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Search Results for " diacylglycerol "

Targets Recommended: 5-HT Receptor PKC

117

抑制剂 & 化合物

13

天然产物

13

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T72322	R 59-022 hydrochloride DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride	5-HT Receptor; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; GPCR/G Protein; Neuroscience
	R 59-022 hydrochloride (DKGI-I hydrochloride) 是一种 5-HT Receptor 拮抗剂，可激活蛋白激酶 C (PKC)。R 59-022 hydrochloride 是一种 DGK 抑制剂 (IC50:2.8 µM),可抑制 OAG 磷酸化为 OAPA。R 59-022 增强血小板中凝血酶诱导的甘油二酯的产生，并抑制嗜中性粒细胞中磷脂酸的产生。
T11037	Diacylglycerol acyltransferase inhibitor-1	Others	Others
	Diacylglycerol Acyltransferase Inhibitor-1, a diacylglycerol acyltransferase (DGAT1) inhibitor, effectively suppresses the activity of DGAT1.
T16709	R 59-022 Diacylglycerol kinase inhibitor I,DKGI-I	Others	Others
	R 59-022 is a 5-HTR antagonist and activates protein kinase C (PKC). R 59-022 is a diacylglycerol kinase inhibitor (IC50=2.8 μM). R 59-022 potentiates thrombin-induced diacylglycerol production in platelets and inhibits phosphatidic acid production in neu
T13373	YM17E	Acyltransferase; AChR	Metabolism; Neuroscience
	YM17E 是一种 ACAT 抑制剂，在体外兔肝微粒体中的 IC50 为 44 nM。
T8236	RHC 80267 U-57908	Others; Phospholipase; COX; Acyltransferase; AChR	Immunology/Inflammation; Metabolism; Neuroscience; Others
	RHC 80267 (U-57908) 是一种选择性二酰基甘油脂酶(DAGL)抑制剂，对犬血小板的IC50为 4 μM。它抑制COX 活性和磷脂酰胆碱的水解，还抑制胆碱酯酶活性，IC50为 4 μM，增强乙酰胆碱引起的松弛。
T12767	RP 70676	Acyltransferase	Metabolism
	RP 70676 是ACAT 抑制剂，抑制大鼠和兔子中 ACAT 的IC50分别为 25 和 44 nM。
T9711	OGT-IN-2	Others	Others
	OGT-IN-2 是 OGT 抑制剂，抑制 sOGT 和 ncOGT 的 IC50分别为 30 μM 和 53 μM。它在关节疾病方面有研究的价值，如关节软骨疾病、骨关节炎。
T15109	DGAT1-IN-1	Transferase	Metabolism
	DGAT1-IN-1是 DGAT1的高效抑制剂，在 Hep3B 细胞过表达 DGAT1裂解物中，测得IC50低于10nM。
T8314	RP-64477 RP64477	Acyltransferase	Metabolism
	RP-64477 是有效的胆固醇酯化酶酰基辅酶 A：胆固醇 O-酰基转移酶 (ACAT) 抑制剂。
T12425	PF-06424439 methanesulfonate	Acyltransferase; Transferase	Metabolism
	PF-06424439 methanesulfonate 是一种口服有效咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂，IC50是14 nM。PF-06424439 methanesulfonate 具有缓慢可逆，时间依赖性的特点，其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。
T6937	PF-04620110 PF04620110,PF 04620110	Acyltransferase; Transferase	Metabolism
	PF-04620110 是一种口服有效的甘油二酯酰基转移酶 -1(DGAT1)选择性抑制剂，IC50为 19 nM。
T26019	R59949 R-59949,R 59949	Others; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Others
	R59949 是一种泛二酰甘油激酶(DGK)抑制剂，IC50为 300 nM。它通过提高内源性配体二酰甘油水平来激活蛋白激酶 C(PKC)。它强烈抑制 Ⅰ 型 DGKα 和 γ 的活性，中度减弱 Ⅱ 型 DGKθ 和 κ 的活性。
T16409	OSMI-1	Others; Acyltransferase	Metabolism; Others
	OSMI-1 是一种 O-GlcNAc 转移酶 (OGT) 抑制剂 (IC50=2.7 μM)，具有口服活性和细胞渗透性。OSMI-1 可以抑制蛋白质 O-GlcNA 酰化，而不会定性地改变细胞表面 N- 或 O- 连接的聚糖。
T10035	10,12-Tricosadiynoic acid TDA,TCDA	Acyltransferase	Metabolism
	10,12-Tricosadiynoic acid 是一种口服有效的酰基辅酶 A 氧化酶-1 (ACOX1) 抑制剂，具有高特异性，选择性，高亲和力的特点。10,12-Tricosadiynoic acid 可改善线粒体脂质和 ROS 代谢，在高脂饮食或肥胖引起的代谢性疾病中有研究的价值。
T23521	VULM 1457	Acyltransferase	Metabolism
	VULM 1457 是有效的胆固醇酰基转移酶抑制剂，具有显著的降血脂活性，并改善了整体心肌缺血再灌注损伤结果。VULM 1457 显著降低肾上腺髓质素的产生和分泌，并下调人肝母细胞上的 AM 受体。VULM 1457 具有研究糖尿病和高胆固醇血症的潜力。
T23550	YM-750 YM 750	Acyltransferase	Metabolism
	YM-750 是一种有效的酰基:胆固醇酰基转移酶(ACAT)抑制剂，IC50为0.18 μM。
T11733	K-604 dihydrochloride	Acyltransferase	Metabolism
	K-604 dihydrochloride 是酰基辅酶 A：胆固醇酰基转移酶 1 的选择性抑制剂，IC50为 0.45±0.06 μM。
T22665	PD 128042 CI 976	Acyltransferase	Metabolism
	PD 128042 (CI 976) 是口服有效的ACAT (酰基辅酶 A: 胆固醇酰基转移酶)选择性抑制剂。它也是LPAT(溶血磷脂酰基转移酶) 抑制剂。它抑制高尔基体相关 LPAT 活性 (IC50=15 μM)。它抑制多种膜运输步骤，包括在内吞和分泌途径中发现的步骤。
T4681	T863 DGAT-3,DGAT-1 inhibitor	Acyltransferase; Transferase	Metabolism
	T863 (DGAT-3) 是口服有效的二酰基甘油酰基转移酶1 选择性抑制剂。T863结合DGAT1的酰基辅酶A 结合位点，抑制三酰甘油在细胞内的合成。
T2753	Avasimibe PD-148515,阿伐麦布,CI-1011	P450; Acyltransferase	Metabolism
	Avasimibe (PD-148515) 是一种口服有效的酰基辅酶 A: 胆固醇酰基转移酶 (ACAT) 抑制剂，对 ACAT1和 ACAT2的 IC50分别为 24 和 9.2 µM。Avasimibe 在前列腺癌中有研究的价值。
T22726	Dioctanoylglycol 2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate	Others	Others
	Dioctanoylglycol (ethane-1,2-diyl dioctanoate) 是二酰基甘油类似物，也是二酰基甘油激酶 (DGK) 抑制剂，其Ki=为58 μM。
T15247	ESI-05 NSC 116966	cAMP	GPCR/G Protein
	ESI-05 (NSC-116966) 是特异性的 cAMP 直接激活交换蛋白 2 (EPAC2) 拮抗剂(IC50:0.4 µM)，能够抑制 cAMP 诱导的 EPAC2 的活化，并 EAPC2 介导的 Rap1 的活化。
T6365	A 922500 A922500,(1R,2R)-2-[[4-[[(苯基氨基)羰基]氨基][1,1-联苯]-4-基]甲酰基]环戊烷羧酸,DGAT-1 Inhibitor 4a	Acyltransferase; Transferase	Metabolism
	A 922500 (DGAT-1 Inhibitor 4a) 是一种口服有效的二酰甘油酰基转移酶 1(DGAT-1)选择性抑制剂，抑制小鼠和人 DGAT-1 的IC50s 分别为9 nM，22 nM。
T12225L	Nevanimibe hydrochloride PD-132301 hydrochloride,ATR101 hydrochloride	Apoptosis; Acyltransferase	Apoptosis; Metabolism
	Nevanimibe hydrochloride (PD-132301 hydrochloride) 是一种口服有效的，选择性酰基辅酶 A：胆固醇 O-酰基转移酶 1 抑制剂，EC50为 9 nM。它抑制 ACAT2，EC50为 368 nM。它诱导细胞凋亡，具有抗肾上腺皮质癌的潜力。
T12426	PF-06424439	Acyltransferase; Transferase	Metabolism
	PF-06424439 是一种口服有效的咪唑并吡啶二酰基甘油酰基转移酶 2 (DGAT2)选择性抑制剂，IC50是 14 nM。PF-06424439 具有缓慢可逆的，时间依赖性的特点，其相对于酰基-CoA 底物以非竞争性模式抑制 DGAT2。
T73053	BAY 2965501	PERK	Apoptosis
	BAY 2965501 是一种有效且具有的选择性二酰基甘油激酶 zeta (DGKζ) 抑制剂，诱导 pERK 激活。BAY 2965501 可用于研究癌症。
T14375	AZD3988	Transferase	Metabolism
	AZD3988 是一种具有口服活性和高效性的二酰甘油酰基转移酶-1（DGAT-1）的抑制剂，可用于研究糖尿病和肥胖。
T9186	Ervogastat PF-06865571	Transferase	Metabolism
	Ervogastat (PF-06865571) 是一种有效且耐受性良好的二酰基甘油酰基转移酶 2 抑制剂。 Ervogastat 可降低非酒精性脂肪性肝炎 (NASH) 中的脂肪变性和肝脏甘油三酯水平。
T11827	Pradigastat ANJ908,LCQ908-NXA,LCQ908A,LCQ-908	Transferase	Metabolism
	Pradigastat (LCQ-908) 是一种具有口服活性、有效性和选择性的二酰基甘油酰基转移酶 1 (DGAT1) 抑制剂，可用于治疗便秘，可用于研究肥胖和糖尿病。
T10954	DAGLβ-IN-1	Others	Others
	DAGLβ-IN-1，一种针对二酰基甘油脂肪酶 β (DAGLβ) 的抑制剂，可用作DAGL特异性活性探针的通用中间体。
T11016	DGAT-1 inhibitor 2	Transferase	Metabolism
	DGAT-1 inhibitor 2是有效的DGAT-1抑制剂，具有减肥功效。
T77761	BMS-502	Others	Others
	BMS-502 是一种二酰基甘油激酶 (DGK) α 和 ζ 的强效双重抑制剂，诱导人和小鼠T细胞的免疫反应，阻断 T 细胞中细胞内检查点信号传导。BMS-502 以剂量依赖的方式刺激免疫反应，可用于研究与免疫相关的疾病。
T71105	AZD2353	Others	Others
	AZD2353 is a potent inhibitor of diacylglycerol acetyl transferase 1 (DGAT1).
T85137	1-Palmitoyl-3-Oleoyl-rac-glycerol 1,3-OP,1-Palmitin-3-Olein,DG(16:0/0:0/18:1)	Others	Others
	1-Palmitoyl-3-oleoyl-rac-glycerol, a diacylglycerol featuring palmitic acid at the sn-1 position and oleic acid at the sn-3 position, serves as a substrate for diacylglycerol acyltransferase (DAGAT) in myotubes.
T24128	H2-005 H2 005	Others	Others
	H2-005 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
T85036	Diheptadecanoin	Others	Others
	Diheptadecanoin is a diacylglycerol characterized by the presence of heptadecanoic acid (margaric acid) at two positions.
T85109	Didocosanoin Dibehenin	Others	Others
	Didocosanoin, a diacylglycerol, incorporates the saturated 22-carbon fatty acid, docosanoic acid, at both of its positions.
T33814	OptoDArG Opto-DArG,Opto DArG	Others	Others
	OptoDArG is a diacylglycerol (DAG) photoswitch, which enables efficient control of TRPC3 by light.
T27692	JNJ-DGAT2-B JNJDGAT2B,JNJ DGAT2 B	Others	Others
	JNJ-DGAT2-B is a selective inhibitor of Diacylglycerol acyltransferase 2.
T85119	1-Oleoyl-3-Arachidoyl-rac-glycerol DG(18:1/0:0/20:0),1-Olein-3-Arachidin	Others	Others
	1-Oleoyl-3-arachidoyl-rac-glycerol is a diacylglycerol with oleic acid at the sn-1 position and arachidic acid at the sn-3 position.
T85066	1,3-Dinervonoyl Glycerol 1,3-Di-15(Z)-Tetracosenoin,1,3-Dinervonin,1,3-Di-15(Z)-Tetracosenoyl Glycerol,DG(24:1/0:0/24:1)	Others	Others
	1,3-Dinervonoyl glycerol, a diacylglycerol, features nervonic acid at the sn-1 and sn-3 positions.
T33788	Oleoyl glutamic acid NSC 513733,Glutamic acid, N-oleoyl-,NSC-513733,NSC513733	Others	Others
	Oleoyl glutamic acid is a diacylglycerol analog.
T85091	1,2-Diarachidoyl-rac-glycerol 1,2-Dieicosanoin,DG(20:0/20:0/0:0),1,2-Dieicosanoyl-rac-glycerol,1,2-Diarachidin	Others	Others
	1,2-Diarachidoyl-rac-glycerol is a diacylglycerol featuring arachidic acid at both the sn-1 and sn-2 positions.
T85105	1,3-Dilinoelaidoyl Glycerol DG(18:2/0:0/18:2),1,3-Dilinoelaidin	Others	Others
	1,3-Dilinoleoyl glycerol, a diacylglycerol, incorporates linoelaidic acid at both the sn-1 and sn-3 positions. This compound emerges from the collision-induced decomposition of synthetic linoleic ammoniated triglycerides.
T85243	1,3-Dieicosenoyl Glycerol cis-11-Dieicosenoin,20:1/20:1-DG,DG(20:1/0:0/20:1),11(Z)-Dieicosenoin,di-cis-11-Eicosenoyl-glycerol	Others	Others
	1,3-Dieicosenoyl glycerol is a diacylglycerol featuring 11(Z)-eicosenoic acid at both the sn-1 and sn-3 positions.
T85088	1,3-Diarachidonoyl Glycerol DG(20:4/0:0/20:4),1,3-Diarachidonin	Others	Others
	1,3-Diarachidonoyl glycerol, a diacylglycerol with arachidonic acid at the sn-1 and sn-3 positions, exhibits cytotoxicity toward 3Y1 and E1A-3Y1 cells at concentrations of 8 to 16 µg/ml.
T85212	1,3-Diarachidoyl Glycerol DG(20:0/0:0/20:0),1,3-Diarachidin,1,3-Dieicosanoin,1,3-Dieicosanoyl Glycerol	Others	Others
	1,3-Diarachidoyl glycerol, a diacylglycerol featuring arachidic acid at the sn-1 and sn-3 positions, is identified within enzymatically randomized pig lard.
T24127	H2-003 H2003	Others	Others
	H2-003 is a selective inhibitor of diacylglycerol acyltransferase 2 (DGAT2).
T85068	Dimyristin Glyceryl Dimyristate	Others	Others
	Dimyristin, a diacylglycerol, features myristic acid at two positions.
T85236	1-Stearoyl-2-Lauroyl-rac-glycerol 18:0/12:0/0:0-DG,1-Stearin-2-Laurin,DG(18:0/12:0/0:0),1-Octadecanoyl-2-Dodecanoylglycerol	Others	Others
	1-Stearoyl-2-lauroyl-rac-glycerol, a diacylglycerol, features stearic acid at the sn-1 position and lauric acid at the sn-2 position. It serves as a substrate for the rat diacylglycerol lipase DDHD2.1.

化合物

R 59-022 hydrochloride

Cat.No: T72322

Synonym: DKGI-I hydrochloride,Diacylglycerol kinase inhibitor I hydrochloride,DKGI-I hydrochloride ; Diacylglycerol kinase inhibitor I hydrochloride

Target: 5-HT Receptor, PKC

Diacylglycerol acyltransferase inhibitor-1

Cat.No: T11037

Target: Others

Cat.No: T16709

Synonym: Diacylglycerol kinase inhibitor I,DKGI-I

Target: Others

Cat.No: T13373

Target: Acyltransferase, AChR

Cat.No: T8236

Synonym: U-57908

Target: Others, Phospholipase, COX, Acyltransferase, AChR

Cat.No: T12767

Target: Acyltransferase

Cat.No: T9711

Target: Others

Cat.No: T15109

Target: Transferase

Cat.No: T8314

Synonym: RP64477

Target: Acyltransferase

PF-06424439 methanesulfonate

Cat.No: T12425

Target: Acyltransferase, Transferase

Cat.No: T6937

Synonym: PF04620110,PF 04620110

Target: Acyltransferase, Transferase

Cat.No: T26019

Synonym: R-59949,R 59949

Target: Others, PKC

Cat.No: T16409

Target: Others, Acyltransferase

10,12-Tricosadiynoic acid

Cat.No: T10035

Synonym: TDA,TCDA

Target: Acyltransferase

Cat.No: T23521

Target: Acyltransferase

Cat.No: T23550

Synonym: YM 750

Target: Acyltransferase

K-604 dihydrochloride

Cat.No: T11733

Target: Acyltransferase

Cat.No: T22665

Synonym: CI 976

Target: Acyltransferase

Cat.No: T4681

Synonym: DGAT-3,DGAT-1 inhibitor

Target: Acyltransferase, Transferase

Cat.No: T2753

Synonym: PD-148515,阿伐麦布,CI-1011

Target: P450, Acyltransferase

Dioctanoylglycol

Cat.No: T22726

Synonym: 2-octanoyloxyethyl octanoate,Dioctanoyl ethylene glycol,Ethylene glycol dioctanoate,ethane-1,2-diyl dioctanoate

Target: Others

Cat.No: T15247

Synonym: NSC 116966

Target: cAMP

Cat.No: T6365

Synonym: A922500,(1R,2R)-2-[[4-[[(苯基氨基)羰基]氨基][1,1-联苯]-4-基]甲酰基]环戊烷羧酸,DGAT-1 Inhibitor 4a

Target: Acyltransferase, Transferase

Nevanimibe hydrochloride

Cat.No: T12225L

Synonym: PD-132301 hydrochloride,ATR101 hydrochloride

Target: Apoptosis, Acyltransferase

Cat.No: T12426

Target: Acyltransferase, Transferase

Cat.No: T73053

Target: PERK

Cat.No: T14375

Target: Transferase

Cat.No: T9186

Synonym: PF-06865571

Target: Transferase

Cat.No: T11827

Synonym: ANJ908,LCQ908-NXA,LCQ908A,LCQ-908

Target: Transferase

Cat.No: T10954

Target: Others

DGAT-1 inhibitor 2

Cat.No: T11016

Target: Transferase

Cat.No: T77761

Target: Others

Cat.No: T71105

Target: Others

1-Palmitoyl-3-Oleoyl-rac-glycerol

Cat.No: T85137

Synonym: 1,3-OP,1-Palmitin-3-Olein,DG(16:0/0:0/18:1)

Target: Others

Cat.No: T24128

Synonym: H2 005

Target: Others

Diheptadecanoin

Cat.No: T85036

Target: Others

Cat.No: T85109

Synonym: Dibehenin

Target: Others

Cat.No: T33814

Synonym: Opto-DArG,Opto DArG

Target: Others

Cat.No: T27692

Synonym: JNJDGAT2B,JNJ DGAT2 B

Target: Others

1-Oleoyl-3-Arachidoyl-rac-glycerol

Cat.No: T85119

Synonym: DG(18:1/0:0/20:0),1-Olein-3-Arachidin

Target: Others

1,3-Dinervonoyl Glycerol

Cat.No: T85066

Synonym: 1,3-Di-15(Z)-Tetracosenoin,1,3-Dinervonin,1,3-Di-15(Z)-Tetracosenoyl Glycerol,DG(24:1/0:0/24:1)

Target: Others

Oleoyl glutamic acid

Cat.No: T33788

Synonym: NSC 513733,Glutamic acid, N-oleoyl-,NSC-513733,NSC513733

Target: Others

1,2-Diarachidoyl-rac-glycerol

Cat.No: T85091

Synonym: 1,2-Dieicosanoin,DG(20:0/20:0/0:0),1,2-Dieicosanoyl-rac-glycerol,1,2-Diarachidin

Target: Others

1,3-Dilinoelaidoyl Glycerol

Cat.No: T85105

Synonym: DG(18:2/0:0/18:2),1,3-Dilinoelaidin

Target: Others

1,3-Dieicosenoyl Glycerol

Cat.No: T85243

Synonym: cis-11-Dieicosenoin,20:1/20:1-DG,DG(20:1/0:0/20:1),11(Z)-Dieicosenoin,di-cis-11-Eicosenoyl-glycerol

Target: Others

1,3-Diarachidonoyl Glycerol

Cat.No: T85088

Synonym: DG(20:4/0:0/20:4),1,3-Diarachidonin

Target: Others

1,3-Diarachidoyl Glycerol

Cat.No: T85212

Synonym: DG(20:0/0:0/20:0),1,3-Diarachidin,1,3-Dieicosanoin,1,3-Dieicosanoyl Glycerol

Target: Others

Cat.No: T24127

Synonym: H2003

Target: Others

Cat.No: T85068

Synonym: Glyceryl Dimyristate

Target: Others

1-Stearoyl-2-Lauroyl-rac-glycerol

Cat.No: T85236

Synonym: 18:0/12:0/0:0-DG,1-Stearin-2-Laurin,DG(18:0/12:0/0:0),1-Octadecanoyl-2-Dodecanoylglycerol

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1691	Glabrol 光甘草酚,光甘草醇	P450; NF-κB; NO Synthase; Acyltransferase	Immunology/Inflammation; Metabolism; NF-κB
	Glabrol 是分离自甘草根的乙醇提取物中的一种异戊二烯类黄酮，是一种有效且非竞争性的酰基辅酶 A：胆固醇酰基转移酶（ACAT）抑制剂，抑制大鼠肝脏微粒体 ACAT 的IC50为 24.6 μM。
T3342	Xanthohumol	Apoptosis; Others; Influenza Virus; COX; Acyltransferase; HSV	Apoptosis; Immunology/Inflammation; Metabolism; Microbiology/Virology; Neuroscience; Others
	Xanthohumol 是从啤酒花中分离到的黄酮类化合物，可抑制 COX-1 和 COX-2 活性，具有抗肿瘤，抗血管生成的作用，还具有抗多种病毒的活性。
T5544	2-Furoic acid Furan-2-carboxylic acid,糠酸	Anti-infection; ATP Citrate Lyase; Endogenous Metabolite; Acyltransferase	Metabolism; Microbiology/Virology
	2-Furoic acid (Furan-2-carboxylic acid) 2-Furoic acid 能够降低血清中胆固醇和甘油三酯的水平，具有抗血脂作用。
T21437	DSPS DSPS (From soybeans),Phosphatidylserine(36:0),磷脂酰丝氨酸,Dioctadecanoylphosphatidylserine,Distearoyl phosphatidylserine	Others	Others
	DSPS (Dioctadecanoylphosphatidylserine) 是一种甘油磷脂，是重要的磷脂膜成分，在细胞周期信号传导中起关键作用。DSPS 可以调节细胞活性，介导细胞凋亡。DSPS 被广泛用作营养补充剂。
TN5814	Digalactosyldiacylglycerol DGDG,双半乳糖二酰甘油
	Digalactosyldiacylglycerol 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN5814，CAS号为 145033-48-3。
T4950	1,2-Dipalmitoyl-sn-glycerol 1,2-双棕榈酸甘油酯,(S)-1,2-Dipalmitin	Endogenous Metabolite; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Metabolism
	1,2-Dipalmitoyl-sn-glycerol ((S)-1,2-Dipalmitin) 是内源性代谢产物的一种。
T69446	Cochlioquinone A	Others	Others
	Cochlioquinone A is an inhibitor of diacylglycerol kinase (DGK) and diacylglycerol acyltransferase (DGAT). It has been shown to reduce the concentration of phosphatidic acid in T cell lymphoma and has also been shown to compete with macrophage inflammatory protein-1α for binding to human CCR5 chemokine receptors.
T40347	Eicosapentaenoic acid methyl ester	Others	Others
	Eicosapentaenoic acid methyl ester is a degradation product derived from monogalactosyl diacylglycerol, which is an apoptosis-inducing anticancer compound.
TN1843	Kushenol K	PDE; HSV	Metabolism; Microbiology/Virology
	Kushenol K is a potent and Selective Inhibitor of cGMP Phosphodiesterase 5, it also has inhibitory effects on diacylglycerol acyltransferase (DGAT). Kushenol K shows weak antiviral activity against Herpes simplex virus types I and II.
TN3255	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone	Others	Others
	7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone shows diacylglycerol acyltransferase (DGAT)1 inhibition with IC(50) values of 47.0 microM (for rat liver microsomes) and 160.7 microM (for HepG2 cell microsomes),
TN3428	Aphadilactone C	Others	Others
	Aphadilactone C shows significant antimalarial activity with the IC50 value of 170 ± 10 nM. It shows potent and selective inhibition against the diacylglycerol O-acyltransferase-1 (DGAT-1) enzyme (IC50 = 0.46 ± 0.09 uM, selectivity index > 217).
T37690	Phenylpyropene A	Others	Others
	Phenylpyropene A is a fungal metabolite originally isolated from P. griseofulvum that has enzyme inhibitory and insecticidal activities.1,2,3 It inhibits acyl-coenzyme A:cholesterol acyltransferase (ACAT; IC50 = 0.8 μM).1 Phenylpyropene A inhibits diacylglycerol acyltransferase (DGAT) in rat liver microsomes (IC50 = 78.7 μM). It induces mortality in 100% of M. persicae when used at a concentration of 5 ppm.3 \|1. Kwon, O.E., Rho, M.C., Song, H.Y., et al. Phenylpyropene A and B, new inhibitors of ...
T75697	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Others	Others
	1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone，为喹诺酮类生物碱，作用为二酰基甘油酰基转移酶抑制剂与血管紧张素II受体阻断剂，其IC50值依次为20.1 μM与34.1 μM。此化合物亦展现对幽门螺杆菌的有效抗活性，MIC值达10 μg/mL。

天然产物

Cat.No: TN1691

Synonym: 光甘草酚,光甘草醇

Target: P450, NF-κB, NO Synthase, Acyltransferase

Cat.No: T3342

Target: Apoptosis, Others, Influenza Virus, COX, Acyltransferase, HSV

Cat.No: T5544

Synonym: Furan-2-carboxylic acid,糠酸

Target: Anti-infection, ATP Citrate Lyase, Endogenous Metabolite, Acyltransferase

Cat.No: T21437

Synonym: DSPS (From soybeans),Phosphatidylserine(36:0),磷脂酰丝氨酸,Dioctadecanoylphosphatidylserine,Distearoyl phosphatidylserine

Target: Others

Digalactosyldiacylglycerol

Cat.No: TN5814

Synonym: DGDG,双半乳糖二酰甘油

1,2-Dipalmitoyl-sn-glycerol

Cat.No: T4950

Synonym: 1,2-双棕榈酸甘油酯,(S)-1,2-Dipalmitin

Target: Endogenous Metabolite, PKC

Cochlioquinone A

Cat.No: T69446

Target: Others

Eicosapentaenoic acid methyl ester

Cat.No: T40347

Target: Others

Cat.No: TN1843

Target: PDE, HSV

7beta-(3-Ethyl-cis-crotonoyloxy)-1alpha-(2-methylbutyryloxy)-3,14-dehydro-Z-notonipetranone

Cat.No: TN3255

Target: Others

Aphadilactone C

Cat.No: TN3428

Target: Others

Phenylpyropene A

Cat.No: T37690

Target: Others

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone

Cat.No: T75697

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01222	DGKA Protein, Human, Recombinant (His) Diacylglycerol kinase alpha,80 kDa diacylglycer...	Human	E. coli
	Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids. Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes. Also plays an important role in the biosynthesis of complex lipids (Probable). Can also phosphorylate 1-alkyl-2-acylglycerol in vitro as efficiently ...
TMPH-03003	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO) Diacylglycerol acyltransferase/mycolyltransferase A...	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 44.6 kDa and the accession number is P9WQP2.
TMPH-03004	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His) Diacylglycerol acyltransferase/mycolyltransferase A...	Mycobacterium tuberculosis	E. coli
	Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 34.1 kDa and the accession number is P9WQP2.
TMPH-03007	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His) Acyl-CoA:diacylglycerol acyltransferase,Fibronectin...	Mycobacterium tuberculosis	E. coli
	Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.1 kDa and the accession number is P9WQN8.
TMPH-02992	FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO) fbpB,30 kDa extracellular protein,Extracellular alpha-antige...	Mycobacterium kansasii	E. coli
	FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 50.6 kDa and the accession number is P21160.
TMPH-03006	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His) 30 kDa extracellular protein,Diacylglycerol acyltra...	Mycobacterium tuberculosis	P. pastoris (Yeast)
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 32.7 kDa and the accession number is P9WQP0.
TMPH-03005	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) 30 kDa extracellular protein,DGAT,Fbps B,Diacylglycerol<...	Mycobacterium tuberculosis	E. coli
	Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 36.2 kDa and the accession number is P9WQP0.
TMPH-01365	SNTG1 Protein, Human, Recombinant (His & Myc) Syntrophin-4,Gamma-1-syntrophin,SNTG1	Human	E. coli
	Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex. May participate in regulating the subcellular location of diacylglycerol kinase-zeta to ensure that diacylglycerol is rapidly inactivated following receptor activation. SNTG1 Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicte...
TMPY-02394	IMPA1 Protein, Human, Recombinant (His) IMPA,inositol(myo)-1(or 4)-monophosphatase 1,IMP	Human	E. coli
	IMPA1 (Inositol Monophosphatase 1) is a Protein Coding gene. This gene encodes an enzyme that dephosphorylates Myo-inositol monophosphate to generate free Myo-inositol, a precursor of phosphatidylinositol, and is, therefore, an important modulator of intracellular signal transduction via the production of the second messenger's myoinositol 1,4,5-trisphosphate and diacylglycerol. Despite its many physiological functions, no clinical phenotype has been assigned to this gene dysfunction to date. Ad...
TMPY-04456	PKC nu Protein, Human, Recombinant (GST) PRKCN,nPKC-NU,PKC-NU,PKD3,EPK2,protein kinase D3	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase D3, also known as Protein kinase C nu type, Protein kinase EPK2, PRKD3, EPK2 and PRKCN, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD3 / PRKCN contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second ...
TMPY-04406	Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST) protein kinase D2,nPKC-D2,PKD2,HSPC187	Human	Baculovirus Insect Cells
	Serine/threonine-protein kinase D2, also known as PRKD2 and PKD2, is a cytoplasm and membrane protein that belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family and PKD subfamily. PRKD2 / PKD2 is widely expressed. It contains one PH domain, two phorbol-ester/DAG-type zinc fingers and one protein kinase domain. PRKD2 / PKD2 is activated by DAG and phorbol esters. Phorbol-ester/DAG-type domains bind DAG, mediating translocation to membranes. Autophosphorylation of Ser-71 an...
TMPY-03495	MID1IP1 Protein, Human, Recombinant (His) MIG12,S14R,MID1 interacting protein 1,THRSPL,STRAIT11499,G12...	Human	E. coli
	MID1IP1 (MID1 Interacting Protein 1) is a Protein Coding gene. The encoded protein belongs to the SPOT14 family. It is a homodimer in the absence of THRSP. MID1IP1 interacts with ACACA and ACACB. Its interaction with THRSP interferes with ACACA binding. It up-regulates ACACA enzyme activity and plays a role in the regulation of lipogenesis in the liver. MID1IP1 is required for efficient lipid biosynthesis, including triacylglycerol, diacylglycerol, and phospholipid. MID1IP1 is involved in the st...
TMPJ-01074	PKCE Protein, Human, Recombinant (His) PRKCE,PKCE,nPKC-ε,nPKC-Epsilon,Protein Kinase C Epsilon Type...	Human	E. coli
	Protein Kinase C Epsilon type is a member of the serine- and threonine-specific protein kinase family that can be activated by calcium and the second messenger diacylglycerol. Protein Kinase C Epsilon contains these domains: one AGC-kinase C-terminal domain, one C2 domain, one protein kinase domain and two phorbol-ester/DAG-type zinc fingers. Protein Kinase C Epsilon phosphorylate a variety of protein targets and has been identified to participate in diverse cellular signaling pathways. It has m...

重组蛋白

DGKA Protein, Human, Recombinant (His)

Cat.No: TMPH-01222

Species: Human

Expression System: E. coli

Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His & SUMO)

Cat.No: TMPH-03003

Species: Mycobacterium tuberculosis

Expression System: E. coli

Ag85A Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03004

Species: Mycobacterium tuberculosis

Expression System: E. coli

Ag85C Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03007

Species: Mycobacterium tuberculosis

Expression System: E. coli

FbpB Protein, Mycobacterium kansasii, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02992

Species: Mycobacterium kansasii

Expression System: E. coli

Ag85B Protein, Mycobacterium tuberculosis, Recombinant (His)

Cat.No: TMPH-03006

Species: Mycobacterium tuberculosis

Expression System: P. pastoris (Yeast)

Ag85B Protein, Mycobacterium tuberculosis, Recombinant (E. coli, His)

Cat.No: TMPH-03005

Species: Mycobacterium tuberculosis

Expression System: E. coli

SNTG1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01365

Species: Human

Expression System: E. coli

IMPA1 Protein, Human, Recombinant (His)

Cat.No: TMPY-02394

Species: Human

Expression System: E. coli

PKC nu Protein, Human, Recombinant (GST)

Cat.No: TMPY-04456

Species: Human

Expression System: Baculovirus Insect Cells

Protein Kinase D2/PRKD2 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04406

Species: Human

Expression System: Baculovirus Insect Cells

MID1IP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03495

Species: Human

Expression System: E. coli

PKCE Protein, Human, Recombinant (His)

Cat.No: TMPJ-01074

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T37044	1,2-Dioleoyl-rac-glycerol-13C3 1,2-Dioleoyl-rac-glycerol-13C3
	1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3 \|1. Yamaguchi, Y., Shirai, Y., Matsubara, T., et al. Phosphorylation and up-reg...
T70882	Orlistat-d3
	Orlistat-d3 is intended for use as an internal standard for the quantification of orlistat by GC- or LC-MS. Orlistat is a digestive lipase inhibitor. It inhibits diacylglycerol lipase α (DAGLα), DAGLβ, α/β-hydrolase domain-containing protein 12 (ABHD12), ABHD16A, and platelet-activating factor acetylhydrolase (PAF-AH; IC50s = 0.06, 0.1, 0.08, 0.03, and 0.05 µM, respectively), as well as pancreatic lipase and hormone-sensitive lipase (IC50s = 0.65 and 2.1 µg/ml, respectively) but does not inhibit...

同位素标记化合物

1,2-Dioleoyl-rac-glycerol-13C3

Cat.No: T37044

Synonym: 1,2-Dioleoyl-rac-glycerol-13C3

Cat.No: T70882

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