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Cat. No. | Product Name | ||
---|---|---|---|
L9700 | 内质网应激化合物库 | 193 compounds | |
193 个内质网应激相关的化合物集合,可用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T8348 |
Phentolamine
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Phentolamine 是一种 alpha-1 和 alpha-2 选择性肾上腺素能受体拮抗剂。 | |||
T7127 |
DC260126
|
Apoptosis; GPR | Apoptosis; Endocrinology/Hormones; GPCR/G Protein |
DC260126 是一种 GPR40 (FFAR1)拮抗剂,对棕榈酸酯诱导的内质网应激和凋亡有保护作用。它剂量依赖性地抑制亚油酸、油酸、棕榈油酸和月桂酸刺激的 GPR40 介导的 Ca2+升高,IC50分别 6.28、5.96、7.07和4.58 μM。 | |||
T21623 |
AS1269574
AS 1269574 |
GPR; TRP/TRPV Channel | Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel |
AS1269574 是口服有效的GPR119激动剂,在表达人 GPR119 的 HEK293 细胞中EC50为 2.5 μM。它激活 TRPA1 阳离子通道,刺激胰高血糖素样肽-1分泌。它仅在高糖条件下特异性诱导胰腺 β 细胞分泌葡萄糖依赖性胰岛素。它在 2 型糖尿病的研究中具有价值。 | |||
T3171 |
GSK137647A
GSK 137647 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
GSK137647A (GSK 137647) 是一种选择性FFA4激动剂,作用于人类和大小鼠FFA4的pEC50分别为6.3、6.1和6.2。 | |||
T40187 |
GNF2133
|
DYRK | Cell Cycle/Checkpoint; Tyrosine Kinase/Adaptors |
GNF2133 是一种有效的特异性 DYRK1A 抑制剂,IC50 为 6.2 nM。 GNF2133 可用于关于 1 型糖尿病的研究。 | |||
T15247 |
ESI-05
NSC 116966 |
cAMP | GPCR/G Protein |
ESI-05 (NSC-116966) 是特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂(IC50:0.4 µM),能够抑制 cAMP 诱导的 EPAC2 的活化,并 EAPC2 介导的 Rap1 的活化。 | |||
TP1376 |
GLP-1(7-37) acetate(106612-94-6 free base)
GLP-1(7-37) acetate |
Others; Glucagon Receptor | GPCR/G Protein; Others |
GLP-1(7-37) acetate 是肠道胰岛素激素,能够促进葡萄糖诱导的胰岛素分泌。 | |||
TP1382L |
HAEGTFTSDVS acetate
HAEGTFTSDVS acetate(864915-61-7 free base) |
Glucagon Receptor | GPCR/G Protein |
HAEGTFTSDVS acetate 是 GLP-1 的一个 N 末端 1-11 残基,GLP-1 可刺激胰腺 β 细胞分泌胰岛素。 | |||
T22860 |
Imeglimin
EMD 387008,EMD-387008,RVT-1501,PXL 008 |
ROS; Mitochondrial Metabolism | Immunology/Inflammation; Metabolism |
Imeglimin (EMD 387008) 是一种可口服的抗糖尿病化合物,可增强线粒体功能、增强胰岛素分泌、促进β细胞增殖并改善小鼠胰岛β细胞存活率。 | |||
TP2017L |
GIP (1-39) acetate
GIP (1-39) acetate(725474-97-5 Free base) |
Others | Others |
GIP (1-39) acetate 是一种从猪肠道中纯化的胃抑制肽 (GIP),可刺激胰岛素分泌。 | |||
TP1863L |
Glucagon (19-29), human acetate
|
Glucagon Receptor | GPCR/G Protein |
Glucagon (19-29), human acetate 是一种从胰高血糖素加工而来的 COOH 末端片段,是一种有效的胰岛素分泌抑制剂。 | |||
TP2018L |
GIP (human) acetate
GIP (human) acetate(100040-31-1 Free base) |
IGF-1R | Tyrosine Kinase/Adaptors |
GIP (human) acetate 是葡萄糖依赖性胰岛素分泌的刺激剂和胃酸分泌的弱抑制剂。 GIP (human) acetate 在脂质代谢和肥胖的发展中起着至关重要的作用。 | |||
T3984 |
GLP-1(7-36), amide
MKC 253,胰高血糖素样肽-1,Human GLP-1-(7-36)-amide,Glucagon-like Peptide 1 (7-36) amide,Glucagon-Like Peptide (GLP) I (7-36), amide, human,GLP-1(7-36),GLP-1-(7-36)-amide |
Glucagon Receptor | GPCR/G Protein |
GLP-1(7-36), amide (MKC 253) 是一种生理性肠降血糖素,能够刺激胰岛素分泌。 | |||
T31976 |
Glymidine sodium
|
Others | Others |
Glymidine sodium 是口服有活性的抗糖尿病药物,也是肝脂肪分解的抑制剂。它通过抑制葡萄糖的形成,也对由于内源性脂质动员抑制而导致的丙酮酸氧化升高具有抑制作用。 | |||
T27937 |
LY2881835
LY 2881835,LY-2881835 |
GPR | Endocrinology/Hormones; GPCR/G Protein |
LY2881835 是一种特异性 G 蛋白偶联受体 40 (GPR40) 激动剂,具有潜在的降血糖活性,可增强的葡萄糖刺激正常瘦小鼠的胰岛素分泌。LY2881835 可用于研究 2 型糖尿病。 | |||
T1088 |
Repaglinide
AG-EE 388 ZW,AG-EE 623ZW,瑞格列奈 |
Potassium Channel; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Repaglinide (AG-EE 623ZW) 是一种能够用于2 型糖尿病的胰岛素促分泌剂。 | |||
T1781 |
GW9508
GW 9508 |
GPR; Potassium Channel | Endocrinology/Hormones; GPCR/G Protein; Membrane transporter/Ion channel |
GW 9508 是一种选择性 G 蛋白偶联受体FFA1(GPR40) 和GPR120激动剂。它是一种葡萄糖敏感性胰岛素促分泌剂和 ATP 敏感性钾通道开放剂,具有抗炎和抗动脉粥样硬化活性。 | |||
T37588L |
GIP (1-30) amide, porcine acetate
|
IGF-1R | Tyrosine Kinase/Adaptors |
GIP (1-30) amide, porcine acetate 是完全葡萄糖依赖性促胰岛素多肽 (GIP) 受体的激动剂。它可弱抑制胃酸分泌,强烈刺激胰岛素。 | |||
T6587 |
Mitiglinide Calcium
KAD-1229,米格列奈钙,S21403,米格列奈 |
ATPase; Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide Calcium (KAD-1229) 是一种 ATP 敏感的 K+通道拮抗剂,具有促胰岛素的作用。Mitiglinide Calcium 对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性。Mitiglinide Calcium 在 2 型糖尿病的研究中具有价值。 | |||
T6646 |
Rosiglitazone hydrochloride
盐酸罗格列酮,BRL-49653 HCl,Rosiglitazone HCl |
Ferroptosis; TRP/TRPV Channel; PPAR; Autophagy | Apoptosis; Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism |
Rosiglitazone hydrochloride (BRL-49653 HCl) 是一种降血糖药物,通过与脂肪细胞中的 PPAR 受体结合来刺激胰岛素分泌。它对 PPARγ1、PPARγ2 和 PPARγ 的EC50值分别为 30 nM、100 nM 和 60 nM。它也是TRPC5的激活剂和TRPM3的抑制剂。 | |||
T13867 |
RH01386
|
Others | Others |
RH01386是可以预防 ER 应激诱导的β细胞功能障碍和死亡、抑制促凋亡基因表达的小分子。它恢复内质网应激受损的葡萄糖刺激的胰岛素分泌反应。对2型糖尿病具有潜在的研究价值。 | |||
T17177 |
TUG-424
TUG424 |
Others | Others |
TUG-424 是一种有效且选择性的游离脂肪酸受体 1 (FFA1/GPR40) 激动剂,EC50 为 32 nM。TUG-424 在 100 nM 处显著增加葡萄糖刺激的胰岛素分泌。TUG-424 可能有助于探索 FFA1 在糖尿病或肥胖等代谢性疾病中的作用。 | |||
T1674 |
Nateglinide
那格列奈,A4166,Senaglinide |
Potassium Channel; Proteasome; PPAR | DNA Damage/DNA Repair; Membrane transporter/Ion channel; Metabolism; Proteases/Proteasome; Ubiquitination |
Nateglinide (Senaglinide) 是 D-苯丙氨酸的一种衍生物,是口服有效的、短效促胰岛素释放化合物,也是 DPP IV 抑制剂。 Nateglinide 抑制胰岛 β 细胞中 ATP 敏感的 K+通道。Nateglinide 在 2 型糖尿病中具有研究价值。 | |||
T78097L |
Mazdutide acetate(2259884-03-0 free base)
Mazdutide acetate(2259884-03-0 free base),OXM-3 acetate,LY-3305677 acetate,IBI-362 acetate |
Glucagon Receptor | GPCR/G Protein |
Mazdutide acetate 是一种高效的胰高血糖素样肽 (GLP-1R) 与胰高血糖素受体 (GCGR) 的共激动剂,是一种胃泌酸调节素类似物。Mazdutide acetate可刺激小鼠胰岛的胰岛素分泌 ,可用于研究肥胖和 2 型糖尿病 (T2D) 。 | |||
T1530 |
Mitiglinide calcium hydrate
KAD-1229 calcium hydrate,米格列奈钙,Mitiglinide calcium,S-21403 calcium hydrate |
Potassium Channel | Membrane transporter/Ion channel |
Mitiglinide calcium hydrate (S-21403 calcium hydrate) 是一种 ATP 敏感的 K+通道 (KATPchannel) 拮抗剂, 属于促胰岛素化合物。它对 Kir6.2/SUR1 复合物 (胰腺-细胞 KATP 通道) 具有高度特异性,在 2 型糖尿病中有研究价值。 | |||
T15368L |
Galantide acetate
Galantide acetate(138579-66-5 Free base) |
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galantide acetate 是一种特殊的甘丙肽受体 (galanin receptor) 拮抗剂,是一种由甘丙肽和 P 物质片段组成的肽段,在大鼠下丘脑可识别两类甘丙肽结合位点 (KD 分别小于 0.1 nM 和 ~6 nM)。Galantide 剂量依赖性 (IC50=1.0 nM) 拮抗甘丙肽介导的葡萄糖诱导的小鼠胰岛胰岛素分泌抑制。Galantide acetate 似乎与单一的 SP 受体群结合 (KD~40 nM)。 | |||
T34470 |
S 9871
RX-801080,RX 801080,S9871,RX801080,S-9871 |
Others | Others |
S 9871, also known as RX 801080, is an imidazoline derivative reported to antagonize imidazoline-stimulated insulin secretion. | |||
TP1141 |
GLP-1(7-36), amide acetate
GLP-1(7-36) Acetate,Human GLP-1-(7-36)-amide Acetate |
||
GLP-1(7-36) Acetate is a major intestinal hormone that stimulates glucose-induced insulin secretion from β cells. | |||
TP2258 |
HNGF6A
|
Others | Others |
increases glucose stimulated insulin secretion and glucose metabolism | |||
T25739 |
Linogliride
McN-3935,McN3935,McN 3935,Linogliridum,Linoglirida |
Others | Others |
Linogliride 是一种基于胍的胰岛素分泌抑制剂,也是 pirogliride 的结构类似物,具有降血糖活性。它可以阻断胰腺β细胞膜上对 ATP 敏感的钾通道,从而刺激胰岛素分泌并改善葡萄糖耐受性。 | |||
T70373 |
AS2575959
|
Others | Others |
AS2575959 is a novel GPR40 agonist, exhibiting glucose metabolism improvement and synergistic effect with sitagliptin on insulin and incretin secretion. | |||
TP2209 |
Xenin-8
|
Others | Others |
neurotensin-like peptide that modulate pancreatic insulin and glucagon secretion/effects | |||
T37892 |
GLP-1(7-36), amide TFA
|
||
GLP-1(7-36), amide TFA is a prominent intestinal hormone known to stimulate glucose-induced insulin secretion from β cells[1]. | |||
T70113 |
ATM-1001
|
Others | Others |
ATM-1001 is an inhibitor of the cancer-associated tropomyosin 3.1 (Tpm3.1), suppressing glucose-stimulated insulin secretion (GSIS) from the pancreatic islets. | |||
T24620 |
PF-06372222
PF-0637222,PF0637222,PF 0637222 |
Others | Others |
PF-06372222 is a small-molecule negative allosteric modulator of the glucagon receptor (GCGR). PF-06372222 is also an antagonist for glucagon-like peptide-1 receptor GLP-1R, which inhibits glucagon secretion and glucose-dependent insulin secretion. | |||
T40518 |
C-Peptide 2, rat
|
||
C-Peptide 2, rat, a 31-amino-acid peptide, serves as a constituent in proinsulin. It possesses the ability to hinder glucose-triggered insulin secretion. | |||
TP1584 |
GIP (1-30) amide,human
GIP (1-30) amide (Human) |
||
GIP (1-30) amide (Human) is an insulin-dependent glucose-dependent polypeptide.The sugar-dependent insulin polypeptide (GIP) is an insulin secreting hormone, which can stimulate the secretion of insulin and reduce the occurrence of postpranal-glycemic dis | |||
T27938 |
LY2922083
LY 2922083,LY-2922083 |
Others | Others |
LY2922083 is a Potent and Selective GPR40 agonist. LY2922083 demonstrates potent, efficacious and durable dose dependent reductions in glucose levels along with significant increases in insulin and GLP-1 secretion. | |||
T25739L |
Linogliride fumarate
McN 3935,McN-3935,McN3935 |
Others | Others |
Linogliride fumarate 是Linogliride 的富马酸盐。Linogliride 是一种基于胍的胰岛素分泌抑制剂,也是pirogliride 的结构类似物,具有降血糖活性。它可以阻断胰腺β细胞膜上对ATP 敏感的钾通道,从而刺激胰岛素分泌并改善葡萄糖耐受性。 | |||
T62836 |
Hit 1
|
Others | Others |
Hit 1 是一种胰岛素降解酶 (IDE) 的激活剂 (EC50: 5.5 μM),能够降低刺激葡萄糖的胰岛素分泌。 | |||
T71251 |
DS-1558
|
Others | Others |
DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyperglycemia and increased insulin secretion during the oral glucose tolerance test in Zucker fatty rats, the model of insulin resistance and glucose intolerance. DS-1558 not only increased the glucose-stimulated insulin secretion by GLP-1 but also potentiated the maximum insulinog... | |||
TP1241 |
Adrenocorticotropic Hormone (ACTH) (18-39), human
ACTH (18-39), human |
||
Adrenocorticotropic Hormone (ACTH) (18-39) is known as the Corticotropin-like Intermediate Lobe Peptide. It stimulates insulin secretion as well as amylase and protein secretion in a dose-dependent manner similar to those of secretin and carbamylcholine. | |||
T69477 |
F81-1144b
|
Others | Others |
F81-1144b is a matrix metalloproteinase inhibitor which reduces secretion of very low density lipoprotein-triacylglycerol, thereby lowering TAG levels in serum and the liver. F81-1144b also lowers VLDL-TAG secretion, de novo FA synthesis in the liver, and serum levels of insulin and glucose. | |||
T71020 |
PF-04671536
|
Others | Others |
PF-04671536 is a highly potent and selective inhibitor of phosphodiesterase 8B (PDE8B) phosphodiesterase 8A (PDE8A). In primary human pancreatic islets, PF-04671536 increases insulin secretion in a glucose-dependent manner. | |||
TP2017 |
GIP (1-39)
|
||
Endogenous truncated form of the incretin hormone GIP. More potent at stimulating glucose-dependent insulin secretion from rat pancreatic β-cells than GIP. | |||
T40808 |
Glucocorticoids receptor agonist 1
|
Others | Others |
Glucocorticoids receptor agonist 1 (GRA-1) is a highly effective arylpyrazole-based compound that acts as an agonist for the glucocorticoid receptor. GRA-1 exhibits strong anti-inflammatory properties while maintaining insulin secretion function. | |||
T40697 |
Glucocorticoids receptor agonist 2
|
Others | Others |
Glucocorticoid receptor agonist 2 is a highly effective anti-inflammatory compound, derived from arylpyrazole, that actively binds to and activates the glucocorticoid receptor. This compound exhibits potent anti-inflammatory properties without disrupting insulin secretion. | |||
TP1630 |
A-71915 TFA (132956-87-7 free base)
A-71915 TFA |
||
A-71915 (TFA) is a selective inhibitor of ANP receptor (atrial natriuretic peptide-receptor), induces apoptosis and decreases insulin secretion in RINm5F pancreatic β-cells. | |||
T69380 |
Cinnamic acid, hydrazide
|
Others | Others |
Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti... | |||
T76041 |
GIP (1-30) amide,human acetate
|
||
GIP (1-30) amide, human acetate 为葡萄糖依赖性促胰岛素多肽(GIP)的片段,作为一种肠降血糖素激素,它能在10^-9至10^-6M的剂量范围内,依赖剂量地促进胰岛素的分泌,并有效减缓餐后血糖波动。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1286 |
Vincamine
Angiopac,Oxybral,Devincan,Novicet,Equipur,长春胺,Perval |
GPR; Others | Endocrinology/Hormones; GPCR/G Protein; Others |
Vincamine (Perval) 是从长春花中提取的单萜类吲哚生物碱,可作为外周血管扩张剂,对脑微血管循环有选择性的血管调节作用。它可改善体内葡萄糖稳态,对 2 型糖尿病具有研究潜力。它是GPR40激动剂,通过改善 β 细胞功能障碍和促进葡萄糖刺激型胰岛素分泌发挥 β 细胞保护作用。 | |||
T2755 |
Rhoifolin
野漆树苷,Apigenin-7-O-rhamnoglucoside,Apigenin 7-O-neohesperidoside,Rhoifoloside |
Others; p38 MAPK; NF-κB; transporter; IGF-1R; Autophagy | Autophagy; MAPK; Metabolism; NF-κB; Others; Tyrosine Kinase/Adaptors |
Rhoifolin (Apigenin 7-O-neohesperidoside) 是从琯溪蜜柚叶子分离的一种黄酮糖苷。它通过 RANKL 诱导的NF-κB 和MAPK 途径改善钛颗粒刺激的骨溶解并减少破骨细胞生成。它通过增强脂联素分泌,胰岛素受体-β的酪氨酸磷酸化和GLUT4易位有助于治疗糖尿病并发症。 | |||
T4S0295 |
Apigenin 7-glucoside
波斯菊,Cosmetin,Cosmosiin,Cosmosioside,Apigenin-7-O-β-D-glucopyranoside,芹甙元-7-葡萄糖苷,Thalictiin,Apigetrin |
Reactive Oxygen Species; HIV Protease | Immunology/Inflammation; Metabolism; Microbiology/Virology; NF-κB; Proteases/Proteasome |
Apigenin 7-glucoside (Cosmosiin) 是一种 ROS 清除剂,具有抗增殖、抗氧化作用。 | |||
T2P2919 |
(2S,3R,4S)-4-Hydroxyisoleucine
(4S)-4-Hydroxy-L-isoleucine,(4S)4-羟基异亮氨酸,Hydroxyisoleucine |
PI3K | PI3K/Akt/mTOR signaling |
(2S,3R,4S)-4-Hydroxyisoleucine (Hydroxyisoleucine) 是分离自胡芦巴中的一种可口服的有效成分,具有抗糖尿病、抗糖尿病肾病的作用。 | |||
T2740 |
trans-Cinnamic acid
Isocinnamic acid,反式肉桂酸,Cinnamic acid,trans-3-Phenylacrylic acid,Phenylacrylic acid,Cinnamylic acid,3-Phenylacrylic acid,肉桂酸,Myricitrine |
Endogenous Metabolite; Antibacterial | Metabolism; Microbiology/Virology |
trans-Cinnamic acid (Myricitrine) 通过改善体内葡萄糖耐量和体外刺激胰岛素分泌而发挥抗糖尿病活性。它是一种杀菌剂,对鱼的病原菌温和气单胞菌的 MIC 值为 250 μg/mL。 | |||
T3863 |
Chikusetsusaponin IVa
竹节参皂苷IVa,Calenduloside F,竹节人参皂苷 IVA |
AMPK | Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
Chikusetsusaponin IVa (Calenduloside F) 是一种三萜皂苷中主要的活性成分,是一种蛋白激酶的激活剂,对血栓及一些代谢性疾病具有抵抗作用。 | |||
TWS1563 |
Incensole
|
Others | Others |
Incensole 是一种 14-membered 二萜类化合物,分离自烯属植物的香精油和乳香树脂中。它能够激活脑中离子通道,并可以缓解焦虑或抑郁,从而显示出抗炎和抗抑郁的特性。 | |||
TN2215 |
Taurochenodeoxycholic acid sodium
牛磺鹅去氧胆酸钠盐,Sodium taurochenodeoxycholate,牛磺鹅去氧胆酸钠 |
Apoptosis; Endogenous Metabolite | Apoptosis; Metabolism |
Taurochenodeoxycholic acid sodium (Sodium taurochenodeoxycholate) 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
TWO2727 |
Propane-1,2,3-triyl tripalmitate
Palmitic Triglyceride,Tripalmitin,Tripalmitoylglycerol,Glycerol Tripalmitate,三棕榈酸甘油酯 |
Others; Endogenous Metabolite | Metabolism; Others |
Propane-1,2,3-triyl tripalmitate (Glycerol Tripalmitate) 是内源性代谢产物的一种。 | |||
TN4577 |
Momordicoside X
|
Others | Others |
Momordicoside X displays moderate insulin secretion activity. | |||
TN4576 |
Momordicine II
|
Others | Others |
Momordicine II may have antidiabetic activity, it significantly stimulated insulin secretion. It also can deter oviposition by L. trifolii significantly. | |||
T40977 |
Cinnamtannin A2
肉桂鞣质A2 |
Others | Others |
Cinnamtannin A2, a tetrameric procyanidin, enhances GLP-1 and insulin secretion in mice while also upregulating the expression of corticotrophin releasing hormone. Additionally, Cinnamtannin A2 exhibits antioxidant, anti-diabetic, and nephroprotective effects. | |||
TN4997 |
Serpentine
|
IGF-1R | Tyrosine Kinase/Adaptors |
Serpentine 是一种玫瑰花根中的生物碱,可用作胰岛素增敏剂,以协助胰岛素降低血糖。Serpentine 可激活 AMPK 磷酸化,从而刺激C2C12细胞对葡萄糖的摄取。Serpentine 可增加了肌肉组织中GSK-3β mRNA的表达,从而增强葡萄糖摄取。Serpentine 显著增加胰高血糖素分泌和肝糖异生。在高脂肪饮食/链脲佐菌素(HFD/STZ)诱导的糖尿病小鼠中,Serpentine 显著延长了胰岛素的降血糖时间,显著降低了外源性胰岛素的使用,抑制了内源性胰岛素的分泌。 | |||
T20232 |
Kazinol B
|
Akt; NO Synthase; AMPK | Chromatin/Epigenetic; Cytoskeletal Signaling; Immunology/Inflammation; PI3K/Akt/mTOR signaling |
Kazinol B 是一氧化氮(NO)产生的抑制剂,是一种具有二甲基吡喃环的异戊烯化黄烷。Kazinol B 通过激活胰岛素-Akt 信号途径和AMPK,增强葡萄糖摄取,从而改善胰岛素敏感性。Kazinol B 刺激脂肪素的基因表达和分泌,可用于研究糖尿病。 | |||
TN1938 |
Mogroside VI
罗汉果甜苷 VI,罗汉果甜苷VI |
Antifection | Microbiology/Virology |
Lo Han Kuo extract is a high intensive sweetening agent with desirable health benefits, such as prevention of dental caries through specific antibacterial properties, no-calorie levels related to obesity, and a low glycemic index to help manage blood suga |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01471 |
Activin A Protein, Human, Mouse, Rat, Cynomolgus, Rhesus, Recombinant
Activin A,INHBA,Inhibin beta A chain,Inhibin β A chain |
Human/Mouse/Rat | HEK293 Cells |
Activin and inhibin are two closely related protein complexes that have almost directly opposite biological effects. Activins, members of the TGF-beta superfamily, are disulfide-linked dimeric proteins originally purified from gonadal fluids as proteins that stimulated pituitary follicle stimulating hormone (FSH) release. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell developm... | |||
TMPY-00545 |
Dermcidin Protein, Human, Recombinant (hFc)
AIDD,PIF,HCAP,dermcidin,DCD-1,DSEP |
Human | HEK293 Cells |
Hepatocellular carcinoma (HCC) is a major contributor to cancer-related deaths due to its often late stage diagnosis, and dermcidin (DCD) may have the potential to be used as a serum biomarker for HCC for more timely diagnoses. Human dermcidin (DCD) is an antimicrobial peptide secreted constitutively by sweat glands. And the role of DCD in ischemic heart disease has drawn increasing attention in particular its relationship with insulin secretion and glycemic control, nitric oxide (NO) synthesis ... | |||
TMPH-02582 |
CELA2A Protein, Mouse, Recombinant (His)
Elastase-2A,ELA2A,CELA2A,Chymotrypsin-like elastase family m... |
Mouse | E. coli |
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. CELA2A Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.7 kDa and the accession number is P05208. | |||
TMPH-01094 |
CELA2A Protein, Human, Recombinant (His)
Chymotrypsin-like elastase family member 2A,CELA2A,ELA2A,Ela... |
Human | P. pastoris (Yeast) |
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. CELA2A Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 27.9 kDa and the accession number is P08217. | |||
TMPH-01093 |
CELA2A Protein, Human, Recombinant (E. coli, His)
Elastase-2A,CELA2A,Chymotrypsin-like elastase family member ... |
Human | E. coli |
Elastase that enhances insulin signaling and might have a physiologic role in cellular glucose metabolism. Circulates in plasma and reduces platelet hyperactivation, triggers both insulin secretion and degradation, and increases insulin sensitivity. CELA2A Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.9 kDa and the accession number is P08217. | |||
TMPH-02716 |
HADH Protein, Mouse, Recombinant (His & SUMO)
Short-chain 3-hydroxyacyl-CoA dehydrogenase,Hydroxyacyl-coen... |
Mouse | E. coli |
Mitochondrial fatty acid beta-oxidation enzyme that catalyzes the third step of the beta-oxidation cycle for medium and short-chain 3-hydroxy fatty acyl-CoAs (C4 to C10). Plays a role in the control of insulin secretion by inhibiting the activation of glutamate dehydrogenase 1 (GLUD1), an enzyme that has an important role in regulating amino acid-induced insulin secretion. HADH Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted... | |||
TMPH-01530 |
INHBA Protein, Human, Recombinant (His & SUMO)
Activin beta-A chain,INHBA,Inhibin beta A chain,Erythroid di... |
Human | E. coli |
Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of a... | |||
TMPJ-01016 |
INHBC Protein, Human, Recombinant (N-His)
Activin Beta-C Chain,INHBC,Inhibin β C Chain,Activin β-C Cha... |
Human | E. coli |
Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins,Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary... | |||
TMPY-02640 |
FAM3B Protein, Human, Recombinant (hFc)
PANDER,ORF9,PRED44,C21orf11,C21orf76,42056,family with seque... |
Human | HEK293 Cells |
Pancreatic derived factor, also known as FAM3B, is an islet-specific secreted cytokine specifically expressed at high levels in the islets of Langerhans of the endocrine pancreas. FAM3B protein is present in alpha- and beta- cells of pancreatic islets, insulin-secreting beta-TC3 cells, and glucagon-secreting alpha-TC cells. FAM3B causes apoptosis of beta-cells as assessed by electron microscopy, annexin Ⅴ fluorescent staining, and flow-cytometric terminal deoxynucleotidyl transferase-mediated dU... | |||
TMPJ-01015 |
INHBC Protein, Human, Recombinant (C-His)
Activin β-C Chain,Activin Beta-C Chain,Inhibin β C Chain,INH... |
Human | HEK293 Cells |
Inhibin beta C chain, also known as activin beta-C chain and INHBC, belongs to the TGF-beta family. INHBC forms a homodimeric or heterodimeric through association with alpha and beta subunits, linked by one or more disulfide bonds. Inhibins are heterodimers of one alpha and one beta subunit. Activins are homo- or heterodimers of beta subunits only. Inhibins/activins regulates many physiological processes, such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell ... | |||
TMPH-01385 |
GLP1R Protein, Human, Recombinant (His)
Glucagon-like peptide 1 receptor,GLP1R |
Human | HEK293 Cells |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220. | |||
TMPY-04388 |
BLK Protein, Human, Recombinant (GST)
MODY11,BLK proto-oncogene, Src family tyrosine kinase |
Human | Baculovirus Insect Cells |
Tyrosine-protein kinase Blk, also known as B lymphocyte kinase, p55-Blk and BLK, is a member of theprotein kinase superfamily, Tyr protein kinase family and SRC subfamily. BLK / p55-Blk is expressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles. BLK / p55-Blk is a src-family protein tyrosine kinase specifically expressed in B-lineage cells of mice. The early onset of Blk expression during B-cell development in the bone marrow and... | |||
TMPH-02676 |
GLP1R Protein, Mouse, Recombinant (His & SUMO)
Glucagon-like peptide 1 receptor,Glp1r |
Mouse | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 30.4 kDa and the accession number is O35659. | |||
TMPH-01384 |
GLP1R Protein, Human, Recombinant (E. coli, His)
GLP1R,Glucagon-like peptide 1 receptor |
Human | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 18.3 kDa and the accession number is P43220. | |||
TMPH-03301 |
GLP1R Protein, Rat, Recombinant (E. coli, His)
Glp1r,Glucagon-like peptide 1 receptor |
Rat | E. coli |
G-protein coupled receptor for glucagon-like peptide 1 (GLP-1). Ligand binding triggers activation of a signaling cascade that leads to the activation of adenylyl cyclase and increased intracellular cAMP levels. Plays a role in regulating insulin secretion in response to GLP-1. GLP1R Protein, Rat, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 17.1 kDa and the accession number is P32301. | |||
TMPY-01960 |
Munc18c/STXBP3 Protein, Human, Recombinant (His & GST)
syntaxin binding protein 3,MUNC18C,UNC-18C,MUNC18-3,PSP |
Human | Baculovirus Insect Cells |
Syntaxin-binding protein 3, also known as Platelet Sec1 protein, Protein unc-18 homolog 3, Protein unc-18 homolog C, Unc-18C, Unc18-3 and STXBP3, is a cytoplasm protein which belongs to the STXBP/unc-18/SEC1 family. STXBP3 is expressed in cells that exhibit granule exocytosis, such as neutrophils, mast cells, platelets and endothelial cells. STXBP3, together with STX4 and VAMP2, may play a role in insulin-dependent movement of GLUT4 and in docking / fusion of intracellular GLUT4-containing vesic... | |||
TMPJ-00190 |
CD38 Protein, Mouse, Recombinant (hFc)
ADP-ribosyl cyclase 1,cyclic ADP-ribose hydrolase,T10,CD38 |
Mouse | HEK293 Cells |
CD38, also called ADP-ribosyl cyclase, is a Type II integral membrane protein with 301 amino acids in length that belongs to the ADP-ribosyl cyclase family.It synthesizes the second messagers cyclic ADP-ribose and nicotinate-adenine dinucleotide phosphate, the former a second messenger for glucose-induced insulin secretion. And also moonlights as a receptor in cells of the immune system. CD38 is expressed in B and T lymphocytes, osteoclasts, and in cardiac, pancreatic, liver and kidney cells. Th... | |||
TMPY-02979 |
HMGN3 Protein, Human, Recombinant (His)
PNAS-24,TRIP7,PNAS-25,high mobility group nucleosomal bindin... |
Human | E. coli |
HMGN3 belongs to the HMGN family and is expressed in the kidney, lung, pancreas, testis, skeletal muscle, heart, thyroid gland, pituitary gland, prostate, and uterus. Members of the HMGN family bind to nucleosomes without any specificity for the underlying DNA sequence. They affect the global and local structure of chromatin, as well as the levels of histone modifications, and thus play a role in epigenetic regulation of gene expression. HMGN3 regulates the expression of the glucose transporter ... | |||
TMPJ-00286 |
ANGPTL3 Protein, Human, Recombinant (hFc)
ANGPTL3,ANGPT5,Angiopoietin-related protein 3,ANG-5,Angiopoi... |
Human | HEK293 Cells |
Angiopoietin-like 3 (ANGPTL3) is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C-terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Full length ANGPTL3 circulates in the plasma as do the proteolytically separated N-and C-terminal segments containing the coiled coil domain and fibrinogen-like domains,respectively. ANGPTL3 directly inhibits ... | |||
TMPY-04394 |
Glucokinase Protein, Human, Recombinant
glucokinase (hexokinase 4),HXKP,MODY2,FGQTL3,LGLK,HKIV,GLK,H... |
Human | E. coli |
Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but ... | |||
TMPY-04455 |
PKC iota Protein, Human, Recombinant (GST)
PKCI,nPKC-iota,protein kinase C, ι,DXS1179E,nPKC-ι,protein k... |
Human | Baculovirus Insect Cells |
Protein kinase C iota type, also known as Atypical protein kinase C-lambda/iota, aPKC-lambda/iota and PRKCI, is a cytoplasm, membrane and nucleus protein which belongs to the protein kinase superfamily, AGC Ser/Thr protein kinase family and PKC subfamily. PRKCI contains one AGC-kinase C-terminal domain, one OPR domain, one phorbol-ester/DAG-type zinc finger and one protein kinase domain. PRKCI is predominantly expressed in lung and brain, but also expressed at lower levels in many tissues includ... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0198 |
Taurochenodeoxycholic Acid-d5 Sodium Salt
|
||
Taurochenodeoxycholic Acid-d5 Sodium Salt 是 Taurochenodeoxycholic Acid Sodium Salt 的氘代化合物。Taurochenodeoxycholic Acid Sodium Salt 的 CAS 号为 6009-98-9。Taurochenodeoxycholic acid sodium 是动物胆汁酸的主要生物活性物质之一。它可诱导细胞凋亡,具有抗炎和免疫调节作用。 | |||
TMID-0115 |
Dehydroepiandrosterone-2,2,3,4,4,6-d6
DHEA-d6 |
||
Dehydroepiandrosterone-2,2,3,4,4,6-d6 是 Dehydroepiandrosterone 的氘代化合物。Dehydroepiandrosterone 的 CAS 号为 53-43-0。Dehydroepiandrosterone 是一种类固醇激素。它通过多种信号传导途径介导其作用,并通过转化成雄激素和雌激素衍生物(例如,雄激素,雌激素,7α和7β DHEA (Prasterone),以及7α和7β表雄甾酮衍生物)在特异性受体上起作用。 |