chemotherapy-induced

Fosaprepitant dimeglumine (MK-0517) 是 Aprepitant 的前药。它是一种神经激肽 1 受体拮抗剂，可用于预防化疗引起的恶心呕吐。

ACY-1083属于小分子抑制剂，是一种高选择性HDAC6抑制剂（IC50=3 nM）,选择性比其他类别的 HDAC 亚型高 260 倍，具有脑穿透性，用于化疗引起的周围神经病变研究.

Phenothiazine (ENT 38) 是一种抗生素，具有杀虫，抗菌，驱虫和杀真菌活性。它也可研究神经系统疾病。

Palonosetron hydrochloride (RS 25259) 是一种 5-HT3 拮抗剂，用于预防和治疗化疗引起的恶心和呕吐。

Anethole trithione (Anetholtrithion) 是硫杂环胆碱，是一种胆汁分泌刺激剂，可增强唾液分泌并增加 mAChR 受体，用于口干症的研究。

Acetyl-L-carnitine hydrochloride (Acetyl L-carnitine hydrochloride) 是一种由内源性左旋肉碱的乙酰化形式的盐酸盐组成的营养补充剂，具有潜在的神经保护、认知增强、抗抑郁和免疫调节活性。还可缓解化疗、糖尿病或其他疾病引起的周围神经病变。此外，乙酰左旋肉碱可能通过增加T淋巴细胞成熟来调节免疫反应，并可能下调促炎细胞因子对病毒(如SARS-CoV-2)的反应。它还可能破坏ACE2信号通路并抑制活性氧(ROS)的产生。

KLS-13019是一种高效和具有口服活性的GPR55受体拮抗剂，是大麻二酚 (CBD) 衍生的神经保护剂，可以逆转化疗诱导的外周神经疼痛 (CIPN)，可用于研究肝性脑病（HE）。

EX-A5758是一种新型推定的小分子 nNOS-NOS1 AP 抑制剂，可抑制炎症性伤害感受和化疗引起的神经性疼痛，并与紫杉醇协同降低肿瘤细胞活力

Trilaciclib是一种短效和口服有效的CDK4/6抑制剂，IC50值分别为1 nM和4 nM，能够短暂和可逆地诱导G1细胞周期阻滞，减轻化疗产生的骨髓抑制和增强抗肿瘤免疫，可用于多种癌症。

(R,R)-Palonosetron Hydrochloride is the active enantiomer of Palonosetron

PF-477736, 亦称为PF-00477736，是一种有效的CHK1抑制剂，具有潜在的化疗增效活性。该化合物通过抑制chk1——一种ATP依赖的丝氨酸-苏氨酸激酶，该激酶是DNA复制监控的S/G2检查点系统的关键组成部分。通过绕过对DNA损伤剂诱导的致命损伤的最后检查点防御，PF-477736可能增强对具有内在检查点缺陷的肿瘤细胞的各种化疗化合物的抗肿瘤效果。

Casopitant (GW679769) 是一种口服有效的神经激肽-1 (NK1) 受体拮抗剂，用于研究化疗引起的恶心和呕吐 (CINV) 以及术后恶心和呕吐 (PONV)。

Mangafodipir 是一种肝细胞特异性造影剂，也被视作CIPN (化疗诱导的周围神经通路)及其他由细胞氧化应激引起的条件抑制剂。Mangafodipir 对化疗的肿瘤杀伤作用不产生负面影响。

TrkA Inhibitor (Compound 18) 是一种具有0.69 μM IC50的CDK2抑制剂，并在抑制效力上优于CDK1。TrkA Inhibitor可用于化疗引起的脱发研究。

MU876 (Compound 32) 是一种 MUS81 抑制剂，IC50 为 0.5 μM。它有效抑制 MUS81 依赖的同源重组 (HR) 和断裂诱导复制 (BIR) 途径，并通过降低癌细胞修复 DNA 损伤的能力，提高其对 Cisplatin 等 DNA 损伤剂的敏感性。MU876 适用于癌症化疗研究。

Axl-IN-21 是一种选择性口服AXL抑制剂，具有Kd值2.7 nM 和IC50值4.0 nM。除了保持激酶的选择性外，它还能有效抑制多种癌症相关激酶，如Mer (Kd= 1.4 nM)、DDR1 (IC50= 22.2 nM)、HIPK4 (Kd= 11.0 nM) 和LOK (Kd= 10 nM)。Axl-IN-21 通过阻断由肿瘤相关成纤维细胞产生的GAS6诱导的AXL/STAT3/ABCG1信号通路，克服肿瘤微环境引发的耐药性，从而恢复化疗药物的敏感性并抑制药物的外排。在MDA-MB-231细胞中，Axl-IN-21 能够抑制由TGF-β1诱导的上皮-间质转化、细胞迁移和侵袭。Axl-IN-21 在非癌细胞中未显示出显著的毒性，适用于研究三阴性乳腺癌和胃癌。

Carba1 是一种具备双重功能的 Carbazole 衍生物，其作用包括激活烟酰胺磷酸核糖转酶 (NAMPT) 以促进 NAD 的合成。Carba1 能与微管蛋白 (tubulin) 上的秋水仙碱结合位点结合，从而提升如 Paclitaxel 等多种化疗药物的抗肿瘤效果。此外，Carba1 具有神经保护特性，并能调节细胞能量代谢。Carba1 适用于癌症研究及化疗诱导的周围神经病变 (CIPN) 的研究。

Dolasetron Mesylate (MDL-73147EF) 是 5-HT3 受体的拮抗剂，可用于治疗化疗后呕吐和恶心的研究。

Palonosetron, a 5-HT3 antagonist with Ki of 0.17 nM, is used in the prevention and treatment of chemotherapy-induced nausea and vomiting (CINV).

Dolasetron Mesylate hydrate (Dalasetron Mesylate Hydrate) 是一种选择性血清素受体拮抗剂，可竞争性阻断血清素对 5HT3 受体的作用，从而抑制化疗和放疗引起的恶心和呕吐。

Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentrations up to 100 μM.2 It increases sirtuin 1 (SIRT1) levels in N2a murine neuroblastoma cells expressing apolipoprotein E4 (ApoE4; IC50 = 2.3 μM) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer's disease when administered at a dose of 20 mg/kg twice daily.3 Alaproclate (40 mg/kg) decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.4References1. Michael, G.B., Eidam, C., Kadlec, K., et al. Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica. Journal of Antimicrobial Chemotherapy 67(6), 1555-1557 (2012).2. Svensson, B.E., Werkman, T.R., and Rogawski, M.A. Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: Studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA. Neuropharmacology 33(6), 795-804 (1994).3. Campagna, J., Soilman, P., Jagodzinska, B., et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci. Rep. 8(1), 17574 (2018).4. Danysz, W.P., A., Kostowski, W., Malatynska, E., et al. Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs. Pharmacol. Toxicol. 62(1), 42-50 (1988). Alaproclate is a selective serotonin reuptake inhibitor (SSRI).1,2 It inhibits depletion of serotonin (5-HT) induced by 4-methyl-α-ethyl-m-tyramine in rat cerebral cortex, hippocampus, hypothalamus, and striatum (EC50s = 18, 4, 8, and 12 mg/kg, respectively).1 Alaproclate inhibits NMDA-evoked currents and depolarization-induced voltage-dependent potassium currents in rat hippocampal neurons (IC50s = 1.1 and 6.9 μM, respectively) and does not inhibit GABA-evoked currents when used at concentrations up to 100 μM.2 It increases sirtuin 1 (SIRT1) levels in N2a murine neuroblastoma cells expressing apolipoprotein E4 (ApoE4; IC50 = 2.3 μM) and in the hippocampus in the FXFAD-ApoE4 transgenic mouse model of Alzheimer's disease when administered at a dose of 20 mg/kg twice daily.3 Alaproclate (40 mg/kg) decreases immobility time in the forced swim test in rats, indicating antidepressant-like activity.4 References1. Michael, G.B., Eidam, C., Kadlec, K., et al. Increased MICs of gamithromycin and tildipirosin in the presence of the genes erm(42) and msr(E)-mph(E) for bovine Pasteurella multocida and Mannheimia haemolytica. Journal of Antimicrobial Chemotherapy 67(6), 1555-1557 (2012).2. Svensson, B.E., Werkman, T.R., and Rogawski, M.A. Alaproclate effects on voltage-dependent K+ channels and NMDA receptors: Studies in cultured rat hippocampal neurons and fibroblast cells transformed with Kv1.2 K+ channel cDNA. Neuropharmacology 33(6), 795-804 (1994).3. Campagna, J., Soilman, P., Jagodzinska, B., et al. A small molecule ApoE4-targeted therapeutic candidate that normalizes sirtuin 1 levels and improves cognition in an Alzheimer's disease mouse model. Sci. Rep. 8(1), 17574 (2018).4. Danysz, W.P., A., Kostowski, W., Malatynska, E., et al. Comparison of desipramine, amitriptyline, zimeldine and alaproclate in six animal models used to investigate antidepressant drugs. Pharmacol. Toxicol. 62(1), 42-50 (1988).

Rolapitant (SCH619734) 是一种高效选择性具有口服活性的神经激肽 1 受体抑制剂，Ki 值为0.66 nM。

(±)14(15)-EpETE是一种含有环氧基团的二十碳四烯酸衍生物，是肠道微生物脂质代谢物，通过靶向GCG/PKA信号抑制Substance P释放减轻大鼠顺铂化疗诱导的恶心和呕吐，通常用于研究炎症和代谢。

Fabesetron (FK1052) is an orally active compound that acts as a dual antagonist, targeting both the 5-HT3 and 5-HT4 receptors. It exhibits efficacy in studying emesis induced by cancer chemotherapy, showing potential for managing both acute and delayed symptoms.