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Search Results for " chemotherapy-induced "

Targets Recommended: Neurokinin receptor

20

抑制剂 & 化合物

3

天然产物

5

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T1790	Fosaprepitant dimeglumine 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。
T68068L	(R)-CJ 11974	Neurokinin receptor	GPCR/G Protein; Neuroscience

T10244	ACY-1083	HDAC	Chromatin/Epigenetic; DNA Damage/DNA Repair
	ACY-1083 是一种选择性和脑穿透性 HDAC6 抑制剂 (IC50：3 nM)，可有效逆转化疗引起的周围神经病变。
T79303	IACS-52825	Others	Others
	IACS-52825是一种选择性DLK抑制剂，具有1.3 nM的Kd值，适用于研究化疗引起的周围神经病变。
T0776	Phenothiazine ENT 38,吩噻嗪	Dopamine Receptor; Antibacterial; Antibiotic; Antifungal	GPCR/G Protein; Microbiology/Virology; Neuroscience
	Phenothiazine (ENT 38) 是一种抗生素，具有杀虫，抗菌，驱虫和杀真菌活性。它也可研究神经系统疾病。
T3716	Rolapitant 罗拉吡坦,SCH619734,罗拉匹坦	Neurokinin receptor	GPCR/G Protein; Neuroscience
	Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂，Ki 值为0.66 nM。
T2589	Dolasetron Mesylate hydrate Dalasetron Mesylate Hydrate,多拉司琼甲磺酸盐一水合物	5-HT Receptor	GPCR/G Protein; Neuroscience
	Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) 是一种选择性血清素受体拮抗剂，可竞争性阻断血清素对 5HT3 受体的作用，从而抑制化疗和放疗引起的恶心和呕吐。
T9955	EX-A5758	NOS	Immunology/Inflammation
	EX-A5758是一种新型推定的小分子 nNOS-NOS1 AP 抑制剂，可抑制炎症性伤害感受和化疗引起的神经性疼痛，并与紫杉醇协同降低肿瘤细胞活力
T22393	Palonosetron RS25259,帕洛诺司琼,RS 25259 197	5-HT Receptor	GPCR/G Protein; Neuroscience
	Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).
T68371	Rolapitant hydrochloride hydrate	Others	Others
	Rolapitant, also known as SCH-619734, is an orally bioavailable, centrally-acting, selective, neurokinin 1 receptor (NK1-receptor) antagonist with potential antiemetic activity. Upon oral administration, rolapitant competitively binds to and blocks the activity of the NK1-receptor in the central nervous system, thereby inhibiting the binding of the endogenous ligand, substance P (SP). This may prevent both SP-induced emesis and chemotherapy-induced nausea and vomiting (CINV). The interaction of ...
T38692	Fabesetron 法贝司琼,FK1052 free base	Others	Others
	Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for managing both acute and delayed symptoms.
T72820	(R)-Casopitant (R)-GW679769	Others	Others
	(R)-Casopitant ((R)-GW679769) 是Casopitant 的异构体。Casopitant 是一种 NK(1)-受体拮抗剂。Casopitant 可用于化疗引起的恶心和呕吐的研究。
T82475	Emfilermin
	Emfilermin，一种重组人白血病抑制因子 (LIF)，适用于研究化疗引发的周围神经病变。
T81424	Polysaccharidase Tremella polysaccharide	Others	Others
	Polysaccharidase (Tremella polysaccharide) 是一种提升免疫功能的真菌多糖。该化合物展现出治疗化疗和放疗导致的白细胞减少症的研究潜力。
T72184	Ac-Tyr-Val-Lys-Asp-aldehyde
	Ac-Tyr-Val-Lys-Asp-aldehyde，一种caspase-1抑制剂，适用于慢性疾病相关贫血、化疗诱导贫血及钻石黑扇贫血的研究。
T60305	ZLc-002	Others	Others
	ZLc-002 是一种选择性的 nNOS-Capon 偶联小分子抑制剂。ZLc-002 抑制炎症和化疗引起的神经性疼痛。ZLc-002 可用于焦虑和炎症研究。
T72866	(Rac)-ZLc-002	Others	Others
	(Rac)-ZLc-002 是nNOS 与一氧化氮合酶 1 衔接蛋白 (NOS1AP) 相互作用的抑制剂，抑制炎症性痛觉和化疗诱导的神经性疼痛，并与 Paclitaxel 协同降低肿瘤细胞活力。
T72623	Nampt activator-3	Others	Others
	NAMPTactivator-3 是一种 NAT 衍生物，是一种 NAMPT 激活剂，EC50为 2.6 μM，KD 为 132 nM。NAMPTactivator-3 有效保护培养细胞免受 FK866 介导的毒性。NAMPTactivator-3 在化疗引起的周围神经病变 (CIPN) 小鼠模型中表现出强大的神经保护功效，没有任何明显的毒性。
T65440	Sodium Thiosulfate Pentahydrate	Others	Others
	Sodium thiosulfate (Pentahydrate) is an antioxidant and antifungal. Sodium thiosulfate protects against cisplatin-induced hearing loss in children and is not associated with serious adverse events attributed to its use[3]. The addition of sodium thiosulfate, administered 6 hours after cisplatin chemotherapy, resulted in a lower incidence of cisplatin-induced hearing loss among children with standard-risk hepatoblastoma, without jeopardizing overall or event-free survival[4]. Calciphylaxis is a p...
T36521	Alaproclate (hydrochloride)	Others	Others
	Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentratio...

化合物

Fosaprepitant dimeglumine

Cat.No: T1790

Synonym: 福沙匹坦二甲葡胺,L785298,福沙吡坦二甲葡胺,MK-0517,Fosaprepitant dimeglumine salt

Target: Neurokinin receptor

Cat.No: T68068L

Target: Neurokinin receptor

Cat.No: T10244

Target: HDAC

Cat.No: T79303

Target: Others

Cat.No: T0776

Synonym: ENT 38,吩噻嗪

Target: Dopamine Receptor, Antibacterial, Antibiotic, Antifungal

Cat.No: T3716

Synonym: 罗拉吡坦,SCH619734,罗拉匹坦

Target: Neurokinin receptor

Dolasetron Mesylate hydrate

Cat.No: T2589

Synonym: Dalasetron Mesylate Hydrate,多拉司琼甲磺酸盐一水合物

Target: 5-HT Receptor

Cat.No: T9955

Target: NOS

Cat.No: T22393

Synonym: RS25259,帕洛诺司琼,RS 25259 197

Target: 5-HT Receptor

Rolapitant hydrochloride hydrate

Cat.No: T68371

Target: Others

Cat.No: T38692

Synonym: 法贝司琼,FK1052 free base

Target: Others

Cat.No: T72820

Synonym: (R)-GW679769

Target: Others

Cat.No: T82475

Polysaccharidase

Cat.No: T81424

Synonym: Tremella polysaccharide

Target: Others

Ac-Tyr-Val-Lys-Asp-aldehyde

Cat.No: T72184

Cat.No: T60305

Target: Others

Cat.No: T72866

Target: Others

Nampt activator-3

Cat.No: T72623

Target: Others

Sodium Thiosulfate Pentahydrate

Cat.No: T65440

Target: Others

Alaproclate (hydrochloride)

Cat.No: T36521

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T1156	Palonosetron hydrochloride 盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259	5-HT Receptor	GPCR/G Protein; Neuroscience
	Palonosetron hydrochloride (RS 25259) 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。
T1285	Anethole trithione 茴三硫,Anetholtrithion	Others; AChR	Neuroscience; Others
	Anethole trithione (Anetholtrithion) 是硫杂环胆碱，是一种胆汁分泌刺激剂，可增强唾液分泌并增加 mAChR 受体，用于口干症的研究。
T2563	Acetyl-L-carnitine hydrochloride Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。

天然产物

Palonosetron hydrochloride

Cat.No: T1156

Synonym: 盐酸帕洛诺司琼,RS 25259 197,Palonosetron HCl,RS 25259

Target: 5-HT Receptor

Anethole trithione

Cat.No: T1285

Synonym: 茴三硫,Anetholtrithion

Target: Others, AChR

Acetyl-L-carnitine hydrochloride

Cat.No: T2563

Synonym: Acetyl L-carnitine hydrochloride,O-Acetylcarnitine,乙酰-L-肉(毒)碱盐酸盐,O-acetyl-L-carnitine,O-Acetyl-L-carnitine hydrochloride

Target: Others, Endogenous Metabolite

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-04830	GAS6 Protein, Mouse, Recombinant (His) growth arrest-specific 6,Gas-6	Mouse	HEK293 Cells
	The growth arrest-specific 6 gene (GAS6) is a member of the family of plasma vitamin K-dependent proteins, which are able to bind to phospholipids using an N-terminal gamma-carboxyglutamic acid domain. GAS6 is a vitamin K-dependent protein, plays a role in the survival, proliferation, migration, differentiation, adhesion, and apoptosis of cells. The growth arrest-specific 6 (GAS6) has been implicated in systemic inflammation and coagulation. Growth arrest-specific 6 (GAS6), plays a role in tumor...
TMPJ-00561	SDC2 Protein, Human, Recombinant (His) CD362,SDC2,HSPG,HSPG1,Syndecan-2,SYND2,Heparan Sulfate Prote...	Human	HEK293 Cells
	Syndecan-2 is a member of the Syndecans family comprised of type I transmembrane heparan sulfate proteoglycans (HSPG) that are involved in the regulation of many cellular processes. Four sub-types of mammalian Syndecans have been reported and among them. Syndecan-2 plays a role in the cancer development. It can affect the basal and chemotherapy-induced apoptosis in osteosarcoma. It can also suppress MMP2 activation, suppressing metastasis.
TMPY-01118	SLC27A4/FATP4 Protein, Human, Recombinant (His) FATP4,IPS,solute carrier family 27 (fatty acid transporter),...	Human	HEK293 Cells
	SLC27A4/ATG4B complex might act as a new potential therapeutic target of lung tumor chemotherapy. The solute carrier 27A (SLC27A) gene family encodes fatty acid transport proteins (FATPs) and includes 6 members. Autism spectrum disorders (ASD) are now recognized as disorders caused by impaired early brain development, it is possible that functional abnormalities of SLC27A genes may contribute to the pathogenesis of ASD. The expression of SLC27A3 and SLC27A4 in human neural stem cells derived fro...
TMPJ-00079	IL-11 Protein, Mouse, Recombinant (hFc) IL-11,Il11,白细胞介素,白介素,Interleukin-11	Mouse	HEK293 Cells
	Interleukin-11(IL-11) is a secreted protein and belongs to the IL-6 superfamily. IL-11 has been demonstrated to improve platelet recovery after chemotherapy-induced thrombocytopenia, induceacute phase proteins, modulate antigen-antibody responses, participate in the regulation of bone cellproliferation and differentiation and could be use as a therapeutic for osteoporosis. IL-11 stimulates the growth of certain lymphocytes and, in the murine model, stimulates an increase in the cortical thicknes...
TMPY-01865	BLMH Protein, Mouse, Recombinant (His) Bh,bleomycin hydrolase,Bmh,AI035728	Mouse	E. coli
	The papain superfamily member bleomycin hydrolase (BLMH) is a cytoplasmic cysteine peptidase that is highly conserved through evolution. The only known activity of the enzyme is metabolic inactivation of the glycopeptide bleomycin (BLM), an essential component of combination chemotherapy regimens for cancer. The papain superfamily member bleomycin hydrolase (BLMH) is a neutral cysteine protease with structural similarity to a 20S proteasome. Bleomycin (BLM), a clinically used glycopeptide antica...

重组蛋白

GAS6 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-04830

Species: Mouse

Expression System: HEK293 Cells

SDC2 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00561

Species: Human

Expression System: HEK293 Cells

SLC27A4/FATP4 Protein, Human, Recombinant (His)

Cat.No: TMPY-01118

Species: Human

Expression System: HEK293 Cells

IL-11 Protein, Mouse, Recombinant (hFc)

Cat.No: TMPJ-00079

Species: Mouse

Expression System: HEK293 Cells

BLMH Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01865

Species: Mouse

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
TMIJ-0144	Palonosetron-d3 HCl
	Palonosetron-d3 HCl 是 Palonosetron HCl 的氘代化合物。Palonosetron HCl 的 CAS 号为 135729-62-3。Palonosetron hydrochloride 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。

同位素标记化合物

Palonosetron-d3 HCl

Cat.No: TMIJ-0144

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