107
6
1
16
4
Cat. No. | Product Name | ||
---|---|---|---|
L2194 | 抗结直肠癌化合物库 | 1545 compounds | |
1545 种与结直肠癌相关的化合物,可以用于高通量和高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T22437 |
Tazofelone
LY-213829 |
Others | Others |
Tazofelone (LY-213829) 是环氧合酶-II (COX-II) 抑制剂。在 CYP3A 介导下,Tazofelone 可转化为亚砜和喹啉代谢物,可用于研究炎症性肠病。 | |||
T1460 |
Dicyclomine hydrochloride
|
AChR | Neuroscience |
Dicyclomine hydrochloride 是口服活性毒蕈碱胆碱能受体拮抗剂。它是一种抗痉挛试剂,在体内可缓解胃肠道平滑肌痉挛。它对 M1 受体亚型和 M2 受体亚型,Ki 分别为5.1和54.6nM,在刷状缘膜和基底质膜中均表现出较高的亲和力。 | |||
T5491 |
GSK3179106
|
c-RET | Apoptosis; Tyrosine Kinase/Adaptors |
GSK3179106 是选择性的、具有口服活性的RET 激酶抑制剂,对人和大鼠 RET 的 IC50 分别为 0.4 nM 和 0.2 nM。它能够减轻炎症后和应激引起的内脏超敏反应,对肠易激综合征具有潜在的应用价值。 | |||
T1752 |
NS6180
|
Potassium Channel | Membrane transporter/Ion channel |
NS6180是一种高效的KCa3.1离子通道选择性抑制剂,IC50值9nM。NS6180阻止T 细胞活化和炎症反应。 | |||
T64336 |
Izilendustat
|
HIF/HIF Prolyl-Hydroxylase | Chromatin/Epigenetic; Metabolism |
tert-butyl 4-[[1-[(4-chlorophenyl)methyl]-3-hydroxy-2-oxopyridin-4-yl]methyl]piperazine-1-carboxylate 是一种脯氨酰羟化酶抑制剂。 | |||
T4084 |
Sibofimloc
VRT-1353385,Antibiotic-202,Antibiotic 202 |
Antibacterial; Antibiotic | Microbiology/Virology |
Sibofimloc (Antibiotic-202) 是一种肠道限制性的,具有口服活性的 FimH 粘附抑制剂,有抗细菌感染活性,被开发用于治疗炎症性肠病的研究。 | |||
T11179 |
Elubrixin
SB-656933 |
IL Receptor; CXCR | Autophagy; GPCR/G Protein; Immunology/Inflammation |
Elubrixin (SB-656933) 是一种有效和特异性的 CXCR2 和 IL-8 受体拮抗剂。 Elubrixin 可用于炎症性疾病的研究,例如炎症性肠病和气道炎症。 | |||
T64337 |
PF-04745637
PF4745637,PF 4745637,PF 04745637,PF-4745637 |
TRP/TRPV Channel | Membrane transporter/Ion channel |
PF-04745637 是TRPA1的选择性拮抗剂,对人 TRPA1 的IC50为 17 nM。 | |||
T22338 |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide
GDC046 |
Others; JAK | Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Others; Stem Cells |
2,6-Dichloro-N-(2-(cyclopropanecarboxamido)pyridin-4-yl)benzamide (GDC046) 是一种具有口服活性的选择性TYK2抑制剂,对 TYK2、JAK1、JAK2 和 JAK3 的Ki 分别为 4.8、0.7、0.7 和 0.4 nM。 | |||
T1006 |
Propantheline bromide
Neopepulsan,溴丙胺太林,Pro-Banthine,Neometantyl |
AChR | Neuroscience |
Propantheline bromide (Pro-Banthine) 是一种抗毒蕈碱剂,用于研究多汗症,遗尿,胃肠和膀胱痉挛。 | |||
T17225 |
Vercirnon
CCX282-B,维塞诺,GSK-1605786,Traficet-EN |
CCR | Immunology/Inflammation; Microbiology/Virology |
Vercirnon (Traficet-EN) 是可口服的选择性 CCR9拮抗剂,可抑制 CCR9 介导的 Molt-4 细胞上 Ca2+移动和趋化性,用于炎症性肠病的研究。 | |||
T2601 |
Vidofludimus
SC12267,4sc-101 |
Dehydrogenase; DNA/RNA Synthesis; Interleukin | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism |
Vidofludimus (SC12267) 是一种新型的二氢乳清酸脱氢酶 (DHODH) 小分子抑制剂,可在不影响淋巴细胞增殖的条件下抑制IL-17的分泌。 | |||
T4691 |
Asimadoline hydrochloride
EMD-61753 hydrochloride,阿西马朵林盐酸盐 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Asimadoline hydrochloride (EMD-61753 hydrochloride) 是一种 κ-阿片(κ-opioid)受体激动剂,对豚鼠和人重组 κ-opioid 的 IC50值分别为 5.6 和 1.2 nM。它可改善糖尿病大鼠的异常性疼痛,具有外周抗炎作用,并有用于肠易激综合征的研究潜力。 | |||
T13385 |
Zamifenacin fumarate
扎非那星富马酸盐,UK-76654 fumarate |
AChR | Neuroscience |
Zamifenacin fumarate (UK-76654 fumarate) 是肠道选择性毒蕈碱M3受体的有效拮抗剂, 可显著降低肠易激综合症的结肠蠕动。 | |||
T1551 |
Tegaserod maleate
HTF-919,马来酸替加色罗,SDZ-HTF-919 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Tegaserod maleate (SDZ-HTF-919) 是选择性5-HT4受体的部分激动剂和5-HT2B 受体的拮抗剂,用于治疗肠易激综合征和便秘。 | |||
T4633 |
Asimadoline
EMD-61753,阿西马朵林 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Asimadoline (EMD-61753) 是一种 κ-阿片(κ-opioid)受体激动剂,对豚鼠和人重组 κ-opioid 的IC50值分别为 5.6 和 1.2 nM。它可改善糖尿病大鼠的异常性疼痛,具有外周抗炎作用,并有用于肠易激综合征的研究潜力。 | |||
T24997 |
ABT-510 acetate
ABT 510 acetate |
Apoptosis | Apoptosis |
ABT-510 acetate 是一种内源性抗血管生成的 TSP 肽抑制剂,是一种凝血酶原类似物,具有抗炎抗癌和抗血管生成活性,能诱导肿瘤细胞凋亡并抑制上皮性卵巢癌正位、同种异体模型中的卵巢肿瘤生长。ABT-510 acetate 可减少小鼠炎症性肠病模型的血管生成和炎症反应,可用于癌症 (尤其是上皮性卵巢癌) 以及炎症性肠病 (IBD) 的研究。 | |||
T27138 |
Declopramide
OXI-104,IMO-B,3-Chloroprocainamide |
Apoptosis | Apoptosis |
Declopramide (OXI-104) 是新型化学增敏剂,具有抗肿瘤活性,可诱导细胞凋亡,可用于研究结直肠癌和炎症性肠病。 | |||
T14551 |
Bevenopran
CB-5945,ADL-5945 |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Bevenopran (CB-5945) is a peripheral antagonist of μ-opioid receptor and can be used in studies about the treatment of opioid-induced bowel dysfunction. | |||
T4319 |
Hispidol
(Z)-Hispidol |
TNF | Apoptosis |
Hispidol ((Z)-Hispidol) 是一种炎症性肠病的潜在治疗剂,可抑制 TNF-α 诱导的单核细胞与结肠上皮细胞的粘附,IC50 为 0.50 μM。 | |||
T0918 |
Trimebutine
曲美布汀,Mebutin |
Opioid Receptor | Endocrinology/Hormones; GPCR/G Protein; Neuroscience |
Trimebutine (Mebutin) 是阿片受体激动剂,有抗毒蕈碱活性。它是解痉剂,可调节肠道和结肠运动,并通过抗毒蕈碱和弱μ-阿片受体激动剂作用缓解腹痛。 | |||
T28698 |
SC-22716
SC 22716,SC22716 |
Aminopeptidase | Metabolism |
SC-22716 是一种具有口服活性的白三烯 A4(LTA4)水解酶抑制剂。SC-22716 具有潜在的抗炎活性,可用于研究炎症性肠病和银屑病。 | |||
T20615 |
Olsalazine
奥沙拉嗪,Dipentium,Salicylic acid |
Others | Others |
Olsalazine (Dipentium) 是一种抗炎药,用于治疗炎症性肠病。它也是一种新型的 DNA 去甲基化剂。 | |||
T4562L |
Ramosetron hydrochloride
盐酸雷莫司琼,YM 060,YM-060,YM060 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ramosetron hydrochloride (YM-060) 是一种 5-HT3 受体拮抗剂,用于治疗以腹泻为主的肠易激综合征和恶心。 | |||
T11492 |
GSK2983559 free acid
|
Others; RIP kinase | Apoptosis; NF-κB; Others |
GSK2983559 free acid 是一种有效的特异性受体相互作用蛋白 2 (RIP2) 抑制剂。 GSK2983559 free acid 在阻断人类炎症性肠病外植体样品和体内的许多促炎细胞因子反应方面表现出优异的活性。 | |||
T11852 |
Linaclotide
|
Guanylate cyclase | GPCR/G Protein |
Linaclotide 是一种有效的选择性鸟苷酸环化酶 C 激动剂,可用于治疗便秘型肠易激综合征 (IBS-C) 和慢性便秘的研究。 | |||
T28043L |
Minesapride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Minesapride是一种新型5-羟色胺4(5-HT4)受体部分激动剂,是一种潜在的胃肠道促动力剂,可用于治疗肠易激综合征伴便秘。 | |||
T5095 |
Oxazolone
4-乙氧基亚甲基-2-苯基-2-唑啉-5-酮,4-Ethoxymethylene-2-phenyl-2-oxazolin-5-one |
Others | Others |
Oxazolone 已被用作半抗原化剂,可在成年斑马鱼肠道组织中诱导炎症反应,并可用作两种形式的炎症性肠病(如克罗恩病和溃疡性结肠炎)的基因表达研究模型。 | |||
T14932L |
Ceruletide Ammonium acetate
FI-6934 Ammonium acetate,Caerulein Ammonium acetate,Ceruletide Ammonium acetate (17650-98-5 free base) |
cholecystokinin | GPCR/G Protein |
Ceruletide Ammonium acetate (FI-6934 Ammonium acetate) 是一种胆囊收缩素 (CCK) 受体激动剂。它是一种安全有效的胆囊动力剂和小肠和胰腺外分泌兴奋剂。 | |||
T22577 |
Antalarmin hydrochloride
|
CRFR; Immunology/Inflammation related | GPCR/G Protein; Immunology/Inflammation |
Antalarmin hydrochloride 是促肾上腺皮质激素释放因子 1 (CRF1) 的拮抗剂。 Antalarmin hydrochloride 具有抗炎作用并抑制与肠易激综合征相关的应激性胃溃疡。 | |||
T60145 |
CCR6 antagonist 1
|
CCR | Immunology/Inflammation; Microbiology/Virology |
CCR6 antagonist 1 是一种 CCR6 拮抗剂,可抑制 CCL20/CCR6 信号通路。 CCR6 antagonist 1 可用于自身免疫介导的炎症性疾病的研究,如炎症性肠病 (IBDs)。 | |||
T38507 |
Renzapride
BRL 24924 |
5-HT Receptor | GPCR/G Protein; Neuroscience |
Renzapride (BRL 24924) 是一种混合 5-羟色胺 4 型 (5-HT4) 激动剂和 5-HT3 受体拮抗剂。Renzapride 可用于研究以便秘为主的肠易激综合征(C-IBS)。 | |||
T6414 |
Bisacodyl
比沙可啶,Fenilaxan,Dulcolax,Brocalax |
Others | Others |
Bisacodyl (Fenilaxan) 是刺激性缓泻剂,可直接作用于结肠以产生排便。它能够直接激活结肠巨噬细胞来增加 PGE2的分泌。PGE2充当旁分泌因子并减少结肠中 AQP3 的表达,抑制水从腔向血管一侧的转移,进而产生通便作用。 | |||
T69984 |
Ticalopride
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ticalopride是一种5-HT3 receptor激动剂,可用于治疗消化系统疾病、口颌疾病、耳鼻咽喉疾病,可用于研究神经性贪食症、胃食管反流和肠易激综合征。 | |||
T60680 |
Tegaserod
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Tegaserod 是一种可口服的 5-HT4R 激动剂和 5-HT2B 受体拮抗剂,对多种5-羟色胺受体具有抑制作用。 Tegaserod 具有抗肿瘤活性,用于治疗肠易激综合征 (IBS)。 | |||
T12970 |
Solabegron
GW 427353,3'-[[2-[(2R)-2-(3-氯苯基)-2-羟基乙基]氨基]乙基]氨基]-[1,1'-联苯基]-3-羧酸 |
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
Solabegron (GW 427353) 是一种β3肾上腺素能受体 (β3-AR)的选择性激动剂, 在中国仓鼠卵巢细胞中测得 EC50=22 nM,可用于研究膀胱过度活跃和肠易激综合征。 | |||
T79600 |
Zharp2-1
|
RIP kinase | Apoptosis; NF-κB |
Zharp2-1是一种 RIPK2 抑制剂,抑制了 MDP 诱导或单核细胞增生李斯特菌感染诱导的炎症细胞因子的转录,缓解MDP诱导的小鼠腹膜炎症状,可用于研究炎症性肠病 (IBD)。 | |||
T9975 |
GPR183
3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide |
Others | Others |
GPR183 (3-(3,4-difluorophenyl)-N-[3-fluoro-5-(morpholin-4-yl)phenyl]propanamide) 是一种趋化受体,在 B 细胞中具有成熟作用,其内源性配体是氧甾醇 7α,25-二羟基胆固醇 (7α,25-OHC)。 GPR183 可用于炎症性肠病 (IBD) 的研究。 | |||
T0786 |
Clidinium bromide
克利溴铵,Ro 2-3773 |
AChR | Neuroscience |
Clidinium bromide (Ro 2-3773) 是季胺抗毒蕈碱剂,可通过减少胃酸和减慢肠道速度,缓解痉挛和腹部疼痛的症状。 | |||
T10865 |
Cot inhibitor-1
|
TNF; MAPK | Apoptosis; MAPK |
Cot inhibitor-1 是一种选择性的 Cot 蛋白激酶(也被称为 Tpl2或 MAP3K8)抑制剂(IC50 为 28 nM)。Cot inhibitor-1 抑制人全血中 TNF-alpha 的产生,其 IC50 为 5.7 nM。Cot 参与多种细胞信号通路,特别是与炎症和免疫反应有关的信号通路。Cot inhibitor-1抑制 Cot 活性,可能对类风湿关节炎、炎症性肠病和某些类型的癌症具有潜在的治疗效果。 | |||
T4562 |
Ramosetron
|
5-HT Receptor | GPCR/G Protein; Neuroscience |
Ramosetron 是一种血清素 5-HT3 受体拮抗剂,用于治疗恶心和呕吐。它被认为比其他一代 5-HT3 拮抗剂如昂丹司琼具有更高的效力和更长的止吐作用。它还适用于治疗“男性以腹泻为主的肠易激综合征”。它仅获准在日本和选定的东南亚国家使用。 | |||
T4615 |
Balsalazide sodium hydrate
巴柳氮钠水合物,Balsalazide disodium dihydrate,巴柳氮钠,Balsalazide disodium salt dihydrate,Balsalazide disodium |
STAT; Interleukin | Immunology/Inflammation; JAK/STAT signaling; Stem Cells |
Balsalazide sodium hydrate (Balsalazide disodium) 可通过调节IL-6/STAT3通路起抑癌作用,可用于治疗炎症性肠病。 | |||
T21967 |
MEG hemisulfate
Mercaptoethylguanidine hemisulfate |
NOS | Immunology/Inflammation |
MEG hemisulfate (Mercaptoethylguanidine hemisulfate) 是一种有效和选择性的诱导型 NO 合酶 (iNOS) 的抑制剂,在组织匀浆中抑制 iNOS,ecNOS 和 bNOS 的 EC50 值分别为 11.5,110 和 60 μM。MEG hemisulfate 也有效的过氧亚硝酸盐清除剂,可抑制过氧亚硝酸盐诱导的氧化过程。MEG hemisulfate 在许多炎症实验模型中具有保护作用,包括缺血/再灌注损伤,牙周炎,失血性休克,炎性肠病以及内毒素和败血性休克。 | |||
T13647 |
Dextran sulfate sodium salt (MW 4500-5500)
DSS,Dextran sulfate sodium salt (MW 4500-5500),硫酸葡聚糖钠盐 |
Apoptosis; HIV Protease | Apoptosis; Microbiology/Virology; Proteases/Proteasome |
Dextran sulfate sodium salt (MW 4500-5500) 是一种脱水葡萄糖的聚合物,分子量范围是4500-5500。Dextran sulfate sodium salt (MW 4500-5500) 通过阻止病毒吸附到宿主细胞中来抑制人免疫缺陷病毒的复制。Dextran sulfate sodium salt (MW 4500-5500) 是常用的炎症性肠病造模药物,可通过硫酸基团引起的高负电荷破坏肠黏膜屏障完整性,从而导致肠屏障受损,巨噬细胞功能失调以及菌群紊乱等现象。 | |||
T34126 |
Prednisolone sodium metazoate
|
Others | Others |
Prednisolone sodium metazoate is used in the treatment of Inflammatory Bowel Disease, Ulcerative Colitis, and GI Disorders. | |||
T30936 |
Cilansetron Hydrochloride
KC-9946,KC9946,KC 9946 |
Others | Others |
Cilansetron Hydrochloride can be used for irritable Bowel Syndrome (IBS) with Diarrhea Predominance. | |||
T38482 |
MM 419447
|
||
MM 419447 is a guanylate cyclase-C agonist, and it is a metabolite of linaclotide. This compound, MM 419447, shows promise in the field of irritable bowel syndrome with constipation (IBS-C) research. | |||
T14966 |
Cimetropium Bromide
西托溴铵,DA-3177 |
AChR | Neuroscience |
Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome. | |||
T17283 |
Zamifenacin
UK-76654 |
Others | Others |
Zamifenacin obviously decreases colonic motility in irritable bowel syndrome. Zamifenacin is an effective gut-selective muscarinic M3 receptor antagonist. | |||
T30236L |
Axelopran sulfate
|
Others | Others |
Axelopran sulfate is used in Oral Therapies for Opioid-induced Bowel Dysfunction in Patients with Chronic Noncancer Pain. |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2718 |
Palmatine chloride
|
Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others |
Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,并改善 DSS 诱发的结肠炎。 | |||
T5S0802 |
Palmatine
巴马汀,Berbericinine,Burasaine |
Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase | Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience |
Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤,预防肠道菌群失调和调节色氨酸分解代谢,从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。 | |||
T0646 |
5-Aminosalicylic Acid
Mesalazine,5-ASA,5-氨基水杨酸,Mesalamine |
NF-κB; Lipoxygenase; COX; Glutathione Peroxidase; Endogenous Metabolite; PAK; PPAR | Cytoskeletal Signaling; DNA Damage/DNA Repair; Immunology/Inflammation; Metabolism; Neuroscience; NF-κB |
5-Aminosalicylic Acid (5-ASA) 是一种特异性的PPARγ激动剂,还抑制 p21-激活激酶1(PAK1) 和NF-κB,具有抗炎活性。 | |||
T2735 |
5-Acetylsalicylic acid
5-乙酰水杨酸(阿司匹林),5-acetyl-2-hydroxybenzoic acid |
Others | Others |
5-Acetylsalicylic acid (5-acetyl-2-hydroxybenzoic acid) 是炎症性肠病中的活性剂,具有抗炎活性。 | |||
T3405 |
[6]-Gingerol
6-Gingerol,gingerol,(S)-(+)-[6]Gingerol,6-姜酚 |
Apoptosis; AMPK | Apoptosis; Chromatin/Epigenetic; PI3K/Akt/mTOR signaling |
[6]-Gingerol ((S)-(+)-[6]Gingerol) 是一种从生姜中分离的活性物质,具有抗癌,抗炎和抗氧化活性。 | |||
T0771 |
Casanthranol
美鼠李皮蒽酚苷,鼠李蒽酚 |
Others | Others |
Casanthranol是从Rhamnus p.的干燥树皮(通常称为cascara sagrada)提取的高浓度的蒽酚苷混合物。Casanthranol 主要用于缓解便秘。Casanthranol通过其对肠壁的作用,促进肌肉收缩的增加,从而帮助肠道运动。 |
Cat. No. | Product Name | Species | Expression System |
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TMPH-02504 |
DEFA5 Protein, Mouse, Recombinant (GST)
Defa5,Alpha-defensin 5,Defensin-related cryptdin-5,Defcr5 |
Mouse | E. coli |
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. DEFA5 Protein, Mouse, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 31.2 kDa and the accession number is P28312. | |||
TMPK-00631 |
DR3/TNFRSF25 Protein, Mouse, Recombinant (His)
TRAMP,TNFRSF12,WSL1,LARD,DR3,WSL,DDR3,TR3,TNFRSF25,APO3,WSL-... |
Mouse | HEK293 Cells |
TNF-like ligand 1 A (TL1A) and death receptor 3 (DR3) are a ligand-receptor pair involved in the pathogenesis of inflammatory bowel disease. Group 3 innate lymphoid cells (ILC3s) regulate intestinal immunity and highly express DR3. | |||
TMPH-02503 |
DEFA1 Protein, Mouse, Recombinant (GST & His)
HP-1,HNP-1,Defensin, alpha 1,DEFA1,DEFA2,MRS,Neutrophil defe... |
Mouse | E. coli |
Probably contributes to the antimicrobial barrier function of the small bowel mucosa. Has antibacterial activity against attenuated mutants of S.typhimurium. DEFA1 Protein, Mouse, Recombinant (GST & His) is expressed in E. coli expression system with N-6xHis-GST tag. The predicted molecular weight is 34.1 kDa and the accession number is P11477. | |||
TMPJ-00504 |
Serpin A8 Protein, Human, Recombinant (His)
AGT and SERPINA8,Angiotensinogen,Serpin A8 |
Human | HEK293 Cells |
Angiotensinogen is involved in maintaining blood pressure and in the pathogenesis of essential hypertension and preeclampsia. Genetic variations in Angiotensinogen are associated with susceptibility to essential hypertension, and can cause renal tubular dysgenesis, a severe disorder of renal tubular development. Defects in the encoding gene have also been associated with non-familial structural atrial fibrillation, and inflammatory bowel disease. | |||
TMPK-00055 |
IL-25/IL-17E Protein, Human, Recombinant (His & Avi), Biotinylated
白介素,IL-17E,IL-25,IL17E,Interleukin-17E,白细胞介素,interleukin-25 |
Human | HEK293 Cells |
IL-25, also known as IL-17E, is a member of the IL-17 cytokine family mostly produced by epithelial cells and innate immune cells. After binding to the IL-17RB/IL-17RA complex, IL-25 induces downstream signaling responses in epithelial cells and type 2 lymphocytes, which initiates, propagates, and sustains type 2 immunity. The function of IL-25 in allergic diseases such as asthma has been well established, and now also is extended to diseases such as inflammatory bowel disease and cancer. | |||
TMPK-01137 |
FAM3D Protein, Human, Recombinant (hFc)
OIT1,EF7,FAM3D |
Human | HEK293 Cells |
The physiological homeostasis of gut mucosal barrier is maintained by both genetic and environmental factors and its impairment leads to pathogenesis such as inflammatory bowel disease. A cytokine like molecule, FAM3D (mouse Fam3D), is highly expressed in mouse gastrointestinal tract. Here, we demonstrate that deficiency in Fam3D is associated with impaired integrity of colonic mucosa, increased epithelial hyper-proliferation, reduced anti-microbial peptide production and increased sensitivity t... | |||
TMPH-01559 |
IL-26 Protein, Human, Recombinant (His)
Protein AK155,Interleukin-26,IL26 |
Human | P. pastoris (Yeast) |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecula... | |||
TMPH-01560 |
IL-26 Protein, Human, Recombinant (His & Trx)
Interleukin-26,Protein AK155,IL26 |
Human | E. coli |
May play a role in local mechanisms of mucosal immunity and seems to have a proinflammatory function. May play a role in inflammatory bowel disease. Activates STAT1 and STAT3, MAPK1/3 (ERK1/2), JUN and AKT. Induces expression of SOCS3, TNF-alpha and IL-8, secretion of IL-8 and IL-10 and surface expression of ICAM1. Decreases proliferation of intestinal epithelial cells. Is inhibited by heparin. IL-26 Protein, Human, Recombinant (His & Trx) is expressed in E. coli expression system with N-6xHis-T... | |||
TMPY-03308 |
ADAM17 Protein, Rat, Recombinant (His)
ADAM metallopeptidase domain 17 |
Rat | HEK293 Cells |
ADAM17 is a member of the ADAM protein family of disintegrins and metalloproteases. ADAM17 is ubiquitously expressed in the human colon, with increased activity in the colonic mucosa of patients with ulcerative colitis, a main form of inflammatory bowel disease. The expression of ADAM17 may be inhibited by ethanol. It is involved in the processing of tumor necrosis factor alpha (TNF-α) at the surface of the cell, and from within the intracellular membranes of the trans-Golgi network. ADAM1... | |||
TMPJ-00213 |
IL-10R beta/IL-10RB Protein, Human, Recombinant (hFc)
Cytokine receptor family 2 member 4,Interleukin-10 receptor ... |
Human | HEK293 Cells |
Interleukin-10 receptor subunit beta(IL10RB), also known as Cytokine receptor class-II member 4,Cytokine receptor family 2 member 4,Interleukin-10 receptor subunit 2, belongs to the type II cytokine receptor family. IL10RB is a single- pass type I membrane protein and contains two fibronectin type-III domains. It is an accessory chain which is essential for the active interleukin 10 receptor complex. Coexpression of IL10RB and IL10RA proteins has been shown to be required for IL10-induced signal... | |||
TMPY-00176 |
FNDC4 Protein, Human, Recombinant (mFc)
fibronectin type III domain containing 4,FRCP1 |
Human | HEK293 Cells |
FNDC4 acts as an anti-inflammatory factor on macrophages and improves mouse model of induced colitis. FNDC4 could suppress osteoclast formation via NF-kappaB pathway and downregulation of CXCL10. Analysis of binding of FNDC4 to different immune cell types reveals strong and specific binding to macrophages and monocytes. FNDC4 treatment of bone marrow-derived macrophages in vitro results in reduced phagocytosis, increased cell survival and reduced proinflammatory chemokine expression. Hence, trea... | |||
TMPJ-00351 |
IL-23R Protein, Human, Recombinant (aa 24-353, hFc)
IL-23 receptor,IL23R,Interleukin-23 receptor,IL-23R |
Human | HEK293 Cells |
Interleukin 23 receptor (IL23R) is a type I cytokine receptor for IL23. IL23 receptor complex is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, and macrophages. In fact, polymorphisms of the I... | |||
TMPY-00493 |
IL-19 Protein, Human, Recombinant (His)
interleukin 19,Interleukin-19,IL-10C,NG.1,ZMDA1,MDA1 |
Human | Baculovirus Insect Cells |
The molecular features at the IL19 locus may modestly alter the establishment of HIV-1 infection. Interleukin (IL) 19, IL-20, and IL-24 belong to the IL-10 cytokine family and have been identified to play a role in the regulation of epidermal functions and inflammation. The expression of IL19 in biopsies of patients with active ulcerative colitis was increased compared with patients with quiescent ulcerative colitis and that colitis was attenuated in IL-19-deficient mice. The disruption of the e... | |||
TMPJ-01219 |
IL-23R Protein, Mouse, Recombinant (hFc)
Il23r,IL-23R,interleukin 23 receptor,Interleukin-23 receptor... |
Mouse | HEK293 Cells |
Interleukin 23 receptor (IL23R), a heterodimer of the IL12 receptor β1 (IL12Rβ1) and IL12Rβ2, is a type I cytokine receptor for IL23. IL23R is comprised of two subunits, the IL12Rβ1 subunit, which is shared with several cytokines, and a subunit that is unique to IL-23. IL23, after binding to IL23R, activates memory T cells and mediates pro-inflammatory activities in part by the production of IL17 through activation of TH17 lymphocytes. IL23R is expressed on T cells, NK cells, dendritic cells, an... | |||
TMPY-04828 |
TFF3 Protein, Human, Recombinant (His)
trefoil factor 3 (intestinal),ITF,P1B,TFI |
Human | HEK293 Cells |
Trefoil factor family (TFF) peptides are involved in the maintenance of epithelial integrity and epithelial restitution. Trefoil factor-3 (TFF3) is an estrogen-regulated gene associated with prognosis in different types of cancer. The presence and localization of TFF3 peptide was associated with the embryonic stage and tissue differentiation. TFF3 peptide distribution specific to the germ layers was not observed. The role of TFF3 peptide in cell migration and differentiation, immune response, an... | |||
TMPY-01033 |
IL-32 Protein, Human, Recombinant (isoform alpha, His)
IL-32δ,IL-32beta,IL32,TAIFc,IL-32γ,白介素,IL-32 Protein(isoform... |
Human | HEK293 Cells |
IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active,... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0066 |
Alosetron-13C-d3
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Alosetron-13C-d3 是 Alosetron 的 13C 和氘代化合物。Alosetron 的 CAS 号为 122852-42-0。 | |||
T70394 |
Deucravacitinib HCl
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Deucravacitinib HCl is a Highly Potent and Selective Allosteric Inhibitor of TYK2. BMS-986165 Blocks Il-12, IL-23 and type I Interferon Signaling and Provides for Robust Efficacy in Preclinical Models of Inflammatory Bowel Disease. MS-986165 potently binds to the Tyk2 pseudokinase domain (Ki = 0.02 nM), and is highly selective against a panel of 265 kinases and pseudokinases. The compound potently inhibited IL-23-, IL-12-, and Type I interferon-driven cellular signaling and transcriptional resp... | |||
TMIJ-0229 |
Mesalamine-d3
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Mesalamine-d3 是 Mesalamine 的氘代化合物。Mesalamine 的 CAS 号为 89-57-6。5-Aminosalicylic Acid 是一种特异性的PPARγ激动剂,还抑制 p21-激活激酶1 (PAK1) 和NF-κB,具有抗炎活性。 | |||
TMIH-0163 |
Clidinium Bromide-d5
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Clidinium Bromide-d5 是 Clidinium Bromide 的氘代化合物。Clidinium Bromide 的 CAS 号为 3485-62-9。Clidinium bromide 是季胺抗毒蕈碱剂,可通过减少胃酸和减慢肠道速度,缓解痉挛和腹部疼痛的症状。 |