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Search Results for " spinal motor "

Targets Recommended: Histamine Receptor

11

抑制剂 & 化合物

4

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T1030	Triprolidine hydrochloride monohydrate 盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride	Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Triprolidine hydrochloride monohydrate 是一种组胺 H1 拮抗剂，用于过敏性鼻炎、哮喘。
T4641	Branaplam LMI 070,NVS-SM1	Others; Potassium Channel; DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Others
	Branaplam (LMI 070) 是一种高效、选择性和口服活性的小分子 SMN2 剪接调节剂，对 SMN 的 EC50为 20 nM。它可提高全长 SMN 蛋白并延长其生存期，也抑制 hERG，IC50为 6.3 μM。
T3336	Rg3039 PF-06687859	Others	Others
	Rg3039 (PF-06687859) 是一种具有口服活性、能够透过血脑屏障的DcpS 抑制剂，其IC50=0.069 nM。
T34399	Rovatirelin KPS-0373,S0373,S-0373,S 0373	AChE	Neuroscience
	Rovatirelin (S-0373) 是一种新合成的促甲状腺激素释放激素（TRH）类似物，通过乙酰胆碱和多巴胺神经传递改善胞嘧啶阿拉伯糖苷诱导的脊髓小脑变性大鼠模型的运动功能障碍。
T24754	Hh-Ag1.5 SAG-1.5,SAG1.5,SAG 1.5	Hedgehog/Smoothened	GPCR/G Protein; Stem Cells
	Hh-Ag1.5 (SAG-1.5) 是一种高效的 Hedgehog (Hh) 激动剂(EC50： 1 nM)和Smoothened (Smo)受体激动剂，对Smo的 EC50 为 1 nM、 Ki值在 0.5 和 2.3 nM 之间。Hh-Ag1.5 介导的重编程打破了非损伤肝脏干细胞的静止状态，从而挽救了肝衰竭。Hh-Ag1.5 诱导 hiPSCs 分化为皮肤前体细胞、脊髓运动神经元和脊髓感觉神经元。
T35689	MTP 131 acetate	Others	Others
	MTP 131 acetate 是一种小的线粒体靶向四肽。
T34664	SMN2-Stablizer-27 SMN2-Stablizer 27,SMN2 Stablizer-27	Others	Others
	SMN2-Stablizer-27 is a stablizer of survival of motor neuron 2 (SMN2), and a post-translationally stablizing SMN protein for the treatment of spinal muscular atrophy (SMA).
T60514	Triprolidine	Others	Others
	Triprolidine 是一种口服活性的组胺H1受体拮抗剂，可用于过敏性鼻炎的研究。Triprolidine 具有脊髓运动和知觉阻止的作用。
T35594	Cuspin-1	Others	Others
	The Survival of Motor Neurons (SMN) protein participates in RNA splicing. Decreases in SMN, typically a consequence of defects in the smn1 gene, result in the death of motor neurons and lead to the neurodegenerative disease, spinal muscular atrophy (SMA). Cuspin-1 is a small molecule upregulator of SMN that has been shown in vitro to increase levels of SMN in SMA patient fibroblasts by 50% at 18 μM. Its mechanism of action is thought to involve increased phosphorylation of ERK to initiate Ras-Ra...
T36373	Urocortin II (mouse) (trifluoroacetate salt)
	Urocortin II is a neuropeptide hormone and member of the corticotropin-releasing factor (CRF) family which includes mammalian CRF , urocortin , urocortin III , frog sauvagine, and piscine urotensin I.1 Mouse urocortin II shares 34 and 42% sequence homology with rat CRF and urocortin . It is expressed in mouse paraventricular, supraoptic, and arcuate nuclei of the hypothalamus, the locus coeruleus, and in motor nuclei of the brainstem and spinal ventral horn. Urocortin II selectively binds to CRF...
T37127	L-AP4 monohydrate L-AP4 monohydrate	Others	Others
	L-AP4 (L-APB) monohydrate is a potent and specific agonist for the group III mGluRs, with EC50s of 0.13, 0.29, 1.0, 249 μM for mGlu4, mGlu8, mGlu6 and mGlu7 receptors, respectively[1][2]. L-AP4 (5-30 μg, intrathecal inhection 4-5 days) significantly increases the paw withdrawal threshold in response to application of von Frey filaments in eight nerve-ligated rats in a dose-dependent manner. Intrathecal administration of different doses of L-AP4 is not associated with any evident motor dysfunctio...

化合物

Triprolidine hydrochloride monohydrate

Cat.No: T1030

Synonym: 盐酸曲普利啶,盐酸曲普利啶一水合物,Triprolidine hydrochloride

Target: Histamine Receptor

Cat.No: T4641

Synonym: LMI 070,NVS-SM1

Target: Others, Potassium Channel, DNA/RNA Synthesis

Cat.No: T3336

Synonym: PF-06687859

Target: Others

Cat.No: T34399

Synonym: KPS-0373,S0373,S-0373,S 0373

Target: AChE

Cat.No: T24754

Synonym: SAG-1.5,SAG1.5,SAG 1.5

Target: Hedgehog/Smoothened

MTP 131 acetate

Cat.No: T35689

Target: Others

SMN2-Stablizer-27

Cat.No: T34664

Synonym: SMN2-Stablizer 27,SMN2 Stablizer-27

Target: Others

Cat.No: T60514

Target: Others

Cat.No: T35594

Target: Others

Urocortin II (mouse) (trifluoroacetate salt)

Cat.No: T36373

L-AP4 monohydrate

Cat.No: T37127

Synonym: L-AP4 monohydrate

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03451	SPF30 Protein, Human, Recombinant (His) SPF30,SMNR,TDRD16C,survival motor neuron domain con...	Human	E. coli
	SMNDC1 gene is a paralog of SMN1 gene, which encodes the survival motor neuron protein, mutations in which are cause of autosomal recessive proximal spinal muscular atrophy. SMNDC1 is a nuclear protein that has been identified as a constituent of the spliceosome complex. SMNDC1 gene is differentially expressed, with abundant levels in skeletal muscle, and may share similar cellular function as the SMN1 gene. SMNDC1 is necessary for spliceosome assembly. Its overexpression causes apoptosis.
TMPJ-00763	ANG Protein, Human, Recombinant RNASE5,ANG,Angiogenin,Ribonuclease 5,血管生成素,RNase 5	Human	E. coli
	Angiogenin belongs to the pancreatic ribonuclease family. Angiogenin is primarily expressed in the liver. It may act as a tRNA-specific ribonuclease that abolishes protein synthesis by specifically hydrolyzing cellular tRNAs. Angiogenin is a potent stimulator of new blood vessel formation. And Angiogenin is endocytosed and translocated to the nucleus by binding to actin on the surface of endothelial cells. Angiogenic activity is regulated by interaction with RNH1 in vivo. In addition, Angiogenin...
TMPY-02196	VAPB Protein, Human, Recombinant (His) ALS8,VAP-B,VAMP (vesicle-associated membrane protein)-associ...	Human	E. coli
	Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein that belongs to the VAMP-associated protein (VAP) family. VAPB contains one MSP domain. VAPB may play a role in vesicle trafficking. VAPB forms a heterodimer with VAPA. VAPB interacts with VAMP1 and VAMP2. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 ( ALS8 ) which is a familial form of amy...
TMPY-01479	SPG3A Protein, Human, Recombinant (GST) HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS...	Human	Baculovirus Insect Cells
	Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and...

重组蛋白

SPF30 Protein, Human, Recombinant (His)

Cat.No: TMPY-03451

Species: Human

Expression System: E. coli

ANG Protein, Human, Recombinant

Cat.No: TMPJ-00763

Species: Human

Expression System: E. coli

VAPB Protein, Human, Recombinant (His)

Cat.No: TMPY-02196

Species: Human

Expression System: E. coli

SPG3A Protein, Human, Recombinant (GST)

Cat.No: TMPY-01479

Species: Human

Expression System: Baculovirus Insect Cells

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