49
36
1
3
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T5449 |
Bamaquimast
L 0042,F 10126 |
Proton pump | Membrane transporter/Ion channel |
Bamaquimast (L 0042) 是一种 proton pump 抑制剂,可用于研究哮喘类的免疫系统疾病和呼吸系统疾病。 | |||
T5424 |
Etosalamide
依托柳胺,Ethosalamide |
Others | Others |
Etosalamide (Ethosalamide) 是一种解热缓解疼痛的试剂。它具有抗炎作用,可用于研究过敏性疾病。 | |||
T21404 |
Fluticasone furoate
Veramyst,Allermist,Avamys,糠酸氟替卡松,Fluticasone furoate |
Glucocorticoid Receptor | Endocrinology/Hormones |
Fluticasone furoate (Avamys) 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
T4348 |
Syk Inhibitor II
|
5-HT Receptor; Syk | Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors |
Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物,可选择性且可逆地抑制 Syk,IC50为 41 nM。 | |||
T12412L |
PDK4-IN-1 hydrochloride
|
Apoptosis; PDK | Apoptosis; PI3K/Akt/mTOR signaling |
PDK4-IN-1 hydrochloride 是一种蒽醌衍生物,对丙酮酸脱氢酶激酶 4有抑制作用,IC50为 84 nM,具有口服活性。它抑制细胞转化和细胞增殖并诱导细胞凋亡。它具有抗过敏,抗糖尿病和抗癌作用。 | |||
T0147 |
Clemastine fumarate
HS-592 (fumarate),富马酸氯马斯汀,Meclastine fumarate,Meclastine (fumarate) |
Autophagy; Histamine Receptor | Autophagy; GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Clemastine fumarate (Meclastine (fumarate)) 是一种合成乙醇胺,具有抗胆碱能、镇静和组胺 H1 拮抗作用。 | |||
T0188 |
Fluticasone (propionate)
丙酸氟替卡松,CCI-187881,氟替卡松丙酸酯,Fluticasone propionate |
Glucocorticoid Receptor; Virus Protease; Estrogen/progestogen Receptor; Phospholipase; Endogenous Metabolite; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Endocrinology/Hormones; Metabolism; Microbiology/Virology |
Fluticasone propionate (CCI-187881) 是一种选择性糖皮质激素受体激动剂,是一种局部抗炎激素,亲和力KD 为 0.5 nM。具有抗病毒活性。 | |||
T15772 |
Lodoxamide tromethamine
U-42585E |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Lodoxamide tromethamine 是一种的肥大细胞稳定剂,具有抗过敏特性,可用于治疗哮喘和过敏性结膜炎的研究。 | |||
T7812 |
Acitazanolast
MTCC,阿扎司特,WP-871 |
Others | Others |
Acitazanolast (WP-871) 是一种抗过敏候选药物。 | |||
T27159 |
DF-1111301
DF1111301,DF 1111301 |
Platelet aggregation; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience; Others |
DF-1111301 是一种具有抗组胺 H1和抗PAF活性的新型抗过敏化合物。 | |||
T15666 |
KP136
AL136 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
KP136 (AL136) 是一种具有口服活性的抗过敏化合物,抑制组胺释放,可用于研究哮喘和过敏性水肿。 | |||
T10945 |
D18024
|
Others | Others |
D18024 是一种酞嗪酮的衍生物,显示出抗过敏和抗组胺活性。 | |||
T21361 |
Alclometasone dipropionate
Vaderm,Sch 22219,Aclovate,Delonal |
Others | Others |
Alclometasone dipropionate (Sch 22219) 是一种人工合成的糖皮质激素,属于类固醇化合物,具有抗增生、抗炎、抗过敏、止痒和收缩血管的作用,可用于研究皮肤炎症。 | |||
T68094 |
Lodoxamide ethyl
|
Others | Others |
lodoxamide ethyl 是一种新的口服活性抗过敏化合物,可用于预防抗原诱导的支气管收缩和阻断皮肤过敏反应。 | |||
T1531 |
Mometasone furoate
糠酸莫美他松,糠酸莫米松,Sch32088 |
Glucocorticoid Receptor | Endocrinology/Hormones |
Mometasone furoate (Sch32088) 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
T0298 |
Dimenhydrinate
茶苯海明,Dramamine,Chloranautine,乘晕宁,Vomex A |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Dimenhydrinate (Vomex A) 是一种乙醇胺和组胺拮抗剂,具有抗过敏活性,可作为抗催吐剂。 | |||
T50001 |
Tinoridine
ethyl 2-amino-6-benzyl-4H,5H,6H,7H-thieno[2,3-c]pyridine-3-carboxylate,替诺立定 |
P450 | Metabolism |
Tinoridine 通过抑制环氧合酶-2(COX-2)的产生来发挥作用,具有抗炎、抗过敏和抗凝血等活性。 | |||
T36716 |
RO0270608
|
Integrin | Cytoskeletal Signaling |
RO0270608,是 R411 的活性代谢物,是一种具有口服活性的双重 α4β1/α4β7 整合素拮抗剂,具有抗炎活性,可调节炎症,可用于研究过敏性炎症反应。 | |||
T3979 |
Emedastine
LY188695,依美斯汀,Emadine |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Emedastine (LY188695) 是一种可口服的,选择性和高亲和力的组胺 H1受体拮抗剂,Ki 值为 1.3 nM。它是苯并咪唑衍生物,可用于过敏性鼻炎、过敏性皮肤疾病和过敏性结膜炎的研究。 | |||
T0977 |
Medrysone
Gimeracil,6α-Methyl-11β-hydroxyprogesterone,6A-甲基-11B-羟孕酮,甲羟松 |
Glucocorticoid Receptor; Others | Endocrinology/Hormones; Others |
Medrysone (6α-Methyl-11β-hydroxyprogesterone) 是局部合成的糖皮质激素,具有代谢、抗炎和抗过敏特性,有潜力用于眼科的眼炎症研究。 | |||
T0219 |
Valdecoxib
伐地考昔,代他考昔,SC 65872 |
COX | Immunology/Inflammation; Neuroscience |
Valdecoxib (SC 65872) 是可口服的高选择性 COX-2抑制剂,对 COX-2 和 COX-1 的 IC50值分别为 5 nM 和 140 μM,可用于治疗骨关节炎、类风湿性关节炎以及痛经和经期症状。 | |||
T25360 |
Eclazolast
RHC2871,RHC-2871,REV2871,REV 2871,RHC 2871 |
Others | Others |
Eclazolast (RHC 2871) 是一种亲脂性抗过敏化合物,在肥大细胞模型中抑制介质释放。Eclazolast 通过在细胞内只影响与Fc(epsilon)RI 相关的直接过程而抑制细胞外分泌。Eclazolast 的效果高度依赖于触发细胞的抗原浓度。 | |||
T41303 |
Isoflupredone
Delta-Fluorocortisone,Isoflupredona,异氟泼尼松,Isoflupredonum,9-Fluoroprednisolone |
Others | Others |
Isoflupredone (Isoflupredonum) 是一种合成的皮质类固醇,通过与动物 (如马) 的糖皮质激素和矿皮质激素受体结合抑制炎症细胞和抑制炎症介质的表达在生物体内发挥作用。Isoflupredone 具有抗炎和免疫抑制作用, 可应用于治疗各种肌肉骨骼、过敏性和全身炎症性疾病。 | |||
T26341 |
Y 9000
Y9000,Y-9000 |
Others | Others |
Y 9000 has anti-allergic activity. | |||
T25605 |
Lambertianic acid
|
Others | Others |
Lambertianic acid is a bioactive chemical that has anti-allergic and antibacterial effects. | |||
T26582 |
AIM-102
|
Others | Others |
AIM-102, a nonsteroidal, immune modulating, anti-inflammatory drug, is used potentially for the treatment of allergic asthma. | |||
T34307 |
Revenast
|
Others | Others |
Revenast 是一种强效抗过敏新化合物。该物质能在人体中迅速而广泛地代谢,从而产生抗过敏作用。 | |||
T63766 |
MrgprX2 antagonist-7
|
Others | Others |
MrgprX2 antagonist-7 是一种抗过敏剂,具有明显的抗过敏效果,能够抑制肥大细胞脱颗粒。 | |||
T69301 |
Picumast dihydrochloride
|
Others | Others |
Picumast dihydrochloride is a prophylactically active anti-allergic compound which combines inhibition of mediator release and action. The activity profile of PDH differs clearly from that of known prophylactic anti-allergic drugs such as DSCG and ketotifen. | |||
T21388 |
Emedastine Difumarate
Rapimine,DSSTox_CID_26911,AL-3432A,富马酸依美斯汀,KB-2413,Emedastine fumarate,KB 2413 |
Others | Others |
Emedastine Difumarate is a selective histamine H1 receptor antagonist with anti-allergic activity, prescribed for allergic conjunctivitis. Upon ocular administration, emedastine causes a dose-dependent inhibition of histamine-stimulated vascular permeabil | |||
T30927 |
CI-959 free acid
UNII-Y8M8A93SU8 |
Others | Others |
CI-959 Free Acid is an orally effective inhibitor of cell activation in vitro and in animal models and also has anti-allergic/anti-inflammatory properties. | |||
T27388 |
FR-A 19
FR-A-19,FRA19 |
Others | Others |
FR-A 19, a Histamine H2 agonist, inhibits the release of IgE-mediated human basophil histamine in a nanomolar range. It has additional potent anti-allergic properties. | |||
T26628 |
Andolast
CR2039,CR-2039,CR 2039 |
Others | Others |
Andolast, also known as CR-2039, an anti-allergic agent for the treatment of bronchial asthma, chronic obstructive pulmonary disease (COPD). Andolast acts at different cellular levels to inhibit immunoglobulin E synthesis. Andolast proved to be significan | |||
T38127 |
pNPS-DHA
|
Others | Others |
pNPS-DHA is an arylamide derivative of docosahexaenoyl ethanolamide that has anti-allergic activity.1It inhibits degranulation of RBL-2H3 mast cells (IC50= 15 μM).pNPS-DHA (1,000 mg/kg) inhibits IgE-dependent passive cutaneous anaphylaxis (PCA) in mice. 1.Kim, I.-H., Kanayama, Y., Nishiwaki, H., et al.Structure-activity relationships of fish oil derivatives with anti-allergic activity in vitro and in vivoJ. Med. Chem.62(21)9576-9592(2019) | |||
T63825 |
Antiallergic agent-1
|
Others | Others |
Antiallergic agent-1 是 Src 家族激酶抑制剂,是一种新的有价值的先导化合物,具有作为抗过敏剂的潜力。 | |||
T60498 |
Chlorpheniramine
|
Others | Others |
Chlorpheniramine 是一种 H1 抗组胺药,用于治疗 IgE 介导的炎症,通常用于治疗过敏性疾病。 | |||
T73972 |
Fexofenadine Impurity F
|
Others | Others |
Fexofenadine Impurity F 是 Fexofenadine 的杂质。 Fexofenadine 是一种H1R 拮抗剂,可用于研究季节性过敏性鼻炎和慢性特发性荨麻疹。 | |||
T76320 |
FIZZ-1 (32-51) (mouse)
|
||
FIZZ-1 (32-51) (mouse) 是一种富含半胱氨酸的分泌性蛋白,主要在过敏性气道炎症中被巨噬细胞、支气管上皮细胞及II型肺泡上皮细胞高度表达,具有对肺成纤维细胞的抗凋亡功能,广泛应用于过敏性肺炎的研究领域。 | |||
T15503 |
HQL-79
|
Others | Others |
HQL-79 is a selective and orally active human hematopoietic prostaglandin D synthase (H-PGDS) inhibitor. It inhibits the synthesis of PGD2 and acts as an anti-allergic agent (Kd: 0.8 μM and IC50: 6 μM). It also shows no obvious effect on COX-1, COX-2, m-P | |||
T11581 |
HSR6071
|
Others | Others |
HSR6071 是一种新型具有口服活性和有效性的抗过敏制剂,能抑制被动皮肤过敏反应 (PCA)。HSR6071 在大鼠实验性哮喘模型中显示出抗哮喘活性。 | |||
T60590 |
Chloropyramine
|
Others | Others |
Chloropyramine 是竞争性可逆 H1 受体拮抗剂,可用于过敏性疾病的研究,例如结膜炎和支气管哮喘。Chloropyramine 表现出抗乳腺癌活性。 | |||
T0217L |
(+)-Dropropizine
(+)-Dropropizine,右羟丙哌嗪 |
Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
(+)-Dropropizine 可以抑制组胺受体,抗过敏,并通过调节参与咳嗽反射的神经肽和干扰感觉神经末梢的刺激激活来减少咳嗽。 | |||
T62691 |
Syk Inhibitor II dihydrochloride dihydrate
|
Others | Others |
Syk Inhibitor II dihydrochloride dihydrate 是一种高度选择性的、有效的、ATP 竞争性 Syk 抑制剂 (IC50: 41 nM)。Syk Inhibitor II dihydrochloride dihydrate 抑制 RBL 细胞释放 5-HT (IC50: 460 nM),对其他激酶的作用较弱。Syk Inhibitor II dihydrochloride dihydrate 表现出抗过敏作用。 | |||
T74118 |
Roxatidine
|
Others | Others |
Roxatidine 是 Roxatidine acetate 的活性代谢产物,是组胺 H2受体拮抗剂。Roxatidine 是抗溃疡药,抑制组胺释放(从而抑制质子分泌)并抑制炎症和血管生成的重要标志物 VEGF-1 的产生。具有抗过敏性炎症作用。 | |||
T73666 |
Proglumetacin
|
Others | Others |
Proglumetacin 是一种口服有效的环加氧酶 (cyclo-oxygenase) 抑制剂。Proglumetacin 可以抑制 SARS-CoVMpro(新冠病毒的主要蛋白酶),其 AC50为 8.9 μM。Proglumetacin 具有抗炎活性,可用于炎症(如类风湿关节炎、过敏性气囊炎)的研究。 | |||
T36713 |
Streptochlorin
|
Others | Others |
Streptochlorin is a bacterial metabolite originally isolated from Streptomyces sp. SF2583 that has diverse biological activities, including antiangiogenic, antiproliferative, and anti-allergic properties. It inhibits TNF-α-induced NF-κB transcriptional activity and decreases proliferation of human umbilical vein endothelial cells (HUVECs) when used at concentrations ranging from 5 to 20 μM. Streptochlorin (12 μg/ml) decreases viability of, as well as induces apoptosis and increases the productio... | |||
T60496 |
Ketorolac hemicalcium
|
Others | Others |
Ketorolac (RS37619) hemicalcium 是一种非选择性的 COX 抑制剂,对 COX-1 的 IC50 为 20 nM,对 COX-2 的 IC50 为 120 nM。 Ketorolac hemicalcium 是一种非甾体类抗炎药 (NSAID),可用作 0.5% 滴眼液,用于研究过敏性结膜炎、黄斑囊样水肿、术中瞳孔缩小和术后眼部炎症和疼痛等。 Ketorolac hemicalcium 也是一种可用于癌症研究的 DDX3 抑制剂 [1] [4]。 | |||
T38350 |
TAS 205
|
Others | Others |
TAS 205 is an inhibitor of hematopoietic prostaglandin D synthase (H-PGDS; IC50= 55.8 nM).1It is selective for H-PGDS over lipocalin-type PGDS (L-PGDS) at 100 μM, as well as over enzyme and receptor panels at 10 μM. TAS 205 inhibits production of prostaglandin D2induced by A23187 in KU812 human and RBL-2H3 rat basophils with IC50values of 78.3 and 181.3 nM, respectively. It inhibits ovalbumin-induced nasal lavage fluid eosinophil infiltration and late-phase nasal obstruction in an ovalbumin-sens... | |||
T63399 |
mTOR/HDAC-IN-1
|
Others | Others |
mTOR/HDAC-IN-1 (Compound 50) 是一个具有选择性的mTOR 和HDAC 双重抑制剂,对mTOR 和HDAC1的IC50分别为0.49和0.91 nM。 mTOR/HDAC-IN-1 可作为抗癌活性分子 (anti-cancer) 进行研究。该化合物的粉末形式不稳定,建议选择其他盐形式产品。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T12651 |
Rabdosiin
(+)-Rabdosiin |
Others | Others |
Rabdosiin ((+)-Rabdosiin) 是一种分离自 Rabdosia japonicaHara 中的咖啡酸四聚体,具有抗过敏、抗 HIV 和抑制 DNA 拓扑异构酶作用。 | |||
T2982 |
Xanthone
Genicide,呫吨酮,氧杂蒽酮,Xanthenone,Benzophenone oxide |
Apoptosis; Others; Influenza Virus; Antibacterial; Antifungal | Apoptosis; Microbiology/Virology; Others |
Xanthone (Xanthenone) 是一种从山竹果中分离得到的天然产物,具有抗炎,抗氧化,抗肿瘤,抗过敏,抗细菌,抗真菌和抗病毒活性。在癌变的不同阶段可控制细胞分裂和生长,凋亡,炎症和转移。 | |||
T2902 |
Costunolide
Costus lactone,NSC 106404,Costunolid,(+)-Costunolide,木香烃内酯 |
Apoptosis; Endogenous Metabolite; Telomerase | Apoptosis; DNA Damage/DNA Repair; Metabolism |
Costunolide (Costus lactone) 是一种天然的倍半萜内酯,具有抗氧化、抗炎、抗过敏、骨重塑、神经保护、促进毛发生长、抗癌和抗糖尿病的特性,可诱导乳腺癌细胞周期阻滞和凋亡。 | |||
T2S0504 |
Ilexoside D
|
Others | Others |
Ilexoside D has ant-allergic, and anti-coagulant activities, it shows anti-tissue factor activity as well as the antithrombotic activity. | |||
T5666 |
Dipotassium glycyrrhizinate
|
Virus Protease | Microbiology/Virology |
Dipotassium glycyrrhizinate 是一种具有抗过敏和抗炎活性的阴离子表面活性剂。 | |||
T3872 |
Nodakenin
紫花前胡苷,(+)-Marmesinin |
AChE | Neuroscience |
Nodakenin ((+)-Marmesinin) 是一种Peucedanum decursivum Maxim 根中的主要香豆素苷。它能够抑制乙酰胆碱酯酶活性,IC50=84.7 μM。 | |||
T4S2164 |
Narirutin
Naringenin-7-O-rutinoside,Isonaringin,芸香柚皮苷,柚皮芸香苷 |
Others; Antibacterial | Microbiology/Virology; Others |
Narirutin (Naringenin-7-O-rutinoside) 是从Citrus unshiu 中分离的活性成分之一,具有抗氧化和抗炎活性。它是一种具有抗结核效力的shikimate 激酶抑制剂。 | |||
T2S2362 |
Dehydrocorydaline nitrate
去氢延胡索甲素硝酸盐,硝酸脱氢紫堇碱 |
BCL; Others; PARP; p38 MAPK; Caspase; Parasite; Autophagy | Apoptosis; Autophagy; Chromatin/Epigenetic; DNA Damage/DNA Repair; MAPK; Microbiology/Virology; Others; Proteases/Proteasome |
Dehydrocorydaline nitrate 是生物碱。Dehydrocorydaline 调节 Bax,Bcl-2蛋白表达,激活 caspase-7,caspase-8,并使 PARP 失活。它能增强 p38 MAPK 活化,具有抗炎、抗癌、抗疟疾等功效。 | |||
TMA1570 |
Sappanone A
|
NF-κB; Nrf2 | Immunology/Inflammation; NF-κB |
Sappanone A 是一种高异黄烷酮,通过调节 Nrf2 和 NF-κB 表现出抗炎作用。Sappanone A 可以减轻卵清蛋白引起的哮喘中的过敏性气道炎症。 | |||
TN1088 |
3,5,6,7,8,3',4'-Heptemthoxyflavone
3,3',4',5,6,7,8-heptamethoxyflavone,3,5,6,7,8,3',4'-七甲氧基黄酮 |
Others | Others |
3,5,6,7,8,3',4'-Heptemthoxyflavone 是来自蜜柑皮中的黄酮,具有抗肿瘤起始活性和抗神经炎症作用。它能通过 cAMP/ERK/CREB 信号诱导脑源性神经营养因子表达,降低 C6 细胞磷酸二酯酶活性。它能抑制胶原酶的活性,增加人真皮成纤维细胞新生细胞中 I 型前胶原含量。 | |||
TN1516 |
Cnidicin
蛇床素,4,9-双[(3-甲基-2-丁烯-1-基)氧基]-7H-呋喃并[3,2-G][1]苯并吡喃-7-酮 |
NOS; NO Synthase | Immunology/Inflammation |
Cnidicin 是一种香豆素,对肥大细胞脱颗粒及 RAW 264.7 细胞产生一氧化氮具有抑制作用。 | |||
T6S0117 |
Avicularin
Fenicularin,扁蓄苷 |
ERK | MAPK |
Avicularin (Fenicularin) 具有抗过敏、抗炎、保肝、抗氧化、抗肿瘤等活性。它能通过调节 NF-κB(p65)、COX-2 和 PPAR-γ 的活性来改善人类肝细胞癌。在 LPS 刺激的 RAW 264.7 巨噬细胞中,它通过抑制 ERK 信号通路产生抗炎活性。 | |||
TN1040 |
Skullcapflavone II
|
COX; Antibacterial; TGF-beta/Smad | Immunology/Inflammation; Microbiology/Virology; Neuroscience; Stem Cells |
Skullcapflavone II 是从黄芩中提取的黄酮,具有抗炎作用。它对 M. aurum 和 M. bovisBCG 具有较强的抗菌活性。它还调节破骨细胞的分化、存活和功能。 | |||
T4S1943 |
Kirenol
奇壬醇,奇任醇,Kirel |
Wnt/beta-catenin | Cytoskeletal Signaling; Stem Cells |
Kirenol (Kirel) 是分离自 Siegesbeckia orientalis 中的,具有抗氧化、抗炎、抗过敏、抗关节炎活性,可用于缓解疼痛的研究。 | |||
T17214 |
Valencene
NSC 148969,NSC-148969,NSC148969 |
Others; Antioxidant; NF-κB | NF-κB; Others; oxidation-reduction |
Valencene (NSC-148969) 是一种从 Cyperus rotundus 中分离出来的倍半萜类化合物,是柑橘类水果和柑橘类衍生气味的香气成分。ValenceneValencene 具有抗过敏、抗炎、抗黑色素生成、和抗氧化活性。通过阻断 NF-κB 通路,Valencene 通过阻断 NF-κB 通路抑制 Th2 趋化因子和促炎性趋化因子的过度表达。 | |||
TN1712 |
Gossypin
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NF-κB; S6 Kinase | MAPK; NF-κB; PI3K/Akt/mTOR signaling |
Gossypin 是一种从Hibiscus vitifolius 中分离得到的黄酮,能够抑制NF-κB 和 NF-κB 的调节基因表达。在小鼠原代骨髓细胞和 RAW264.7 细胞中,它也可抑制 RANKL 诱导的破骨细胞形成。它具有抗氧化、抗炎、抗癌、抗衰老、抗糖尿病和保护肝脏的活性。 | |||
TN1470 |
Cassiaside B2
决明子苷B2 |
Phosphatase; MAO; 5-HT Receptor | GPCR/G Protein; Metabolism; Neuroscience |
Cassiaside B2 是蛋白酪氨酸磷酸酶1B (PTP1B) 和人单胺氧化酶A (hMAO-A) 的抑制剂。Cassiaside B2是 5-HT2C 受体的激动剂, 具有抗过敏活性。Cassiaside B2 是萘吡喃酮参比提取物(NRE)的有效成分之一。 | |||
T5S1285 |
(+)-(3R,8S)-Falcarindiol
Falcarindiol,镰叶芹二醇 |
Others | Others |
(+)-(3R,8S)-Falcarindiol 是一种从胡萝卜中得到的聚乙炔,有抗炎、抗肿瘤和抗脂质过氧化活性。它具有抗分歧杆菌作用,对Mycobacterium tuberculosisH37Ra 的 MIC 和 IC50值分别为 24 μM 和 6 μM。 | |||
T4518 |
Licochalcone D
|
ERK; NF-κB | MAPK; NF-κB |
Licochalcone D 是一种 NF-κB p65的有效抑制剂,是一种存在于 Glycyrrhiza inflate 中的黄酮类化合物,具有抗氧化、抗炎、抗癌等作用。 | |||
T5S1286 |
(+)-Columbianetin
二氢山芹醇,(S)-Columbianetin,Columbianetin |
Antifungal | Microbiology/Virology |
(+)-Columbianetin ((S)-Columbianetin) 是 Columbianetin 的异构体。其中Columbianetin 是一种植物抗毒素,与芹菜贮藏过程中对病原体的抗性有关,具有良好的抗真菌和抗炎作用。 | |||
T3S1612 |
kuwanon G
桑黄酮G,Moracenin B,桑黄酮 G,Kuwanone G |
Phosphatase; Antibacterial; Bombesin Receptor; AChR; AChE; Glucosidase | GPCR/G Protein; Metabolism; Microbiology/Virology; Neuroscience |
Kuwanon G (Moracenin B) 是一种从桑树中得到的黄酮类蛙皮素受体拮抗剂,具有杀菌作用。 | |||
TN5062 | Stigmast-4-ene-3,6-dione | ||
Stigmast-4-ene-3,6-dione has anti-inflammatory and anti-allergic properties. | |||
T39570 |
Cycloartenyl ferulate
Cycloartenolferulate,Cycloartenolferulicacidester,环木菠萝烯醇阿魏酸酯 |
Others | Others |
Cycloartenyl ferulate (also known as cycloartenol ferulate) is a representative triterpene alcohol with diverse biological properties, such as antioxidant, anti-allergic, anti-inflammatory, and anticancer activities. | |||
TN3483 |
Bakkenolide D
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IL Receptor; Histamine Receptor | GPCR/G Protein; Immunology/Inflammation; Neuroscience |
Bakkenolide D has anti-allergic effect, it and bakkenolide D demonstrates inhibitory effect on the trachea contraction induced by histamine in vitro, they have obvious anti-histamine activities. | |||
TN7449 |
8-Hydroxy-5,7-dimethoxyflavanone
|
Others | Others |
8-Hydroxy-5,7-dimethoxyflavanone (PDMF) is a phytochemical with tumor-preventive properties, promoting p53-driven G2/M cell cycle arrest and apoptosis. It is a potent anti-allergic agent for preventing IgE-driven hypersensitivity reactions and possesses anti-inflammatory activity. | |||
TN4429 |
Leucodin
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MMP; TNF | Apoptosis; Proteases/Proteasome |
Leucodin shows high anti-hypercholesterolemic potential. Leucodin may have anti-allergic activity, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner with IC50 of 80 microM. | |||
TN3513 |
Bis-5,5-nortrachelogenin
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Others | Others |
Bis-5,5-nortrachelogenin has anti-allergic activity, it inhibited NO production with IC50 value of 48.6 microM. | |||
TN3836 |
Desacetylmatricarin
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Others | Others |
Desacetylmatricarin has anti-allergic property, it shows a potent inhibitory activity upon the beta-hexosaminidase release from RBL-2H3 cells in a dose-dependent manner and the IC50 of 7.5 microM. | |||
TN1845 |
Kushenol N
|
Others | Others |
Kushenol N may have anti-allergic activity, it demonstrates significant inhibition of the release of beta-hexosaminidase from cultured RBL-2H3 cells . | |||
TN3936 |
ent-16-Kaurene-3beta,15beta,18-triol
|
Others | Others |
ent-16-Kaurene-3beta,15beta,18-triol, ent-16-kaurene-3beta,15beta-diol,abbeokutone,and helioscopinolide A possess appreciable anti-allergic activities in RBL-2H3 cells model with IC50 values ranging from 22.5 to 42.2 microM. | |||
TN4392 |
Koaburaside
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IL Receptor; TNF; Influenza Virus | Apoptosis; Immunology/Inflammation; Microbiology/Virology |
Koaburaside exhibits antioxidant activity with an IC50 value of 9.0μM, it shows weak inhibitory activity against influenza A neuraminidase. Koaburaside may have anti-allergic inflammatory activity, it can suppress histamine release from mast cells. | |||
TN5033 |
Skullcapflavone I
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IL Receptor; Caspase; Prostaglandin Receptor | Apoptosis; GPCR/G Protein; Immunology/Inflammation; Proteases/Proteasome |
Skullcapflavone I has anti-inflammatory and anti-allergic potential, it can significantly inhibit LPS stimulated NO and PGE(2) release in J774A.1 macrophages and inhibit LPS induced IL-6 production in a concentration dependent manner. Skullcapflavone I se | |||
TN3325 |
9-O-Feruloyl-5,5'-dimethoxylariciresinol
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IL Receptor; TNF | Apoptosis; Immunology/Inflammation |
(+)-9'-O-trans-feruloyl-5,5'-dimethoxylariciresinol may have anti-allergic inflammatory effect, it can inhibit release of histamine from mast cells. It shows cytotoxicity against a small panel of human tumor cell lines, with ED50 values of 9.86 to approxi | |||
TN2511 |
Britannilactone diacetate
1,6-O,O-Diacetylbritannilactone |
IL Receptor; PARP; ROS; MAPK; Caspase; JAK; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; DNA Damage/DNA Repair; Immunology/Inflammation; JAK/STAT signaling; MAPK; Proteases/Proteasome; Stem Cells |
1,6-O,O-Diacetylbritannilactone(OODBL) has anti-inflammatory activity, it has a potential therapeutic efficacy on inflammatory diseases especially allergic airway disease as a lead compound. OODBL has anti-asthmatic activity, it reduces leukotriene C4 pro | |||
TN3870 |
Iriflophenone 2-O-Rhamnoside
Dimethylmatairesinol |
Others | Others |
Dimethylmatairesinol can reduce the amount of Immunoglobulin E (IgE) secreted by human myeloma U266 cells, it has potential as an anti-allergic agent. Dimethylmatairesinol also exhibits significant cytotoxicity against three human tumor cells(A-549 lung c | |||
TN4489 | Manassantin A | ERK; cAMP; TNF; NF-κB; MAPK; COX; HIF; Prostaglandin Receptor; JNK; STAT | Angiogenesis; Apoptosis; Chromatin/Epigenetic; GPCR/G Protein; Immunology/Inflammation; JAK/STAT signaling; MAPK; Neuroscience; NF-κB; Stem Cells |
Manassantin A is a high potent HIF-1 inhibitor, it protects the gastric mucosa from ethanol-induced acute gastric injury, and suggest that these protective effects might be associated with COX/PGE2 stimulation, inhibition of iNOS production and NF-κB act |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00323 |
Nectin-2 Protein, Mouse, Recombinant (hFc)
Herpes Virus Entry Mediator B,PVRL2,Poliovirus Receptor-Rela... |
Mouse | HEK293 Cells |
CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens ju... |
Cat. No. | Product Name | Target | Signaling Pathways |
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TMIJ-0328 |
Mometasone furoate-d3
|
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Mometasone furoate-d3 是 Mometasone furoate 的氘代化合物。Mometasone furoate 的 CAS 号为 83919-23-7。Mometasone furoate 是糖皮质激素受体激动剂,具有抗炎和抗过敏作用。它是皮质固醇类试剂,动物模型中,可局部应用于气道炎症、慢性皮肤湿疹、哮喘。 | |||
TMIJ-0505 |
Fluticasone Furoate-d3
|
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Fluticasone Furoate-d3 是 Fluticasone Furoate 的氘代化合物。Fluticasone Furoate 的 CAS 号为 397864-44-7。Fluticasone furoate 是一种合成的三氟化皮质类固醇,衍生自氟替卡松,Kd 为 0.3 nM。Fluticasone furoate 具有有效的抗炎、抗哮喘活性和低全身暴露。Fluticasone furoate 可用作过敏性鼻炎治疗研究的鼻喷雾剂。 | |||
TMID-0006 |
Budesonide-d8
mixture of diastereomers-d8 |
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Budesonide-d8 是 Budesonide 的氘代化合物。Budesonide 的 CAS 号为 51333-22-3。Budesonide 是吸入型糖皮质类固醇,是一种口服具有活性的糖皮质激素受体激动剂。它能够减小肺部肿瘤的体积,逆转 DNA 低度甲基化,调节基因的 mRNA 表达。它是能够用于哮喘的抗炎药。 |