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Cat. No. | Product Name | ||
---|---|---|---|
L7900 | 成骨分子库 | 317 compounds | |
317 种成骨相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L2140 | 癌细胞分化化合物库 | 406 compounds | |
406 个诱导肿瘤细胞分化化合物的独特集合,可用于高通量筛选和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7469 |
Alendronic Acid
alendronate,阿仑膦酸 |
Others | Others |
Alendronic Acid (alendronate) 是法呢基二磷酸合酶(FDPS)抑制剂,是一种双膦酸盐。它能够抑制破骨细胞介导的骨吸收,对绝经后骨质疏松症,恶性高钙血症和 Paget 病具有疗效。 | |||
T40498L |
Dentonin acetate
Dentonin acetate (400090-20-2 Free base) |
Others | Others |
Dentonin acetate 增强骨生成并促进未成熟贴壁细胞的存活。 Dentonin acetate 是一种源自 MEPE 的合成片段,可用于磷酸盐稳态和骨代谢的研究。 | |||
T37603L |
Osteogenic Growth Peptide (10-14) acetate
Osteogenic Growth Peptide (10-14) acetate(105250-85-9 Free base) |
Src | Angiogenesis; Tyrosine Kinase/Adaptors |
Osteogenic Growth Peptide (10-14) acetate (Osteogenic Growth Peptide) 是一种 Src 抑制剂,是一种有效的有丝分裂原和促成骨和造血因子。Osteogenic Growth Peptide (10-14) acetate 负责与 OGP 受体结合并激活细胞内 Gi 蛋白激酶信号通路。 | |||
T13794 |
Neridronate
|
Others | Others |
Neridronate is an aminobisphosphonate,for the treatment of osteogenesis imperfecta (OI) and Paget’s disease of bone (PDB). | |||
T40498 |
Dentonin
AC-100 |
||
Dentonin (AC-100) is a synthetic fragment derived from MEPE that enhances osteogenesis by promoting osteoprogenitor adhesion and facilitating the survival of immature adherent cells. It does not have a significant effect on mature osteoblasts. Dentonin is useful for research on phosphate homeostasis and bone metabolism. | |||
T81173 |
Setrusumab
BPS 804 |
||
Setrusumab (BPS 804)是一种针对sclerostin的全人源单克隆抗体,具有提升骨骼强度的效能,常用于研究成骨不全症(OI)及癌症治疗。 | |||
T83848 |
VnP-16 TFA
|
||
VnP-16是一种合成肽段,对应vitronectin的氨基酸270-281,vitronectin是一种具有细胞附着、迁移和扩散等多功能作用的糖蛋白。该肽段在9.1 µg/cm2浓度下应用于细胞板时,能促进人类成骨细胞的附着和扩散,此效应可通过β1整合素的siRNA敲除被逆转。VnP-16诱导人类皮肤来源的间充质前体细胞和MC3T3-E1小鼠颅骨成骨前体细胞的成骨作用。在体内,VnP-16减少IL-1α诱导的骨质流失并减少小鼠颅骨中破骨细胞的数量。它还在卵巢切除引起的骨质疏失小鼠模型中增加骨矿物质密度并减少松质骨流失。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN2081 |
Maohuoside A
|
MAPK | MAPK |
Maohuoside A 是从 E. koreanum 中分离出的单一化合物,具有促进成骨作用。它能够利用 MAPK 信号通路骨及形态发生蛋白 (BMP) ,促进骨髓间充质干细胞的成骨作用。 | |||
T6S1966 |
Curculigoside
Curculigoside A,仙茅苷 |
Antioxidant; NF-κB; JAK; STAT | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; NF-κB; oxidation-reduction; Stem Cells |
Curculigoside (Curculigoside A) 是仙茅中的主要皂苷,具有显著的抗氧化、抗骨质疏松、抗抑郁和神经保护作用。它通过调节JAK/STAT/NF-κB 信号传导途径,具有抗关节炎作用。 | |||
TN5447 |
Apigenin 7-O-methylglucuronide
芹菜素-7-O-β-D-葡萄糖醛酸甲酯,Apigenin-7-O-β-D-glucuronide methyl ester |
||
Apigenin 7-O-methylglucuronide did not affect GAG level or secretion, may potentially be used in osteogenesis imperfecta (OI) type I pharmacotherapy in patients with normal GAG content. Apigenin 7-O-methylglucuronide which normalized collagen synthesis in | |||
TN1778 |
Isoformononetin
异刺芒柄花素,黄豆苷元杂质 |
IL Receptor; Antifection | Immunology/Inflammation; Microbiology/Virology |
Isoformononetin shows fungitoxic activity against Cladosporium sphaerospermum; it also has immunomodulatory activity, it inhibits the differentiation of Th17 cells and B-cell lymphopoesis to promote osteogenesis in estrogen-deficient bone loss conditions. |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPH-01016 |
GDF10 Protein, Human, Recombinant (His)
Bone-inducing protein,Bone morphogenetic protein 3B,GDF10,Gr... |
Human | E. coli |
Growth factor involved in osteogenesis and adipogenesis. Plays an inhibitory role in the process of osteoblast differentiation via SMAD2/3 pathway. Plays an inhibitory role in the process of adipogenesis. GDF-10 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 16.1 kDa and the accession number is P55107. | |||
TMPY-01380 |
Cyclophilin B Protein, Human, Recombinant (His)
CYPB,peptidylprolyl isomerase B (cyclophilin B),HEL-S-39,SCY... |
Human | HEK293 Cells |
PPIB is identified as a candidate gene for OI-IX. Osteogenesis imperfecta (OI) is an inherited disorder of connective tissue typically caused by defects in either COL1A1 or COL1A2. A number of other genes causative of this disorder have been found, including PPIB, which forms one subunit of the prolyl 3-hydroxylase enzyme complex. Patients with OI caused by PPIB mutation should have appropriate early and regular management of their hearing. | |||
TMPK-00387 |
FGFR3 beta (IIIc) Protein, Human, Recombinant (His & Avi), Biotinylated
HSFGFR3EX,FGF R3,EC 2.7.10,CD333,FGFR3 β (IIIc),CEK2,FGFR3,J... |
Human | HEK293 Cells |
Four distinct genes encoding closely related FGF receptors, FGF R1-4, are known. All four genes for FGF Rs encode proteins with an N-terminal signal peptide, three immunoglobulin (Ig)-like domains, an acid‑box region containing a run of acidic residues between the IgI and IgII domains, a transmembrane domain and the split tyrosine-kinase domain.FGFR3 is tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell p... | |||
TMPJ-01294 |
SOST Protein, Mouse, Recombinant (His)
Sost,Sclerostin |
Mouse | HEK293 Cells |
Sclerostin (SOST) is a member of the cerberus/DAN family, a group of secreted glycoproteins characterized by a cysteine-knot motif. Cerberus/DAN family members are putative BMP antagonists, and include Dan, Cerberus, Gremlin, PRDC, and Caronte. While the overall sequence identity between members of the family is low, they have conserved spacing of six cysteine residues. Cerberus and Dan have an additional cysteine residue used for dimerization; however, SOST does not and is secreted as a monomer... | |||
TMPY-03504 |
CBFB Protein, Human, Recombinant (His)
core-binding factor, β subunit,core-binding factor, beta sub... |
Human | E. coli |
CBFB is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). CBFB is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enh... |