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Search Results for " propagation "

Targets Recommended: Cysteine Protease Parasite

15

抑制剂 & 化合物

1

化合物库

5

重组蛋白

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Cat. No.	Product Name
L1200	表观遗传库		953 compounds
	953 种表观遗传学研究相关的生物活性小分子的特有集合，用于表观遗传学研究及其相关的检测和高通量、高内涵筛选；

化合物库

表观遗传库

Cat.No: L1200

Compounds: 953

Cat. No.	Product Name	Target	Signaling Pathways
T12909	SID 26681509	Cysteine Protease; Parasite	Microbiology/Virology; Proteases/Proteasome
	SID 26681509 是可逆的，竞争性的人组织蛋白酶 L 选择性抑制剂，IC50为 56 nM。它抑制Plasmodium falciparum 的体外繁殖，IC50为15.4 μM，抑制Leishmania major，IC5012.5 μM。
T0378	Oxybuprocaine hydrochloride Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐	Sodium Channel	Membrane transporter/Ion channel
	Oxybuprocaine hydrochloride (Oxybuprocaine HCl) 是可逆的钠通道阻断剂，可防止角膜，结膜和巩膜中疼痛神经的冲动传播。Oxybuprocaine hydrochloride 专用于眼科与耳鼻喉科。
T13048	SynuClean-D SC-D	Others	Others
	SynuClean-D (SC-D) 是一种 α-突触核蛋白聚集的抑制剂，能够破坏成熟的淀粉样蛋白原纤维，抑制原纤维繁殖，防止帕金森氏病动物模型中多巴胺能神经元的变性。
T0802	Procaine hydrochloride Novocaine HCl,Procaine HCl,盐酸普鲁卡因	Histone Demethylase; 5-HT Receptor; DNA/RNA Synthesis; Sodium Channel; NMDAR; AChR	Cell Cycle/Checkpoint; Chromatin/Epigenetic; DNA Damage/DNA Repair; GPCR/G Protein; Membrane transporter/Ion channel; Neuroscience
	Procaine hydrochloride (Novocaine HCl) 是DNA 脱甲基剂，是一种苯甲酸衍生物，具有局部麻醉和抗心律失常特性。
T35141	WW-781 WW 781,NK 2935	Others	Others
	WW-781 is used to measure action potential propagation in the heart.
T70971	VGD020	Others	Others
	VGD020 is a CD4 and sortilin inhibitor. It displayed activity for sortilin down-modulation and reduction of progranulin-induced breast cancer stem cell propagation.
T75331	Brilliant green	Others	Others
	Brilliant green, a cationic dye, is utilized for coloring silk and wool. Additionally, it halts the propagation of mold, intestinal parasites, and fungus, proving effective against Gram-positive bacteria [1] [2].
T71191	Covidcil-19	Others	Others
	Covidcil-19 binds to the revised attenuator hairpin structure of the SARS-CoV-2 frameshifting element (FSE) with high affinity (Kd = 11 nM). It stabilizes the hairpin's folded state and reduces frameshifting efficiency in cells. Covidcil-19 inhibits viral propagation and reduces viral infectivity by > 3.5 orders of magnitude.
T36910	PF 04449913 maleate	Others	Others
	Potent Smo antagonist (IC50 = 5 nM). Attenuates the leukemia-initiation potential of AML cells in a serial transplantation mouse model. Also eliminates self-propagation capacity of AML cells. Munchhof et al (2011) Discovery of PF-04449913, a potent and orally bioavailable inhibitor of smoothened. ACS Med.Chem.Lett. 3 106 PMID:24900436 \|Fukushima et al (2016) Small-molecule Hedgehog inhibitor attenuates the leukemia-initiation potential of acute myeloid leukemia cells. Cancer Sci. 107 1422 PMID:2...
T74866	Antibacterial agent 116	Others	Others
	Antibacterial agent 116 是一种含二苯甲酮的水杨酰苯胺类化合物。Antibacterial agent 116 能抑制肽聚糖的形成而具有较强的抗菌活性。Antibacterial agent 116 可作为光亲和探针标记 Acinetobacter baumannii 的青霉素结合蛋白 (PBP1b)，干扰肽聚糖链的生长，阻断其增殖。
T63831	SID 26681509 quarterhydrate	Others	Others
	SID 26681509 quarterhydrate 是可逆的、有效的、选择性的、竞争性的人组织蛋白酶 L (human cathepsin L) 抑制剂 (IC50: 56 nM)。SID 26681509 quarterhydrate 能够抑制Plasmodium falciparum 的体外繁殖 (IC50: 15.4 μM)，并抑制Leishmania major (IC50: 12.5 μM)，且不抑制组织蛋白酶 G 的活性。
T75152	ARC19499	Others	Others
	ARC19499 是一种核酸适配体，与组织因子通路抑制剂(TFPI)特异性结合，阻断 TFPI 对factor Xa 和 TF/factor VIIa 复合物的抑制作用。ARC19499 纠正血友病A 和B 血浆中的凝血酶生成，并恢复凝血。
T78060	ProTx II TFA	Sodium Channel	Membrane transporter/Ion channel
	ProTx-II TFA是选择性作用于Nav1.7钠通道的阻滞剂，具有0.3 nM的IC50值，选择性比其他钠通道亚型高出至少100倍。该化合物抑制钠离子通道，通过减少通道电导及使激活电压向更正的电位移动，从而阻断痛觉感受器中动作电位的传导。
T23210	Quinacrine (dihydrochloride hydrate) Quinacrine (hydrochloride hydrate) (83-89-6 free base)	Others	Others
	Quinacrine is a compound that is commonly used as an anti-protozoal agent. It inhibits voltage-dependent sodium channels (IC50: 3.3 μM） and suppresses aldehyde oxidase (IC50: 3.3 μM). Quinacrine prevents misfolding of prion protein (EC50: 0.3 μM). As an e
T38142	Phosphatidylethanolamines (soy)	Others	Others
	Phosphatidylethanolamine is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial m...

化合物

Cat.No: T12909

Target: Cysteine Protease, Parasite

Oxybuprocaine hydrochloride

Cat.No: T0378

Synonym: Risedronic Acid,Oxybuprocaine HCl,奥布卡因盐酸盐

Target: Sodium Channel

Cat.No: T13048

Synonym: SC-D

Target: Others

Procaine hydrochloride

Cat.No: T0802

Synonym: Novocaine HCl,Procaine HCl,盐酸普鲁卡因

Target: Histone Demethylase, 5-HT Receptor, DNA/RNA Synthesis, Sodium Channel, NMDAR, AChR

Cat.No: T35141

Synonym: WW 781,NK 2935

Target: Others

Cat.No: T70971

Target: Others

Brilliant green

Cat.No: T75331

Target: Others

Cat.No: T71191

Target: Others

PF 04449913 maleate

Cat.No: T36910

Target: Others

Antibacterial agent 116

Cat.No: T74866

Target: Others

SID 26681509 quarterhydrate

Cat.No: T63831

Target: Others

Cat.No: T75152

Target: Others

Cat.No: T78060

Target: Sodium Channel

Quinacrine (dihydrochloride hydrate)

Cat.No: T23210

Synonym: Quinacrine (hydrochloride hydrate) (83-89-6 free base)

Target: Others

Phosphatidylethanolamines (soy)

Cat.No: T38142

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-05822	Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)	HBV-D	E. coli
	Hepatitis B virus (HBV) capsid assembly is a critical step in the propagation of the virus and is mediated by the core protein. The first cytoplasmic step in the formation of an infectious HBV virion is the formation of a capsid containing pregenomic RNA (pgRNA) and the viral polymerase (Pol). HBV capsid assembly is an attractive target for new antiviral therapies.
TMPH-02605	Complement C4-B Protein, Mouse, Recombinant (His) C3 and PZP-like alpha-2-macroglobulin domain-containing prot...	Mouse	E. coli
	Non-enzymatic component of C3 and C5 convertases and thus essential for the propagation of the classical complement pathway. Covalently binds to immunoglobulins and immune complexes and enhances the solubilization of immune aggregates and the clearance of IC through CR1 on erythrocytes. Catalyzes the transacylation of the thioester carbonyl group to form ester bonds with carbohydrate antigens.
TMPK-00972	PK-1/PROK1 Protein, Mouse, Recombinant (hFc) PROK1,Mambakine,Prokineticin-1,EG-VEGF	Mouse	HEK293 Cells
	PK-1 (Ac10) is a baculovirus-encoded serine/threonine kinase,a pk-1 knockout AcMNPV failed to produce infectious progeny, while the pk-1 repair virus could rescue this defect.the kinase activity of PK-1 is essential in regulating viral propagation. Electron microscopy revealed that pk-1 deletion affected the formation of normal nucleocapsids.PK-1 appears to phosphorylate some viral or cellular proteins that are essential for DNA packaging to regulate nucleocapsid assembly.
TMPH-00028	Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP) Protein Rep78	AAV-2	E. coli
	Plays an essential role in the initiation of viral DNA synthesis. Binds specifically to an inverted terminal repeat element (ITR) on the 3' and 5' ends of the viral DNA, where it cleaves a site specifically to generate a priming site for initiation of the synthesis of a complementary strand. Plays also a role as transcriptional regulator, DNA helicase and as key factors in site-specific integration of the viral genome. Regulates host PKA activity by interacting with host PRKX as a mechanism of i...
TMPH-01692	MAPK3 Protein, Human, Recombinant (His) MAP kinase isoform p44,p44-ERK1,MAPK3,Extracellular signal-r...	Human	E. coli
	Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important role in the MAPK/ERK cascade. They participate also in a signaling cascade initiated by activated KIT and KITLG/SCF. Depending on the cellular context, the MAPK/ERK cascade mediates diverse biological functions such as cell growth, adhesion, survival and differentiation through the regulation of transcription, translation, c...

重组蛋白

Hepatitis B Virus (HBV)(ayw/France/Tiollais/1979) Capsid protein (His)

Cat.No: TMPY-05822

Species: HBV-D

Expression System: E. coli

Complement C4-B Protein, Mouse, Recombinant (His)

Cat.No: TMPH-02605

Species: Mouse

Expression System: E. coli

PK-1/PROK1 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPK-00972

Species: Mouse

Expression System: HEK293 Cells

Adeno-associated virus 2 (isolate Srivastava/1982) Rep78 Protein (His & MBP)

Cat.No: TMPH-00028

Species: AAV-2

Expression System: E. coli

MAPK3 Protein, Human, Recombinant (His)

Cat.No: TMPH-01692

Species: Human

Expression System: E. coli

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