29
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12
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T35044 |
Velaresol
BW12C79,BW 12C,BW 12C79,BW-12C79,BW-12C |
Others | Others |
Velaresol (BW 12C79) 可用于研究肿瘤、镰刀型贫血症和消化系统疾病。 | |||
T68056 |
Donetidine
|
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Donetidine 是一种组胺 H2 受体拮抗剂,可用于治疗消化系统疾病。 | |||
T0517 |
Pancreatin
Pancreatic enzymes,pancrelipase,胰酶 |
Others | Others |
Pancreatin (pancrelipase) 是一种含有胰腺消化酶的猪胰腺提取物。 | |||
T1201 |
Sulpiride
Aiglonyl,舒必利,Dogmatil,Sulpyrid,Dolmatil,Dobren |
Dopamine Receptor | GPCR/G Protein; Neuroscience |
Sulpiride (Aiglonyl) 是一种多巴胺 D2 受体拮抗剂,可用作抗抑郁药、抗精神病药和助消化剂发挥治疗作用。 | |||
T68035 |
Capeserod
SL-650155,SL-65.0155 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Capeserod 是一种潜在的 5-HT4 receptor(5-羟色胺受体4)激动剂,可用于研究消化系统疾病和神经系统疾病。 | |||
T9420 |
prifinium bromide
|
Others | Others |
Prifinium bromide 是抗胆碱能试剂,能够改善痉挛,具有止吐效果。 | |||
T68091L |
Ledoxantrone trihydrochloride
Ledoxantrone trihydrochloride(113457-05-9 Free base) |
Topoisomerase | DNA Damage/DNA Repair |
Ledoxantrone trihydrochloride 是一种 Top II 抑制剂,具有抗癌活性,可用于研究消化系统疾病和泌尿系统疾病。 | |||
T63806 |
CFTR corrector 8
|
CFTR | Membrane transporter/Ion channel |
CFTR corrector 8 is a highly effective modulator of the cystic fibrosis transmembrane conductance regulator (CFTR). This compound is specifically designed for utilization in research related to cystic fibrosis, a genetic disorder primarily affecting the lungs and digestive system [1]. | |||
T8385 |
Metoclopramide hydrochloride hydrate
盐酸甲氧氯普胺,甲氧氯普胺盐酸水合物,Metoclopramide monohydrochloride monohydrate |
Dopamine Receptor; 5-HT Receptor | GPCR/G Protein; Neuroscience |
Metoclopramide hydrochloride hydrate (Metoclopramide monohydrochloride monohydrate) 是5-HT3和多巴胺D2受体拮抗剂,IC50值分别为 308 和 483 nM,可用于恶心呕吐、胃食管反流和胃轻瘫的研究。 | |||
T69984 |
Ticalopride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ticalopride是一种5-HT3 receptor激动剂,可用于治疗消化系统疾病、口颌疾病、耳鼻咽喉疾病,可用于研究神经性贪食症、胃食管反流和肠易激综合征。 | |||
T4994 |
Tocofersolan
Vitamin E-TPGS,Tocophersolan,TPGS,D-α-Tocopherol polyethylene glycol 1000 succinate,托可索仑,维生素E聚乙二醇琥珀酸酯 |
Others | Others |
Tocofersolan (TPGS) 是合成的 α-生育酚的聚乙二醇衍生物。 | |||
T0992 |
Carbenoxolone disodium
Biogastrone,Duogastrone,甘珀酸钠,Bioral |
Gap Junction Protein | Cytoskeletal Signaling |
Carbenoxolone disodium (Duogastrone) 是甘草酸的活性代谢物和人11β-HSD 和细菌3α, 20β-HSD 的抑制剂。它是一种缝隙连接的解耦剂,可抑制牛痘病毒生长,用于消化性、食道和口腔溃疡和炎症的相关研究。 | |||
T61699 |
Osunprotafib
AC 484,Osunprotafib,AC484,ABBV-CLS-484 |
Phosphatase | Metabolism |
ABBV-CLS-484 (Osunprotafib) 是一种具有亚纳摩尔活性的有效的PTPN2抑制剂,具有抗肿瘤活性,可增强T细胞抗肿瘤免疫力。ABBV-CLS-484可用于治疗肿瘤、食管癌和消化系统疾病。 | |||
T34123 |
Pranazepide
FR120480,FK 480,FR-120480 |
cholecystokinin | GPCR/G Protein |
Pranazepide (FK 480) 是一种小分子胆囊收缩素受体拮抗剂,可用于研究消化系统疾病和胰腺炎。 | |||
T25206 |
Casokefamide
beta Casomorphin 4027 |
Others | Others |
Casokefamide is a peripherally-specific, synthetic opioid pentapeptide. It was derived from the β-casomorphin sequence and designed with the intention of improving resistance to digestive enzymes so that it could be used as an antidiarrheal medicine. | |||
T35788 |
Orlistat Degradation Product (sodium salt)
|
Others | Others |
Orlistat degradation product is a degradation product of the digestive lipase inhibitor orlistat . It is formed via hydrolytic and thermal degradation as well as digestion by human carboxyl ester lipase. | |||
T78347 |
Serratia marcescens nuclease
|
Others | Others |
Serratia marcescens nuclease,为一种非特异性核酸酶,因具备强大消化DNA与RNA活性,应用范围广泛。 | |||
T80881 |
Valosin (porcine)
|
||
Valosin (porcine)是一种含有25个氨基酸的生物活性肽,最近从猪肠中分离得到,主要用于消化系统研究。 | |||
T60813 |
Alizapride
|
Others | Others |
Alizapride 是多巴胺受体 (dopamine receptor) 的拮抗剂。Alizapride 可以用于人体消化系统疾病,是一种有效的止吐剂。 | |||
T82163 |
Human enteropeptidase-IN-3
|
Others | Others |
Human enteropeptidase-IN-3是一种肽类酶抑制剂,主要作用于肠肽酶,具有长效抑制功能。该化合物广泛应用于研究肠道消化相关疾病。 | |||
T72547 |
Plm IV inhibitor-2
|
Others | Others |
Plm IV inhibitor-2 是一种有效的Plm IV 抑制剂,对Plm IV、II 和 I 的IC50分别为24 nM、70 nM 和 0.3 μM。适用于研究Plasmodium 寄生虫引起的疟疾。 | |||
T0194L2 |
Chloroquine dihydrochloride
Chloroquine HCl,NSC 14050,Aralen hydrochloride,NSC14050,Chloroquine hydrochloride,Aralen HCl,NSC-14050 |
Others | Others |
Chloroquine is a medication preventing and treating malaria in areas where malaria is known to be sensitive to its effects. It is also sometimes used for amebiasis that is occurring outside the intestines, rheumatoid arthritis, and lupus erythematosus. Ch | |||
T37545 |
cis-9,10-Methyleneoctadecanoic Acid
|
Others | Others |
cis-9,10-Methyleneoctadecanoic acid is a cyclopropane fatty acid that has been found in bacteria and the digestive gland of P. globosa. It is a component of S. aureus cell membranes and levels decrease upon treatment with carvacrol. cis-9,10-Methyleneoctadecanoic acid is secreted by H. pylori and enhances histamine- and dibutyryl cAMP-stimulated acid secretion in isolated guinea pig parietal cells. It also activates protein kinase C (PKC) in a calcium-dependent manner. | |||
T12404 |
CCK-A receptor inhibitor 1
|
cholecystokinin | GPCR/G Protein |
CCK-A receptor inhibitor 1 是一种有效的缩胆囊素 A (CCK-A) 受体抑制剂(IC50:340 nM)。CCK-A receptor inhibitor 1 可用于研究与消化系统相关的疾病。 | |||
T69215 |
Ambrein
|
Others | Others |
Ambrein is a triterpene alcohol that is the chief constituent of ambergris, a secretion from the digestive system of the sperm whale, and has been suggested as the possible active component producing the supposed aphrodisiac effects of ambergris. It serves as the biological precursor for a number of aromatic derivatives such as ambroxan and is thought to possess fixative properties for other odorants. It has been shown to act as an analgesic and it has been proven to increase sexual behavior in ... | |||
T77117 | Toripalimab | ||
Toripalimab 是一个国产抗肿瘤 PD-1抗体。Toripalimab 是一种靶向 PD-1的选择性人源化单克隆抗体。Toripalimab 能够与 PD-1结合并阻断与其配体相互作用。Toripalimab 具有强效抗肿瘤作用,可用于黑色素瘤、肺癌、消化道肿瘤、肝胆和胰腺肿瘤、神经内分泌肿瘤、鼻咽癌和尿路上皮癌等肿瘤的研究。 | |||
T81182 |
Secretin (swine)
|
||
Secretin (swine)为源自猪的神经内分泌激素,由十二指肠黏膜S细胞产生,具有27个氨基酸的多肽结构,并针对分泌素受体起作用。此激素在各类成熟肠内分泌细胞亚群中表达,受脂肪酸的促进。它主要激发胰腺释放水和碳酸氢盐,同时在消化系统、中枢神经系统和能量代谢方面具有广泛应用。 | |||
T31194 |
Dalapon
Basfapon B,Dowpon M,Dawpon-Rae |
Others | Others |
Dalapon is a selective herbicide used to control perennial grasses. The major use of dalapon is on food crops including sugarcane and sugar beets. Its use is no longer authorized in France. The National Institute for Occupational Safety and Health in the | |||
T8761 |
[Leu15]-Gastrin I human
Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2 |
Others | Others |
[Leu15]-Gastrin I human (Amino Acid Sequence Glp-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Leu-Asp-Phe-NH2) 基因编码人体内的蛋白质 [Leu15]-胃泌素 I。在人类染色体中,GAST 基因定位于 17q21.2。胃窦中的 G 细胞产生 [Leu15]-胃泌素 I 的前体前胃泌素。前胃泌素经过裂解和加工产生胃泌素,它对整个胃肠道上皮细胞具有营养作用。胃泌素对消化系统的生长至关重要,并刺激壁细胞产生胃酸。胃泌素通过称为胆囊收缩素(CCK) 或 CCK-B 受体 (CCK-BR) 的 G 蛋白偶联受体发挥其功能。胃泌素的释放受到食物的刺激,尤其是蛋白质饮食,并受到非常低的 pH 值的抑制。萎缩性胃炎、幽门螺杆菌感染和长期服用质子泵抑制剂感染可能导致胃泌素过度表达。胃腺癌显示高水平的胃泌素。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TN1148 |
Isopsoralenoside
|
Estrogen Receptor/ERR; Estrogen/progestogen Receptor; Antibacterial | Endocrinology/Hormones; Microbiology/Virology |
Isopsoralenoside 是补骨脂多糖中的一种苯并呋喃苷。它在消化道内容物中可迅速代谢为补骨脂素。它具有雌激素样活性、促进成骨细胞增殖活性、抗肿瘤活性和抗菌活性。 | |||
TN1008 |
Psoralenoside
|
CaMK; Calcium Channel; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; Neuroscience |
Psoralenoside 是源于补骨脂中的苯并呋喃苷,具有抗肿瘤、抗菌、促进成骨细胞增殖和雌激素样活性。它对组胺 H1、钙调素和电压门控 l 型钙通道具有较高的亲和力。 | |||
T2O2733 |
L-Cystine
Cystine Acid,cystine,胱氨酸,L-胱氨酸 |
Antioxidant; Ferroptosis; Endogenous Metabolite | Apoptosis; Metabolism; oxidation-reduction |
L-Cystine (Cystine Acid) 是一种从半胱氨酸氨基酸硫醇侧链氧化获得的含硫衍生物。它起到抗氧化剂的作用,保护组织免受辐射和污染,减缓衰老过程。它还有助于蛋白质合成。 | |||
T2973 |
Astragaloside IV
AST-IV,黄芪甲苷IV,AS-IV,黄芪皂苷 IV |
MMP; ERK; Estrogen/progestogen Receptor; JNK | Endocrinology/Hormones; MAPK; Proteases/Proteasome |
Astragaloside IV (AS-IV) 是从黄芪中分离得到的一种皂苷,抑制ERK1/2和JNK 激活,在乳腺癌细胞 MDA-MB-231 中,下调(MMP)-2和(MMP)-9的信号通路。 | |||
T82725 |
Chrysanthellin A
|
||
Chrysanthellin A, 主要皂苷化合物,源自Chrysanthellum americanum提取物,适用于研究消化功能障碍。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01011 |
FGF-9 Protein, Mouse, Recombinant (His)
heparin-binding growth factor-9,GAF,HBGF-9,Glia-activating f... |
Mouse | E. coli |
Fibroblast growth factor-9 (FGF-9) is an approximately 26 kDa secreted glycoprotein of the FGF family. Secreted mouse FGF-9 lacks the N-terminal 1-3 aa and shares >98% sequence identity with rat, human, equine, porcine and bovine FGF-9. FGF-9 plays an important role in the regulation of embryonic development, cell proliferation, cell differentiation and cell migration. In the mouse embryo the location and timing of FGF-9 expression affects development of the skeleton, cerebellum, lungs, heart, v... | |||
TMPH-02256 |
Trypsin-3 Protein, Human, Recombinant (His)
Trypsin III,Mesotrypsinogen,PRSS3,Trypsin-3,Serine protease ... |
Human | E. coli |
Digestive protease that cleaves proteins preferentially after an Arg residue and has proteolytic activity toward Kunitz-type trypsin inhibitors. | |||
TMPY-02480 |
Chymotrypsin C Protein, Human, Recombinant (His)
ELA4,CLCR,chymotrypsin C (caldecrin) |
Human | HEK293 Cells |
Chymotrypsin C (abbreviated for CTRC), also known as caldecrin or elastase4, is a digestive enzyme of the peptidase S1 family. This enzyme is synthesized as an inactivate chymotrypsinogen. On cleavage by trypsin into two parts that activate each other by removing two small peptides in a trans-proteolysis, chymotrypsin C produced. N-linked glycosylation of human CTRC is required for efficient folding and secretion, however, the N-linked glycan is unimportant for enzyme activity or inhibitor bindi... | |||
TMPH-00203 |
Bla g 2 Protein, Blattella germanica, Recombinant (His & Myc)
Bla g 2,Aspartic protease Bla g 2,Allergen Bla g II |
Blattella germanica | E. coli |
Functions as a digestive enzyme in the cockroach. Bla g 2 Protein, Blattella germanica, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 43.4 kDa and the accession number is P54958. | |||
TMPJ-00481 |
CELA3A Protein, Human, Recombinant (His)
Elastase-3A,ELA3A,Elastase IIIA,CELA3A,Chymotrypsin-Like Ela... |
Human | HEK293 Cells |
Chymotrypsin-Like Elastase Family Member 3A (CELA3A) is an enzyme that contains one peptidase S1 domain. ELA3A belongs to the peptidase S1 family of the Elastase subfamily. ELA3A is secreted from the pancreas as a zymogen and, like other serine proteases such as trypsin, chymotrypsin and kallikrein, it has a digestive function in the intestine. ELA3A may also function in the intestinal transport and metabolism of cholesterol. ELA3A is efficient protease with alanine specificity but only little e... | |||
TMPY-03262 |
B3GNT6 Protein, Human, Recombinant (aa 44-384, His)
BGnT-6,UDP-GlcNAc:βGal β-1,3-N-acetylglucosaminyltransferase... |
Human | Baculovirus Insect Cells |
B3GNT6 belongs to the glycosyltransferase 31 family. B3GNT6 play s an important role in the synthesis of mucin-type O-glycans in digestive organs. It catalyzes the transfer of GlcNAc from UDP-GlcNAc to GalNAcalpha1-Ser/Thr (Tn antigen) to form the core 3 structure (GlcNAcbeta1-3GalNAcalpha1-Ser/Thr). Core 3 structure exists in O-glycan which is an important precursor in the biosynthesis of mucin-type glycoproteins. Loss of core 3 could lead to the production of secreted mucins, then bacteria wou... | |||
TMPJ-00953 |
ADH7 Protein, Human, Recombinant (His)
Retinol Dehydrogenase,Alcohol Dehydrogenase Class 4 μ/σ Chai... |
Human | HEK293 Cells |
Alcohol dehydrogenase class 4 mu/sigma chain (ADH7) is a cytoplasm enzyme which is a member of the alcohol dehydrogenase family. The expression of this gene makes it much more abundant in the stomach than the liver, thus it differs from the other known gene family members. ADH7 may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good subst... | |||
TMPY-01416 |
OLFM4 Protein, Human, Recombinant (His)
hGC-1,GC1,OLM4,bA209J19.1,GW112,olfactomedin 4,OlfD,hOLfD,UN... |
Human | HEK293 Cells |
Olfactomedin-4, also known as G-CSF-stimulated clone 1 protein, Antiapoptotic protein GW112, and OLFM4, is a secreted protein that contains one olfactomedin-like domain. The OLFM4 gene was recently reported to inhibit various apoptotic pathways and promote the proliferation of cancer cells, suggesting that OLFM4 might serve as a diagnostic marker for human cancers. Thus, OLFM4 mRNA might be a useful tool to support the diagnosis of cancer, irrespective of the clinical stages. It is overexpressed... | |||
TMPY-03222 |
PNLIP Protein, Human, Recombinant (His)
PL,pancreatic lipase,PTL,PNLIPD |
Human | HEK293 Cells |
PNLIP is an enzyme that belongs to the lipase family. Secreted from the pancreas, PNLIP is the primary lipase that hydrolyzes dietary fat molecules in the human digestive system, converting triglyceride substrates found in ingested oils to monoglycerides and free fatty acids. Bile salts secreted from the liver and stored in gallbladder are released into the duodenum where they coat and emulsify large fat droplets into smaller droplets, thus increasing the overall surface area of the fat, which a... | |||
TMPY-00561 |
Neurotensin Protein, Human, Recombinant (hFc)
NMN-125,NTS1,NN,NT/N,neurotensin,NT |
Human | HEK293 Cells |
NTS (Neurotensin) is a Protein Coding gene. This gene encodes a common precursor for two peptides, neuromedin N and neurotensin. NTS is a neuropeptide distributed in the central nervous and digestive systems. It belongs to the neurotensin family. NTS is an endogenous tridecapeptide of the central nervous system and the gastrointestinal tract of different mammalian species including the human. The human gene encoding neurotensin has previously been assigned to chromosome 12 but no regional locali... | |||
TMPJ-01274 |
ERO1L Protein, Human, Recombinant (His)
ERO1-L-Alpha,ERO1-L-α,Oxidoreductin-1-L-α,Endoplasmic Oxidor... |
Human | HEK293 Cells |
ERO1-Like Protein α (ERO1L) is an enzyme that belongs to the EROs family. ERO1L is expressed at high level in esophagus and upper digestive tract. ERO1L is an essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. ERO1L acts by oxidizing directly P4HB/PDI isomerase through a direct disulfide exchange. It associates with ERP44, demonstrating that it does not oxidize all PDI related proteins and can discriminate between PDI and related proteins. It... | |||
TMPY-03353 |
CEL Protein, Mouse, Recombinant (His)
1810036E18Rik,carboxyl ester lipase,BAL |
Mouse | Baculovirus Insect Cells |
CEL-maturity onset diabetes of the young (MODY), diabetes with pancreatic lipomatosis and exocrine dysfunction, is due to dominant frameshift mutations in the acinar cell carboxyl ester lipase gene (CEL). Bile-salt activated carboxylic ester lipase (CEL) is a major triglyceride, cholesterol ester and vitamin ester hydrolytic enzyme contained within pancreatic and lactating mammary gland secretions. Carboxyl ester lipase is a digestive pancreatic enzyme encoded by the CEL gene. Mutations in CEL c... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0324 |
Sulpiride-d5
|
||
Sulpiride-d5 是 Sulpiride 的氘代化合物。Sulpiride 的 CAS 号为 15676-16-1。Sulpiride 是一种多巴胺 D2 受体拮抗剂,可用作抗抑郁药、抗精神病药和助消化剂发挥治疗作用。 | |||
T70882 |
Orlistat-d3
|
||
Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit... |