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Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
规格 | 价格 | 库存 | 数量 |
---|---|---|---|
2 mg | ¥ 1,210 | 5日内发货 | |
25 mg | ¥ 6,760 | 6-8周 | |
50 mg | ¥ 8,790 | 6-8周 | |
100 mg | ¥ 13,600 | 6-8周 |
产品描述 | Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome. |
体外活性 | Cimetropium decreases the labeled ACh release induced by electrical field stimulation under the muscarinic autoinhibition blocked-condition, in the superfusion experiments of the preparation which has been preloaded with labeled choline [2]. Cimetropium has a potent antimuscarinic effect in inhibition of contraction of longitudinal muscle preparations. Cimetropium Bromide behaves as a competitive antagonist of muscarinic-mediated contractions in isolated colonic preparations from both species, with affinity values (pA2) ranging between 7.41 and 7.82 [1]. |
体内活性 | Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration (ID50: 27.9 μg/kg); both tonic and phasic components of contractile response are affected. Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli when administered intravenously to conscious dogs provided with a colonic Thiry fistula. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension [1]. |
别名 | 西托溴铵, DA-3177 |
分子量 | 438.36 |
分子式 | C21H28BrNO4 |
CAS No. | 51598-60-8 |
存储 | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
溶解度信息 | H2O: 50 mg/mL (114.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
溶液配制表 | ||||||||||||||||||||||||||||||||||||
H2O
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