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TMPH-00941
|
RIG-I Protein, Human, Recombinant (His)
RIGI,DEAD box protein 58,Antiviral innate immune
|
Human
|
E. coli
|
|
RIG-I Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 53.3 kDa and the accession number is O95786. |
|
TMPJ-01464
|
IL-2 Superkine Protein, Human, Recombinant (L100F, R101D, L105V, I106V, I112F)
TCGF,Aldesleukin,T-Cell Growth Factor,IL-2,Interleukin-2,IL2
|
Human
|
HEK293 Cells
|
|
Interleukin-2(IL-2) is an interleukin, a type of cytokine signaling molecule in the immune system，belongs to the IL-2 family. It is a powerful immunoregulatory lymphokine produced by T-cells in response to antigenic or mitogenic stimulation. IL-2/IL-2R signaling is required for T-cell proliferation and other fundamental functions that are essential for the immune response. IL-2 stimulates growth and differentiation of B-cells, NK cells, lymphokine-activated killer cells, monocytes, macrophages... |
|
TMPY-06981
|
IL-1 alpha/IL-1A Protein, Human, Recombinant (E. coli)
interleukin 1 α,IL1,白介素,IL-1F1,IL1-α,IL-1A,IL1F1,白细胞介素,IL-1 ...
|
Human
|
E. coli
|
|
IL-1 alpha is a member of the interleukin 1 cytokine family. Cytokines are proteinaceous signaling compounds that are major mediators of the immune response. They control many different cellular functions including proliferation, differentiation, and cell survival/apoptosis but are also involved in several pathophysiological processes including viral infections and autoimmune diseases. Cytokines are synthesized under various stimuli by a variety of cells of both the innate (monocytes, macrophage... |
|
TMPY-02904
|
TLR4 Protein, Human, Recombinant (His)
TLR-4,TOLL,toll-like receptor 4,ARMD10,TLR4,CD284
|
Human
|
Baculovirus Insect Cells
|
|
TLR4, also known as TLR-4, is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. TLR4 is most abundantly expressed... |
|
TMPY-00322
|
DEC-205 Protein, Human, Recombinant (His)
GP200-MR6,CD205,CLEC13B,lymphocyte antigen 75,LY-75,DEC-205
|
Human
|
HEK293 Cells
|
|
LY75 (Lymphocyte Antigen 75) is a Protein Coding gene. It is broadly expressed in the lymph node, appendix, and other tissues. LY75 knockdown in SKOV3 cells resulted in predominant upregulation of functional pathways implicated in cell proliferation and metabolism, while pathways associated with cell signaling and adhesion, complement activation, and immune response were mostly suppressed. Moreover, LY75 suppression had an opposite effect on EOC cell lines with the epithelial phenotype (A2780s a... |
|
TMPJ-00387
|
IL-4R alpha Protein, Mouse, Recombinant (hFc)
Soluble IL-4R-alpha,Interleukin-4 receptor subunit alpha,Sol...
|
Mouse
|
HEK293 Cells
|
|
Interleukin-4 receptor subunit alpha(IL-4RA), alos known as Soluble IL-4 receptor subunit alpha, belongs to the type I cytokine receptor family and type 4 subfamily. It expressed in both Th1 and Th2 cells. It functions as receptor for both interleukin 4 and interleukin 13 and couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and chemokine and mucus production at sites of allergic ... |
|
TMPJ-01465
|
GM-CSF/CSF2 Protein, Human, Recombinant (E. coli)
Colony-Stimulating Factor,CSF2,CSF,Sargramostim,集落刺激因子,Molgr...
|
Human
|
E. coli
|
|
Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryo... |
|
TMPY-04396
|
C-ABL/ABL1 Protein, Human, Recombinant (GST)
v-abl,ABL,JTK7,ABL proto-oncogene 1, non-receptor tyrosine k...
|
Human
|
Baculovirus Insect Cells
|
|
c-Abl belongs to the class of tyrosine kinases and is the prototype of a subfamily which includes two members, c-Abl and Arg (Abl-related gene). Both proteins are localized at the cell membrane, actin cytoskeleton and cytosol, and c-Abl is present in the nucleus as well. c-Abl is a non-receptor tyrosine kinase that participates in multiple signaling pathways linking the cell surface, cytoskeleton, and the nucleus. Recent in vitro studies have also linked c-Abl to amyloid-beta-induced toxicity an... |
|
TMPY-02550
|
Eotaxin/CCL11 Protein, Human, Recombinant (His)
SCYA11,chemokine (C-C motif) ligand 11
|
Human
|
E. coli
|
|
CCL11 or chemokine (C-C motif) ligand 11 is a member of the chemokine (C-C motif) ligand family. Chemokin (C-C motif) ligand 11 is a member of the chemokine family. There are four members of the chemokine family: C-C kemokines, C kemokines, CXC kemokines and CX3C kemokines. The C-C kemokines have two cysteines nearby the amino terminus. There have been at least 27 distinct members of this subgroup reported for mammals, called C-C chemokine ligands (CCL)-1 to 28. Chemokines are a family of small ... |
|
TMPY-01648
|
TREML2 Protein, Human, Recombinant (His)
TLT2,dJ238O23.1,triggering receptor expressed on myeloid cel...
|
Human
|
HEK293 Cells
|
|
Trem-like transcript 2 protein, also known as Triggering receptor expressed on myeloid cells-like protein 2, TREML2 and TLT2, is a single-pass type I membrane protein that contains one Ig-like V-type (immunoglobulin-like) domain. TREML2 is detected in cultured B cells, T cell leukemia and monocyte leukemia. TREML2 is expressed constitutively on CD8 T-cells and induced on CD4 T-cells after activation. TREML2 is a cell surface receptor that may play a role in the innate and adaptive immune respons... |
|
TMPH-02271
|
BTK Protein, Human, Recombinant (His)
BPK,AGMX1,ATK,B-cell progenitor kinase,Tyrosine-protein kina...
|
Human
|
Baculovirus Insect Cells
|
|
Non-receptor tyrosine kinase indispensable for B lymphocyte development, differentiation and signaling. Binding of antigen to the B-cell antigen receptor (BCR) triggers signaling that ultimately leads to B-cell activation. After BCR engagement and activation at the plasma membrane, phosphorylates PLCG2 at several sites, igniting the downstream signaling pathway through calcium mobilization, followed by activation of the protein kinase C (PKC) family members. PLCG2 phosphorylation is performed in... |
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TMPH-02937
|
TLR11 Protein, Mouse, Recombinant (His & Myc)
Toll-like receptor 11,Toll-like receptor 12,Tlr11
|
Mouse
|
E. coli
|
|
Participates in the innate immune response to microbial agents. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. TLR11 Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 25.7 kDa and the accession number is Q6R5P0. |
|
TMPH-01552
|
IRF1 Protein, Human, Recombinant (GST & His)
IRF1,Interferon regulatory factor 1
|
Human
|
Baculovirus Insect Cells
|
|
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. Regulates transcription of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired imm... |
|
TMPK-01231
|
CLEC2D Protein, Human, Recombinant (hFc & Avi), Biotinylated
OCILmember D,LLT1,CLAX,CLEC2D,CLAXLLT-1,LLT-1,OCIL
|
Human
|
HEK293 Cells
|
|
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. |
|
TMPH-02493
|
ADAMDEC1 Protein, Mouse, Recombinant (His)
A disintegrin and metalloproteinase domain-like protein decy...
|
Mouse
|
E. coli
|
|
May play an important role in the control of the immune response and during pregnancy. ADAMDEC1 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.9 kDa and the accession number is Q9R0X2. |
|
TMPK-01230
|
CLEC2D Protein, Human, Recombinant (hFc & Avi)
Lectin-like NK cell receptor,LLT-1,OCIL,LLT1,Lectin-like tra...
|
Human
|
HEK293 Cells
|
|
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Pre-eclampsia and HIV infection have opposing immune responses. The contrasting expression of CLEC2D in HIV infection and pre-eclampsia is demonstrative of the immunosuppressive and pro-inflammatory roles of the respective pathologies. However, this implication may be confounded by highly active anti-retroviral treatment (HAART). |
|
TMPH-01984
|
CLECL1P Protein, Human, Recombinant (His & Myc)
Putative C-type lectin-like domain family 1,DC-associated le...
|
Human
|
Baculovirus Insect Cells
|
|
May function in mediating immune cell-cell interactions. May act as a T-cell costimulatory molecule, enhancing anti-CD3-induced proliferation. May play a role in the interaction of dendritic cells with T-cells and the cells of the adaptive immune response. CLECL1P Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 13 kDa and the accession number is Q8IZS7. |
|
TMPJ-00665
|
ADAMDEC1 Protein, Human, Recombinant (His)
a disintegrin and metalloproteinase domain-like protein decy...
|
Human
|
HEK293 Cells
|
|
ADAM DEC1 protein is expressed highly in the small intestine and appendix, moderately in lymph node, mucosal lining of the colon, thymus, spleen and very weakly in the bone marrow. ADAM DEC1 is induced during DC maturation and up-regulated in response to T-cell signals. It may play an important role in the control of the immune response and during pregnancy. |
|
TMPH-02100
|
Serpin B4 Protein, Human, Recombinant (His & SUMO)
Leupin,Squamous cell carcinoma antigen 2,Serpin B4,SERPINB4,...
|
Human
|
E. coli
|
|
May act as a protease inhibitor to modulate the host immune response against tumor cells. Serpin B4 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 60.9 kDa and the accession number is P48594. |
|
TMPJ-00291
|
IL-6R alpha/CD126 Protein, Human, Recombinant (Avi & His), Biotinylated
IL-6R-α,IL-6R-alpha,Interleukin-6 receptor subunit alpha,Int...
|
Human
|
HEK293 Cells
|
|
Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. IL6Ra is a part of the receptor for interleukin 6 cytokine. IL6Ra binds to IL6 with low affinity, but does not transduce a signal. Signal activation necessitates an association with IL6ST. Activation may lead to the regulation of the immune response, acute-phase reactions and hematopoiesis. Low concentration of a soluble form of IL6 receptor acts as an... |
|
TMPH-01020
|
BTN3A1 Protein, Human, Recombinant (Yeast, His)
Butyrophilin subfamily 3 member A1,BTN3A1,CD277,BTF5
|
Human
|
P. pastoris (Yeast)
|
|
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (Yeast, His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 26.2 kDa and the... |
|
TMPH-02442
|
IL-2 Protein, Rhesus macaque, Recombinant (His & Myc & SUMO)
Interleukin-2,T-cell growth factor,IL2
|
Rhesus
|
E. coli
|
|
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. IL-2 Protein, Rhesus macaque, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 35.5 kDa and the accession numbe... |
|
TMPJ-00440
|
BTNL4 Protein, Mouse, Recombinant (His)
EG632126,BTNL4,NG11,BTN3A3
|
Mouse
|
HEK293 Cells
|
|
Butyrophilin-like 4, also known as BTLN4, BTN3A3 (human) and BTN3A2 (rat) is an approximately 65 kDa member of the butyrophilin family that may play a role in immune regulation. BTNL4 shows striking sequence similarity to Skint1, is also largely restricted to an epithelial tissue (the small intestine) replete with T cells, plays a role in T-cell responses in the adaptive immune response. |
|
TMPH-03207
|
IL-2 Protein, Rabbit, Recombinant (His)
T-cell growth factor,IL2,Interleukin-2
|
Rabbit
|
E. coli
|
|
Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells. IL-2 Protein, Rabbit, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.1 kDa and the accession number is O77620. |
|
TMPJ-01252
|
CLEC2D Protein, Mouse, Recombinant (His)
Clec2d,Clr-b,Clrb,Ocil,Osteoclast inhibitory lectin,C-type l...
|
Mouse
|
HEK293 Cells
|
|
C-type lectin domain family 2, member D (CLEC2D) is implicated in the immune response. Sensing tissue damage is an ancient function of immune cells that is central to the regulation of inflammation, tissue repair, and immunity. The C-type lectin receptor Clec2d as a sensor of cell death, which directly detects histones released during necrosis and thus contributes to inflammation and immunopathology. The Clec2d pathway may also be exploited to favor a pro-inflammatory anti-tumor response. And tu... |
|
TMPH-01021
|
BTN3A1 Protein, Human, Recombinant (E. coli, His)
CD277,Butyrophilin subfamily 3 member A1,BTN3A1,BTF5
|
Human
|
E. coli
|
|
Plays a role in T-cell activation and in the adaptive immune response. Regulates the proliferation of activated T-cells. Regulates the release of cytokines and IFNG by activated T-cells. Mediates the response of T-cells toward infected and transformed cells that are characterized by high levels of phosphorylated metabolites, such as isopentenyl pyrophosphate. BTN3A1 Protein, Human, Recombinant (E. coli, His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular wei... |
|
TMPK-00181
|
PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated
SLEB2,PD-1,PDCD1,PD1,CD279
|
Mouse
|
HEK293 Cells
|
|
Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 Protein (Primary Amine Labeling), Mouse, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 42.9 kDa and the accessio... |
|
TMPH-02585
|
ACOD1 Protein, Mouse, Recombinant (His & Myc)
Cis-aconitate decarboxylase,Cis-aconitic acid decarboxylase,...
|
Mouse
|
Baculovirus Insect Cells
|
|
Cis-aconitate decarboxylase that catalyzes production of itaconate and is involved in the inhibition of the inflammatory response. Acts as a negative regulator of the Toll-like receptors (TLRs)-mediated inflammatory innate response by stimulating the tumor necrosis factor alpha-induced protein TNFAIP3 expression via reactive oxygen species (ROS) in LPS-tolerized macrophages. Involved in antimicrobial response of innate immune cells; ACOD1-mediated itaconic acid production contributes to the anti... |
|
TMPH-01550
|
Interferon kappa/IFNK Protein, Human, Recombinant (His & SUMO)
Interferon kappa,IFNK
|
Human
|
E. coli
|
|
May play a role in the regulation of immune cell function. Cytokine that imparts cellular protection against viral infection in a species-specific manner. Activates the interferon-stimulated response element signaling pathway. It is able to directly modulate cytokine release from monocytes and dendritic cells. Binds heparin. |
|
TMPH-01133
|
Complement C8b Protein, Human, Recombinant (His)
Complement component C8 beta chain,C8B,Complement component ...
|
Human
|
E. coli
|
|
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. Complement C8b Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 67.0 kDa and the accession number is P07358. |
|
TMPK-00688
|
PD-1 Protein, Canine, Recombinant (aa 25-170, hFc)
CD279,PDCD1,SLEB2,PD1,PD-1
|
Canine
|
HEK293 Cells
|
|
Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 Protein, Canine, Recombinant (aa 25-170, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 43.00 kDa and the accession number is A0A090BAM7. |
|
TMPK-00180
|
PD-1 Protein, Human, Recombinant (aa 25-167, hFc & Avi), Biotinylated
PD-1,PDCD1,CD279,SLEB2,PD1
|
Human
|
HEK293 Cells
|
|
Programmed cell death protein 1, also known as PD-1 and CD279 , is a protein found on the surface of cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self tolerance by suppressing T cell inflammatory activity. PD-1 Protein, Human, Recombinant (aa 25-167, hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 44.7 kDa and the accession nu... |
|
TMPH-02989
|
ESAT-6 Protein, Mycobacterium bovis, Recombinant (His & Myc)
ESAT-6,6 kDa early secretory antigenic target,esxA
|
Mycobacterium bovis
|
E. coli
|
|
A secreted protein. Acts as a strong host T-cell antigen. Plays a number of roles in modulating the host's immune response to infection as well as being responsible for bacterial escape into the host cytoplasm. ESAT-6 Protein, Mycobacterium bovis, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 17.2 kDa and the accession number is P0A565. |
|
TMPJ-00175
|
B7-H4 Protein, Rhesus macaque, Recombinant (hFc)
V-set domain containing T cell activation inhibitor 1,B7x,B7...
|
Rhesus
|
HEK293 Cells
|
|
B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins.It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine production and development of cytotoxicity. When expressed on the cell surface of tumor macrophages, plays an important role, together with regulatory T-cells (Treg), in the s... |
|
TMPK-01201
|
BPIFA1/LUNX Protein, Human, Recombinant
Lung-specific protein X,BPI fold-containing family A member ...
|
Human
|
E. coli
|
|
Bactericidal/permeability-increasing fold containing family A, member 1 (BPIFA1) is a secretory protein found in human upper aerodigestive tract mucosa. This innate material is secreted in mucosal fluid or found in submucosal tissue in the human soft palate, lung, uvula, and nasal cavity. BPIFA1 is a critical component of the innate immune response that prevents upper airway diseases. |
|
TMPY-02597
|
IL-37 Protein, Human, Recombinant
FIL1Z,IL-37,白细胞介素,IL37,IL1F7,IL-1RP1,FIL1(ζ),IL1RP1,FIL1,白介素...
|
Human
|
E. coli
|
|
Interleukin 1 family member 7, or interleukin 37 (IL1F7 / IL37 / IL-1H4) is a secretory protein belonging to the Interleukin 1 family. IL-1F7 was localized in human peripheral monocytic cells. It has been localized the expression of IL-1F7b protein in discrete cell populations including plasma cells and tumor cells. These data suggest that IL-1F7 may be involved in immune response, inflammatory diseases, and/or cancer. Through constructing an adenoviral vector that allows high-level expression i... |
|
TMPJ-01325
|
TOLLIP Protein, Human, Recombinant (His)
Toll-Interacting Protein,TOLLIP
|
Human
|
E. coli
|
|
Toll-Interacting Protein (TOLLIP) is a member of the tollip family. TOLLIP localizes to the cytoplasm. It contains one C2 domain and one CUE domain. TOLLIP is an inhibitory adaptor protein for Toll-like receptors (TLR). The Toll-like receptors pathway is a part of the immune system that recognize structurally conserved molecular patterns of microbial pathogens, resulting in an inflammatory immune response. TOLLIP constitutes a complex with Tom1 to regulate endosomal transferring of ubiquitinated... |
|
TMPK-00127
|
CLEC4A Protein, Mouse, Recombinant (hFc)
HDCGC13P,Clec4a2,DCIR,CD367,CLECSF6,DCIRLLIR,LLIR,CLEC4A,DDB...
|
Mouse
|
HEK293 Cells
|
|
Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. silencing of Clec4a2 expression via skin delivery of shRNA produces an effective antitumor response and that Clec4a2 shRNA may have therapeutic potential as an adjuvant for cancer immunotherapy. CLEC4A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.3 kDa and the accession num... |
|
TMPK-00596
|
SECTM1 Protein, Human, Recombinant (hFc)
SECTM1,K-12
|
Human
|
HEK293 Cells
|
|
SECTM1 is a T/NK cell "co-stimulatory" molecule that is expressed in the peripheral blood by neutrophils and monocytes.Human monocytic cells also displayed a pronounced negative regulation of SECTM1 mRNA expression by LPS, while at the protein level SECTM1 expression was also shown to be regulated by IFN and LPS. This tight regulation of SECTM1 gene expression and rapid upregulation highlights its relevance in the innate immune response. |
|
TMPK-00126
|
CLEC4A Protein, Human, Recombinant (hFc)
DCIR,LLIR,CD367,DDB27,CLECSF6,HDCGC13P,DCIRLLIR,Clec4a2,CLEC...
|
Human
|
HEK293 Cells
|
|
Clec4a has been reported to be an immune suppressor of dendritic cells (DCs), but its potential role in cancer therapy remains to be elucidated. silencing of Clec4a2 expression via skin delivery of shRNA produces an effective antitumor response and that Clec4a2 shRNA may have therapeutic potential as an adjuvant for cancer immunotherapy. CLEC4A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.7 kDa and the accession num... |
|
TMPY-00248
|
Lymphotoxin Beta Protein, Cynomolgus, Recombinant (His)
Lymphotoxin β,lymphotoxin β (TNF superfamily, member 3),lymp...
|
Cynomolgus
|
Baculovirus Insect Cells
|
|
LTB (Lymphotoxin Beta) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. Lymphotoxin beta is a type II membrane protein of the TNF family. It anchors lymphotoxin-alpha to the cell surface through heterotrimer formation. Heat-labile enterotoxin B subunit (LTB) of enterotoxigenic Escherichia coli (ETEC) is both a strong mucosal adjuvant and immunogen. It is a subunit vaccine candidate to be used against ETEC-induced diarrhea. It has already been expressed in seve... |
|
TMPK-01298
|
BST2 Protein, Cynomolgus, Recombinant (His)
HM1.24 antigen,PDCA-1,BST2,TETHERIN,BST-2,NPC-A-7,CD317
|
Cynomolgus
|
HEK293 Cells
|
|
Interferon-induced BST2 (bone marrow stromal cell antigen 2) inhibits viral replication by tethering enveloped virions to the cell surface to restrict viral release and by inducing the NFKB-dependent antiviral immune response. BST2 expression was significantly increased during porcine epidemic diarrhea virus (PEDV) infection of Vero cells by IRF1 targeting its promoter. Both the BST2 and N protein interacted with the E3 ubiquitin ligase MARCHF8/MARCH8 and the cargo receptor. |
|
TMPY-00587
|
GABARAP Protein, Human, Recombinant (His & MBP)
GABARAP-a,GABA(A) receptor-associated protein,ATG8A,MM46
|
Human
|
E. coli
|
|
The Atg8/LC3/GABARAP family of proteins, a group that has structural homology with ubiquitin, connects with a large set of binding partners to function in macroautophagy (hereafter autophagy). GABARAP in tumorigenesis in vivo by delaying cell death and its associated immune-related response. GABARAPs are uniquely required for antimicrobial host defense through cytosolic distribution of interferon-inducible GTPases. GABARAPs as the first known direct interaction partners of Nef that are essential... |
|
TMPJ-00608
|
SLAMF9 Protein, Mouse, Recombinant (His)
Slamf9,SLAM family member 9
|
Mouse
|
HEK293 Cells
|
|
Mouse SLAM family member 9(Slamf9) is a single-pass type I membrane protein. The SLAMF9 gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. The slamf9 protein may play a role in the immune response. |
|
TMPH-01607
|
LCE3A Protein, Human, Recombinant (His)
Late envelope protein 13,LCE3A,Late cornified envelope prote...
|
Human
|
E. coli
|
|
A structural component of the cornified envelope of the stratum corneum involved in innate cutaneous host defense (Probable). Possesses defensin-like antimicrobial activity against a broad spectrum of Gram-positive and Gram-negative bacteria, both aerobic and anaerobic species. Upon inflammation, may regulate skin barrier repair by shaping cutaneous microbiota composition and immune response to bacterial antigens. LCE3A Protein, Human, Recombinant (His) is expressed in E. coli expression system ... |
|
TMPJ-01432
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CA125/MUC16 Protein, Human, Recombinant (hFc & AVI), Biotinylated
mucin 16, cell surface associated,CA-125,CA125 ovarian cance...
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Human
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HEK293 Cells
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MUC16, also known as the CA125 antigen, is a mucin protein that may be found in type I transmembrane or secreted forms that are used monitor the progress of epithelial ovarian cancer therapy. MUC16 is over-expressed by tumor cells including ovarian and mesothelial cancers. The transmembrane form can adhere to mesothelin in the peritoneum, facilitating metastasis of ovarian cancer to the peritoneal cavity. MUC16 also binds galectin-1 on immune cells and enhances its expression on tumor cells. MUC... |
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TMPK-00790
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Complement factor H/CFH Protein, Human, Recombinant (His)
ARMD4,AHUS1,H factor 1,HF1,AMBP1,FH,FHL1,HUS,CFHL3,ARMS1,HF2...
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Human
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HEK293 Cells
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Factor H is the major soluble inhibitor of complement, where its binding to self markers (i.e., particular glycan structures) prevents complement activation and amplification on host surfaces. Not surprisingly, mutations and polymorphisms that affect recognition of self by factor H are associated with diseases of complement dysregulation, such as age-related macular degeneration and atypical haemolytic uremic syndrome. In addition, pathogens (i.e., non-self) and cancer cells (i.e., altered-self)... |
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TMPH-03577
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Staphopain B Protein, S. aureus, Recombinant (GST)
Staphopain B,sspB,Staphylopain B,Staphylococcal cysteine pro...
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Staphylococcus aureus
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E. coli
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Cysteine protease that plays an important role in the inhibition of host innate immune response. Degrades host elastin, fibrogen, fibronectin and kininogen. Blocks phagocytosis of opsonised S. aureus by neutrophils and monocytes by inducing their death in a proteolytic activity-dependent manner. Decreases surface expression of the 'don't eat me' signal CD31 on neutrophils. Cleaves host galectin-3/LGALS3, thereby inhibiting the neutrophil-activating ability of the lectin. Staphopain B Protein, S.... |
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TMPH-02622
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DOCK8 Protein, Mouse, Recombinant (E. coli, His)
DOCK8,Dedicator of cytokinesis protein 8
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Mouse
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E. coli
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Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP. During immune responses, required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC. Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane. Is involved in NK cell cytotoxicity controlling polarization of microtubule-organizing cent... |
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TMPJ-00176
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B7-H4 Protein, Human, Recombinant (hFc & Avi), Biotinylated
B7H4T-cell costimulatory molecule B7x,FLJ22418,B7XPRO1291,B7...
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Human
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HEK293 Cells
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B7 Homolog 4 (B7-H4) is glycosylated member of the B7 family of immune costimulatory proteins. Mature human B7-H4 consists of a 235 amino acid (aa) extracellular domain (ECD) with two Ig-like V-type domains, a 21 aa transmembrane segment, and a 2 aa cytoplasmic tail. It is widely expressed, including in kidney, liver, lung, pancreas, placenta, prostate, spleen, testis and thymus. B7-H4 negatively regulates T-cell-mediated immune response by inhibiting T-cell activation, proliferation, cytokine ... |
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