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Search Results for " deregulation "

Targets Recommended: Apoptosis CDK

3

抑制剂 & 化合物

5

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T10898	Samuraciclib hydrochloride ICEC0942 hydrochloride,CT7001 hydrochloride	Apoptosis; CDK	Apoptosis; Cell Cycle/Checkpoint
	Samuraciclib hydrochloride (ICEC0942 hydrochloride) 是一种具有选择性，ATP 竞争性和口服活性的CDK7抑制剂，IC50为 41 nM。它以 GI50值为 0.2-0.3 µM 来抑制乳腺癌细胞系的生长，具有抗肿瘤作用。
T41240	Verrucarin A	Others	Others
	Verrucarin A (Muconomycin A) 是一种 D 型大环真菌毒素。Verrucarin A 是一种蛋白质合成 (protein synthesis) 的抑制剂，来源于Myrothecium verrucaria，可抑制白血病细胞系生长，并激活巨噬细胞 caspases、凋亡和炎症信号。Verrucarin A 能有效提高 p38 MAPK 的磷酸化，降低 ERK/Akt 的磷酸化。Verrucarin A 通过 p21 和 p53 的诱导引起细胞周期调控的解除。
T37679	3-hydroxy Palmitic Acid	Others	Others
	3-hydroxy Palmitic acid is a form of the 16:0 lipid palmitic acid . The lipid A part of lipopolysaccharides contain various 3-hydroxy fatty acids, making oxylipins such as 3-hydroxy palmitic acid useful as chemical markers of endotoxins. In R. solanacearum, 3-hydroxy palmitic acid is converted by an S-adenosyl methionine-dependent methyltransferase to 3-hydroxy palmitic acid methyl ester, which acts as a quorum sensing signal molecule for post-transcriptional modulation of genes involved in viru...

化合物

Samuraciclib hydrochloride

Cat.No: T10898

Synonym: ICEC0942 hydrochloride,CT7001 hydrochloride

Target: Apoptosis, CDK

Cat.No: T41240

Target: Others

3-hydroxy Palmitic Acid

Cat.No: T37679

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPK-01170	Hepcidin/HAMP Protein, Mouse, Recombinant (GST) Hamp1,LEAP-1,PLTR,HFE2B,LEAP1,Hepc1,Hepc	Mouse	E. coli
	Hepcidin, the main regulator of iron metabolism, is synthesized and released by hepatocytes in response to increased body iron concentration and inflammation. Deregulation of hepcidin expression is a common feature of genetic and acquired iron disorders: in Hereditary Hemochromatosis (HH) and iron-loading anemias low hepcidin causes iron overload, while in Iron Refractory Iron Deficiency Anemia (IRIDA) and anemia of inflammation (AI), high hepcidin levels induce iron-restricted erythropoiesis.
TMPJ-01425	SARS-CoV-2 NSP1 Protein (His) SARS-CoV 2 nsp1,SARS-CoV 2 Leader protein	SARS-CoV-2	E. coli
	The Severe Acute Respiratory Syndrome (SARS) Coronavirus (CoV) is an enveloped, positive-stranded RNA viruses that can cause a severe respiratory disease. Its genome consists of a ∼30 kb linear, non-segmented, capped, polycistronic, polyadenylated RNA molecule, the first two-third of which is directly translated into two large polyproteins. These two polypeptides are processed into 16 non-structural proteins (nsps), forming the replicase complex, which is active in the cytoplasm in close associa...
TMPY-00990	Lefty-A Protein, Human, Recombinant (hFc) LEFTYA,left-right determination factor 2,LEFTA,TGFB4,EBAF	Human	HEK293 Cells
	left-right determination factor 2 (Lefty2), also known as Left-right determination factor A (Lefty A), endometrial bleeding associated factor (left-right determination, factor A transforming growth factor-beta superfamily), and transforming growth factor beta-4, is a member of the TGF-beta family of proteins. This protein is secreted and plays a role in left-right asymmetry determination of organ systems during development. Lefty2/Lefty A may also play a role in endometrial bleeding. Mutations i...
TMPY-00918	SFRP1 Protein, Human, Recombinant (His) SARP2,secreted frizzled-related protein 1,FRP-1,FRP1,FRP,Frz...	Human	HEK293 Cells
	Secreted frizzled-related protein 1, also known as sFRP1, is a 35 kDa prototypical member of the SFRP family. SFRP family consists of five secreted glycoproteins in humans acting as extracellular signaling ligands. Each is approximately 3 amino acids in length and contains a cysteine-rich domain (CRD) that shares 3-5% sequence homology with the CRD of Frizzled (Fz) receptors, a putative signal sequence, and a conserved hydrophilic carboxy-terminal domain. SFRPs act as soluble modulators of Wnt s...
TMPY-04558	NEK7 Protein, Human, Recombinant (His & GST) NIMA-related kinase 7	Human	Baculovirus Insect Cells
	NIMA (never in mitosis gene a)-related kinase 7, NEK7 belongs to the NIMA subfamily, NEK Ser/Thr protein kinase family, protein kinase superfamily. NEKs (NIMA-related kinases) are mammalian serine/threonine (Ser/Thr) protein kinases structurally related to Aspergillus NIMA (Never in Mitosis, gene A), which plays essential roles in mitotic signaling. NEKs share an amino-terminal catalytic domain related to NIMA, an Aspergillus kinase involved in the control of several aspects of mitosis, and dive...

重组蛋白

Hepcidin/HAMP Protein, Mouse, Recombinant (GST)

Cat.No: TMPK-01170

Species: Mouse

Expression System: E. coli

SARS-CoV-2 NSP1 Protein (His)

Cat.No: TMPJ-01425

Species: SARS-CoV-2

Expression System: E. coli

Lefty-A Protein, Human, Recombinant (hFc)

Cat.No: TMPY-00990

Species: Human

Expression System: HEK293 Cells

SFRP1 Protein, Human, Recombinant (His)

Cat.No: TMPY-00918

Species: Human

Expression System: HEK293 Cells

NEK7 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04558

Species: Human

Expression System: Baculovirus Insect Cells

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