108
30
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148
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Cat. No. | Product Name | Form | Specificity Of Inhibition |
---|---|---|---|
C0114 |
Magrose Beads Strep-Tactin
Strep-tag Ⅱ蛋白纯化磁珠 |
Suspension in bottle | 适用于从任何表达系统,包括杆状病毒、哺乳动物细胞、酵母和细菌中含有 Strep-Tag II 标签蛋白的分离纯化。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T2164 |
Wiskostatin
|
Others | Others |
Wiskostatin 是神经元 Wiskott-Aldrich 综合征蛋白介导的肌动蛋白聚合的选择性抑制剂,能够不可逆的使细胞 ATP 水平快速下降。 | |||
T8473 |
MLS000532223
|
Rho; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
MLS000532223 是一种具有高亲和力的 Rho 家族 GTPases 选择性抑制剂,其EC50=16~120 μM。它能阻止几种 GTPases 同 GTP 的结合。 | |||
T9107 |
NP-G2-044
|
Others | Others |
NP-G2-044 是fascin 蛋白抑制剂,具有口服活性,IC50值约为 2 μM。它可阻断肿瘤转移并增强抗肿瘤免疫应答。 | |||
T23372 |
SMIFH2
|
Others | Others |
SMIFH2 是formin 特异性抑制剂。它利用 Formins 阻碍肌动蛋白聚合,影响肌动蛋白细胞骨架。 | |||
T22260 |
Aminopurvalanol A
|
CDK | Cell Cycle/Checkpoint |
Aminopurvalanol A 是一种竞争性、选择性和细胞渗透性的Cyclins/Cdk 复合物抑制剂,优先靶向G2/M 期转变进而抑制癌细胞分化。它通过抑制生理获能依赖性肌动蛋白聚合而抑制精子受精能力。 | |||
T5860 |
CK-869
|
Microtubule Associated | Cytoskeletal Signaling |
CK-869 是一种肌动蛋白相关蛋白 2/3 复合体抑制剂,其 IC50值为 7 μM。 | |||
T5007 |
Benproperine phosphate
磷酸苯丙哌林,Blascorid,Pirexyl phosphate |
Others; Microtubule Associated | Cytoskeletal Signaling; Others |
Benproperine phosphate (Pirexyl phosphate) 是一种具有口服活性的,肌动蛋白相关蛋白 2/3 复合亚基 2 (ARPC2) 抑制剂。它通过削弱 Arp2/3 功能来减弱肌动蛋白的聚合反应速率。它可抑制癌细胞迁移和肿瘤转移,有用于治疗止咳的潜力。 | |||
T1855 |
ZCL278
ZCL 278 |
CDK; Ras | Cell Cycle/Checkpoint; GPCR/G Protein; MAPK |
ZCL278 是一种选择性 Cdc42 GTPase 抑制剂,与Cdc42结合,Kd 为 11.4 μM。 | |||
T10826 |
CK-666
|
HIV Protease; Microtubule Associated | Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome |
CK-666 是一种肌动蛋白相关蛋白 Arp2/3 复合物的细胞渗透性抑制剂。 它与 Arp2/3 复合物结合,稳定复合物的非活性状态,阻止 Arp2 和 Arp3 亚基进入活化的丝状短节距构象。 | |||
T7764 |
CCG-222740
|
ROCK; Rho; Ras | Cell Cycle/Checkpoint; Cytoskeletal Signaling; GPCR/G Protein; MAPK; Stem Cells |
CCG-222740 是一种口服有效的选择性Rho/MRTF 途径抑制剂。它也是 α-平滑肌的肌动蛋白表达抑制剂,可减少皮肤纤维化并阻止黑色素瘤转移。 | |||
T1820 |
CK-636
CK-0944636,CK 636 |
Microtubule Associated | Cytoskeletal Signaling |
CK-636 (CK-0944636)是一种具有细胞渗透性的Arp2/3复合体抑制剂,能抑制肌动蛋白的聚合,对人,裂殖酵母和牛的IC50值分别为4、24 和 32 μM。 | |||
T7144 |
BTS
N-Tosylbenzylamine,N-苄基-对甲苯磺酸胺,N-Benzyl-p-toluenesulfonamide |
ATPase; Myosin | Cytoskeletal Signaling; Membrane transporter/Ion channel |
BTS (N-Tosylbenzylamine) 是一种选择性骨骼肌肌球蛋白 II 亚片段 1 (S1) ATPase 活性抑制剂,可特异性抑制骨骼肌快速纤维的收缩。它对肌动蛋白和 Ca2+刺激的肌球蛋白 S1 ATPase 的 IC50值约为 5 µM。 | |||
T13041 |
Surfactin
|
HSV | Microbiology/Virology |
Surfactin 是一种有效的环状脂肽生物表面活性剂,可介导单价和二价阳离子(如钙)穿过脂质双层膜的通量,具有抗菌、抗真菌、抗支原体和溶血作用。 | |||
T9501 |
Enterobactin
Enterochelin |
Others | Others |
Enterobactin (Enterochelin) 是一种高亲和力铁载体,可为微生物系统获取铁。 | |||
TQ0033 |
Zegocractin
CM-4620,N-(5-(6-Chloro-2,2-difluorobenzo[d][1,3]dioxol-5-yl)pyrazin-2-yl)-2-fluoro-6-methylbenzamide,CM4620 |
Calcium Channel | Membrane transporter/Ion channel; Metabolism |
Zegocractin (CM-4620) 是一种钙离子释放激活通道的抑制剂,对Orai1/STIM1和Orai2/STIM1的IC50值分别为 119 和 895 nM。 | |||
T1996 |
Defactinib
PF-04554878,VS-6063 |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Defactinib (VS-6063) 是新型的 FAK 抑制剂,能够时间和剂量依赖性的抑制 FAK 在 Tyr397 位点磷酸化。 | |||
T24695 |
Quinabactin
LC-66C6,ABA mimics 1,AM1,LC66C6,LC 66C6 |
Others | Others |
Quinabactin (LC-66C6) 是一种有效的磺酰胺脱落酸 ABA 激动剂。Quinabactin 促进成年拟南芥和大豆植物的保卫细胞关闭、抑制水分流失,抑制种子萌发,提高耐旱性。 | |||
T82705 |
Clovibactin
|
Antibiotic | Microbiology/Virology |
Clovibactin为一种新型抗生素,能有效消灭耐药细菌病原体,且未观察到耐药性。该化合物能从未培养的土壤细菌中提取。 | |||
T81391 |
Prolactin-Releasing Peptide (12-31), rat
|
||
Prolactin-Releasing Peptide (12-31), rat 为催乳素释放肽的一个段落,对 GPR10 受体具有高度亲和性,并能在转染了 PrRP 受体的 CHOK1 细胞中激发钙离子动员。 | |||
T123940 |
Infractin
|
Others | Others |
Infractin 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T123940。 | |||
T124888 |
Actinine
|
Others | Others |
Actinine 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T124888。 | |||
T30912 |
Chrysobactin
|
Others | Others |
Chrysobactin has siderophore activity that is isolated from Erwinia chrysanthemi. | |||
T25767 |
Lysobactin
Katanosin A, 7-L-isoleucine-,Katanosin B |
||
Lysobactin, also known as katanosin B, is an effective antibiotic with in vivo efficacy against Staphylococcus aureus and Streptococcus pneumoniae. It was previously shown to inhibit peptidoglycan (PG) biosynthesis. | |||
T80397 |
Darobactin
|
Antibiotic | Microbiology/Virology |
Darobactin为一种有效的抗生素,其针对多种重要革兰氏阴性病原体展现出显著的抑制作用,无论是在体外实验还是动物感染模型中均有证实。 | |||
T81390 |
Prolactin-Releasing Peptide (1-31) (rat)
|
||
Prolactin-Releasing Peptide (1-31) (rat) 通过减少禁食诱导的大鼠食物摄入,有效提升血浆LH、FSH及睾酮水平。 | |||
T78006 |
Prolactin Releasing Peptide (1-31), human acetate
|
||
ProlactinReleasing Peptide (1-31), human (acetate) 是一款针对 GPR10 的高亲和力配体,并具备诱导催乳素释放的功能。该肽段与人类和大鼠的 GPR10 结合力极强,Ki 值分别为 1.03 nM 和 0.33 nM,适用于针对下丘脑-垂体轴进行的生物医学研究。 | |||
T34952 |
Trinactin
Akd1D,Akd 1D,Akd-1D |
Others | Others |
Trinactin is a nonactin homolog that has Immunosuppressive effects. | |||
T126026 |
Purpactin A
|
Others | Others |
Purpactin A 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T126026,CAS号为 133806-59-4。 | |||
T25996 |
Protactin
|
Others | Others |
Protactin, a new antibiotic metabolite, is a possible precursor of the actinomycins. | |||
T35857 |
Actinopyrone A
|
Others | Others |
Actinopyrone A is a pyrone isolated from S. pactum with diverse biological activities. It has selective and potent antimicrobial activity against H. pylori (MIC = 0.1 ng/mL) with no activity against other Gram-negative bacteria including E. coli, K. pneumoniae, P. aeruginosa, and B. fragilis. Actinopyrone A also mildly inhibits growth of Gram-positive bacteria and dermatophytes with MIC values ranging from <6.25 to 25 μg/mL. Intravenous administration of actinopyrone A (30 μg/kg) increases coron... | |||
T68795 |
Actinomycin D1
|
Others | Others |
Actinomycin D1 is a DNA inhibitor. | |||
T31386 |
Desferriferribactin
Desferri-ferribactin |
Others | Others |
Desferriferribactin is a biogenetic precursor of pyoverdin. | |||
T18906 |
7-Aminoactinomycin D
7-AAD |
Others | Others |
7-Aminoactinomycin D is a fluorescent DNA stain. | |||
T68797 |
Actinomycin D2
|
Others | Others |
Actinomycin D2 is a DNA inhibitor. | |||
T125603 |
Surfactin C2
|
Others | Others |
Surfactin C2 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T125603,CAS号为 171039-18-2。 | |||
T26257 |
Teixobactin
|
Others | Others |
Teixobactin is a recently described antibiotic . It is a new class produced by a hitherto undescribed soil microorganism (provisionally named Eleftheria terrae). | |||
T34174 |
Pseudobactin
Ferric pseudobactin |
Others | Others |
Pseudobactin is a linear hexapeptide fluorescent iron transport agent (siderophore) from plant growth promoter Pseudomonas B10. | |||
T29677 |
Aerobactin
|
Others | Others |
Aerobactin, as a bacterial iron chelating agent (siderophore), can be found in E. coli. It is a virulence factor that can enable E. coli to sequester iron in iron-poor environments. | |||
T60486 |
Mycobactin-IN-1
|
Others | Others |
Mycobactin-IN-1 (compound 44) 是一种吡唑啉类似物。Mycobactin-IN-1 与分支菌素生物合成途径中的关键酶,水杨酸-AMP 连接酶 (MbtA) 结合。Mycobactin-IN-1 是分支菌素生物合成的抑制剂,具有抗分枝杆菌的作用。 | |||
TP2451 |
Arthrofactin
|
||
Arthrofactin is a lipopeptide biosurfactant. | |||
T15092 |
Defactinib hydrochloride
VS-6063 hydrochloride,PF 04554878 hydrochloride |
FAK | Angiogenesis; Cytoskeletal Signaling; Tyrosine Kinase/Adaptors |
Defactinib hydrochloride (PF 04554878 hydrochloride) (VS-6063 hydrochloride; PF 04554878 hydrochloride) 是一种新型 FAK 抑制剂,抑制 FAK 在 Tyr397 位点磷酸化,这种作用具有时间和剂量依赖性。 | |||
TP1769 |
Prolactin Releasing Peptide (1-31), human
|
||
Prolactin Releasing Peptide (1-31), human is a high affinity GPR10 ligand that cause the release of the prolactin. Human and rat Prolactin Releasing Peptide (1-31) binds to GPR10 with Kis of 1.03 and 0.33 nM, respectively.Prolactin-releasing peptide is a | |||
T39319 |
Actinomycin X2
放线菌素X2;放线菌素V,Actinomycin V |
||
Actinomycin X2 (Actinomycin V) is a compound synthesized by various species of Streptomyces. It displays potent inhibition against methicillin-resistant Staphylococcus aureus (MRSA), with a minimum inhibitory concentration (MIC) of 0.25 μg/mL. Actinomycin X2 possesses potential applications in the treatment of both cancer and bacterial infections. | |||
T60833 |
Mycobactin-IN-2
|
Others | Others |
Mycobactin-IN-2 (化合物 49) 是与水杨酰-AMP 连接酶 (MbtA) 结合的分枝杆菌素生物合成抑制剂,MbtA 是分枝杆菌素生物合成途径的关键酶。 | |||
T72817 |
Colibactin 742
|
Others | Others |
Colibactin 742 是一种稳定的大肠杆菌素衍生物,可诱导DNA 链间交联、激活 Fanconi Anemia DNA 修复途径和 G2/M 期阻滞。 | |||
T33537 |
Mycobactin P
|
Others | Others |
Mycobactin P is one of iron(III) chelating compounds produced by most species of Mycobacteria which act as growth factors. | |||
T124952 |
Homononactinic acid
|
Others | Others |
Homononactinic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124952,CAS号为 35986-06-2。 | |||
T69869 |
Cyanabactin
|
Others | Others |
Cyanabactin is a novel ABA receptor agonist. It preferentially activates Pyrabactin Resistance 1 (PYR1) with low nanomolar potency. | |||
T37052 |
Tetranactin
|
Others | Others |
Tetranactin is a macrotetrolide and a monovalent cation ionophore that has been found in S. aureus and has antibacterial, insecticidal, and mitogenic activities. It exhibits an equilibrium permeability ratio 1,000-fold greater for lithium than sodium or cesium ions accross bilayer membranes at low voltages. Tetranactin inhibits the growth of Gram-positive bacteria and C. miyabeanus and R. solani fungi when used at concentrations less than 0.9 μg/ml. Tetranactin (0.5-1.5 μg per insect) dose-depen... | |||
T124910 |
Arthrobactin
|
Others | Others |
Arthrobactin 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T124910,CAS号为 39007-57-3。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T3234 |
Dihydroactinidiolide
R-(-)Dihydro actinidiolide,二氢猕猴桃内酯 |
Others | Others |
Dihydroactinidiolide (R-(-)Dihydro actinidiolide) 是一种植物生长抑制剂,也是基因表达的调节剂,存在于植物叶片和果实中,能够负责拟南芥中的光适应。它具有抗氧化活性,抗菌活性,抗癌活性和神经保护作用。 | |||
T8177 |
Galactinol
|
Others | Others |
Galactinol Hydrate 清除羟基自由基并保护植物细胞免受氧化损伤。 | |||
TN6246 |
Actinodaphnine
|
||
Actinodaphnine 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 TN6246,CAS号为 517-69-1。 | |||
TN3346 |
Actinidic acid
|
Others | Others |
Actinidic acid is a triterpene phytoalexin from unripe kiwi fruit. | |||
T64891 |
(±)-Dihydroactinidiolide
|
Others | Others |
(±)-Dihydroactinidiolide 是一种天然产物,可用于生命科学领域的相关研究。其产品编号为 T64891,CAS号为 15356-74-8。 | |||
T14121 |
Actinonin
(-)-Actinonin |
Aminopeptidase | Metabolism |
Actinonin ((-)-Actinonin) is a naturally occurring antibacterial agent produced by Actinomyces and a potent reversible peptide deformylase (PDF) inhibitor with a Ki of 0.28 nM, it also is an apoptosis inducer. Actinonin inhibits aminopeptidase M, aminopeptidase N and leucine aminopeptidase, it also inhibits MMP-1, MMP-3, MMP-8, MMP-9, and hmeprin α with Ki values of 300 nM, 1,700 nM, 190 nM, 330 nM, and 20 nM, respectively. Actinonin has antiproliferative and antitumor activities[1][2][3][4][5]. | |||
T25827 |
Monactin
|
Others | Others |
Monactin is a Marcrotetrolide antibiotic produced by cycloheximide producing species of Streptomyces. It is a homolog of nonactin from the same species. | |||
T7097 |
Cytochalasin B
Phomin,细胞松弛素 B,细胞松弛素B |
Arp2/3 Complex | Cytoskeletal Signaling |
Cytochalasin B is a mycotoxin binding to the barbed end of actin filaments. It can disrupt the formation of actin polymers (Kd: 1.4-2.2 nM for F-actin). | |||
T21513 |
Cytochalasin H
(16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate,细胞松驰素 H |
MMP | Proteases/Proteasome |
Cytochalasin H ((16-Benzyl-5,12-dihydroxy-5,7,14-trimethyl-13-methylidene-18-oxo-17-azatricyclo[9.7.0.01,15]octadeca-3,9-dien-2-yl) acetate) 是肌动蛋白掺入细丝的有效抑制剂。 | |||
T13864 |
Resolvin D1
RvD1 |
Apoptosis | Apoptosis |
Resolvin D1 (RvD1) 是一种内源性促进炎症消解介质,可通过调节肌动蛋白聚合阻断促进炎症的中性粒细胞迁移,减少 TNF-α 介导的炎症在巨噬细胞中的作用,并增强巨噬细胞对凋亡细胞的吞噬作用。 | |||
TN1711 |
Gossypetin
|
Antioxidant; p38 MAPK; MAPK; Antibacterial | MAPK; Microbiology/Virology; oxidation-reduction |
Gossypetin 是一种可从Rhodiola rosea Linn.中提取的六羟基化的类黄酮,是一种有效的 MKK3 和 MKK6 抑制剂,可强烈减弱 MKK3/6-p38 信号传导途径。Gossypetin 具有抗突变、抗动脉粥样硬化、抗氧化以及细胞保护和抗菌作用,它通过下调溶酶体酪蛋白酶 K 的活性和诱导肌动蛋白环破骨细胞中的自噬相关蛋白来抑制骨吸收。 | |||
TN2143 |
3,7,4'-Trihydroxyflavone
Resokaempferol,5-Deoxykampferol |
DNA | DNA Damage/DNA Repair |
3,7,4'-Trihydroxyflavone(5-Deoxykampferol) 是从黄檀心材中分离得到的一种具有 DNA 断链活性的黄酮类化合物,可抑制 NF-κB 配体 (RANKL) 受体激活剂诱导的 RAW 264.7 细胞和骨髓巨噬细胞中的破骨细胞分化、肌动蛋白环形成和骨吸收。 | |||
T20945 |
2,4-D
Hedonal,Macondray,2,4-D acid,Chloroxone,2,4-二氯苯氧乙酸 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
2,4-Dichlorophenoxyacetic acid (Hedonal) 是一种合成生长素,用作植物生长调节剂,也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分,用于破坏肌动蛋白细胞骨架,以控制根系伸长和细胞生成。 | |||
T3S1471 |
Cucurbitacin IIA
葫芦素Iia,Dihydrocucurbitacin Q1,Hemslecin A,Curcurbitacin IIA |
Apoptosis; Survivin | Apoptosis |
Cucurbitacin IIA (Dihydrocucurbitacin Q1) 是从园果雪胆中分离得到的一种三萜烯,可诱导细胞凋亡和增强自噬,有助于葫芦素IIA 对炎症相关疾病的抗炎活性。它可降低癌细胞中生存素的表达,降低磷酸化组蛋白 H3 的水平,增加裂解的 PARP 的水平。 | |||
T5S1981 |
alpha-Cyperone
(+)-α-Cyperone,α-香附酮,α-Cyperone |
Others; Endogenous Metabolite | Metabolism; Others |
alpha-Cyperone (α-Cyperone) 与 IL-6, Cox-2, Cdc42, Nck-2, Rac1 的表达下调相关,从而能够抑制炎症反应。 | |||
T4839 |
Ac-Ala-OH
N-Acetylalanine,N-Acetyl-L-alanine,N-乙酰-L-丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
Ac-Ala-OH (N-Acetyl-L-alanine) 是鸟嘌呤核苷酸结合蛋白G(I)/G(S)/G(O) γ -2亚基、髓鞘碱性蛋白、GTP-结合核蛋白 Ran、原肌球蛋白 α - 4链、HIV-1 Rev 结合蛋白2、Xaa-Pro 二肽酶、胸腺酶 β -10、肌动蛋白样蛋白3、丙氨酸转氨酶、丝氨酸/苏氨酸蛋白磷酸酶PP1 - β催化亚基、10 kda 热休克蛋白(线粒体)、钙调蛋白和 β -1-syntrophin 的底物。 | |||
T8274 |
3-Methyl-L-histidine
|
Endogenous Metabolite | Metabolism |
3-Methyl-L-histidine 是一种肉类尤其是鸡肉摄入和大豆制品摄入的生物标记。 | |||
T15721 |
Latrunculin A
LAT-A |
Others | Others |
Latrunculin A is a toxin isolated from the red sea sponge Latrunculia magnifica. Latrunculin A binds to actin monomers and it also inhibits polymerization of actin (Kds: 0.1, 0.4, 4.7 μM, and 0.19 μM for ATP-actin, ADP-Pi-actin, ADP-actin, and G-actin, re | |||
T15039 |
Cytochalasin E
|
Others | Others |
Cytochalasin E is a potent actin depolymerization agent and an epoxide containing Aspergillus-derived fungal metabolite. Cytochalasin E also inhibits angiogenesis and tumor growth. It binds and caps the barbed end of actin filaments to prevent actin elong | |||
T11712 |
Jasplakinolide
Jaspamide,NSC-613009 |
Microtubule Associated; Antifungal | Cytoskeletal Signaling; Microbiology/Virology |
Jasplakinolide(Jaspamide) 是一种来自海洋海绵 (marine sponge) 的天然环状肽,是一种有效的肌动蛋白聚合反应 (actin polymerization) 诱导剂。Jasplakinolide 具有抗真菌和抗肿瘤活性,可以稳定先前存在的肌动蛋白丝。Jasplakinolide 与鬼笔环肽竞争性结合 F-肌动蛋白,对 F-肌动蛋白的 Kd 值为 15 nM。 | |||
T35782 |
Swinholide A
MK-7684 |
Antifungal | Microbiology/Virology |
Swinholide A 是可从海绵中提取的聚酮化合物,可于肌动蛋白结合,使肌动蛋白二聚化,Kd 约为 50 nM。Swinholide A 是一种细胞毒素,可稳定肌动蛋白二聚体并切断肌动蛋白丝。Swinholide A 具有抗真菌 (antifungal)活性,可破坏细胞的肌动蛋白细胞骨架。 | |||
T35609 |
19-O-Acetylchaetoglobosin A
|
Others | Others |
19-O-Acetylchaetoglobosin A is a fungal metabolite originally isolated fromC. globosumthat has actin polymerization inhibitory and cytotoxic activities.1,2It inhibits actin polymerization in a cell-free assay when used at a concentration of 2 μM.219-O-Acetylchaetoglobosin A (3.2, 10, and 32 μg/ml) is cytotoxic to HeLa cervical cancer cells.1 1.Umeda, M., Ohtsubo, K., Saito, M., et al.Cytotoxicity of new cytochalasans from Chaetomium globosumExperientia31(4)435-438(1975) 2.Sekita, S., Yoshihira, ... | |||
TN1533 |
Cucurbitacin A
|
ROCK | Cell Cycle/Checkpoint; Cytoskeletal Signaling; Stem Cells |
Cucurbitacin I, cytotoxic triterpenoid sterols isolated from plants, elicits the formation of actin/phospho-myosin II co-aggregates by stimulation of the RhoA/ROCK pathway and inhibition of LIM-Kinase. | |||
T40298 |
Phallacidin
|
Others | Others |
Phallacidin, a phallotoxin family member, targets and binds to F-actin in mushroom toxins. | |||
T38799 |
2,3-Bis(3-indolylmethyl)indole
|
Others | Others |
2,3-Bis(3-indolylmethyl)indole exhibits concentration-dependent inhibition of RANKL-induced osteoclastogenesis, actin ring formation, and bone resorption. | |||
T3229 |
Cytochalasin D
|
ATPase; p38 MAPK; Calcium Channel; Akt; PI3K | Cytoskeletal Signaling; MAPK; Membrane transporter/Ion channel; Metabolism; PI3K/Akt/mTOR signaling |
Cytochalasin D is an actin inhibitor, the removal of actin stress fibers is crucial for the chondrogenic differentiation. It may be an inhibitor of some fertilization processes such as sperm penetration or sperm head decondensation. Cytochalasin D inhibit | |||
TN7265 |
16-epi Latrunculin B
|
Others | Others |
16-epiLatrunculin B, a stereoisomer of the actin polymerization inhibitor latrunculin B, was initially isolated from the Red Sea sponge N. magnifica. At concentrations of 5-10 µg/ml, it disrupts microfilament activity in actin disruption assays and exhibits cytotoxic effects on mouse KA31T and NIH3T3 tumor cells, with GI50 values of 1 and 4 µg/ml, respectively. Furthermore, it shows antiviral activity against herpes simplex type 1 virus, with an ED50 of 1 µg/ml. | |||
T10928 |
Cytochalasin A
|
HIV Protease | Microbiology/Virology; Proteases/Proteasome |
Cytochalasin A is a cell-permeable fungal toxin and is an oxidized derivative of cytochalasin B. Cytochalasin A is an inhibitor of HIV-1 protease (IC50 = 3 μM), inhibits actin polymerization and interferes with microtubule assembly by reacting with sulfhy | |||
T75520 |
Aplyronine A
|
Others | Others |
Aplyronine A是具有特异性肌动蛋白解聚活性、抗肿瘤及促凋亡功能的化合物,适用于癌症、肌肉收缩、细胞运动和细胞分裂等研究领域。 | |||
T20636 |
Latrunculin B
LAT-B,LATB,NSC 339663,NSC339663,NSC-339663,LAT B,INS115644 |
Antifungal | Microbiology/Virology |
Latrunculin B 是一种 来自红海海绵的生物碱,是一种肌动蛋白聚合 (actin polymerization) 抑制剂,具有抗真菌和抗原生动物活性。Latrunculin B 调节肺静脉电生理特征并减轻牵张性心律失常的发生,可用于研究青少年青光眼。 |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPJ-01036 |
Beta-Actin Protein, Human, Recombinant (His)
Actin Cytoplasmic 1,β-Actin,Beta-Actin... |
Human | E. coli |
Actins are ubiquitous globular and highly conserved proteins that are involved in various types of cell motility, structure, and integrity. Three main groups of actin isoforms, alpha, beta and gamma have been identified. The alpha actins are found in muscle tissues and are a major constituent of the contractile apparatus. The beta and gamma actins co-exist in most cell types as components of the cytoskeleton, and as mediators of internal cell motility. ACTB is a major constituent of the contract... | |||
TMPH-00435 |
Beta-Actin Protein, Cricetulus griseus, Recombinant (His)
ACTB,Actin, cytoplasmic 1,Beta-actin |
Chinese hamster | E. coli |
Beta-Actin Protein, Cricetulus griseus, Recombinant (His) is expressed in E. coli. | |||
TMPH-00881 |
ACTA1 Protein, Human, Recombinant (His)
Actin, alpha skeletal muscle,Alpha-actin-1 |
Human | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 45.8 kDa and the accession number is P68133. | |||
TMPH-00883 |
ACTL7A Protein, Human, Recombinant (His & SUMO)
Actin-like protein 7A,Actin-like-7-alpha |
Human | E. coli |
ACTL7A Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 64.6 kDa and the accession number is Q9Y615. | |||
TMPH-01983 |
POTEKP Protein, Human, Recombinant (His & Myc)
Kappa-actin,POTE ankyrin domain family member K,Put... |
Human | E. coli |
POTEKP Protein, Human, Recombinant (His & Myc) is expressed in E. coli. | |||
TMPH-00882 |
ACTA2 Protein, Human, Recombinant (His)
Alpha-actin-2,Actin, aortic smooth muscle,... |
Human | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. ACTA2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 47.8 kDa and the accession number is P62736. | |||
TMPJ-00790 |
GSN Protein, Human, Recombinant (mFc)
ADF,Actin-depolymerizing factor,Brevin,Gelsolin,GSN... |
Human | HEK293 Cells |
Gelsolin is a calcium-activated actin filament severing and capping protein found in many cell types and as a secreted form in the plasma of vertebrates. Gelsolin is composed of six of these domains, termed G1-6. Some reaseraches show that gelsolin can act as a transcriptional cofactor in signal transduction and its own expression and function can be influenced by epigenetic changes. The difference in the expression levels of cytoplasmic and plasma gelsolin suggests that these two different form... | |||
TMPY-01823 |
PTK9 Protein, Human, Recombinant
MGC41876,twinfilin actin binding protein 1,A6,MGC23... |
Human | E. coli |
PTK9 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 29 kDa and the accession number is Q12792-4. | |||
TMPH-01342 |
Filamin-A Protein, Human, Recombinant (His & Myc)
FLNA,Filamin-1,Actin-binding protein 280,Alpha-fila... |
Human | E. coli |
Filamin-A Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 38.0 kDa and the accession number is P21333. | |||
TMPH-01379 |
GSN Protein, Human, Recombinant (His)
GSN,Actin-depolymerizing factor,Brevin,AGEL,Gelsoli... |
Human | E. coli |
Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. GSN Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 33.5 kDa and the accession number is P06396. | |||
TMPH-00006 |
Actin-1 Protein, Absidia glauca, Recombinant (His & Myc)
ACT1 |
Absidia glauca | E. coli |
Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. | |||
TMPY-00358 |
Arp3/ACTR3 Protein, Human, Recombinant (His & GST)
ARP3,ARP3 actin-related protein 3 homolog (yeast) |
Human | Baculovirus Insect Cells |
Arp3/ACTR3 Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 75.1 kDa and the accession number is A0A024RAI1. | |||
TMPY-03863 |
CAPG Protein, Human, Recombinant
capping protein (actin filament), gelsolin-like,HEL... |
Human | E. coli |
CAPG, also known as actin Regulatory Protein CAPG, is a a member of the gelsolin/villin family. Members of this family are actin-regulatory proteins. CAPG reversibly blocks the barbed ends of F-actin filaments in a Ca2+ and phosphoinositide-regulated manner, but does not sever preformed actin filaments. By capping the barbed ends of actin filaments, CAPG contributes to the control of actin-based motility in non-muscle cells. CAPG may also play an important role in macrophage function. | |||
TMPY-01822 |
PTK9 Protein, Human, Recombinant (His & GST)
PTK9,MGC41876,A6,MGC23788,twinfilin actin binding p... |
Human | E. coli |
PTK9 Protein, Human, Recombinant (His & GST) is expressed in E. coli expression system with His and GST tag. The predicted molecular weight is 57 kDa and the accession number is Q12792-4. | |||
TMPH-00885 |
ACTL8 Protein, Human, Recombinant (E. coli, His & Myc)
Actin-like protein 8,CT57,Cancer/testis antigen 57 |
Human | E. coli |
ACTL8 Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 46.9 kDa and the accession number is Q9H568. | |||
TMPH-00884 |
ACTL8 Protein, Human, Recombinant (His & Myc)
Cancer/testis antigen 57,CT57,Actin-like protein 8 |
Human | Baculovirus Insect Cells |
ACTL8 Protein, Human, Recombinant (His & Myc) is expressed in Baculovirus insect cells with N-10xHis and C-Myc tag. The predicted molecular weight is 45.4 kDa and the accession number is Q9H568. | |||
TMPH-01971 |
MICAL2 Protein, Human, Recombinant (His)
MICAL C-terminal-like protein,MICAL2,Molecule interactin... |
Human | P. pastoris (Yeast) |
MICAL2 Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-01320 |
CAPZA2 Protein, Human, Recombinant (His & SUMO)
CAPZA2,CapZ alpha-2,F-actin-capping protein subunit... |
Human | E. coli |
F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. CAPZA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 48.8 kDa and the accession number is P47755. | |||
TMPH-01916 |
PIP Protein, Human, Recombinant (His)
gp17,Secretory actin-binding protein,Gross cystic d... |
Human | E. coli |
PIP Protein, Human, Recombinant (His) is expressed in E. coli. | |||
TMPH-02160 |
SMARCB1 Protein, Human, Recombinant (His)
BRG1-associated factor 47,SNF5 homolog,Integrase interactor ... |
Human | E. coli |
SMARCB1 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 49.0 kDa and the accession number is Q12824. | |||
TMPH-01905 |
SMARCA2 Protein, Human, Recombinant (His)
Probable global transcription activator SNF2L2,SWI/SNF-relat... |
Human | P. pastoris (Yeast) |
SMARCA2 Protein, Human, Recombinant (His) is expressed in Yeast. | |||
TMPH-01906 |
SMARCA2 Protein, Human, Recombinant (His & SUMO)
BRG1-associated factor 190B,SNF2-alpha,SWI/SNF-related matri... |
Human | E. coli |
SMARCA2 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli. | |||
TMPH-02159 |
SMARCC1 Protein, Human, Recombinant (His & SUMO)
SWI/SNF-related matrix-associated actin-dependent r... |
Human | E. coli |
SMARCC1 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 41.5 kDa and the accession number is Q92922. | |||
TMPH-00841 |
SMARCA4 Protein, Human, Recombinant (His)
ATP-dependent helicase SMARCA4,Mitotic growth and transcript... |
Human | E. coli |
SMARCA4 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 37.1 kDa and the accession number is P51532. | |||
TMPH-02217 |
SMARCA4 Protein, Human, Recombinant (His)
Transcription activator BRG1,Protein brahma homolog 1,SWI/SN... |
Human | P. pastoris (Yeast) |
Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl... | |||
TMPY-04778 |
Prolactin Protein, Human, Recombinant (His)
prolactin |
Human | Baculovirus Insect Cells |
Prolactin Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 24.3 kDa and the accession number is P01236. | |||
TMPY-00720 |
Contactin 1 Protein, Human, Recombinant (His)
contactin 1,F3,GP135,MYPCN |
Human | HEK293 Cells |
Contactin 1 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 110 kDa and the accession number is A0A024R104. | |||
TMPY-02424 |
Prolactin Protein, Mouse, Recombinant (His)
AV290867,Prl1a1,prolactin |
Mouse | Baculovirus Insect Cells |
Prolactin Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 23.8 kDa and the accession number is Q9CPQ2. | |||
TMPY-01053 |
Prolactin Receptor Protein, Human, Recombinant (His)
hPRLrI,PRLR,MFAB,HPRL,prolactin receptor |
Human | HEK293 Cells |
Prolactin Receptor Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P16471-1. | |||
TMPY-02434 |
Prolactin Receptor Protein, Rat, Recombinant (His)
prolactin receptor,RATPRLR,MGC105486 |
Rat | HEK293 Cells |
Prolactin Receptor Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P05710-1. | |||
TMPY-02860 |
TAG1/Contactin 2 Protein, Mouse, Recombinant (His)
contactin 2 (axonal),TAG-1,D130012K04Rik,Tax |
Mouse | HEK293 Cells |
TAG1/Contactin 2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 108.7 kDa and the accession number is Q61330. | |||
TMPY-00721 |
TAG1/Contactin 2 Protein, Human, Recombinant (His)
TAX1,contactin 2 (axonal),FAME5,TAX,AXT,TAG-1 |
Human | HEK293 Cells |
TAG1/Contactin 2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 109 kDa and the accession number is A1ML24. | |||
TMPY-00722 |
Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc)
PCS,contactin 3 (plasmacytoma associated),BIG-1,PAN... |
Human | HEK293 Cells |
Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 134.5 kDa and the accession number is Q9P232. | |||
TMPY-03905 |
Lymphotactin/XCL1 Protein, Canine, Recombinant (His)
chemokine (C motif) ligand 1 |
Canine | Baculovirus Insect Cells |
Lymphotactin/XCL1 Protein, Canine, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 11.34 kDa and the accession number is A0A8C0PT44. | |||
TMPY-00723 |
Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His)
BIG-1,PCS,contactin 3 (plasmacytoma associated),PAN... |
Human | HEK293 Cells |
Contactin 3 Protein, Human, Recombinant (708 Asp/Asn, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 109.2 kDa and the accession number is Q9P232. | |||
TMPH-00835 |
Prolactin Protein, Horse, Recombinant (His)
Prolactin,PRL |
Horse | E. coli |
Prolactin acts primarily on the mammary gland by promoting lactation. Prolactin Protein, Horse, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 29.0 kDa and the accession number is P12420. | |||
TMPH-03122 |
Prolactin Protein, Pig, Recombinant (His & SUMO)
Prolactin,PRL |
Sus scrofa (Pig) | E. coli |
Prolactin acts primarily on the mammary gland by promoting lactation. Prolactin Protein, Pig, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 39.0 kDa and the accession number is P01238. | |||
TMPY-02687 |
Lymphotactin/XCL1 Protein, Human, Recombinant (His)
SCM1,SCM-1,SCYC1,LTN,LPTN,SCM-1a,ATAC,SCM1A,chemokine (C mot... |
Human | Baculovirus Insect Cells |
Lymphotactin/XCL1 Protein, Human, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 11.6 kDa and the accession number is P47992. | |||
TMPY-03135 |
Contactin 3 Protein, Rat, Recombinant (His)
contactin 3 (plasmacytoma associated) |
Rat | HEK293 Cells |
Contactin 3 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 109.2 kDa and the accession number is Q62682. | |||
TMPY-02984 |
Prolactin Receptor Protein, Mouse, Recombinant (His)
Pr-1,Pr-3,AI987712,prolactin receptor,Prlr,Prlr-rs1 |
Mouse | HEK293 Cells |
Prolactin Receptor Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 26 kDa and the accession number is P07321. | |||
TMPH-00037 |
Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His)
ltxA,Leukotoxin |
Aggregatibacter actinomycetemcomitans | P. pastoris (Yeast) |
Virulence factor that plays an important role in immune evasion. Lyses human lymphocytes and monocytes. Binds to the LFA-1 integrin on the surface of the host cell and to cholesterol-containing membranes, which probably results in large LtxA-LFA-1 clusters in lipid rafts. Shows also beta-hemolytic activity on certain types of growth media. Leukotoxin Protein, Aggregatibacter actinomycetemcomitans, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 38.3 kD... | |||
TMPY-06668 |
Act d 8 Protein, Actinidia deliciosa, Recombinant
|
Actinidia deliciosa | P. pastoris (Yeast) |
Act d 8 Protein, Actinidia deliciosa, Recombinant is expressed in P. pastoris yeast expression system. The predicted molecular weight is 26.7 kDa. | |||
TMPY-02610 |
Lymphotactin/XCL1 Protein, Mouse, Recombinant (His)
SCM-1a,AI661682,chemokine (C motif) ligand 1,SCM-1,LTN,ATAC,... |
Mouse | Baculovirus Insect Cells |
Lymphotactin/XCL1 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 11.5 kDa and the accession number is P47993. | |||
TMPY-02755 |
Lymphotactin/XCL1 Protein, Cynomolgus, Recombinant (His)
chemokine (C motif) ligand 1 |
Cynomolgus | Baculovirus Insect Cells |
Lymphotactin/XCL1 Protein, Cynomolgus, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 11.6 kDa. | |||
TMPH-00834 |
Prolactin Protein, Horse, Recombinant (hFc)
PRL,Prolactin |
Horse | HEK293 Cells |
Prolactin acts primarily on the mammary gland by promoting lactation. Prolactin Protein, Horse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFC tag. The predicted molecular weight is 51.9 kDa and the accession number is P12420. | |||
TMPH-03355 |
Prolactin Protein, Rat, Recombinant (His)
Prolactin,Prl |
Rat | E. coli |
Prolactin acts primarily on the mammary gland by promoting lactation. Prolactin Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 26.6 kDa and the accession number is P01237. | |||
TMPY-03676 |
Contactin 1 Protein, Mouse, Recombinant (His)
CNTN,F3cam,AW495098,usl,contactin 1 |
Mouse | HEK293 Cells |
Contactin 1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 69.4 kDa and the accession number is P12960. | |||
TMPY-01566 |
Prolactin Receptor Protein, Mouse, Recombinant (His & hFc)
prolactin receptor,Prlr,Pr-3,Pr-1,Prlr-rs1,AI987712 |
Mouse | HEK293 Cells |
Prolactin Receptor Protein, Mouse, Recombinant (His & hFc) is expressed in HEK293 mammalian cells with His and hFc tag. The predicted molecular weight is 52.5 kDa and the accession number is Q08501-1. | |||
TMPH-00206 |
Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO)
prn,P.93,Pertactin autotransporter |
Bordetella pertussis | E. coli |
Agglutinogen that binds to eukaryotic cells; a process mediated by the R-G-D sequence. Pertactin may have a role in bacterial adhesion, and thus play a role in virulence. May contribute to the disease state of whooping cough. Pertactin autotransporter Protein, Bordetella pertussis, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 45.8 kDa and the accession number is P14283. | |||
TMPY-03163 |
Contactin 3 Protein, Rat, Recombinant (hFc)
contactin 3 (plasmacytoma associated) |
Rat | HEK293 Cells |
Contactin 3 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 134.8 kDa and the accession number is Q62682. | |||
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Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TMIJ-0417 |
2,4-D-d3
|
||
2,4-D-d3 是 2,4-D 的氘代化合物。2,4-D 的 CAS 号为 94-75-7。2,4-Dichlorophenoxyacetic acid 是一种合成生长素,用作植物生长调节剂,也用作植物细胞培养基中的补充剂。它是除草剂中的一种活性成分,用于破坏肌动蛋白细胞骨架,以控制根系伸长和细胞生成。 |