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Cat. No. | Product Name | ||
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L9300 | 大环化合物库 | 210 compounds | |
210 种活性已知的大环化合物,用于高通量、高内涵筛选; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T10492 |
BD-AcAc 2
Ketone Ester |
Reactive Oxygen Species | Immunology/Inflammation; Metabolism; NF-κB |
BD-AcAc 2 (Ketone Ester) 是一种酮单酯,是口服营养酮的来源。小鼠口服 BD-AcAc 2 后可提高血浆 乙酰乙酸和β-羟基丁酸水平、血液钠离子、血糖水平和血肌酐水平。BD-AcAc 2 可以一定程度预防脓毒症小鼠的肌无力。BD-AcAc 2 显示出提高动物机体耐力和运动能力的潜力。BD-AcAc 2 还可用于研究糖尿病或帕金森病。 | |||
T3966 |
Tirasemtiv
CK-2017357,泰拉生替 |
Others | Others |
Tirasemtiv (CK-2017357) 是一种快速骨骼肌型肌钙蛋白复合物激活剂。 | |||
T33944 |
PF-06260414
PF 06260414,PF06260414,PF-6260414,PF 6260414,PF6260414 |
Others | Others |
PF-06260414 is a selective androgen receptor modulator or SARM used to treat muscle weakness. | |||
T76860 |
Bimagrumab
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Bimagrumab (Anti-ACVR2B Reference Antibody) 是一种人单克隆抗体,可阻断激活素 II 型受体 (ActRII),对ActRIIB 和ActRIIA 的KD 值分别为 1.7 pM 和 434 pM。Bimagrumab 可用于病理性肌肉损失和无力的研究。 | |||
T83688 |
R 715 TFA
[Ac-Lys-[D-βNal7,Ile8]des-Arg9]-BK,Ac-Lys-Arg-Pro-Pro-Gly-Phe-Ser-D2Nal-Ile-OH |
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R 715是一种布拉迪肾上腺素B1受体拮抗剂。它抑制在表达布拉迪肾上腺素B1受体的孤立人类脐带中由布拉迪肾上腺素引发的收缩(pA2 = 8.49)。R 715(200、400及600 µg/kg)通过尾部闪烁测试减少了由链脲佐菌素(STZ)诱导的糖尿病神经病变小鼠模型中尾部撤回的潜伏期。它还在以髓磷脂少突胶质细胞糖蛋白(MOG)(35-55)(MOG35-55)抗原肽诱导的实验性自体免疫性脑炎(EAE)小鼠模型中,通过每天1 mg/kg的剂量减少了后肢无力和瘫痪的发病率,改善对称步态,并减少脊髓炎症灶点数、神经元脱髓鞘以及病灶单核细胞侵袭。R 715(0.01 nmol/动物,脑室内)能在自发性高血压大鼠中降低平均动脉血压并增加心率。 | |||
T83910 |
S1PL-IN-31
Sphingosine-1-Phosphate Lyase Inhibitor 31,S1PL Inhibitor 31,S1P Lyase Inhibitor 31 |
Others | Others |
S1PL-IN-31是一种鞘氨醇-1-磷酸(S1P)裂解酶的抑制剂(IC50 = 210 nM),同时也是Smoothened(Smo)受体的对抗剂(IC50 = 440 nM)。在体内,S1PL-IN-31 (每天2 mg/kg)能够防止实验性自身免疫性脑炎(EAE)模型大鼠中,由髓鞘少突胶质细胞糖蛋白(MOG)肽段MOG29-152诱发的颈部及胸部淋巴细胞渗透和神经肌肉虚弱。该化合物降低了大鼠的淋巴细胞总数及CD4+ T细胞、CD8+ T细胞和B细胞的水平。S1PL-IN-31 (每天3及10 mg/kg剂量)在雄性和雌性大鼠心脏和淋巴结中增加了S1P水平,并且在雌性大鼠中降低了心率。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
TC0025 |
Testosterone acetate
NSC523836,NSC-523836,NSC 523836,醋酸睾酮 |
Others | Others |
Testosterone acetate (NSC-523836) 是一种 Testosterone 前药,是一种天然存在的雄激素睾酮酯。它可用于阳痿、虚弱、疲劳和性腺机能减退的研究。 |
Cat. No. | Product Name | Species | Expression System |
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TMPJ-00876 |
FAH Protein, Human, Recombinant (His)
Fumarylacetoacetate Hydrolase,β-Diketonase,FAH,FAA,Fumarylac... |
Human | HEK293 Cells |
Fumarylacetoacetase belongs to the FAH family. Fumarylacetoacetase is primary expressed in liver and kidney. It exists as a homodimer and catalyzes the hydrolysis of 4-fumarylacetoacetate into fumarate and acetoacetate. Defects in Fumarylacetoacetase cause tyrosinemia type 1, which is congenital metabolism defect characterized by elevated levels of tyrosine in the blood and urine, and hepatorenal manifestations. Typical features include renal tubular injury, self-mutilation, hepatic necrosis, ep... | |||
TMPJ-00158 |
Apolipoprotein A-I/APOA1 Protein, Human, Recombinant
Apolipoprotein A-I,APOA1,Apo-AI,ApoA-I |
Human | E. coli |
Apolipoprotein A1 (APOA1) is a secreted protein which belongs to the Apolipoprotein A1/A4/E family. APOA1 is the major protein component of high density lipoprotein (HDL) in plasma. APOA1 plays a critical role in various biological processes, such as Cholesterol metabolism, Lipid metabolism and transport, Steroid metabolism. APOA1 promotes cholesterol efflux from tissues to the liver and thus helps to clear cholesterol from arteries. Defects in this gene resulted in HDL deficiencies, including T... | |||
TMPY-04557 |
PHKG1 Protein, Human, Recombinant (GST)
phosphorylase kinase, γ 1 (muscle),phosphorylase kinase, gam... |
Human | Baculovirus Insect Cells |
Phosphorylase b kinase gamma catalytic chain, skeletal muscle isoform, also known as Phosphorylase kinase subunit gamma-1 and PHKG1, is a member of the protein kinase superfamily and CAMK Ser/Thr protein kinase family. PHKG1 is the catalytic member of a 16 subunit protein kinase complex that contains equimolar ratios of 4 subunit types. The complex is a crucial glycogenolytic regulatory enzyme. Muscle glycogenosis caused by phosphorylase kinase (Phk) deficiency may lead to exercise intolerance, ... | |||
TMPY-01479 |
SPG3A Protein, Human, Recombinant (GST)
HSN1D,atlastin GTPase 1,FSP1,atlastin1,GBP3,SPG3,SPG3A,AD-FS... |
Human | Baculovirus Insect Cells |
Atlastin-1, also known as Spastic paraplegia 3 protein A, Guanine nucleotide-binding protein 3, GTP-binding protein 3, GBP3, ATL1 and SPG3A, is a multi-pass membrane protein which belongs to theGBP family and atlastin subfamily. ATL1 / SPG3A is expressed predominantly in the adult and fetal central nervous system. Expression of ATL1 / SPG3A in adult brain is at least 5-fold higher than in other tissues. ATL1 / SPG3A is detected predominantly in pyramidal neurons in the cerebral cortex and... | |||
TMPY-02840 |
Ubiquitin Activating Enzyme E1/UBA1 Protein, Human, Recombinant (His & GST)
UBE1,ubiquitin-like modifier activating enzyme 1,UBA1A,SMAX2... |
Human | Baculovirus Insect Cells |
UBE1, also known as UBA1, belongs to the ubiquitin-activating E1 family. UBE1 gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. UBE1 catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. It also catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation by first adenylating its C-terminal glycine residue w... | |||
TMPY-02196 |
VAPB Protein, Human, Recombinant (His)
ALS8,VAP-B,VAMP (vesicle-associated membrane protein)-associ... |
Human | E. coli |
Vesicle-associated membrane protein-associated protein B / C, also known as VAMP-B/VAMP-C, VAMP-associated protein B/C, VAP-B/VAP-C and VAPB, is a single-pass type IV membrane protein that belongs to the VAMP-associated protein (VAP) family. VAPB contains one MSP domain. VAPB may play a role in vesicle trafficking. VAPB forms a heterodimer with VAPA. VAPB interacts with VAMP1 and VAMP2. Defects in VAPB are the cause of amyotrophic lateral sclerosis type 8 ( ALS8 ) which is a familial form of amy... |