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Search Results for " mevalonate "

Targets Recommended: Endogenous Metabolite Autophagy

8

抑制剂 & 化合物

5

天然产物

3

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T41286	N6-Isopentenyladenosine	Endogenous Metabolite; Autophagy	Autophagy; Metabolism
	N6-Isopentenyladenosine 是甲羟戊酸途径的终产物，是一种具有抗黑色素瘤活性的自噬抑制剂。 N6-Isopentenyladenosine 是一种在细胞分裂素中发现的 RNA 修饰，可调节植物生长/分化，提高翻译的效率和准确性。
T72531	6-Fluoromevalonate Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one	Others	Others
	6-Fluoromevalonate 是甲羟戊酸-焦磷酸脱羧酶抑制剂。
T38570	DMAPP triammonium Dimethylallyl diphosphate triammonium,Dimethylallyl Pyrophosphate triammonium salt	Others	Others
	DMAPP triammonium (Dimethylallyl diphosphate triammonium) 是一种异戊二烯类化合物的前提物质之一，参与甲羟戊酸 (MVA) 途径，可用于研究与代谢相关的疾病。
T35589	Geranyl pyrophosphate triammonium	Others	Others
	Geranyl pyrophosphate is an intermediate in the mevalonate pathway. It is formed from dimethylallyl pyrophosphate and isopentenyl pyrophosphate by geranyl pyrophosphate synthase. Geranyl pyrophosphate is used in the biosynthesis of farnesyl pyrophosphate , geranylgeranyl pyrophosphate , cholesterol, terpenes, and terpenoids.
T15709	Lapaquistat acetate TAK-475	Others	Others
	Lapaquistat acetate is a squalene synthase inhibitor. It also blocks the conversion of farnesyl diphosphate (FPP) to squalene. Lapaquistat acetate is used to Mevalonate Kinase Deficiency (MKD), it is effective at lowering low-density lipoprotein cholester
T35740	FR900098 (sodium salt)	Others	Others
	FR900098 is a derivative of fosmidomycin that has antimalarial activity (IC50s = 170, 170, and 90 nM for HB3, A2, and Dd2 P. falciparum strains, respectively). FR900098 inhibits DOXP reductoisomerase, a key enzyme in the non-mevalonate pathway of isoprenoid biosynthesis, in vitro in a dose-dependent manner. FR900098 (>10 mg/kg, i.p.) eradicated P. vinckei parasites within four days in mice.
T72416	Antimalarial agent 18	Others	Others
	Antimalarial agent 18 是一种有效抗疟剂，展现出电子、亲脂性和铁疏性特质。该化合物隶属于酰氧基甲基系列，可视为磷霉素的替代品，后者是针对非甲羟戊酸类异戊二烯生物合成途径的有效IspC抑制剂。Antimalarial agent 18 对恶性疟原虫和鲍曼疟原虫的生长抑制作用显著，其IC50值分别为50 nM和390 nM。
T73755	Farnesyl pyrophosphate	Others	Others
	Farnesyl pyrophosphate (Farnesyl diphosphate) 是一种由15个碳原子组成的异戊二烯类化合物，作为甲羟戊酸 (MVA) 途径的关键代谢中间体。它充当TRPM2 (TRP Channel) 的激动剂，通过激活并打开TRPM2通道，促使离子流入细胞。此外，Farnesyl pyrophosphate 在胆固醇合成、泛醌合成、蛋白质法尼基化修饰以及香叶基-香叶基焦磷酸 (GGPP) 合成过程中扮演着至关重要的底物角色。

化合物

N6-Isopentenyladenosine

Cat.No: T41286

Target: Endogenous Metabolite, Autophagy

6-Fluoromevalonate

Cat.No: T72531

Synonym: Tetrahydro-4-fluoromethyl-4-hydroxy-2H-pyran-2-one

Target: Others

DMAPP triammonium

Cat.No: T38570

Synonym: Dimethylallyl diphosphate triammonium,Dimethylallyl Pyrophosphate triammonium salt

Target: Others

Geranyl pyrophosphate triammonium

Cat.No: T35589

Target: Others

Lapaquistat acetate

Cat.No: T15709

Synonym: TAK-475

Target: Others

FR900098 (sodium salt)

Cat.No: T35740

Target: Others

Antimalarial agent 18

Cat.No: T72416

Target: Others

Farnesyl pyrophosphate

Cat.No: T73755

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN6714	Geranylgeraniol FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095	Apoptosis	Apoptosis
	Geranylgeraniol (FT0626663) 是一种类异戊二烯，存在于水果、蔬菜和谷物中，包括大米。 Geranylgeraniol (FT0626663) 抑制生长并诱导各种肿瘤细胞的凋亡。 Geranylgeraniol (FT0626663) 保护单核细胞免受他汀类药物诱导的细胞毒性并抑制分枝杆菌的生长。
T1353	DL-Mevalonolactone 甲瓦龙酸内酯,Mevalonolactone	Others; Endogenous Metabolite	Metabolism; Others
	DL-Mevalonolactone ，一种人内源性代谢物，是甲羟戊酸的 δ-lactone 形式，甲羟戊酸途径的一个前体。它能够降低大脑中线粒体膜电位 (∆Ψm)，Ca2+的保留能力和NAD (P) H 的含量 , 而且还诱导线粒体肿胀。DL-Mevalonolactone 诱导炎症和氧化应激反应，降低线粒体膜电位。
T19427	Mevalonic acid	Others	Others
	Mevalonic acid is essential for cell growth and proliferation,Mevalonic acid is a precursor in the mevalonate pathway.
T38478	Mevalonic acid 5-pyrophosphate tetralithium Mevalonicacid5-diphosphatetetralithium,Mevalonic acid 5-pyrophosphate tetralithium,5-Diphosphomevalonic acid tetralithium	Others	Others
	Mevalonic acid 5-pyrophosphate (also known as 5-Diphosphomevalonic acid) tetralithium is an endogenous metabolite involved in the mevalonate pathway.
TN1655	Ganoderal A	Others	Others
	The oxygenated sterols( 26-oxygenosterols ganoderol A, ganoderol B, ganoderal A, and ganoderic acid Y) from G. lucidum can inhibit cholesterol biosynthesis via conversion of acetate or mevalonate as a precursor of cholesterol.

天然产物

Geranylgeraniol

Cat.No: TN6714

Synonym: FT-0626663,Tetraprenol,CJ24095,CJ 24095,FT0626663,香叶基香叶醇,CJ-24095

Target: Apoptosis

DL-Mevalonolactone

Cat.No: T1353

Synonym: 甲瓦龙酸内酯,Mevalonolactone

Target: Others, Endogenous Metabolite

Cat.No: T19427

Target: Others

Mevalonic acid 5-pyrophosphate tetralithium

Cat.No: T38478

Synonym: Mevalonicacid5-diphosphatetetralithium,Mevalonic acid 5-pyrophosphate tetralithium,5-Diphosphomevalonic acid tetralithium

Target: Others

Cat.No: TN1655

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04476	MVK Protein, Human, Recombinant (His & GST) POROK3,LRBP,MVLK,MK,mevalonate kinase	Human	Baculovirus Insect Cells
	Mevalonate kinase belongs to the GHMP kinase family, Mevalonate kinase subfamily. It can be found in a wide variety of organisms from bacteria to mammals. Mevalonate kinase may be a regulatory site in the cholesterol biosynthetic pathway. Defects in mevalonate kinase can cause mevalonic aciduria (MEVA). It is an accumulation of mevalonic acid which causes a variety of symptoms such as psychomotor retardation, dysmorphic features, cataracts, hepatosplenomegaly, lymphadenopathy, anemia, hypotonia,...
TMPY-04767	PMVK Protein, Human, Recombinant (His) PMK,PMKA,phosphomevalonate kinase,HUMPMKI,PMKASE	Human	E. coli
	PMVK is a peroxisomal enzyme that catalyzes the conversion of mevalonate 5-phosphate into mevalonate 5-diphosphate, the fifth reaction of the cholesterol biosynthetic pathway. Studies in rat show that the message level and the enzyme activity of PMVK is regulated by sterol, and that this regulation is coordinated with 3-hydroxy-3-methylglutaryl coenzyme A reductase, the rate-limiting enzyme of cholesterol biosynthesis.
TMPH-02717	HMGCS1 Protein, Mouse, Recombinant (His & SUMO) Hmgcs1,3-hydroxy-3-methylglutaryl coenzyme A synthase,Hydrox...	Mouse	E. coli
	Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis. HMGCS1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 73.6 kDa and the accession number is Q8JZK9.

重组蛋白

MVK Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04476

Species: Human

Expression System: Baculovirus Insect Cells

PMVK Protein, Human, Recombinant (His)

Cat.No: TMPY-04767

Species: Human

Expression System: E. coli

HMGCS1 Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02717

Species: Mouse

Expression System: E. coli

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