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Search Results for " postprandial "

Targets Recommended: Glucokinase

18

抑制剂 & 化合物

5

天然产物

1

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T30142	ARRY-403 AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151	Glucokinase	Metabolism
	ARRY-403 是一种新型葡萄糖激酶激活剂，可降低 2 型糖尿病患者的空腹和餐后血糖，可用于治疗糖尿病。
T83969	Casein	Hydroxylase	Metabolism
	Casein 是一种具有多种作用的牛奶蛋白，参与新型药物递送系统，通过其胃内凝血特性以不同的方式影响餐后氨基酸递送。
T16083	Mizagliflozin GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base	SGLT	GPCR/G Protein
	Mizagliflozin (GSK-1614235 free base) 是口服有效的、选择性的 SGLT1抑制剂，对人 SGLT1 的 Ki 值为 27 nM。Mizagliflozin 对 SGLT1 的选择性是 SGLT2的303 倍。它是抗糖尿病药物，可以改善餐后血糖波动。它在改善慢性便秘方面具有潜在的作用。
T30118	Arbaclofen placarbil XP 19986,XP19986,XP-19986	Others	Others
	Arbaclofen placarbil( XP19986) is a GABA(B) receptor agonist.Arbaclofen Placarbil is a novel R-baclofen prodrug with improved absorption, distribution, metabolism, and elimination properties compared to R-baclofen. And it can reduce postprandial reflux in
T6203L	Saxagliptin hydrochloride BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118	Others	Others
	Saxagliptin is a new oral hypoglycemic of the new dipeptidyl peptidase-4 (DPP-4) inhibitor class of drugs. Saxagliptin is a competitive DPP4 inhibitor that slows the inactivation of the incretin hormones and reducing fasting and postprandial glucose conce
T29154	WB403 WB-403,WB 403	Others	Others
	WB403 is a TGR5 activator. WB403 significantly decreases fasting blood glucose, postprandial blood glucose and HbA1c, improves glucose tolerance in type 2 diabetic mice. WB403 increases pancreatic β-cells and restores the normal distribution pattern of α-
T29448	50F10 50 F 10,50-F-10	Others	Others
	50F10 is a stabilizer for the active LPL dimer. It can act by preventing angptl4- and heat-induced inactivation of LPL and reducing postprandial triglyceride levels.
T25375	Enprostil RS-84135,RS 84135,Gardrin,RS84135	Others	Others
	Enprostil is a synthetic PGE2 analog that has an inhibitory effect on gastric acid secretion, a mucoprotective effect, and a postprandial lowering effect on gastrin. It has efficient and safe in the therapy of gastroduodenal ulcers.
TP1566	GIP (1-30) amide (Human) (TFA)
	GIP (1-30) amide (Human) TFA is a glucose-dependent insulinotropic polypeptide fragment. Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone that stimulates insulin secretion and reduces postprandial glycaemic excursions.
T26718	AZD6370 AZD-6370,AZD 6370	Others	Others
	AZD-6370 is a glucokinase activator. AZD-6370 decreases fasting and postprandial glucose in type 2 diabetes mellitus patients with effects influenced by dosing regimen and food. AZD-6370 do not affect the central counterregulatory response to hypoglycemia
T14382	AZD7687	Others	Others
	AZD7687 is a potent and selective DGAT1 inhibitor with an IC50 value of 80 nM (hDGAT1). IC50 value: 80 nM [1] Target: DGAT1 in vitro: Plasma AZD7687 exposure was measured repeatedly. AZD7687 markedly reduced postprandial TAG excursion with a steep concent
T71340	Mizagliflozin sebacate	Others	Others
	Mizagliflozin sebacate is a sodium-glucose transporter inhibitor. It is expected to improve postprandial hyperglycemia by suppressing glucose absorption from the intestine with a novel mechanism of action different from that of conventional alpha-glucosidase inhibitors. Mizagliflozin blocks intestinal glucose absorption and reduce GIP secretion in rats and humans, suggesting SGLT1 glucose transport is critical for GIP release.
T35798	Massarigenin C	Others	Others
	Massarigenin C is a fungal metabolite that has been found inM. flavoroseaand has enzyme inhibitory activities.1,2Massarigenin C inhibits neuraminidasein vitro(IC50= 4.15 μM).2It is also an inhibitor of yeast α-glucosidase (IC50= 1.25 mM).1It reduces the postprandial peak in blood glucose levels in an oral sucrose tolerance test in normo- and hyperglycemic mice when administered at doses of 3.2, 10, and 31.6 mg/kg.
T82923	Bamadutide SAR425899
	Bamadutide (SAR425899)是一种高效的GLP-1/GIP受体激动剂，主要通过增强β细胞功能和降低葡萄糖吸收速率，从而改善餐后血糖控制。该化合物适用于2型糖尿病的研究。
T68471	(+/-)- Adomeglivant	Others	Others
	(+/-)- Adomeglivant, also known as LY2409021, is a potent and selective glucagon receptor antagonist. LY2409021 lowers blood glucose in healthy people and in those with type 2 diabetes. Blockade of glucagon signalling in patients with type 2 diabetes is well tolerated and results in substantial reduction of fasting and postprandial glucose with minimal hypoglycaemia, but with reversible increases in aminotransferases. Inhibition of glucagon signalling by LY2409021 is a promising potential treatm...
T72909	D-(+)-Sorbose	Others	Others
	D-(+)-Sorbose，一种 D-Sorbose 的活性对映异构体，可抑制双糖酶活性并对大鼠餐后血糖和胰岛素水平有抑制作用。D-Sorbose 作为甜味剂有助于预防相关疾病，如 2 型糖尿病。
T76041	GIP (1-30) amide,human acetate
	GIP (1-30) amide, human acetate 为葡萄糖依赖性促胰岛素多肽（GIP）的片段，作为一种肠降血糖素激素，它能在10^-9至10^-6M的剂量范围内，依赖剂量地促进胰岛素的分泌，并有效减缓餐后血糖波动。
T37522	Teneligliptin	Others	Others
	Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Teneligliptin (MP-513) inhibits all these DPP-4 enzymes in a concentration-dependent manner. The IC50s of Teneligliptin (MP-513) for rhDPP-4, human plasma, and rat plasma are 0.889, 1.75, and 1.35 nM, respectively. A study of enzyme inhibition kinetics is conducted for Teneligliptin (M...

化合物

Cat.No: T30142

Synonym: AMG-151,ARRY 403,ARRY403,ARRY-403,AMG151,AMG 151

Target: Glucokinase

Cat.No: T83969

Target: Hydroxylase

Cat.No: T16083

Synonym: GSK-1614235 free base,KGA-3235 free base,DSP-3235 free base

Target: SGLT

Arbaclofen placarbil

Cat.No: T30118

Synonym: XP 19986,XP19986,XP-19986

Target: Others

Saxagliptin hydrochloride

Cat.No: T6203L

Synonym: BMS477118,Saxagliptin,BMS 477118,Saxagliptin HCl,BMS-477118

Target: Others

Cat.No: T29154

Synonym: WB-403,WB 403

Target: Others

Cat.No: T29448

Synonym: 50 F 10,50-F-10

Target: Others

Cat.No: T25375

Synonym: RS-84135,RS 84135,Gardrin,RS84135

Target: Others

GIP (1-30) amide (Human) (TFA)

Cat.No: TP1566

Cat.No: T26718

Synonym: AZD-6370,AZD 6370

Target: Others

Cat.No: T14382

Target: Others

Mizagliflozin sebacate

Cat.No: T71340

Target: Others

Cat.No: T35798

Target: Others

Cat.No: T82923

Synonym: SAR425899

(+/-)- Adomeglivant

Cat.No: T68471

Target: Others

Cat.No: T72909

Target: Others

GIP (1-30) amide,human acetate

Cat.No: T76041

Cat.No: T37522

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T3675	1-Deoxynojirimycin Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin	PI3K; Glucosidase	Metabolism; PI3K/Akt/mTOR signaling
	1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖，预防糖尿病。
T21344	1-Deoxynojirimycin hydrochloride Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin	PI3K; Antibacterial; Antibiotic; Glucosidase	Metabolism; Microbiology/Virology; PI3K/Akt/mTOR signaling
	1-Deoxynojirimycin hydrochloride (Moranoline) 是一种口服有效的 α-葡萄糖苷酶抑制剂，具有降血糖、减肥和抗病毒的作用，可抑制餐后血糖，预防糖尿病。
TJS0387	Desoxyrhaponticin 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin	Apoptosis; Fatty Acid Synthase	Apoptosis; Metabolism
	Desoxyrhaponticin (Deoxyrhaponticin) 是来自西藏营养食品唐古特大黄中的一种二苯乙烯苷。它是脂肪酸合成酶抑制剂，抑制细胞内 FAS 活性，下调人乳腺癌 MCF-7细胞中 FAS 的表达。它是控制糖尿病餐后高血糖的潜在药物。
T2S0731	Trilobatin 三叶苷,三叶甙,P-Phlorizin	Amylase	Metabolism
	Trilobatin (P-Phlorizin) 是源自Lithocarpus polystachyusRehd 的甜味剂，是一种HIV-1抑制剂，靶向 Gp41 包膜蛋白，具有神经保护作用。它还是SGLT1/2抑制剂，可选择性诱导人肝母细胞瘤细胞增殖。
T80007	Stevisalioside A	Phosphatase	Metabolism
	Stevisalioside A (Compound 2)，一种从甜叶菊根提取的化合物，展现出抗糖尿病的口服活性。该化合物有效抑制PTP1B，IC50为526.8 μM，并能降低Stevisalioside A引起的高血糖小鼠血糖水平，改善餐后血糖峰值及口服葡萄糖和胰岛素耐量测试结果。

天然产物

1-Deoxynojirimycin

Cat.No: T3675

Synonym: Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin

Target: PI3K, Glucosidase

1-Deoxynojirimycin hydrochloride

Cat.No: T21344

Synonym: Moranoline,去氧野艽霉素盐酸盐,AT2220,Duvoglustat hydrochloride,1-Deoxynojirimycin,DNJ,deoxynojirimycin

Target: PI3K, Antibacterial, Antibiotic, Glucosidase

Desoxyrhaponticin

Cat.No: TJS0387

Synonym: 去氧土大黄苷,Deoxyrhapontin,脱氧土大黄苷,Deoxyrhaponticin

Target: Apoptosis, Fatty Acid Synthase

Cat.No: T2S0731

Synonym: 三叶苷,三叶甙,P-Phlorizin

Target: Amylase

Stevisalioside A

Cat.No: T80007

Target: Phosphatase

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02622	Aldolase B Protein, Human, Recombinant (GST) aldolase B, fructose-bisphosphate,ALDO2,ALDB	Human	E. coli
	The aldolase family members involved in metabolism and glycolysis are present in three isoforms: ALDOA, ALDOB, and ALDOC. Aldolases are differentially expressed in human tissues, and aberrant expression has been observed in several human diseases and cancer types. Via GATA6, metastatic cells in the liver upregulate the enzyme aldolase B (ALDOB), which enhances fructose metabolism and provides fuel for major pathways of central carbon metabolism during tumor cell proliferation. Targeting ALDOB or...

重组蛋白

Aldolase B Protein, Human, Recombinant (GST)

Cat.No: TMPY-02622

Species: Human

Expression System: E. coli

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