Chlorpheniramine is an H1 anti-histamine agent for IgE-mediated inflammation that is commonly used for allergic diseases.

Chlorpheniramine has an inhibitory effects with an value of IC 50 is 43μM on proton currents in BV2 microglial cells [1]. Cell Viability Assay Cell Line: Murine microglial BV2 cells [1]. Concentration: 100 μM Incubation Time: 5 min Result: Inhibited proton currents with moderate potency.

Chloropheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) enhances white blood cells in the peripheral blood [2].. Animal Model: Sprague-Dawley (SD) rats [2]. Dosage: 50, 100 and 200 μg/kg Administration: Chlorpheniramine (50, 100 and 200 μg/kg; IM; 3 times, at intervals of 1 week) Result: Enhanced white blood cells in the peripheral blood, mostly due to the increases of B cells and monocytes, but not T cells and NK cells.