neuron injury

5,7-Dichlorokynurenic acid (5,7-dichlorokynurenic acid sodium) 是一种专门针对于NMDA 受体甘氨酸位点的竞争性拮抗剂(KB:65 nM)。它是犬尿酸的衍生物，可降低大鼠皮质细胞培养物中 NMDA 诱导的神经元损伤程度。

TREK inhibitor-3 (Cpd8l) 是一种能透过血脑屏障的选择性 TREK-1 抑制剂，其IC50为0.81 μM。此化合物具有神经保护作用，可以显著减少氧糖剥夺/复氧 (OGD/R) 导致的皮质神经元死亡，并改善大脑中动脉闭塞/再灌注 (MCAO/R) 模型小鼠的脑损伤。TREK inhibitor-3 适用于缺血性脑卒中的研究。

ATF3-IN-1 是一种抑制铁死亡 (ferroptosis) 和 ATF3 的化合物。其通过影响 ATF3/SLC7A11/GPX4 通路以抑制氧化应激和铁死亡，从而发挥抗缺血性中风的作用。它可减少缺血/再灌注 (I/R) 损伤，提高神经元存活率，具备神经保护效应，适用于缺血性中风的研究。

Rasagiline-13C3is intended for use as an internal standard for the quantification of rasagiline by GC- or LC-MS. Rasagiline is an inhibitor of monoamine oxidase B (MAO-B; IC50= 4.43 nM for the rat brain enzyme).1It is selective for MAO-B over MAO-A (IC50= 412 nM for the rat brain enzyme). It inhibits serum and NGF withdrawal-induced apoptosis of PC12 cells when used at concentrations ranging from 0.01 to 100 μM.2Rasagiline inhibits rat brain MAO-Bin vivo(ED50= 0.1 mg/kg).1It reduces cerebral edema in a mouse model of traumatic brain injury.2Rasagiline (0.1 mg/kg) reduces cortical and hippocampal levels of full-length and soluble amyloid precursor protein (APP) in rats and mice. It also reduces α-synuclein-induced substantia nigral neuron loss and improves motor dysfunction in a mouse model of Parkinson's disease.3Formulations containing rasagiline have been used in the treatment of Parkinson's disease. 1.Youdim, M.B.H., Gross, A., and Finberg, J.P.Rasagiline [N-propargyl-1R(+)-aminoindan], a selective and potent inhibitor of mitochondrial monoamine oxidase BBrit. J. Pharmacol.132(2)500-506(2001) 2.Youdim, M.B.H., and Weinstock, M.Molecular basis of neuroprotective activities of rasagiline and the anti-Alzheimer drug TV3326 [(N-propargyl-(3R) aminoindan-5-YL)-ethyl methyl carbamate]Cell. Mol. Neurobiol.21(6)555-573(2001) 3.Kang, S.S., Ahn, E.H., Zhang, Z., et al.α-Synuclein stimulation of monoamine oxidase-B and legumain protease mediates the pathology of Parkinson's diseaseEMBO J.37(12)e98878(2018)

3'-Methoxypuerarin 是一种提取自葛根中的异黄酮，具有神经元保护作用。

3'-Methoxypuerarin (Standard) 是 3'-Methoxypuerarin 的标准品。适用于定量分析、质量控制及生化实验等相关研究。3'-Methoxypuerarin 是一种提取自葛根中的异黄酮，具有神经元保护作用。

Neuron-specific enolase, Human (EC 4.2.1.11) 是一种烯醇化酶，可作为创伤性脑损伤 (TBI)、心脏骤停后中风、缺氧性脑病及急性脊髓损伤 (SCI) 的生物标志物。