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Search Results for " adrenal gland "

Targets Recommended: Others

12

抑制剂 & 化合物

4

天然产物

11

重组蛋白

3

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
TP1031	Tetracosactide Tetracosactrin,替可克肽	Others	Others
	Tetracosactide (Tetracosactrin) 是一种肾上腺皮质激素 (ACTH) 的类似物，能够刺激肾上腺皮质激素分泌。
T35664	Tetracosactide acetate	Others	Others
	Tetracosactide acetate 是一种合成的多肽，可刺激肾上腺释放皮质类固醇，如皮质醇。Tetracosactide acetate 在溃疡性结肠炎和克罗恩病、青少年和成人类风湿性关节炎和骨关节病方面有研究的价值。
TP1238L	ACTH 1-14 acetate(25696-21-3 free base) Adrenocorticotropic Hormone Fragment 1-14 acetate	Adrenergic Receptor	GPCR/G Protein; Neuroscience
	ACTH 1-14 acetate(25696-21-3 free base) (Adrenocorticotropic Hormone Fragment 1-14 acetate) 是促肾上腺皮质激素的片段，可调节皮质醇和雄激素的产生。促肾上腺皮质激素 (ACTH)，也称为促肾上腺皮质激素，由垂体前叶产生和分泌。作为对生物应激的反应，ACTH 是下丘脑-垂体-肾上腺轴的重要组成部分。
T29207	ZD 7155 ZD 7155,ZD-7155	Others	Others
	ZD 7155 hydrochloride is a potent and selective competitive antagonist for the angiotensin II type 1 (AT1) receptor. It displaces [125I]-angiotensin II binding in guinea pig adrenal gland membranes with an IC50 value of 3.8 nM.
T38046	Cholesteryl Homo-γ-Linolenate	Others	Others
	Cholesteryl homo-γ-linolenate is a cholesterol ester. It accumulates in the adrenal gland of rabbits fed a diet high in linolenic acid. Levels of cholesteryl homo-γ-linolenate are decreased and positively correlate with cognitive decline in HIV-infected humans.
T82149	Hydrin 1′
	Hydrin 1′，在(Xenopus)神经垂体中首次发现，此化合物在爪蟾肾上腺中显示出显著的类固醇释放活性。
T31845	Forasartan SC52458,SC 52458,SC-52458	Others	Others
	Forasartan is a non - peptide angiotensin II receptor antagonist with antihypertensive activity. Forasartan and angiotensin II compete to bind AT1 receptor subtypes in vascular smooth muscle, thereby blocking angiotensin II-mediated vasoconstriction, lead
T36428	PACAP-related Peptide (human) (trifluoroacetate salt)	PACAP	GPCR/G Protein
	PACAP-related peptide (PRP) is an endogenous 29-amino acid peptide that belongs to the secretin/glucagon superfamily of peptides, which includes secretin , glucagon , glucagon-like peptide-1 , GLP-2 , and pituitary adenylate cyclase-activating polypeptide . It is expressed in normal human pancreas and adrenal gland tissue and in some tumors that produce vasoactive intestinal peptide (VIP). PRP (1-29) is secreted by CHO-K1 cells that express human recombinant preproPACAP.
T85153	18-hydroxy-11-deoxy Corticosterone 18-Hydroxydeoxycorticosterone,18-OH-DOC	Others	Others
	18-Hydroxy-11-deoxy Corticosterone (18-OH-DOC) is a mineralocorticoid produced by the zona fasciculata of the adrenal gland, with its biosynthesis regulated by adrenocorticotropic hormone (ACTH) and angiotensin II. This regulation heightens 18-OH-DOC production in isolated human adrenal glomerulosa cells and allows for its formation from 11-deoxy corticosterone (DOC) in human SK-MEL188 melanoma cells. As an intermediate in progesterone metabolism, 18-OH-DOC can be converted to aldosterone in rat...
TP1247	ACTH (1-13) Adrenocorticotropic Hormone (1-13),ACTH 1-13
	ACTH (1-13) is a 13-aa peptide, with cytoprotective effects in the model of ethanol induced gastric lesions in rats.Adrenocorticotropic hormone (ACTH), also known as corticotropin, is produced and secreted by the anterior pituitary gland. ACTH is an impor
T80069	PACAP (6-27) (human, ovine, rat) Pituitary adenylate cyclase-activating peptide (6-27)
	PACAP (6-27) (human, ovine, rat) 是一种对PACAP受体具有拮抗作用的化合物，可以抑制犬肾上腺对外源性VIP的反应。此化合物在心血管疾病和神经系统疾病研究中展现出应用潜力。
T75715	Nonapeptide-1 acetate salt
	Nonapeptide-1 (Melanostatine-5) acetate salt，一种多肽类激素，是 MC1R 选择性拮抗剂 (Ki: 40 nM)。 Nonapeptide-1 acetate salt 是一种竞争性的α-MSH 拮抗剂，可有效抑制黑素细胞中 α-MSH 诱导的细胞内 cAMP 和黑素体扩散 (IC50分别为 2.5 nM 和 11 nM)。 Nonapeptide-1 acetate salt 抑制黑色素合成，可用于研究皮肤色素沉着和肾上腺类固醇生成的调节、皮肤癌。

化合物

Cat.No: TP1031

Synonym: Tetracosactrin,替可克肽

Target: Others

Tetracosactide acetate

Cat.No: T35664

Target: Others

ACTH 1-14 acetate(25696-21-3 free base)

Cat.No: TP1238L

Synonym: Adrenocorticotropic Hormone Fragment 1-14 acetate

Target: Adrenergic Receptor

Cat.No: T29207

Synonym: ZD 7155,ZD-7155

Target: Others

Cholesteryl Homo-γ-Linolenate

Cat.No: T38046

Target: Others

Cat.No: T82149

Cat.No: T31845

Synonym: SC52458,SC 52458,SC-52458

Target: Others

PACAP-related Peptide (human) (trifluoroacetate salt)

Cat.No: T36428

Target: PACAP

18-hydroxy-11-deoxy Corticosterone

Cat.No: T85153

Synonym: 18-Hydroxydeoxycorticosterone,18-OH-DOC

Target: Others

Cat.No: TP1247

Synonym: Adrenocorticotropic Hormone (1-13),ACTH 1-13

PACAP (6-27) (human, ovine, rat)

Cat.No: T80069

Synonym: Pituitary adenylate cyclase-activating peptide (6-27)

Nonapeptide-1 acetate salt

Cat.No: T75715

Cat. No.	Product Name	Target	Signaling Pathways
T20302	Deoxycorticosterone Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone	Endogenous Metabolite	Metabolism
	Deoxycorticosterone (Desoxycortone) 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。
T2748	Cortodoxone 可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol	Glucocorticoid Receptor; Endogenous Metabolite	Endocrinology/Hormones; Metabolism
	Cortodoxone (11-Desoxycortisol) 是糖皮质类固醇激素，能够氧化为皮质醇。
T3S0488	Syringaresinol diglucoside Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷	Others	Others
	Syringaresinol diglucoside (Syringaresinol-di-O-glucoside) 是一种提取自竹叶中的天然化合物。
T5S2343	Acetylshikonin 乙酰紫草素,Acetyl shikonin	Others; P450; AChE	Metabolism; Neuroscience; Others
	Acetylshikonin 来源于紫草根，具有抗癌、抗炎作用。它是一种 AChE 抑制剂，具有很强的抗凋亡活性。它是一种非选择性的细胞色素 P450抑制剂，对所有 P450 亚型抑制的 IC50值范围为 1.4-4.0 μM。

天然产物

Deoxycorticosterone

Cat.No: T20302

Synonym: Desoxycorticosterone,去氧皮质酮,Desoxycorticosteronum,Desoxycortone

Target: Endogenous Metabolite

Cat.No: T2748

Synonym: 可托多松,11-Deoxycortisol,cortexolone,17α,21-dihydroxyprogesterone,Reichstein's substance S,11-Desoxycortisol

Target: Glucocorticoid Receptor, Endogenous Metabolite

Syringaresinol diglucoside

Cat.No: T3S0488

Synonym: Syringaresinol-di-O-glucoside,丁香树脂醇双葡萄糖苷

Target: Others

Cat.No: T5S2343

Synonym: 乙酰紫草素,Acetyl shikonin

Target: Others, P450, AChE

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPJ-00662	RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli) Receptor activator of nuclear factor kappa-B ligand,Receptor...	Human	E. coli
	CD254, also known as RANKL, TNFSF11, TRANCE, OPGL and ODF, is a type II membrane protein of the tumor necrosis factor (TNF) superfamily, and affects the immune system and control bone regeneration and remodeling. RANKL is the ligand of nuclear factor (NF)-κB (RANK). When RANKL binds to RANK, it will undergo trimerization and then bind to an adaptor molecule TNF receptor-associated factor 6 (TRAF6). This results in the activation of several downstream signaling cascades, including the NFκB, mitog...
TMPJ-00842	FGF-2 Protein, Rat, Recombinant bFGF,Heparin-Binding Growth Factor 2,FGFB,Fibroblast Growth ...	Rat	E. coli
	FGF-basic is a members of the Fibroblast Growth Factors (FGFs) family. The family constitutes a large family of proteins involved in many aspects of development including cell proliferation, growth, and differentiation. They act on several cell types to regulate diverse physiologic functions including angiogenesis, cell growth, pattern formation, embryonic development, metabolic regulation, cell migration, neurotrophic effects, and tissue repair. FGF-basic is a non-glycosylated heparin binding g...
TMPJ-00349	RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His) CD265 antigen,FEO,TRANCER,ODFR,ODFROSTS,TRANCE R,TNFRSF11A,O...	Human	HEK293 Cells
	Receptor Activator of Nuclear Factor κ B (RANK), also known as CD265, TRANCE Receptor or TNFRSF11A, is member of the tumor necrosis factor receptor (TNFR) molecular superfamily. RANK is the receptor for RANK-Ligand (RANKL) and part of the RANK/RANKL/OPG signaling pathway that regulates osteoclast differentiation and activation. It plays a vital role in bone remodeling and repair, immune cell function, lymph node development, thermal regulation, and mammary gland development. RANK is constitutive...
TMPJ-01319	TINAGL1 Protein, Human, Recombinant (His) LCN7,Tubulointerstitial nephritis antigen-like (TINAGL1),Oxi...	Human	HEK293 Cells
	TINAGL1 is a secreted protein and contains one SMB (somatomedin-B) domain. TINAGL1 is expressed in aorta, lymph nodes, heart, bone marrow, placenta, lung, kidney, skeletal muscle, pancreas, thyroid, adrenal gland and so on. TINAGL1 may be implicated in the adrenocortical zonation and in mechanisms for repressing the CYP11B1 gene expression in adrenocortical cells.
TMPY-02839	Adrenomedullin Protein, Human, Recombinant (hFc) AM,PAMP,adrenomedullin	Human	HEK293 Cells
	Adrenomedullin consists of 52 amino acids and is a member of the adrenomedullin family. It s a a hypotensive peptide and has 1 intramolecular disulfide bond. It seems that adrenomedullin has a slight homology with the calcitonin gene-related peptide. Adrenomedullin has a highly expression in pheochromocytoma and adrenal medulla. It also can be detected in lung, ventricle and kidney tissues. Adrenomedullin and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been report...
TMPJ-00962	AKR1C3 Protein, Human, Recombinant (His) 3-Alpha-HSD Type 2,17-β-Hydroxysteroid Dehydrogenase Type 5,...	Human	HEK293 Cells
	AKR1C3, is an enzyme which belongs to the aldo/keto reductase family. It is expressed in many tissues including adrenal gland, brain, kidney, liver, lung, mammary gland, placenta, small intestine, colon, spleen, prostate and testis. AKR1C3 catalyzes the conversion of aldehydes and ketones to alcohols. It catalyzes the reduction of prostaglandin (PG) D2, PGH2 and phenanthrenequinone (PQ) and the oxidation of 9-alpha,11-beta-PGF2 to PGD2,which functions as a bi-directional 3-alpha-, 17-beta- and ...
TMPY-01117	MRAP Protein, Human, Recombinant (hFc) FALP,FGD2,melanocortin 2 receptor accessory protein,GCCD2,B2...	Human	HEK293 Cells
	MRAP (Melanocortin 2 Receptor Accessory Protein) is a Protein Coding gene. This gene encodes a melanocortin receptor-interacting protein. It belongs to the MRAP family. MRAP, which contains a single transmembrane domain, has a unique structure, an antiparallel homodimer. MRAP is a single transmembrane domain accessory protein and a critical component of the hypothamo pituitary-adrenal axis. MRAP is highly expressed in the adrenal gland and is essential for adrenocorticotropin hormone (ACTH) rece...
TMPY-01551	Serpin B8 Protein, Mouse, Recombinant (His) CAP-2,serpin peptidase inhibitor, clade B (ovalbumin), membe...	Mouse	Baculovirus Insect Cells
	Serpins are the largest and most diverse family of serine protease inhibitors which are involved in a number of fundamental biological processes such as blood coagulation, complement activation, fibrinolysis, angiogenesis, inflammation and tumor suppression and are expressed in a cell-specific manner.Mouse SerpinB8, also known as Cytoplasmic antiproteinase 2, Peptidase inhibitor 8, SerpinB8, PI-8, SERPINB8 and CAP2, is a member of the Serpin superfamily. SERPINB8 was broadly expressed. In normal...
TMPY-02172	Midkine Protein, Human, Recombinant midkine (neurite growth-promoting factor 2),NEGF2,MK,ARAP	Human	Baculovirus Insect Cells
	Midkine (MK or MDK) also known as neurite growth-promoting factor 2 (NEGF2) is a basic heparin-binding growth factor of low molecular weight, and forms a family with pleiotrophin. Midkine is a retinoic acid-responsive, heparin-binding growth factor expressed in various cell types during embryogenesis. It promotes angiogenesis, cell growth, and cell migration. Midkine is also expressed in several carcinomas, suggesting that it may play a role in tumorigenesis, perhaps through its effects on angio...
TMPY-01875	SCGN Protein, Human, Recombinant (His) SEGN,SECRET,DJ501N12.8,CALBL,secretagogin, EF-hand calcium b...	Human	E. coli
	Secretagogin, also known as SCGN, is a secreted protein that is detectable in human serum after ischemic neuronal damage. It is a recently described calcium-binding protein. Secretagogin / SCGN is expressed at high levels in the pancreatic islets of Langerhans and to a much lesser extent in the gastrointestinal tract (stomach, small intestine and colon), the adrenal medulla and cortex and the thyroid C-cells. In the brain, the expression of Secretagogin / SCGN is restricted to distinct subtypes ...
TMPY-01929	ECE1 Protein, Human, Recombinant (His) RP3-329E20.1,endothelin converting enzyme 1,ECE	Human	HEK293 Cells
	Endothelin-converting enzyme 1, also known as ECE-1, is a single-pass type II membrane protein which belongs to thepeptidase M13 family. ECE-1 converts big endothelin-1 to endothelin-1. ECE-1 is a membrane metalloprotease that generates endothelin from its direct precursor big endothelin. Four isoforms of ECE-1 are produced from a single gene through the use of alternate promoters. These isoforms share the same extracellular catalytic domain and contain unique cytosolic tails, which resul...

重组蛋白

RANKL/TNFSF11/CD254 Protein, Human, Recombinant (E. coli)

Cat.No: TMPJ-00662

Species: Human

Expression System: E. coli

FGF-2 Protein, Rat, Recombinant

Cat.No: TMPJ-00842

Species: Rat

Expression System: E. coli

RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, His)

Cat.No: TMPJ-00349

Species: Human

Expression System: HEK293 Cells

TINAGL1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01319

Species: Human

Expression System: HEK293 Cells

Adrenomedullin Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02839

Species: Human

Expression System: HEK293 Cells

AKR1C3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00962

Species: Human

Expression System: HEK293 Cells

MRAP Protein, Human, Recombinant (hFc)

Cat.No: TMPY-01117

Species: Human

Expression System: HEK293 Cells

Serpin B8 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01551

Species: Mouse

Expression System: Baculovirus Insect Cells

Midkine Protein, Human, Recombinant

Cat.No: TMPY-02172

Species: Human

Expression System: Baculovirus Insect Cells

SCGN Protein, Human, Recombinant (His)

Cat.No: TMPY-01875

Species: Human

Expression System: E. coli

ECE1 Protein, Human, Recombinant (His)

Cat.No: TMPY-01929

Species: Human

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0109	11-Deoxycorticosterone-d8
	11-Deoxycorticosterone-d8 是 11-Deoxycorticosterone 的氘代化合物。11-Deoxycorticosterone 的 CAS 号为 64-85-7。Deoxycorticosterone 是由肾上腺产生的类固醇代谢物。 Deoxycorticosterone 是醛固酮前体，具有盐皮质激素活性。
TMID-0111	11-Deoxycortisol-2,2,4,6,6-d5
	11-Deoxycortisol-2,2,4,6,6-d5 是 11-Deoxycortisol 的氘代化合物。11-Deoxycortisol 的 CAS 号为 152-58-9。Cortodoxone是糖皮质类固醇激素，能够氧化为皮质醇。
TMID-0115	Dehydroepiandrosterone-2,2,3,4,4,6-d6 DHEA-d6
	Dehydroepiandrosterone-2,2,3,4,4,6-d6 是 Dehydroepiandrosterone 的氘代化合物。Dehydroepiandrosterone 的 CAS 号为 53-43-0。Dehydroepiandrosterone 是一种类固醇激素。它通过多种信号传导途径介导其作用，并通过转化成雄激素和雌激素衍生物（例如，雄激素，雌激素，7α和7β DHEA (Prasterone)，以及7α和7β表雄甾酮衍生物）在特异性受体上起作用。

同位素标记化合物

11-Deoxycorticosterone-d8

Cat.No: TMID-0109

11-Deoxycortisol-2,2,4,6,6-d5

Cat.No: TMID-0111

Dehydroepiandrosterone-2,2,3,4,4,6-d6

Cat.No: TMID-0115

Synonym: DHEA-d6

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