白细胞介素 (Interleukins, ILs)

IL-23 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 58.3 kDa and the accession number is Q9EQ14&P43432.

IL-4 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 13.4 kDa and the accession number is P07750.

IL-1 beta IL-1F2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P10749.

IL-2 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.4kDa and the accession number is P04351.

IL-6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 21.9 kDa and the accession number is P08505.

IL-4 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.1 kDa and the accession number is P05112-1.

IL-1 beta IL-1F2 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17 kDa and the accession number is P01584.

IL-1 alpha IL-1A Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-Fc tag. The predicted molecular weight is 54 KDa and the accession number is P01583.

IL-13 Protein, Human, Recombinant is expressed in CHO mammalian cells. The predicted molecular weight is 12.5 kDa and the accession number is AAK53823.1.

Mouse interleukin-7(IL-7) is the member of hemopoietin family which is important to the differentiation, proliferation, and survival of lymphocyte. Mouse IL-7 shares approximately 88% aa sequence identity with rat IL-7 and 58-60% with human, equine, bovine, ovine, porcine, feline and canine IL-7. It is widely expressed in primary and secondary lymphoid tissues cell and stromal epithelial cells of the thymus, bone marrow, and intestines. IL-7 activation of IL-7 R alpha is critical for both T cell and B cell lineage development. It is important for proliferation during certain stages of B-cell maturation. IL-7 contributes to the maintenance of all naïve and memory T cells, mainly by promoting expression of the anti-apoptotic protein Bcl-2. It is required for optimal T cell-dendritic cell interaction.

IL-3 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.7 kDa and the accession number is P01586.

IL-6 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 20.95 kDa and the accession number is P05231.

IL-13 Protein, Mouse, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 12.35 kDa and the accession number is P20109.

IL-4 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 18 KDa and the accession number is P05112.

IL-10 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.6 kDa and the accession number is P22301.

IL-7 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15 kDa and the accession number is P10168.

IL-7 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 17.5 kDa and the accession number is P13232-1.

IL-17A Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 15.7 kDa and the accession number is Q16552.

IL-10 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.9 kDa and the accession number is A0A7R8GUQ3.

IL-1 beta IL-1F2 Protein, Rat, Recombinant (mature form) is expressed in E. coli expression system. The predicted molecular weight is 17.4 kDa and the accession number is Q63264-1.

IL-27 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 49.5 kDa and the accession number is O35228&Q8K3I6.

IL-11 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.1 kDa and the accession number is AAH12506.1.

IL-25 IL17E Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 20 kDa and the accession number is Q8VHH8.

IL-13 Protein, Mouse, Recombinant (aa 22-131, His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 14-30 KDa and the accession number is P20109.

IL-2 Protein, Human, Recombinant (E. coli) is expressed in E. coli expression system. The accession number is P60568.

IL-22 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 16.9 kDa and the accession number is A0A7R8C389.

Mouse Interleukin 33 (IL-33) is a 30 kDa proinflammatory cytokine which may also regulates gene transcription in producer cells. IL-33 is constitutively expressed in smooth muscle and airway epithelia. IL-33 was identified based on sequence and structural homology with IL-1 family cytokines. It is up‑regulated in arterial smooth muscle, dermal fibroblasts, and keratinocytes following IL-1 alpha or IL‑1 beta stimulation. IL-33 is structurally related to IL-1, which induces helper T cells to produce type 2 cytokines and acts through the receptor IL1RL-1. BindingIL-33 to this receptor activates NF-kappa-B and MAP kinases and induces in vitro Th2 cells to produce cytokines. In vivo, IL-33 induces the expression of IL-4, IL-5, IL-13 and also leads to severe pathological changes in mucosal organs.

IL-18 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18.2 kDa and the accession number is P70380-1.

IL-15 & IL-15RA Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 34.46 kDa and the accession number is P48346-1 & Q60819-1.

Interleukin-17 is a potent pro-inflammatory cytokine produced by activated memory T cells. There are at least six members of the IL-17 family in humans and in mice. Mature mouse IL-17A shares 61% and 89% amino acid sequence identity with human and rat IL-17A, respectively. As IL-17 shares properties with IL-1 and TNF-alpha, it may induce joint inflammation and bone and cartilage destruction. This cytokine is found in synovial fluids of patients with rheumatoid arthritis, and produced by rheumatoid arthritis synovium. It increases IL-6 production, induces collagen degradation and decreases collagen synthesis by synovium and cartilage and proteoglycan synthesis in cartilage. IL-17 is also able to increase bone destruction and reduce its formation. Blocking of interleukin-17 with specific inhibitors provides a protective inhibition of cartilage and bone degradation.

IL-12 Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 111.5 kDa and the accession number is P43431&P43432.

IL-9 Protein, Mouse, Recombinant (His) is expressed in Baculovirus insect cells with His tag. The predicted molecular weight is 15.6 kDa and the accession number is P15247.

IL-13 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 13-30 KDa and the accession number is AAH96139.

IL-16 Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 14.5 kDa and the accession number is O54824-1.

IL-27 Protein, Human, Recombinant (His) is expressed in CHO mammalian cells with His tag. The predicted molecular weight is 56 kDa and the accession number is NP_005746.2&NP_663634.2.

IL-2 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 15.4 kDa and the accession number is P60568.

IL-1 alpha IL-1A Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 18 kDa and the accession number is P01583.

IL-11 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 19.2 kDa and the accession number is A3KPB8.

IL-31 Protein, Cynomolgus, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 16.8 kDa and the accession number is A0A8J8XFW3.

IL-21 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 14.3kDa and the accession number is Q9ES17.

IL-12 Protein, Human, Recombinant is expressed in HEK293 mammalian cells. The predicted molecular weight is 57.2 kDa and the accession number is P29459-1&NP_002178.2.

IL-17F Protein, Mouse, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 17.8 kDa and the accession number is Q7TNI7-1.

IL15RA is a high-affinity receptor for interleukin-15. Il15ra associates as a heterotrimer with the IL-2 receptor beta and gamma subunits to initiate signal transduction. It can signal both in cis and trans where IL15R from one subset of cells presents IL15 to neighboring IL2RG-expressing cells. Il15ra is expressed in special cells including a wide variety of Tand B cells and non-lymphoid cells.IL-15 is a cytokine that regulates T cell and natural killer cell activation and proliferation. IL-15 binds to the alpha subunit of the IL-15RA with high affinity. IL-15 also binds to the beta and gamma chains of the IL-2 receptor, but not the alpha subunit of the IL2 receptor. IL-15 is structurally and functionally related to IL-2. Both cytokines share some subunits of receptors, allowing them to compete for and negatively regulate each other's activity. The number of CD8+ memory T cells is controlled by a balance between IL-15 and IL-2. Despite their many overlapping functional properties, IL-2 and IL-15 are, in fact, quite distinct players in the immune system. IL-15 is constitutively expressed by a wide variety of cell types and tissues, including monocytes, macrophages and DCs.

IL-32 is a recently discovered cytokine that induces various proinflammatory cytokines (TNF-alpha, IL-1beta, IL-6) and chemokines in both human and mouse cells through the NF-kappaB and p38 MAPK inflammatory signal pathways. It is regulated robustly by other major proinflammatory cytokines and is crucial to inflammation and immune responses. Four of the IL-32 isoforms (alpha, beta, gamma, and delta) are the most representative IL-32 transcripts, and the gamma isoform of IL-32 is the most active, although all isoforms are biologically active. IL-32, a cytokine produced mainly by T, natural killer, and epithelial cells induces significant amounts of TNFalpha and MIP-2 and increases the production of both cytokines in a dose-dependent manner. IL-32 has been implicated in inflammatory disorders, Mycobacterium tuberculosis infections, inflammatory bowel disease, and influenza A virus infection, as well as in some autoimmune diseases, such as rheumatoid arthritis, ulcerative colitis, and in the human stomach cancer, human lung cancer, and breast cancer tissues. Thus, IL-32 expression might be valuable as a biomarker for cancer.

IL-36 alpha IL-1F6 Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is Q9JLA2-1.

IL-1 alpha IL-1A Protein, Mouse, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 18 kDa and the accession number is P01582.

Interleukin (IL)-20 is a member of the IL-10 family of cytokines, which has been reported to participate in autoimmune inflammatory diseases. However, the potential role of IL-20 in hepatocellular carcinoma (HCC) progression has not yet been investigated. In addition, IL-20 expression was significantly associated with tumor size, metastasis, TNM stage and poor prognosis in patients with HCC. IL-20 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with N-His tag. The predicted molecular weight is 19.5 kDa and the accession number is Q9JKV9.

IL-17A Protein, Rat, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 21.0 kDa and the accession number is Q61453.