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Search Results for " mellitus "

Targets Recommended: GPR

101

抑制剂 & 化合物

18

天然产物

1

化合物库

9

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name
L2540	肠道微生物代谢化合物库		614 compounds
	614 种肠道微生物代谢物的集合，可以用于高通量和高内涵筛选；

化合物库

肠道微生物代谢化合物库

Cat.No: L2540

Compounds: 614

Cat. No.	Product Name	Target	Signaling Pathways
T2701	GSK1292263	GPR	Endocrinology/Hormones; GPCR/G Protein
	GSK1292263 是口服具有活性的 GPR119 激动剂，对人和大鼠 GPR119的pEC50分别为 6.9 和 6.7，它可用于研究 2 型糖尿病 (T2DM) 。
T9022	AZD9977 AZD 9977	Glucocorticoid Receptor	Endocrinology/Hormones
	AZD9977 是一种选择性的，有效的，具有口服活性的盐皮质激素受体 (MR) 调节剂，可用于研究心力衰竭和慢性肾病。
T15432	GSK256073	GPR; Others	Endocrinology/Hormones; GPCR/G Protein; Others
	GSK256073 是一种口服有活性的GPR109A 选择性激动剂，也是一种持久的人HCA2激动剂(pEC50:7.5) 。它能够减少脂降解，而显著改善葡萄糖稳态，对 2 型糖尿病和血脂异常具有潜在的研究价值。
T2711	Chembridge-5861528 TCS 5861528	TRP/TRPV Channel	Membrane transporter/Ion channel
	Chembridge-5861528 (TCS 5861528) 是有效的 TRPA1离子通道阻断剂。
T6237	Trelagliptin SYR-472,曲格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Trelagliptin (SYR-472) 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病 (T2DM) 的研究。
T23521	VULM 1457	Acyltransferase	Metabolism
	VULM 1457 是有效的胆固醇酰基转移酶抑制剂，具有显著的降血脂活性，并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌，并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。
T1088	Repaglinide AG-EE 388 ZW,AG-EE 623ZW,瑞格列奈	Potassium Channel; PPAR	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Repaglinide (AG-EE 623ZW) 是一种能够用于2 型糖尿病的胰岛素促分泌剂。
T8780	AMG131 INT-131,AMG-131,CHS 131	PPAR	DNA Damage/DNA Repair; Metabolism
	AMG131 (CHS 131) 是一种新型非噻唑烷二酮(TZD) 选择性过氧化物酶体增殖物激活受体 (PPAR) γ 调节剂，可用于治疗 2 型糖尿病。
T1603	Glipizide CP 28720,K 4024,格列吡嗪	Potassium Channel; PPAR; ABC	DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Glipizide (CP 28720) 是一种有效的、具有口服活性的磺酰脲类抗糖尿病试剂 (anti-diabetic agent)，在 2 型糖尿病的研究中具有价值，但不适用于1 型糖尿病。Glipizide 是通过部分阻断郎格汉斯胰岛细胞中 ATP 敏感钾通道 (KATP)发挥活性。
T0334	Rosiglitazone BRL49653,罗格列酮	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone (BRL49653) 是一种 PPARγ 激动剂、TRPC5 激活剂和 TRPM3 抑制剂，具有口服活性。Rosiglitazone 也是一种降糖剂，是噻唑烷二酮类胰岛素增敏剂。
T7369L	Gemigliptin Tartrate(911637-19-9 free base) 吉格列汀酒石酸盐,LC15-0444 tartrate	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Gemigliptin Tartrate (LC15-0444 tartrate) 是一种选择性的，可逆的，竞争性的二肽基肽酶 4 (DPP-4) 抑制剂，对于人重组 DPP-4 的IC50=10.3 nM。Gemigliptin tartrate 具有很强的抗糖基化活性，能够用于晚期糖基化终产物相关的糖尿病并发症的研究。
T2296	Trelagliptin succinate 曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Trelagliptin succinate (SYR-472 succinate) 是一种有效的，具有口服活性的DPP-4抑制剂，IC50=4 nM。它可以改善体内血糖控制，能够用于2 型糖尿病(T2DM) 的研究。
T6646	Rosiglitazone hydrochloride 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl	Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy	Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism
	Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物，通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。
T1637	Deferoxamine Mesylate desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺	Mitophagy; Beta Amyloid; Others; Ferroptosis; HIF/HIF Prolyl-Hydroxylase; Autophagy	Apoptosis; Autophagy; Chromatin/Epigenetic; Metabolism; Neuroscience; Others
	Deferoxamine Mesylate (DFOM) 是一种铁螯合剂和铁死亡抑制剂。Deferoxamine Mesylate 可将游离铁结合成稳定的复合物，减少铁的积累。Deferoxamine Mesylate 可以上调 HIF-1α 水平，诱导细胞凋亡。
T3104	Globalagliatin LY2608204	Glucokinase	Metabolism
	Globalagliatin (LY2608204) 是一种葡萄糖激酶 (GK) 活化剂，EC50=42 nM。
T31992	Granotapide	CETP	Metabolism
	Granotapide 是一种微粒体甘油三酯转移蛋白（MTP）抑制剂，治疗和而预防动脉硬化，冠状动脉疾病，代谢综合征，肥胖，糖尿病，糖尿病前期和高血压。
T6961	PX-478 PX-478 2HCl	HIF/HIF Prolyl-Hydroxylase; HIF; Autophagy	Angiogenesis; Autophagy; Chromatin/Epigenetic; Metabolism
	PX-478 是一种 HIF-1α 抑制剂，具有选择性、口服活性和血脑屏障渗透性。PX-478 具有抗肿瘤活性，还可以保护糖尿病中的胰腺 β 细胞功能，用于 2 型糖尿病的研究。
TP1469	Lixisenatide acetate (320367-13-3 free base) Lixisenatide acetate	Glucagon Receptor	GPCR/G Protein
	Lixisenatide acetate 是一种胰高血糖素样肽 1 受体的激动剂，可用于研究 2 型糖尿病。
T2316	Omarigliptin MK-3102,奥格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Omarigliptin (MK-3102) 是高效选择性 DPP4抑制剂，IC50=为1.6nM。
T27706	K-111 BM 170744,K111,K 111,BM170744,BM-170744	PPAR	DNA Damage/DNA Repair; Metabolism
	K-111 (BM-170744) 是一种可口服的过氧化物酶体增殖物激活受体（PPAR）-α 激动剂和胰岛素增强剂，可用于研究肥胖型糖尿病和代谢综合征。
T0490	Chlorpropamide Diabinese,氯磺丙脲	ATPase; ABC	Membrane transporter/Ion channel
	Chlorpropamide (Diabinese) 是口服降糖剂，可用于研究非胰岛素依赖型糖尿病。
T2385	Ipragliflozin 伊格列净,ASP1941	SGLT	GPCR/G Protein
	Ipragliflozin (ASP1941) 是一种口服有效的，选择性的 SGLT2抑制剂，对人 SGLT2 和 SGLT1，大鼠 SGLT2 和 SGLT1，小鼠 SGLT2 和 SGLT1 的 IC50分别为 7.38 和 1876 nM，6.73 和 1166 nM，5.64 和 1380 nM。Ipragliflozin 具有抗糖尿病活性。
T77784	WAY-297848	Glucokinase	Metabolism
	WAY-297848 是一种新型的 glucokinase 激活剂，可用于预防或治疗高血糖、糖尿病、肥胖症、血脂异常和代谢综合征。
T14130	Adomeglivant LY2409021	Glucagon Receptor	GPCR/G Protein
	Adomeglivant (LY2409021) 是一种高效的选择性胰高血糖素受体 (GluR) 变构拮抗剂，主要用于2型糖尿病的研究。
TP1796	Albiglutide TFA (782500-75-8 free base) Albiglutide TFA	Glucagon Receptor	GPCR/G Protein
	Albiglutide TFA (782500-75-8 free base) (Albiglutide TFA) 是一种长效 GLP-1 受体激动剂，用于治疗 2 型糖尿病 (T2DM)。
T22387	NSC 55655 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione	Others	Others
	NSC 55655 (5-[(2-Nitrophenyl)methylene]-2,4-thiazolidinedione) 具有抗菌和抗氧化活性，抑制 B. subtilis, S. aureus, K. pneumonia, E. coli, S. typhi ，A. niger 和 C. albicans 的增殖，可用于糖尿病。
T27841	Lobeglitazone Sulfate CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang	NOD	Immunology/Inflammation; NF-κB
	Lobeglitazone Sulfate（CKD-501 Sulfate）是一种新型噻唑烷二酮,具有抗炎活性，抑制LPS诱导的NLRP3炎症小体活化和肝脏炎症，可用于研究 2 型糖尿病 (T2DM)。
T78223	γ-Glu-Tyr gamma-Glutamyltyrosine,gamma-GLU-TYR
	γ-Glu-Tyr (gamma-Glutamyltyrosine) 是一种对二肽基肽酶-IV (DPP-IV) 具有竞争性抑制作用的 kokumi 肽，可用于研究糖尿病。
T7133	Anagliptin SK-0403,阿拉格列汀	Proteasome; DPP-4	Proteases/Proteasome; Ubiquitination
	Anagliptin (SK-0403) 是一种选择性的二肽酰肽酶 4 抑制剂，IC50=3.8 nM，对 DPP-8/9 的选择性相对较弱，IC50分别为 68 和 60 nM。
T15244	Ertugliflozin L-pyroglutamic acid 埃格列净,PF-04971729 L-pyroglutamic acid	Others; SGLT	GPCR/G Protein; Others
	Ertugliflozin L-pyroglutamic acid (PF-04971729 L-pyroglutamic acid) 是一种特异性和口服活性的 hSGLT2 抑制剂，IC50 为 0.877 nM。 Ertugliflozin L-pyroglutamic acid 可用于治疗 2 型糖尿病的研究。
T16479	PF-04937319	Others; Glucokinase	Metabolism; Others
	PF-04937319 是一种葡萄糖激酶激活剂 (EC50 =154.4 μM)。 PF-04937319 保持降糖功效，同时降低许多其他 GKA 观察到的低血糖风险。 PF-04937319可用于治疗2型糖尿病的研究。
T14283	amyloid P-IN-1	Beta Amyloid	Neuroscience
	amyloid P-IN-1 可用于研究血清淀粉样蛋白 P 成分耗尽的疾病，例如阿尔茨海默病、淀粉样变性、骨关节炎和 2 型糖尿病。
T77781	Lotiglipron PF-07081532	Glucagon Receptor	GPCR/G Protein
	Lotiglipron (PF-07081532) 是一种具有口服活性和有效性的 GLP-1R 激动剂，能够降低血糖和体重，可用于研究 2 型糖尿病 (T2DM) 和过度肥胖。
T1471	Duloxetine hydrochloride Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Duloxetine hydrochloride ((S)-Duloxetine hydrochloride) 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki=4.6 nM，可用于广泛性焦虑症的研究。
T37359	Myristoyl-L-carnitine chloride L-Myristoylcarnitine chloride	Endogenous Metabolite	Metabolism
	Myristoyl-L-carnitine chloride (L-Myristoylcarnitine chloride) 是人体的代谢物之一，与遗传代谢疾病有关。Tetradecanoylcarnitine 是研究糖尿病和自身免疫性肝炎的潜在标记物。
T17315	(±)-CPSI-1306 cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one	Others	Others
	(±)-CPSI-1306 (2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one) 是一种巨噬细胞迁移抑制因子 (MIF) 拮抗剂，可用于关于非胰岛素依赖型糖尿病 (NIDDM) 的研究以及预防急性和慢性 UVB 暴露对皮肤的有害影响。
T78169	Enpp-1-IN-16	PDE	Metabolism
	Enpp-1-IN-16 是一种靶向 ENPP1 的抑制剂，具有潜在的抗癌症活性。Enpp-1-IN-16 可用于研究胰岛素抵抗与II型糖尿病和软骨钙化病和骨关节炎类由 ENPP1介导的各类疾病。
T36310	AKT-IN-6 INCB-047775	Akt	Cytoskeletal Signaling; PI3K/Akt/mTOR signaling
	AKT-IN-6 (INCB-047775)对ATK 有抑制作用。Akt 是对生长因子、细胞因子和其他细胞刺激的细胞信号传导的重要组成部分。Akt 的异常激活与2型糖尿病和癌症的发生密切相关。
T68043	Ciamexon Ciamexone,BM 41332,BM41332,BM-41332	Others	Others
	Ciamexon (Ciamexone) 是一种新型的免疫调节剂，在自身免疫性疾病的实验模型中具有良好的效果，几乎没有显示出细胞毒性。Ciamexon 可用于研究内分泌眼病和糖尿病，在短时间给药后眼科疾病得到轻微改善。
T4460	Dapagliflozin ((2S)-1,2-propanediol, hydrate) BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate	SGLT	GPCR/G Protein
	Dapagliflozin ((2S)-1,2-propanediol, hydrate) (BMS-512148 (2S)-1,2-propanediol, hydrate) 是 Dapagliflozin 1,2-propanediol, hydrate 的 S 型异构体，是竞争性葡萄糖协同转运蛋白2 抑制剂，可促进尿液中葡萄糖的排泄，可用于糖尿病的研究。它诱导 HIF1表达并减轻肾脏 IR 损伤。
T0242	Sitagliptin 西他列汀,MK0431,西格列汀	Proteasome; DPP-4; Autophagy	Autophagy; Proteases/Proteasome; Ubiquitination
	Sitagliptin (MK0431) 是一种有效的 DPP4抑制剂，在 Caco-2 细胞中，IC50值为 19 nM。它是一种新型口服降糖药，可单独使用或与二甲双胍或噻唑烷二酮联合用于治疗 2 型糖尿病。
T15810	LY2922470	GPR	Endocrinology/Hormones; GPCR/G Protein
	LY2922470 是选择性口服有效的GPR40激动剂，作用于人 GPR40、小鼠 GPR40、大鼠 GPR40 的EC50值分别为 7 nM、1 nM、3 nM。它可降低血糖水平，同时显著增加胰岛素和 GLP-1，有潜力用于 2 型糖尿病的研究。
T2389	Dapagliflozin 达格列净,BMS-512148	SGLT; HIF	Angiogenesis; Chromatin/Epigenetic; GPCR/G Protein
	Dapagliflozin (BMS-512148) 是一种葡萄糖协同转运蛋白2 (SGLT2) 抑制剂，可与靶点竞争性结合。Dapagliflozin 可用于 2 型糖尿病的治疗，可以减少肾脏的葡萄糖重吸收，增加尿液中葡萄糖的排泄，从而降低血浆葡萄糖水平。
T11127	Dutogliptin tartrate PHX-1149	Others	Others
	Dutogliptin tartrate is an effective and selective oral dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
T30149	AS-1669058 oxalate AS-1669058,AS 1669058,AS1669058	Others	Others
	AS-1669058 is a G-protein-coupled receptor 119 (GPR119) agonist for the treatment of type 2 diabetes mellitus.
T11128	Dutogliptin PHX-1149 free base	Others	Others
	Dutogliptin (PHX-1149 free base) is an oral, effective and selective dipeptide-peptide-4 (DPP4) inhibitor for the treatment of type 2 diabetes mellitus.
T31263	Deanol aceglumate Otrun,Deanolo aceglumato,Risatarun,Deanoli aceglumas	Others	Others
	Deanol aceglumate is combination of deanol and N-acetyl-L-glutamic acid. deanol aceglumate can effect Hepatoprotective on stress-induced gastropathy and diabetes mellitus.
T40374	Pal-Glu(OSu)-OH	Others	Others
	Pal-Glu(OSu)-OH is a side chain specific to Liraglutide, which is a glucagon-like peptide-1 (GLP-1) receptor agonist employed in type 2 diabetes mellitus research.
T80712	α-Glucosidase-IN-38	Glucosidase	Metabolism
	α-Glucosidase-IN-38 (Compound 11j) is an effective α-glucosidase inhibitor with an IC50 of 12.44±0.38 μM, playing a significant role in diabetes mellitus (DM).
T68500	AZD-2207	Others	Others
	AZD-2207 is a cannabinoid receptor CB1 antagonist and highly lipophilic compound for the treatment of type 2 diabetes mellitus and obesity.

化合物

Cat.No: T2701

Target: GPR

Cat.No: T9022

Synonym: AZD 9977

Target: Glucocorticoid Receptor

Cat.No: T15432

Target: GPR, Others

Chembridge-5861528

Cat.No: T2711

Synonym: TCS 5861528

Target: TRP/TRPV Channel

Cat.No: T6237

Synonym: SYR-472,曲格列汀

Target: Proteasome, DPP-4

Cat.No: T23521

Target: Acyltransferase

Cat.No: T1088

Synonym: AG-EE 388 ZW,AG-EE 623ZW,瑞格列奈

Target: Potassium Channel, PPAR

Cat.No: T8780

Synonym: INT-131,AMG-131,CHS 131

Target: PPAR

Cat.No: T1603

Synonym: CP 28720,K 4024,格列吡嗪

Target: Potassium Channel, PPAR, ABC

Cat.No: T0334

Synonym: BRL49653,罗格列酮

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Gemigliptin Tartrate(911637-19-9 free base)

Cat.No: T7369L

Synonym: 吉格列汀酒石酸盐,LC15-0444 tartrate

Target: Proteasome, DPP-4

Trelagliptin succinate

Cat.No: T2296

Synonym: 曲格列汀琥珀酸盐,琥珀酸曲格列汀,SYR-472 succinate,SYR472

Target: Proteasome, DPP-4

Rosiglitazone hydrochloride

Cat.No: T6646

Synonym: 盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl

Target: Ferroptosis, TRP/TRPV Channel, PPAR, Autophagy

Deferoxamine Mesylate

Cat.No: T1637

Synonym: desferrioxamine B,Desferrioxamine B mesylate,DFO,DFOM,去铁铵,甲磺酸去铁胺

Target: Mitophagy, Beta Amyloid, Others, Ferroptosis, HIF/HIF Prolyl-Hydroxylase, Autophagy

Cat.No: T3104

Synonym: LY2608204

Target: Glucokinase

Cat.No: T31992

Target: CETP

Cat.No: T6961

Synonym: PX-478 2HCl

Target: HIF/HIF Prolyl-Hydroxylase, HIF, Autophagy

Lixisenatide acetate (320367-13-3 free base)

Cat.No: TP1469

Synonym: Lixisenatide acetate

Target: Glucagon Receptor

Cat.No: T2316

Synonym: MK-3102,奥格列汀

Target: Proteasome, DPP-4

Cat.No: T27706

Synonym: BM 170744,K111,K 111,BM170744,BM-170744

Target: PPAR

Cat.No: T0490

Synonym: Diabinese,氯磺丙脲

Target: ATPase, ABC

Cat.No: T2385

Synonym: 伊格列净,ASP1941

Target: SGLT

Cat.No: T77784

Target: Glucokinase

Cat.No: T14130

Synonym: LY2409021

Target: Glucagon Receptor

Albiglutide TFA (782500-75-8 free base)

Cat.No: TP1796

Synonym: Albiglutide TFA

Target: Glucagon Receptor

Cat.No: T22387

Synonym: 5-[(2-nitrophenyl)methylidene]thiazolidine-2,4-dione

Target: Others

Lobeglitazone Sulfate

Cat.No: T27841

Synonym: CKD501 Sulfate,CKD501,CKD-501 Sulfate,CKD 501 Sulfate,CKD 501,CKD-501,Lobeglitazone Sulfate. trade name Duvie, Chong Kun Dang

Target: NOD

Cat.No: T78223

Synonym: gamma-Glutamyltyrosine,gamma-GLU-TYR

Cat.No: T7133

Synonym: SK-0403,阿拉格列汀

Target: Proteasome, DPP-4

Ertugliflozin L-pyroglutamic acid

Cat.No: T15244

Synonym: 埃格列净,PF-04971729 L-pyroglutamic acid

Target: Others, SGLT

Cat.No: T16479

Target: Others, Glucokinase

Cat.No: T14283

Target: Beta Amyloid

Cat.No: T77781

Synonym: PF-07081532

Target: Glucagon Receptor

Duloxetine hydrochloride

Cat.No: T1471

Synonym: Duloxetine HCl,盐酸度洛西汀,LY-248686 hydrochloride,(S)-Duloxetine hydrochloride,LY-248686 HCl

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Myristoyl-L-carnitine chloride

Cat.No: T37359

Synonym: L-Myristoylcarnitine chloride

Target: Endogenous Metabolite

Cat.No: T17315

Synonym: cpsi-1306,2-(3-(2,4-Difluorophenyl)-4,5-dihydroisoxazol-5-yl)-1-morpholinoethan-1-one

Target: Others

Cat.No: T78169

Target: PDE

Cat.No: T36310

Synonym: INCB-047775

Target: Akt

Cat.No: T68043

Synonym: Ciamexone,BM 41332,BM41332,BM-41332

Target: Others

Dapagliflozin ((2S)-1,2-propanediol, hydrate)

Cat.No: T4460

Synonym: BMS-512148 (2S)-1,2-propanediol, hydrate,达格列净 (2S)-1,2-丙二醇水合物,Dapagliflozin propanediol monohydrate

Target: SGLT

Cat.No: T0242

Synonym: 西他列汀,MK0431,西格列汀

Target: Proteasome, DPP-4, Autophagy

Cat.No: T15810

Target: GPR

Cat.No: T2389

Synonym: 达格列净,BMS-512148

Target: SGLT, HIF

Dutogliptin tartrate

Cat.No: T11127

Synonym: PHX-1149

Target: Others

AS-1669058 oxalate

Cat.No: T30149

Synonym: AS-1669058,AS 1669058,AS1669058

Target: Others

Cat.No: T11128

Synonym: PHX-1149 free base

Target: Others

Deanol aceglumate

Cat.No: T31263

Synonym: Otrun,Deanolo aceglumato,Risatarun,Deanoli aceglumas

Target: Others

Pal-Glu(OSu)-OH

Cat.No: T40374

Target: Others

α-Glucosidase-IN-38

Cat.No: T80712

Target: Glucosidase

Cat.No: T68500

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1788	Isookanin	Amylase	Metabolism
	Isookanin 在多种疾病领域有研究价值，包括肿瘤，皮疹，蛇和昆虫叮咬，糖尿病，腹泻。它可作为抗病毒剂对抗 HSV 和水痘带状疱疹病毒。它也具有抗氧化特性。
T0247	Acarbose 阿卡波糖,BAY g 5421	Glucosidase	Metabolism
	Acarbose (BAY g 5421) 是一种具有口服具有活力 α-葡萄糖苷酶 (alpha-glucosidase) 抑制剂 (IC50=11 nM)，是一种降糖药。它能提高磺脲类药物或胰岛素的降血糖作用。
T3675	1-Deoxynojirimycin Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin	PI3K; Glucosidase	Metabolism; PI3K/Akt/mTOR signaling
	1-Deoxynojirimycin (Moranoline) 是一种口服具有活性的 α-葡萄糖苷酶抑制剂。它具有降血糖、减肥和抗病毒的活性。它抑制餐后血糖，预防糖尿病。
T7846	Aegeline	Others; Antifungal	Microbiology/Virology; Others
	Aegeline 是从 Aegle marmelos 的叶子中分离出来的一种生物碱酰胺，有抗高血糖和抗血脂异常的活性。
T4854	Acetoacetic acid lithium salt LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂	Others; Endogenous Metabolite	Metabolism; Others
	Acetoacetic acid lithium salt (Lithium 3-Oxobutyrate) 是内源性代谢产物的一种。
T5528	Cyanidin Chloride	Antioxidant	oxidation-reduction
	Cyanidin Chloride 是一种花青素的亚类，具有抗氧化和抗癌活性。它能够抑制破骨细胞形成，羟基磷灰石吸收和 NF-κB 配体 (RANKL) 诱导的破骨细胞标记基因表达的受体激活。
TN1449	Brandioside 2'-O-Acetylpoliumoside,2'-Acetylpoliumoside	Antioxidant	oxidation-reduction
	Brandioside (2'-Acetylpoliumoside) 是可从马鞭草科植物 Callicarpa dichotoma Raeuschel 提取得到的苯丙素类糖苷，具有抗氧化活性，可削弱谷氨酸诱导的神经毒性，可用于研究糖尿病。
T0461L	Berberine sulfate AI3-61947,Berberin sulfate,Berberine sulphate,Berberal
	Berberine sulfate (Berberal) 是苄基异喹啉生物碱原小檗碱类的季铵盐，可用于研究2型糖尿病、腹部肥胖和代谢相关脂肪性肝病。
T1273	Diacerein 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein	IL Receptor; Interleukin	Immunology/Inflammation
	Diacerein (Fisiodar) 是一种慢效具有白介素-1β 抑制效果的蒽醌类化合物。
T5S0384	Rhapontin Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside	Apoptosis; Others	Apoptosis; Others
	Rhapontin (Ponticin) 是药用大黄的一种成分，可减轻KK/Ay 糖尿病小鼠肝脏脂肪变性，改善血糖和血脂，表明其具有显着的降糖作用，有望成为治疗2型糖尿病及其并发症的新药。
T3S0364	L-Arginine L-精氨酸,L-Arg,(S)-(+)-Arginine	IL Receptor; Endogenous Metabolite; NO Synthase	Immunology/Inflammation; Metabolism
	L-Arginine (L-Arg) 是内皮型一氧化氮合酶(eNOS) 的底物。L-Arginine 通过阳离子氨基酸转运体家族转运到血管平滑肌细胞，并被代谢成一氧化氮、多胺或 L-脯氨酸。
T19117	3-Deoxyglucosone 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose	GPX; Glucagon Receptor	GPCR/G Protein; oxidation-reduction
	3-Deoxyglucosone(3-Deoxy-D-glucosone) 是美拉德反应和多元醇反应的中间体途径合成。3-Deoxyglucosone 与蛋白质氨基快速反应形成晚期糖基化末端蛋白 (AGEs)。3-Deoxyglucosone 可使谷胱甘肽过氧化物酶失活，可与低葡萄糖协同作用以增强 GLP-1 分泌，可以作为糖尿病生物学检测的标志物。
T3S1612	kuwanon G 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G	Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase	GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience
	Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂，具有杀菌作用。
TN3972	Epimedokoreanin B	Apoptosis; Others; Antibacterial	Apoptosis; Microbiology/Virology; Others
	Epimedokoreanin B （EKB）是一种从韩国淫羊藿中分离出的异戊烯化类黄酮，在人非小细胞肺癌（NSCLC）A549和NCI-H292细胞中展现出抗癌活性。Epimedokoreanin B 还具有抗炎和抗菌活性，可有清除 DPPH 自由基的活性，能以剂量依赖的方式抑制 MCF-7 和 HepG2 的增殖。Epimedokoreanin B 能显著抑制 N (δ) -（羧甲基）赖氨酸（CML）和 N (Ï) -（羧甲基）精氨酸（CMA）的形成，可通过抑制高级糖化终产物（AGEs）预防糖尿病的临床并发症。
T8274	3-Methyl-L-histidine	Endogenous Metabolite	Metabolism
	3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。
T78485	D-Glucosamine 6-phosphate Glucosamine-6-phosphate	Endogenous Metabolite	Metabolism
	D-Glucosamine 6-phosphate为内源性代谢分子，谷氨酰胺果糖-6-磷酸氨基转移酶(GFAT)介导合成。该化合物常用于糖尿病研究领域。
T79939	Quercetin 3-(6″-caffeoylsophoroside)	Others	Others
	Quercetin 3-(6″-caffeoylsophoroside) 是一种 α-淀粉酶的口服抑制剂，其 IC50 值为 73.66 μg/mL。该化合物含于碎米荠水合甲醇提取物中，有助于降低氧化应激并抑制 α-淀粉酶，因而展现出抗糖尿病活性。此外，Quercetin 3-(6″-caffeoylsophoroside) 也适用于糖尿病相关的科学研究。
TN5119	Taxoquinone	Tyrosinase; Antifection	Microbiology/Virology; Proteases/Proteasome
	Taxoquinone has strong antibacterial effect, it could be used as a promising antibacterial agent in food industry to inhibit the growth of certain important foodborne pathogens. It (100 ug/disc) displays potential anticandidal effect against Candia albica

天然产物

Cat.No: TN1788

Target: Amylase

Cat.No: T0247

Synonym: 阿卡波糖,BAY g 5421

Target: Glucosidase

1-Deoxynojirimycin

Cat.No: T3675

Synonym: Duvoglustat,Moranoline,1-脱氧野尻霉素,moranolin

Target: PI3K, Glucosidase

Cat.No: T7846

Target: Others, Antifungal

Acetoacetic acid lithium salt

Cat.No: T4854

Synonym: LithoTab acetoacetate,Lithium acetoacetate,Lithium 3-Oxobutyrate,乙酰乙酸锂

Target: Others, Endogenous Metabolite

Cyanidin Chloride

Cat.No: T5528

Target: Antioxidant

Cat.No: TN1449

Synonym: 2'-O-Acetylpoliumoside,2'-Acetylpoliumoside

Target: Antioxidant

Berberine sulfate

Cat.No: T0461L

Synonym: AI3-61947,Berberin sulfate,Berberine sulphate,Berberal

Cat.No: T1273

Synonym: 双醋瑞因,Diacerhein,Fisiodar,Diacetylrhein

Target: IL Receptor, Interleukin

Cat.No: T5S0384

Synonym: Ponticin,土大黄苷,Rhaponiticin,Rhaponticin,Rhapontigenin glucoside

Target: Apoptosis, Others

Cat.No: T3S0364

Synonym: L-精氨酸,L-Arg,(S)-(+)-Arginine

Target: IL Receptor, Endogenous Metabolite, NO Synthase

3-Deoxyglucosone

Cat.No: T19117

Synonym: 3-Deoxy-D-glucosone,2-keto-3-Deoxyglucose

Target: GPX, Glucagon Receptor

Cat.No: T3S1612

Synonym: 桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G

Target: Phosphatase, Antibacterial, Bombesin Receptor, AChR, AChE, Glucosidase

Epimedokoreanin B

Cat.No: TN3972

Target: Apoptosis, Others, Antibacterial

3-Methyl-L-histidine

Cat.No: T8274

Target: Endogenous Metabolite

D-Glucosamine 6-phosphate

Cat.No: T78485

Synonym: Glucosamine-6-phosphate

Target: Endogenous Metabolite

Quercetin 3-(6″-caffeoylsophoroside)

Cat.No: T79939

Target: Others

Cat.No: TN5119

Target: Tyrosinase, Antifection

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-00395	Insulin Protein, Human, Recombinant IDDM1,MODY10,ILPR,IDDM2,IRDN,IDDM,insulin,INS	Human	P. pastoris (Yeast)
	INS (Insulin) is a Protein Coding gene. This gene encodes insulin, a peptide hormone that plays a vital role in the regulation of carbohydrate and lipid metabolism. After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. The binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. Diseases associated with ...
TMPJ-00071	EPO/Erythropoietin Protein, Human, Recombinant (His) Erythropoietin,EPO,红细胞生长素,Epoetin	Human	HEK293 Cells
	Erythropoietin (EPO) is a glycoprotein hormone that is principally known for its role in erythropoiesis, where it is responsible for stimulating proliferation and differentiation of erythroid progenitor cells. Erythropoietin is a member of the EPO/TPO family. It is a secreted, glycosylated cytokine composed of four alpha helical bundles. The differentiation of CFU-E (Colony Forming Unit-Erythroid) cells into erythrocytes can only be accomplished in the presence of EPO. Physiological levels of EP...
TMPY-03962	AFM Protein, Human, Recombinant (His) afamin,ALBA,ALB2,ALF	Human	HEK293 Cells
	Afamin is an 87 kDa glycoprotein with five predicted N-glycosylation sites. Afamin's glycan abundance contributes to conformational and chemical inhomogeneity presenting great challenges for molecular structure determination. Afamin, a human plasma glycoprotein and putative transporter of hydrophobic molecules, has been shown to act as extracellular chaperone for poorly soluble, acylated Wnt proteins, forming a stable, soluble complex with functioning Wnt proteins. The 2.1-Å crystal structure of...
TMPK-01128	LRG1 Protein, Mouse, Recombinant (His) Leucine-rich α-2-glycoprotein,Leucine-rich alpha-2-glycoprot...	Mouse	HEK293 Cells
	Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammali...
TMPK-00526	LRG1 Protein, Cynomolgus, Recombinant (His) Leucine-rich α-2-glycoprotein,LRG1,LRG,Leucine-rich alpha-2-...	Cynomolgus	HEK293 Cells
	Diabetic nephropathy (DN) is an important public health concern of increasing proportions and the leading cause of end-stage renal disease (ESRD) in diabetic patients. It is one of the most common long-term microvascular complications of diabetes mellitus that is characterized by proteinuria and glomerular structural changes. LRG1 is a novel pro-angiogenic factors involved in the abnormal angiogenesis and renal fibrosis in DN. LRG1 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 ma...
TMPJ-01199	BTN2A1 Protein, Human, Recombinant (His) BT2.1,BTN2A1,Butyrophilin subfamily 2 member A1,BTF1	Human	HEK293 Cells
	Butyrophilin 2A1 (BTN2A1) is an approximately widely expressed and variably glycosylated type I transmembrane glycoprotein. Mature human Butyrophilin 2A1 consisits of a 220 amino acid (aa) extracellular domain with two immunoglobulin-like domains, a 21 aa transmembrane segment, and a 258 aa cytoplasmic domain. Alternative splicing generates additional isoforms of human Butyrophilin 2A1 that lack the first Ig like domain or transmembrane segment as well as isoforms with substitutions and deletion...
TMPJ-00014	Resistin Protein, Human, Recombinant (His) Resistin,C/EBP-epsilon-regulated myeloid-specific secreted c...	Human	E. coli
	Resistin known as adipose tissue-specific secretory factor (ADSF) or C/EBP-epsilon-regulated myeloid-specific secreted cysteine-rich protein (XCP1) that seems to suppress insulin ability to stimulate glucose uptake into adipose cells. The length of the resistin pre-peptide in human is 108 amino acid residues and in the mouse and rat it is 114 aa; the molecular weight is ~12.5 kDa. Resistin is a cytokine whose physiologic role has been the subject of much controversy regarding its involvement wit...
TMPY-04394	Glucokinase Protein, Human, Recombinant glucokinase (hexokinase 4),HXKP,MODY2,FGQTL3,LGLK,HKIV,GLK,H...	Human	E. coli
	Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but ...
TMPY-04122	ATOX1 Protein, Human, Recombinant (His) HAH1,ATX1,antioxidant 1 copper chaperone	Human	E. coli
	ATOX1 is a cytoplasmic copper chaperone that interacts with the copper-binding domain of the membrane copper transporters ATP7A and ATP7B. ATOX1 has also been suggested to have a potential anti-oxidant activity. As the trace element copper is essential, but extremely toxic in high concentrations, intracellular copper concentrations are tightly controlled. Once in the cell, copper is distributed by metallochaperones, including the small cytoplasmic protein ATOX1. ATOX1 plays an important role in ...

重组蛋白

Insulin Protein, Human, Recombinant

Cat.No: TMPY-00395

Species: Human

Expression System: P. pastoris (Yeast)

EPO/Erythropoietin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00071

Species: Human

Expression System: HEK293 Cells

AFM Protein, Human, Recombinant (His)

Cat.No: TMPY-03962

Species: Human

Expression System: HEK293 Cells

LRG1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01128

Species: Mouse

Expression System: HEK293 Cells

LRG1 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00526

Species: Cynomolgus

Expression System: HEK293 Cells

BTN2A1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01199

Species: Human

Expression System: HEK293 Cells

Resistin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00014

Species: Human

Expression System: E. coli

Glucokinase Protein, Human, Recombinant

Cat.No: TMPY-04394

Species: Human

Expression System: E. coli

ATOX1 Protein, Human, Recombinant (His)

Cat.No: TMPY-04122

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T19548	Repaglinide D5 AG-EE 623ZW D5,瑞格列奈 D5	Others	Others
	Repaglinide D5 is deuterium labeled Repaglinide. Repaglinide is an insulin secretagogue for treatment type-2 diabetes mellitus.
TMIH-0205	Duloxetine-d3 HCl
	Duloxetine-d3 HCl 是 Duloxetine HCl 的氘代化合物。Duloxetine HCl 的 CAS 号为 136434-34-9。Duloxetine hydrochloride 是一种 5-羟色胺-去甲肾上腺素重吸收 (serotonin-norepinephrine reuptake) 抑制剂 (SNRI)，Ki=4.6 nM，可用于广泛性焦虑症的研究。
T35790	Palmitic acid-1,2,3,4-13C4 Palmitic Acid-13C (C1, C2, C3, and C4 labeled)
	Palmitic acid-13C (C1, C2, C3, and C4 labeled) is intended for use as an internal standard for the quantification of palmitic acid by GC- or LC-MS. Palmitic acid is a common 16-carbon saturated fat that represents 10-20% of human dietary fat intake and comprises approximately 25 and 65% of human total plasma lipids and saturated fatty acids, respectively.1,2Acylation of palmitic acid to proteins facilitates anchoring of membrane-bound proteins to the lipid bilayer and trafficking of intracellula...

同位素标记化合物

Cat.No: T19548

Synonym: AG-EE 623ZW D5,瑞格列奈 D5

Target: Others

Duloxetine-d3 HCl

Cat.No: TMIH-0205

Palmitic acid-1,2,3,4-13C4

Cat.No: T35790

Synonym: Palmitic Acid-13C (C1, C2, C3, and C4 labeled)

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