(-)-α-Pinene ((1S)-(-)-Alpha-Pinene) 是一种单萜类化合物，通过延长 GABAergic 突触传递、作为 GABAA-BZD 受体的部分调节剂并直接与 GABAA 受体的 BZD 结合位点结合来增强 NREMS 的数量而不影响 NREMS 的强度。
T0958	Penicillin G sodium salt 青霉素钠,Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium	GABA Receptor; Antibacterial; Antibiotic	Membrane transporter/Ion channel; Microbiology/Virology; Neuroscience
	Penicillin G sodium(Benzylpenicillin sodium) salt 是一种 β-内酰胺类抗生素。
T0894	Thiamine hydrochloride 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺（维生素B1）,Thiamine chloride hydrochloride	Apoptosis; HBV; Endogenous Metabolite	Apoptosis; Metabolism; Microbiology/Virology
	Thiamine hydrochloride (Vitamin B1) 是一种必需的微量营养素，是许多中枢代谢酶的辅因子。
T3606	γ-Oryzanol 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza	DNA Methyltransferase	Chromatin/Epigenetic
	γ-Oryzanol (Gamma-Oryzanol) 是一种从米糠油中分离出来的营养提取物，是含有甾醇和阿魏酸的混合物，有助于破坏皮肤中的自由基。它有效抑制小鼠纹状体中的 DNA 甲基转移酶(DNMTs)。它抑制DNMT1和DNMT3a，IC50分别为 3.2 和 22.3 μM。
TN6028	Gardneramine
	Gardneramine has a mild central depressive effect. Gardneramine and hirsutine show a local anesthetic action, they also can inhibit the ganglionic transmission of the dog urinary bladder and that the blockade of the nicotinic receptor plays a main role.
T83454	13-Hydroxylupanine hydrochloride Hydroxylupanine hydrochloride
	13-Hydroxylupanine是甜羽扇豆中一种典型的生物碱。它具有阻断神经节传递、降低心肌收缩力以及收缩子宫平滑肌的作用。
T19274	delta-Valerobetaine Δ-Valerobetaine	Endogenous Metabolite	Metabolism
	delta-Valerobetaine 是一种饮食依赖性肥胖原，是微生物组衍生的代谢物，是三甲胺 N-氧化物 (TMAO) 的前体。delta-Valerobetaine对小鼠的学习和记忆过程有害，可调节抑制性突触传递和神经元网络活动。
T75447	Asperaculane B	Others	Others
	Asperaculane B，一种真菌代谢产物，以IC50 7.89 µM抗恶性疟原虫传播，同时以IC50 3 µM抑制无性恶性疟原虫的发育，对人类细胞无毒。
T82003	Juniferdin
	Juniferdin是一种抑制Protein disulfide isomerase (PDI)，IC50为3.5 μM，旨在阻断HIV传播的化合物。此外，Juniferdin展现出细胞毒性并能抑制血小板聚集。
TN3472	Axillaridine A	Others	Others
	Axillaridine A is a new cholinesterase inhibitors, it may act as potential leads in the discovery of clinically useful inhibitors for nervous-system disorders, particularly by reducing memory deficiency in Alzheimer's disease patients by potentiating and

天然产物

Theaflavine-3,3'-digallate

Cat.No: T4S0554

Synonym: TFBG,theaflavin digallate,3,3’-二没食子酸酯茶黄素

Target: Others

Cat.No: T9299

Synonym: D-亮氨酸,(R)-Leucine

Target: Endogenous Metabolite

Cat.No: TN1202

Synonym: 左旋-α-蒎烯,左旋-alpha-蒎烯,(1S)-(-)-Alpha-Pinene

Target: Virus Protease, GABA Receptor, Endogenous Metabolite, Antibacterial

Penicillin G sodium salt

Cat.No: T0958

Synonym: 青霉素钠,Penicillin G Sodium,Benzylpenicillin sodium salt,Benzylpenicillin Sodium

Target: GABA Receptor, Antibacterial, Antibiotic

Thiamine hydrochloride

Cat.No: T0894

Synonym: 盐酸硫胺素,Vitamin B1,Vitamin B1 hydrochloride,Thiamine HCl,盐酸硫胺（维生素B1）,Thiamine chloride hydrochloride

Target: Apoptosis, HBV, Endogenous Metabolite

Cat.No: T3606

Synonym: 谷维素,Gamma-Oryzanol,Oliver,γ-谷维素,Gammariza

Target: DNA Methyltransferase

Cat.No: TN6028

13-Hydroxylupanine hydrochloride

Cat.No: T83454

Synonym: Hydroxylupanine hydrochloride

delta-Valerobetaine

Cat.No: T19274

Synonym: Δ-Valerobetaine

Target: Endogenous Metabolite

Cat.No: T75447

Target: Others

Cat.No: T82003

Cat.No: TN3472

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00135	BDNF Protein, Human/Murine/Rat, Recombinant BDNF,Abrineurin,Brain-Derived Neurotrophic Factor	Human,Mouse,Rat	E. coli
	Brain-Derived Neurotrophic Factor (BDNF) is a member of the neurotrophin family. Along with other structurally related neurotrophic factors NGF, NT-3 and NT-4, BDNF binds with high affinity to the TrkB kinase receptor. It also binds with the LNGFR (for low-affinity nerve growth factor receptor, also known as p75). BDNF promotes the survival, growth and differentiation of neurons. It serves as a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. ...
TMPY-05510	BDNF Protein, Mouse, Recombinant (His) brain-derived neurotrophic factor	Mouse	HEK293 Cells
	BDNF is a member of thenerve growth factorfamily. It is highly expressed in hippocampus, amygdala, cerebral cortex and cerebellum. It also can be detected in heart, lung, skeletal muscle, testis, prostate and placenta. BDNF is induced by cortical neurons, and is necessary for survival of striatal neurons in the brain. During development, BDNF promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. It participates in axonal growth,...
TMPY-01442	DMBT1 Protein, Human, Recombinant (His) GP340,deleted in malignant brain tumors 1,muclin	Human	HEK293 Cells
	Deleted in malignant brain tumors 1 protein, also known as glycoprotein 34, surfactant pulmonary-associated D-binding protein, DMBT1 and GP34, is a secreted protein which belongs to theDMBT1 family. DMBT1 contains 2CUB domains, 14SRCR domains and 1ZP domain. It is highly expressed in alveolar and macrophage tissues. In some macrophages, expression is detected on the membrane, and in other macrophages, it is strongly expressed in the phagosome/phagolysosome compartments. Defects in DMBT1 are invo...
TMPK-01192	Varicella-zoster virus (strain Oka vaccine) Envelope glycoprotein E Protein (His) Envelope glycoprotein E,ORF68,gE	Varicella-zoster virus (strain Oka vaccine)	HEK293 Cells
	VZV glycoprotein E (gE) is most abundantly expressed on the surface of infected cells, and is an essential component for virus replication and cell-to-cell transmission. It is also the main target of virus-specific antibodies and T cell responses that is often selected as vaccine candidate antigen.
TMPH-03722	Coagulase/fibrinolysin Protein, Yersinia pestis, Recombinant (His & Myc) Plasminogen activator,Pla,Coagulase/fibrinolysin	Yersinia pestis	E. coli
	Seems to play an essential role in plague transmission by mediating flea blockage in a temperature-dependent fashion. Fibrinolytic activity prevails at 37 degrees Celsius whereas coagulase expression predominates at lower temperatures (<30 degrees Celsius). Activates plasminogen by cleaving it.
TMPH-00134	AcMNPV Viral cathepsin Protein (His & SUMO) Cysteine proteinase,Viral cathepsin,VCATH,V-cath	AcMNPV	E. coli
	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. Accumulates within infected cells as an inactive proenzyme (proV-CATH), which is activated by proteolytic cleavage upon cell death. AcMNPV Viral cathepsin Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.9 kDa and the accession number is P25783.
TMPH-02528	SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar) Slc7a10,Solute carrier family 7 member 10,Asc-type amino aci...	Mouse	P. pastoris (Yeast)
	Sodium-independent, high affinity transport of small neutral D- and L-amino acids and amino acid-related compounds. May play a role in the modulation of glutamatergic transmission through mobilization of D-serine at the glutamatergic synapse. SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar) is expressed in yeast with N-His tag. The predicted molecular weight is 22.5 kDa and the accession number is P63115.
TMPH-00060	ApNPV Viral cathepsin Protein (His & Myc) V-cath,Viral cathepsin,Cysteine proteinase (CP),VCATH	ApNPV	E. coli
	Cysteine protease that plays an essential role in host liquefaction to facilitate horizontal transmission of the virus. May participate in the degradation of foreign protein expressed by the baculovirus system. ApNPV Viral cathepsin Protein (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.1 kDa and the accession number is Q91CL9.
TMPH-01231	DIP2A Protein, Human, Recombinant (His) DIP2A,DIP2,Disco-interacting protein 2 homolog A,C21orf106,D...	Human	Baculovirus Insect Cells
	Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes.
TMPH-01230	DIP2A Protein, Human, Recombinant (hFc) DIP2 homolog A,Disco-interacting protein 2 homolog A,KIAA018...	Human	HEK293 Cells
	Catalyzes the de novo synthesis of acetyl-CoA in vitro. Promotes acetylation of CTTN, possibly by providing the acetyl donor, ensuring correct dendritic spine morphology and synaptic transmission. Binds to follistatin-related protein FSTL1 and may act as a cell surface receptor for FSTL1, contributing to AKT activation and subsequent FSTL1-induced survival and function of endothelial cells and cardiac myocytes.
TMPH-00837	BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) Alpha-insect toxin BjaIT,Bj-alpha-IT	Hottentotta judaicus	E. coli
	Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. This toxin is active against insects (para/tipE). BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 14.4 kDa and the accession number is Q56TT9.
TMPK-01233	LAMP5 Protein, Human, Recombinant (hFc) BADLAMP,C20orf103,LAMP-5,dJ1119D9.3,UNC-43,BAD-LAMP	Human	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Human, Recombinant (hFc) is expressed in HEK293 ma...
TMPH-02404	LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) Alpha-insect toxin LqhaIT,Lqh-alpha-IT	Yellow scorpion	E. coli
	Alpha toxins bind voltage-independently at site-3 of sodium channels (Nav) and inhibit the inactivation of the activated channels, thereby blocking neuronal transmission. The dissociation is voltage-dependent. This toxin is active on insects. It is also highly toxic to crustaceans and has a measurable but low toxicity to mice. LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 23.5 kDa and ...
TMPK-01152	CHRDL1 Protein, Human, Recombinant (His) VOPT,Ventroptin,Neuralin-1,dA141H5.1,CHL,Chordin-like 1,CRDL...	Human	E. coli
	CHRDL1 (Chordin-like 1) is a secreted protein that acts as an antagonist of bone morphogenetic protein (BMP). BMP plays a role as an activator of BMP receptor II (BMPR II), which mediates extracellular to intracellular signal transmission and is involved in carcinogenesis and metastasis.The hypermethylation of the CHRDL1 promoter in gastric cancer, which induced low expression of CHRDL1 and decreased its secretion to the supernatant.
TMPK-00659	LAMP5 Protein, Cynomolgus, Recombinant (His) C20orf103,BAD-LAMP,BADLAMP,LAMP-5,UNC-43,dJ1119D9.3	Cynomolgus	HEK293 Cells
	Lysosome-associated membrane protein 5 (LAMP5) is a mammalian ortholog of the Caenorhabditis elegans protein, UNC-46, which functions as a sorting factor to localize the vesicular GABA transporter UNC-47 to synaptic vesicles. In the mouse forebrain, LAMP5 is expressed in a subpopulation of GABAergic neurons in the olfactory bulb and the striato-nigral system, where it is required for fine-tuning of GABAergic synaptic transmission. LAMP5 Protein, Cynomolgus, Recombinant (His) is expressed in HEK2...
TMPH-01609	LGI1 Protein, Human, Recombinant (His & Myc) Leucine-rich glioma-inactivated protein 1,Epitempin-1,LGI1	Human	E. coli
	Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival.
TMPH-03280	Dystrophin Protein, Rat, Recombinant (His) Dystrophin,Dmd	Rat	P. pastoris (Yeast)
	Anchors the extracellular matrix to the cytoskeleton via F-actin. Ligand for dystroglycan. Component of the dystrophin-associated glycoprotein complex which accumulates at the neuromuscular junction (NMJ) and at a variety of synapses in the peripheral and central nervous systems and has a structural function in stabilizing the sarcolemma. Also implicated in signaling events and synaptic transmission. Dystrophin Protein, Rat, Recombinant (His) is expressed in yeast with C-6xHis tag. The predicted...
TMPY-01742	Acetylcholinesterase Protein, Mouse, Recombinant (His) Acre,Chrne,acetylcholinesterase (Yt blood group)	Mouse	HEK293 Cells
	Acetylcholinesterase, also known as ACHE, is an enzyme that degrades (through its hydrolytic activity) the neurotransmitter acetylcholine, producing choline and an acetate group. Acetylcholinesterase plays a crucial role in nerve impulse transmission at cholinergic synapses by rapid hydrolysis of the neurotransmitter acetylcholine (ACh). ACHE appears to be a potential therapeutic target at muscle injuries including organophosphate myopathy. It is an externally oriented membrane-bound enzyme and ...
TMPJ-01068	FKBP25/FKBP3 Protein, Human, Recombinant (His) 25 kDa FKBP,FKBP-3,Peptidyl-prolyl cis-trans isomerase FKBP3...	Human	E. coli
	FKBP25 contains 1 PPIase FKBP-type domain, belongs to the FKBP-type PPIase family. FK506- and rapamycin-binding proteins (FKBPs) constitute a family of receptors for the two immunosuppressants which inhibit T-cell proliferation by arresting two distinct cytoplasmic signal transmission pathways. FKBP3 is a cis-trans prolyl isomerase enzyme that binds the immunosuppressants FK506 and rapamycin, as well as histone deacetylases, the transcription factor YY1, casein kinase II, and nucleolin. It has a...
TMPH-02669	GJA1 Protein, Mouse, Recombinant (His & Myc) Gap junction 43 kDa heart protein,Gja1,Gap junction alpha-1 ...	Mouse	Baculovirus Insect Cells
	Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibi...
TMPJ-00694	BRD4 Protein, Human, Recombinant (His & Flag) MCAP,HUNK1,HUNKI,bromodomain-containing protein 4	Human	E. coli
	Bromodomain-containing protein 4 (BRD4) is a member of the BET class chromatin reader proteins that bind acetylated histones and play a key role in transcriptional regulation and transmission of epigenetic memory. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure. BRD bromodomains serve as recognition motifs for ...
TMPJ-00554	Vinculin Protein, Human, Recombinant Metavinculin,VCL,Vinculin	Human	E. coli
	Vinculin is a focal adhesion and cytoskeletal protein that distributed mainly at cell-cell junctions and cell-extracellular matrix (ECM) adhesion that belongs to the Vinculin/α-Catenin family. Vinculin is an Actin-binding protein and component of the Actin-Linking Functional module that senses and feels the mechanical properties of the extracellular environment. Vinculin is also a key factor that couples, transmits, transduces, and regulates mechanical force between the cytoskeleton and adhesion...
TMPY-04407	LOK Protein, Human, Recombinant (His) serine/threonine kinase 10,PRO2729,LOK	Human	E. coli
	Serine / threonine-protein kinase 1, also known as Lymphocyte-oriented kinase, STK1 and LOK, belongs to the protein kinase superfamily, STE Ser / Thr protein kinase family and STE2 subfamily. Protein kinases constitute a large superfamily of enzymes with key regulatory functions in nearly all signal transmission processes of eukaryotic cells. The Ste2 family of serine/threonine kinases plays an important role in numerous cellular functions such as growth, apoptosis, and morphogenesis. STK1 is si...
TMPY-02955	CABP5 Protein, Human, Recombinant (His) calcium binding protein 5,CABP3	Human	E. coli
	CABP3, also known as CABP5, belongs to a subfamily of calcium binding proteins, which share similarity to calmodulin. Calcium binding proteins are an important component of calcium mediated cellular signal transduction. Expression of CABP3 gene is retina-specific. The mouse homolog of CABP3 has been shown to express in the inner nuclear layer of the retina, suggested its role in neuronal functioning. The specific function of CABP3 gene is unknown. Study of the transcripts and genomic structure r...
TMPY-04414	MUSK Protein, Human, Recombinant (aa 433-783, His & GST) FADS,CMS9,muscle, skeletal, receptor tyrosine kinase	Human	Baculovirus Insect Cells
	Muscle, skeletal receptor tyrosine-protein kinase, also known as Muscle-specific tyrosine-protein kinase receptor, Muscle-specific kinase receptor, and MUSK, is a single-pass type I membrane protein that belongs to the protein kinase superfamily and tyr protein kinase family. MUSK contains one FZ (frizzled) domain, three Ig-like C2-type (immunoglobulin-like) domains, and one protein kinase domain. This protein is a muscle-specific tyrosine kinase receptor and it may play a role in clustering of ...

重组蛋白

BDNF Protein, Human/Murine/Rat, Recombinant

Cat.No: TMPJ-00135

Species: Human,Mouse,Rat

Expression System: E. coli

BDNF Protein, Mouse, Recombinant (His)

Cat.No: TMPY-05510

Species: Mouse

Expression System: HEK293 Cells

DMBT1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01442

Species: Human

Expression System: HEK293 Cells

Varicella-zoster virus (strain Oka vaccine) Envelope glycoprotein E Protein (His)

Cat.No: TMPK-01192

Species: Varicella-zoster virus (strain Oka vaccine)

Expression System: HEK293 Cells

Coagulase/fibrinolysin Protein, Yersinia pestis, Recombinant (His & Myc)

Cat.No: TMPH-03722

Species: Yersinia pestis

Expression System: E. coli

AcMNPV Viral cathepsin Protein (His & SUMO)

Cat.No: TMPH-00134

Species: AcMNPV

Expression System: E. coli

SLC7A10 Protein, Mouse, Recombinant (His & SUMOstar)

Cat.No: TMPH-02528

Species: Mouse

Expression System: P. pastoris (Yeast)

ApNPV Viral cathepsin Protein (His & Myc)

Cat.No: TMPH-00060

Species: ApNPV

Expression System: E. coli

DIP2A Protein, Human, Recombinant (His)

Cat.No: TMPH-01231

Species: Human

Expression System: Baculovirus Insect Cells

DIP2A Protein, Human, Recombinant (hFc)

Cat.No: TMPH-01230

Species: Human

Expression System: HEK293 Cells

BjaIT Protein, Hottentotta judaicus, Recombinant (His & Myc)

Cat.No: TMPH-00837

Species: Hottentotta judaicus

Expression System: E. coli

LAMP5 Protein, Human, Recombinant (hFc)

Cat.No: TMPK-01233

Species: Human

Expression System: HEK293 Cells

LqhaIT Protein, Leiurus hebraeus, Recombinant (His & SUMO)

Cat.No: TMPH-02404

Species: Yellow scorpion

Expression System: E. coli

CHRDL1 Protein, Human, Recombinant (His)

Cat.No: TMPK-01152

Species: Human

Expression System: E. coli

LAMP5 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00659

Species: Cynomolgus

Expression System: HEK293 Cells

LGI1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01609

Species: Human

Expression System: E. coli

Dystrophin Protein, Rat, Recombinant (His)

Cat.No: TMPH-03280

Species: Rat

Expression System: P. pastoris (Yeast)

Acetylcholinesterase Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01742

Species: Mouse

Expression System: HEK293 Cells

FKBP25/FKBP3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01068

Species: Human

Expression System: E. coli

GJA1 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02669

Species: Mouse

Expression System: Baculovirus Insect Cells

BRD4 Protein, Human, Recombinant (His & Flag)

Cat.No: TMPJ-00694

Species: Human

Expression System: E. coli

Vinculin Protein, Human, Recombinant

Cat.No: TMPJ-00554

Species: Human

Expression System: E. coli

LOK Protein, Human, Recombinant (His)

Cat.No: TMPY-04407

Species: Human

Expression System: E. coli

CABP5 Protein, Human, Recombinant (His)

Cat.No: TMPY-02955

Species: Human

Expression System: E. coli

MUSK Protein, Human, Recombinant (aa 433-783, His & GST)

Cat.No: TMPY-04414

Species: Human

Expression System: Baculovirus Insect Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0377	Thiamine Hydrochloride-13C4
	Thiamine Hydrochloride-13C4 是 Thiamine Hydrochloride 的 13C 的标记化合物。Thiamine Hydrochloride 的 CAS 号为 67-03-8。Thiamine hydrochloride 是一种必需的微量营养素，是许多中枢代谢酶的辅因子。
TMIJ-0314	Baclofen-d4
	Baclofen-d4 是 Baclofen 的氘代化合物。Baclofen 的 CAS 号为 1134-47-0。Baclofen 是 γ-氨基丁酸 (GABA) 的亲脂性衍生物，是可口服的选择性代谢型 GABA-B 受体激动剂，具有高血脑屏障渗透率，用于治疗因脊髓损伤和多发性硬化引起的痉挛。

同位素标记化合物

Thiamine Hydrochloride-13C4

Cat.No: TMIJ-0377

Cat.No: TMIJ-0314

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