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Search Results for " hepatic enzyme "

Targets Recommended: Others

12

抑制剂 & 化合物

3

天然产物

8

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T4410	LM10	Others	Others
	LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶，它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。
T6595	Moexipril hydrochloride 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925	Apoptosis; RAAS	Apoptosis; Endocrinology/Hormones
	Moexipril hydrochloride (Moexipril HCl) 是一种有口服活性的，不含巯基的血管紧张素转化酶抑制剂，可治疗高血压和充血性心力衰竭。
T31815	Flumecinol Zyxorin	Others	Others
	Flumecinol is a hepatic enzyme (cytochrome P-450 monooxygenases) inducer.
T73994	Nedosiran sodium	Others	Others
	Nedosiran sodium 是一种靶向乳酸脱氢酶 (LDH)的 RNA 干扰剂 (RNAi)。Nedosiran sodium?可用于研究并发终末期肾病 (ESRD)的原发性高草酸尿症 (PH)。
T12610	(R)-3-Hydroxy Midostaurin (R)-CGP52421	Others	Others
	(R)-3-Hydroxy Midostaurin is a potent inhibitor of kinases,is a major metabolite of midostaurin undergoing by the hepatic CYP3A4 enzyme,has the potential for acute myeloid leukemia (AML).
T83064	Anti-hepatic fibrosis agent 2	Others	Others
	Fibrosis agent 2为针对Ewing肉瘤断点区域1 (EWSR1) 的特定抗纤维化化合物。
T39273	Lumasiran ALN-G01	Others	Others
	Lumasiran (ALN-G01), a siRNA product, inhibits hepatic oxalate production by targeting glycolate oxidase. By silencing the gene encoding glycolate oxidase, Lumasiran depletes this enzyme and thereby prevents the synthesis of oxalate, the toxic metabolite directly linked to the clinical manifestations of Primary hyperoxaluria type 1 (PH1).
T78059	Glucagon (Human) Hyperglycemic-glycogenolytic factor,Glukagon	Others	Others
	Glucagon 对蛋白质和氨基酸的代谢产生显著的调节作用。它抑制了氨基酸与肝脏、肌肉以及胰腺蛋白的结合，增加氮的排出，并促进肝脏内尿素的合成。同时，Glucagon 增加了肝脏中转氨酶和尿素循环酶的浓度，提高了肝脏对氨基酸的摄取，并加强了氨基酸与肝糖原之间的结合，从而降低了血液中的氨基酸浓度。
T69380	Cinnamic acid, hydrazide	Others	Others
	Cinnamic acid, hydrazide is an unsaturated carboxylic acid and precursor to aspartame via enzyme-catalysed amination to phenylalanine. Cinnamic acid may be useful in prevention or treatment of Diabetes through various mechanism of actions including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibiti...
T62129	HIV-1 inhibitor-16	Others	Others
	HIV-1 inhibitor-16 (compound 7a) 是一种高效的 HIV-1抑制剂，对野生型 HIV-1 的 EC50为 1.3 nM。HIV-1 inhibitor-16 对 HIV-1 K103N、E138K、Y181C 和 L100I 病毒株也有一定的抑制活性，EC50分别为 5.4 nM、9.2 nM、22 nM 和 35 nM。HIV-1 inhibitor-16 具有良好的溶解性和肝微粒体稳定性，未表现出明显的 CYP 酶抑制活性或急性毒性。
T37522	Teneligliptin	Others	Others
	Teneligliptin (MP-513) is a potent chemotype prolylthiazolidine-based DPP-4 inhibitor, which competitively inhibits human plasma, rat plasma, and human recombinant DPP-4 in vitro, with IC50s of approximately 1 nM. Teneligliptin (MP-513) inhibits all these DPP-4 enzymes in a concentration-dependent manner. The IC50s of Teneligliptin (MP-513) for rhDPP-4, human plasma, and rat plasma are 0.889, 1.75, and 1.35 nM, respectively. A study of enzyme inhibition kinetics is conducted for Teneligliptin (M...
T35712	Debutyldronedarone hydrochloride SR35021 hydrochloride	Others	Others
	N-Desbutyl dronedarone is an active metabolite of the antiarrhythmic agent dronedarone .1,2,3It is formed from dronedarone by cytochrome P450s (CYPs) and monoamine oxidase (MAO) in human hepatocyte preparations.4N-Desbutyl dronedarone inhibits the binding of 3,3’,5-triiodo-L-thyronine to the thyroid hormone receptors TRα1and TRβ1(IC50s = 59 and 280 μM for the chicken and human receptors, respectively).1It inhibits CYP2J2-mediated formation of 14,15-EET from arachidonic acid and soluble epoxide h...

化合物

Cat.No: T4410

Target: Others

Moexipril hydrochloride

Cat.No: T6595

Synonym: 莫昔普利盐酸盐,Moexipril HCl,RS-10085,SPM 925,CI-925

Target: Apoptosis, RAAS

Cat.No: T31815

Synonym: Zyxorin

Target: Others

Nedosiran sodium

Cat.No: T73994

Target: Others

(R)-3-Hydroxy Midostaurin

Cat.No: T12610

Synonym: (R)-CGP52421

Target: Others

Anti-hepatic fibrosis agent 2

Cat.No: T83064

Target: Others

Cat.No: T39273

Synonym: ALN-G01

Target: Others

Glucagon (Human)

Cat.No: T78059

Synonym: Hyperglycemic-glycogenolytic factor,Glukagon

Target: Others

Cinnamic acid, hydrazide

Cat.No: T69380

Target: Others

HIV-1 inhibitor-16

Cat.No: T62129

Target: Others

Cat.No: T37522

Target: Others

Debutyldronedarone hydrochloride

Cat.No: T35712

Synonym: SR35021 hydrochloride

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4916	D-Glucaric acid potassium D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid	Others; Endogenous Metabolite	Metabolism; Others
	D-Glucaric acid potassium (D-Saccharic acid potassium salt) 是内源性代谢产物的一种。
T0186	Docetaxel trihydrate RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物	Apoptosis; BCL; Microtubule Associated	Apoptosis; Cytoskeletal Signaling
	Docetaxel trihydrate (RP-56976 Trihydrate) 是一种抗肿瘤试剂，抑制微管解聚的IC50值为 0.2 μM。它是紫杉醇的半合成类似物，能减弱 bcl-2 和 bcl-xL 基因表达的影响。它阻滞G2/M 细胞周期，导致细胞凋亡。
T5S0106	Peimisine 贝母辛,Ebeiensine	RAAS; AChR	Endocrinology/Hormones; Neuroscience
	Peimisine (Ebeiensine) 非竞争性拮抗气管平滑肌 M 受体，抑制 Ach 引起的平滑肌收缩。它兴奋 β 受体和拮抗内钙释放，促进一氧化氮释放，可舒张气管平滑肌，有平喘作用。

天然产物

D-Glucaric acid potassium

Cat.No: T4916

Synonym: D-Saccharic acid potassium salt,Glucosaccharic acid,D-葡萄糖二酸单钾盐,Glucaric Acid

Target: Others, Endogenous Metabolite

Docetaxel trihydrate

Cat.No: T0186

Synonym: RP-56976 (Trihydrate),RP56976 (NSC 628503) Trihydrate,多西他赛三水合物

Target: Apoptosis, BCL, Microtubule Associated

Cat.No: T5S0106

Synonym: 贝母辛,Ebeiensine

Target: RAAS, AChR

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00479	KHK Protein, Human, Recombinant (His) KHK,Hepatic fructokinase,Ketohexokinase	Human	HEK293 Cells
	Ketohexokinase, also known as Hepatic fructokinase, is a member of the carbohydrate kinase PfkB family. It exits as a homodimer and most abundant in liver, kidney, gut, spleen and pancreas. Low levels also found in adrenal, muscle, brain and eye.This enzyme catalyzes conversion of fructose to fructose-1-phosphate. It is the first enzyme with a specialized pathway that catabolizes dietary fructose. Defects in KHK are the cause of fructosuria.
TMPY-01587	SULT2A1 Protein, Human, Recombinant (His) hSTa,HST,ST2,ST2A1,STD,DHEAS,ST2A3,sulfotransferase family, ...	Human	E. coli
	Hydroxysteroid sulfotransferase ( SULT2A1 ) is a key enzyme in the testicular and hepatic metabolism of 5alpha-androstenone, which is a major component of the off-odor and off-flavor in pork known as boar taint. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar amon...
TMPJ-01142	CDO1 Protein, Human, Recombinant (His) CDO-I,CDO,Cysteine Dioxygenase Type I,CDO1,Cysteine Dioxygen...	Human	E. coli
	Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic c...
TMPJ-00834	ACADM Protein, Human, Recombinant (His) ACADM,Medium-Chain Specific Acyl-CoA Dehydrogenase Mitochond...	Human	E. coli
	Medium-Chain Specific Acyl-CoA Dehydrogenase (ACADM) is a mitochondrial fatty acid beta-oxidation that belongs to the acyl-CoA dehydrogenase family. ACADM is a homotetramer enzyme that catalyzes the initial step of the mitochondrial fatty acid beta-oxidation pathway. ACADM is specific for acyl chain lengths of 4 to 16. It is essential for converting these particular fatty acids to energy, especially during fasting periods. Defects in ACADM cause medium-chain acyl-CoA dehydrogenase deficiency, a ...
TMPY-01100	GPT2 Protein, Rat, Recombinant (His) glutamic pyruvate transaminase (alanine aminotransferase) 2	Rat	Baculovirus Insect Cells
	Alanine aminotransferase (ALT), also known as glutamate pyruvate transaminase (Gpt), is a pyridoxal enzyme that catalyzes the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate and plays a key role in the intermediary metabolism of glucose and amino acids. As a key enzyme for gluconeogenesis, Gpt is a widely-used serum marker for liver injury. Two ALT isoenzymes have been identified, ALT1 and ALT2 (GPT1 and GPT2), which are encoded by separate genes and share ...
TMPJ-00817	HO-1 Protein, Human, Recombinant HO,HMOX1,HO-1,Heme Oxygenase 1,HO1	Human	E. coli
	Heme Oxygenase 1 (HO-1) is an enzyme in endoplasmic reticulum that belongs to the heme oxygenase family. HO-1 cleaves the heme ring at the alpha methene bridge to form Biliverdin. Biliverdin is subsequently converted to Bilirubin by Biliverdin reductase. In physiological state, the highest activity of HO-1 is found in the spleen, where senescent erythrocytes are sequestrated and destroyed. HO-1 activity is highly inducible by its substrate heme and by various non-heme substances such as heavy me...
TMPY-02803	IDO2 Protein, Human, Recombinant (His) indoleamine 2,3-dioxygenase 2,INDOL1	Human	E. coli
	IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human ti...
TMPY-04394	Glucokinase Protein, Human, Recombinant glucokinase (hexokinase 4),HXKP,MODY2,FGQTL3,LGLK,HKIV,GLK,H...	Human	E. coli
	Glucokinase belongs to the bacterial glucokinase family. Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but ...

重组蛋白

KHK Protein, Human, Recombinant (His)

Cat.No: TMPJ-00479

Species: Human

Expression System: HEK293 Cells

SULT2A1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01587

Species: Human

Expression System: E. coli

CDO1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01142

Species: Human

Expression System: E. coli

ACADM Protein, Human, Recombinant (His)

Cat.No: TMPJ-00834

Species: Human

Expression System: E. coli

GPT2 Protein, Rat, Recombinant (His)

Cat.No: TMPY-01100

Species: Rat

Expression System: Baculovirus Insect Cells

HO-1 Protein, Human, Recombinant

Cat.No: TMPJ-00817

Species: Human

Expression System: E. coli

IDO2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02803

Species: Human

Expression System: E. coli

Glucokinase Protein, Human, Recombinant

Cat.No: TMPY-04394

Species: Human

Expression System: E. coli

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