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TMPH-00951
|
PYCARD Protein, Human, Recombinant (His & Myc)
Caspase recruitment domain-containing protein 5,PYD and CARD...
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Human
|
HEK293 Cells
|
|
PYCARD Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q9ULZ3. |
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TMPH-00950
|
PYCARD Protein, Human, Recombinant (E. coli, His & Myc)
Target of methylation-induced silencing 1,PYCARD,Ca...
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Human
|
E. coli
|
|
PYCARD Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.1 kDa and the accession number is Q9ULZ3. |
|
TMPK-00678
|
CALCA/CGRP Protein, Mouse, Recombinant (hFc)
CGRP,Katacalcin,PDN-21,CGRP-I,CGRP1,Calcitonin 1,Calcitonin,...
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Mouse
|
HEK293 Cells
|
|
Specific fragments of methylation changes in the target gene (Calca) were identified by IGV analysis. CGRP was applied to compare the effects on ASCs-T2DM morphology via phalloidin staining, proliferation through CCK-8 assay, and osteogenic differentiation with osteogenic staining, qPCR, and repair of calvarial defect. Furthermore, 5-azacytidine (5-az) was used to intervene ASCs-T2DM to verify the relationship between the methylation level of the target fragment and expression of Calca. |
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TMPY-04722
|
DcR1/TRAILR3 Protein, Human, Recombinant (His)
TRAILR3,TRID,DCR1,TRAIL-R3,CD263,DCR1-TNFR,tumor necrosis fa...
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Human
|
HEK293 Cells
|
|
TNFRSF10C CNV in patients with CRC is associated with distant metastatic disease. A high frequency of CGI methylation in the TNFRSF10C promoter results in inactivation of the gene and enhancement of tumor growth in most PC cell lines (except CFPAC-1). Inactivation of TNFRSF10C by CpG island (CGI) hypermethylation can play an important role in PC progression and be potentially useful as a diagnostic marker and a new therapeutic approach for PC. |
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TMPH-02246
|
TGS1 Protein, Human, Recombinant (His & SUMO)
CLL-associated antigen KW-2,Cap-specific guanine-N2 methyltr...
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Human
|
E. coli
|
|
Catalyzes the 2 serial methylation steps for the conversion of the 7-monomethylguanosine (m(7)G) caps of snRNAs and snoRNAs to a 2,2,7-trimethylguanosine (m(2,2,7)G) cap structure. The enzyme is specific for guanine, and N7 methylation must precede N2 methylation. Hypermethylation of the m7G cap of U snRNAs leads to their concentration in nuclear foci, their colocalization with coilin and the formation of canonical Cajal bodies (CBs). Plays a role in transcriptional regulation. |
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TMPH-01698
|
MORC4 Protein, Human, Recombinant (His & Myc)
MORC4,Zinc finger CW-type domain protein 4,MORC family CW-ty...
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Human
|
E. coli
|
|
Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0. |
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TMPY-02957
|
DYDC2 Protein, Human, Recombinant (GST)
DPY30 domain containing 2
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Human
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E. coli
|
|
DPY30 domain containing 2 belongs to the dpy-30 family. Dumpy-30 family members act as determinants of male fertility and interaction partners of metal-responsive transcription factor 1 (MTF-1) in Drosophila. MTF-1 plays a key role in transition metal detoxification and homeostasis. It binds to metal response elements (MREs). Two candidate dMTF-1 interactors are related to the small regulatory protein Dumpy-30 (Dpy-30) of the worm C. elegans. Dpy-30 is the founding member of a protein family inv... |
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TMPH-02708
|
HNMT Protein, Mouse, Recombinant (His & Myc)
Hnmt,Histamine N-methyltransferase
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Mouse
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E. coli
|
|
Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. HNMT Protein, Mouse, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 41.1 kDa and the accession number is Q91VF2. |
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TMPY-04424
|
MST3 Protein, Human, Recombinant (His)
HEL-S-95,STE20,MST3B,RP11-111L24.5,MST3,STK3,serine/threonin...
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Human
|
Baculovirus Insect Cells
|
|
Aberrant STK24 expression was an independent prognostic indicator in lung adenocarcinoma patients. Its dysregulation was associated with its DNA copy number alteration and methylation. STK24/CCM3-regulated exocytosis plays an important role in the protection of kidneys from ischemia-reperfusion injury. |
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TMPY-02420
|
HEMK2 Protein, Human, Recombinant (His)
N-6 adenine-specific DNA methyltransferase 1 (putative),HEMK...
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Human
|
E. coli
|
|
N6AMT1 (N-6 Adenine-Specific DNA Methyltransferase 1) is a Protein Coding gene. 2 alternatively spliced human isoforms have been reported. This gene encodes an N(6)-adenine-specific DNA methyltransferase. It belongs to the eukaryotic/archaeal PrmC-related family. The encoded enzyme may be involved in the methylation of release factor I during translation termination. N6AMT1 has a significant role in determining susceptibility to arsenic toxicity and carcinogenicity because of its specific activi... |
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TMPY-02340
|
HNMT Protein, Human, Recombinant (GST)
HMT,HNMT-S1,HNMT-S2,histamine N-methyltransferase
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Human
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E. coli
|
|
HNMT (Histamine N-methyltransferase) is a Protein Coding gene. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. HNMT, the major enzyme for the metabolism of histamine in the rat brain, is potently inhibited by 9-amino-1,2,3,4-tetrahydroacridine (tacrine). Methylation is an important pathway in the biotransformation of many drugs, neurotransmitters, and xenobiotic compounds. Histamine N-methyltransferase (HNMT) catalyzes the N ... |
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TMPY-03046
|
APCDD1 Protein, Human, Recombinant (hFc)
HYPT1,B7323,adenomatosis polyposis coli down-regulated 1,HTS...
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Human
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HEK293 Cells
|
|
Osteosarcoma (OS) is the most common type of bone tumor in children and adults. The expression of APCDD1, a Wnt antagonist, was reduced in OS tissues and cells compared to adjacent normal tissue and osteoblast cells, respectively. Mechanistically, this was due to increased levels of methylation in the promoter region of the APCDD1 gene. Consistently, the DNA methyltransferase inhibitor 5-AZA-dC, reduced DNA methylation in the APCDD1 promoter, and restored APCDD1 expression in OS tissue and cells... |
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TMPY-05168
|
Syndecan-2 Protein, Mouse, Recombinant (His)
AA960457,4833414L08Rik,Hspg1,Synd2,syndecan 2,syndecan-2
|
Mouse
|
HEK293 Cells
|
|
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Syndecan-2 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 14.8 kDa and the accession number is P43407. |
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TMPK-01308
|
TAG-72 Protein, Canine, Recombinant (His)
mRNA-methyltransferase,mRNA (guanine-N(7))-methyltransferase...
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Canine
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E. coli
|
|
The guanine-N7 methyltransferase domain of vaccinia virus mRNA capping enzyme is a heterodimer composed of a catalytic subunit and a stimulatory subunit. Cap (guanine-N7) methylation is an essential step in eukaryal mRNA synthesis and a potential target for antiviral, antifungal, and antiprotozoal drug discovery. |
|
TMPY-01708
|
DOT1L Protein, Human, Recombinant
DOT1,KMT4,DOT1-like histone H3K79 methyltransferase
|
Human
|
E. coli
|
|
Histone-lysine N-methyltransferase, H3 lysine-79 specific, also known as Histone H3-K79 methyltransferase, DOT1-like protein, Lysine N-methyltransferase 4 and DOT1L, is a nucleus protein which belongs to theDOT1 family. In contrast to other lysine histone methyltransferase, DOT1L does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones. DOT1L is an histone methyltransferase. It methylates 'Lys-79' of histone H3. Nucleosome... |
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TMPY-02378
|
14‑3‑3 theta/YWHAQ Protein, Human, Recombinant (GST)
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activati...
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Human
|
E. coli
|
|
The recently identified 14-3-3 tau, whose corresponding gene name is YWHAQ, is in a hypoxia-treated human trophoblast cell line. YWHAQ may play a role in epigenetic regulation of placental genes in the onset of Preeclampsia (PE). Moreover, there was a closer relationship between blood pressure and methylation levels of the YWHAQ promoter. |
|
TMPY-04417
|
DAPK1 Protein, Human, Recombinant (aa 1-363, His & GST)
DAPK,death-associated protein kinase 1,ROCO3
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Human
|
Baculovirus Insect Cells
|
|
Death-associated protein kinase 1, also known as DAP kinase 1, DAPK1 and DAPK, is a cytoplasm protein which belongs to theprotein kinase superfamily, CAMK Ser / Thr protein kinase family and DAP kinase subfamily. DAPK1 contains tenANK repeats, onedeath domain and oneprotein kinase domain. DAPK1 is a calcium / calmodulin-dependent serine/threonine kinase which acts as a positive regulator of apoptosis. DAPK1 gene is a candidate tumor suppressor (TSG) and the abnormal methylation of DAPK1 g... |
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TMPK-00723
|
RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc)
CD265,Rank,FEO,ODFR,NF-KB,OSTS,TNFRSF11A,OPTB7,NFKB,TRANCER,...
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Mouse
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HEK293 Cells
|
|
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Mouse, Recombinant (hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 47.0 kDa and the acce... |
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TMPY-04249
|
Syndecan-2 Protein, Human, Recombinant (His)
syndecan 2,HSPG1,CD362,SYND2,HSPG
|
Human
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HEK293 Cells
|
|
The key players in the miR-20a-5p/SDC2 axis may be a potential diagnostic biomarker and therapeutic target for OS patients. SDC2 methylation as a blood-based DNA test for early detection of colorectal cancer (CRC). Syndecan-2 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 15.4 kDa and the accession number is A0A024R9D1. |
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TMPH-01477
|
Histone H1.3 Protein, Human, Recombinant (His & MBP)
Histone H1s-2,H1-3,Histone H1.3,Histone H1c
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Human
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E. coli
|
|
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation. HIST1H1D Protein, Human, Recombinant (His & MBP) is expressed in E. coli expression system with N-MBP and C-6xHis tag. The predicted molecula... |
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TMPH-01529
|
INMT Protein, Human, Recombinant (His & SUMO)
Thioether S-methyltransferase,INMT,Aromatic alkylamine N-met...
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Human
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E. coli
|
|
Functions as thioether S-methyltransferase and is active with a variety of thioethers and the corresponding selenium and tellurium compounds, including 3-methylthiopropionaldehyde, dimethyl selenide, dimethyl telluride, 2-methylthioethylamine, 2-methylthioethanol, methyl-n-propyl sulfide and diethyl sulfide. Plays an important role in the detoxification of selenium compounds. Catalyzes the N-methylation of tryptamine and structurally related compounds. |
|
TMPY-00624
|
PEAR1 Protein, Rat, Recombinant (His)
platelet endothelial aggregation receptor 1
|
Rat
|
Baculovirus Insect Cells
|
|
Platelet endothelial aggregation receptor-1 (PEAR1), an epidermal growth factor repeat-containing transmembrane receptor, is known to participate in platelet contact-induced activation. Platelet endothelial aggregation receptor 1 (PEAR1) triggers platelet aggregation and is expressed in platelets and endothelial cells.PEAR1 encodes the Platelet-Endothelial Aggregation Receptor 1, a contact receptor involved in platelet function and megakaryocyte and endothelial cell proliferation. PEAR1 expressi... |
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TMPY-01584
|
PR-Set7 Protein, Human, Recombinant
SET8,SET07,PR-Set7,SET domain containing (lysine methyltrans...
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Human
|
E. coli
|
|
KMT5A (known as PR-Set7/9, SETD8 and SET8), a member of the SET domain containing methyltransferase family specifically targeting H4K20 for methylation, has been implicated in multiple biological processes. Inhibition of KMT5A attenuated proliferation and induced apoptosis. Elevated KMT5A expression was significantly correlated with extrathyroidal extension, lymph node metastasis and advanced pathological stage of papillary thyroid cancer. KMT5A may be a novel oncogenic factor, specifically a re... |
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TMPH-01697
|
MORC3 Protein, Human, Recombinant (His & SUMO)
Zinc finger CW-type coiled-coil domain protein 3,MORC3,Nucle...
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Human
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E. coli
|
|
Nuclear factor which forms MORC3-NBs (nuclear bodies) via an ATP-dependent mechanism. Sumoylated MORC3-NBs can also associate with PML-NBs. Recruits TP53 and SP100 to PML-NBs, thus regulating TP53 activity. Binds RNA in vitro. May be required for influenza A transcription during viral infection. Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3. The order of binding preference is ... |
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TMPH-00886
|
ATF7IP2 Protein, Human, Recombinant (His)
MCAF2,ATF7-interacting protein 2,Activating transcription fa...
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Human
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E. coli
|
|
Recruiter that couples transcriptional factors to general transcription apparatus and thereby modulates transcription regulation and chromatin formation. Can both act as an activator or a repressor depending on the context. Mediates MBD1-dependent transcriptional repression, probably by recruiting complexes containing SETDB1. The complex formed with MBD1 and SETDB1 represses transcription and probably couples DNA methylation and histone H3 'Lys-9' trimethylation (H3K9me3) activity (Probable). AT... |
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TMPH-01526
|
KMT2E Protein, Human, Recombinant (His & Myc)
Inactive histone-lysine N-methyltransferase 2E,Myeloid/lymph...
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Human
|
E. coli
|
|
Associates with chromatin regions downstream of transcriptional start sites of active genes and thus regulates gene transcription. Chromatin interaction is mediated via the binding to tri-methylated histone H3 at 'Lys-4' (H3K4me3). Key regulator of hematopoiesis involved in terminal myeloid differentiation and in the regulation of hematopoietic stem cell (HSCs) self-renewal by a mechanism that involves DNA methylation. Also acts as an important cell cycle regulator, participating in cell cycle r... |
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TMPK-00351
|
RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc)
NF-KB,ODFR,PDB2,Rank,OSTS,NFKB,OPTB7,TNFRSF11A,LOH18CR1,CD26...
|
Human
|
HEK293 Cells
|
|
TNFRSF11A, also known as receptor activator of NF-κB (RANK), activates several signaling pathways, such as NF-κB, JNK, ERK, p38α, and Akt/PKB. RANK/TNFRSF11A is a novel and frequent target for de novo methylation in gliomas, which affects apoptotic activity and focus formation thereby contributing to the molecular pathogenesis of gliomas. RANK/TNFRSF11A Protein, Human, Recombinant (aa 30-212, hFc) is expressed in HEK293 mammalian cells with C-hFc tag. The predicted molecular weight is 46.85 kDa ... |
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TMPJ-01118
|
GNMT Protein, Human, Recombinant (His)
GNMT,Glycine N-Methyltransferase
|
Human
|
E. coli
|
|
Glycine N-Methyltransferase (GNMT) is a tetrameric cytosolic protein. GNMT catalyzes the synthesis of N-methylglycine from glycine using S-adenosylmethionine (AdoMet) as the methyl donor. It can affects DNA methylation by regulating the ratio of S-adenosylmethionine to S-adenosylhomocystine, playing an important role in maintaining normal AdoMet levels. GNMT is highly expressed in liver. As a major folate-binding protein, GNMT takes part in the detoxification pathway. Defects in GNMT are the cau... |
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TMPH-02105
|
ASH2L Protein, Human, Recombinant (His & SUMO)
ASH2-like protein,ASH2L,ASH2L1,Set1/Ash2 histone methyltrans...
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Human
|
E. coli
|
|
Transcriptional regulator. Component or associated component of some histone methyltransferase complexes which regulates transcription through recruitment of those complexes to gene promoters. Component of the Set1/Ash2 histone methyltransferase (HMT) complex, a complex that specifically methylates 'Lys-4' of histone H3, but not if the neighboring 'Lys-9' residue is already methylated. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. May p... |
|
TMPY-04770
|
RIOK1 Protein, Human, Recombinant (His & GST)
AD034,RRP10,bA288G3.1,RIO kinase 1
|
Human
|
Baculovirus Insect Cells
|
|
RIOK1, also known as RIO kinase 1, is a member of the RIO family of atypical serine protein kinases first characterized in yeast. RIOK1 and RIOK2 proteins are present in organisms from Archaea to humans. RIOK1 functions as a new interactor of protein arginine methyltransferase 5 (PRMT5), competes with pICln for binding and modulates PRMT5 complex composition and substrate specificity. RioK1 and pICln bind to PRMT5 in a mutually exclusive fashion. This results in a PRMT5-WD45/MEP5 core structure ... |
|
TMPY-02379
|
EED Protein, Human, Recombinant (His & GST)
HEED,WAIT1,embryonic ectoderm development
|
Human
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Baculovirus Insect Cells
|
|
EED is essential for regulating the repressive histone modification, histone 3 lysine 27 tri-methylation (H3K27me3) at many developmental genes. EED depletion significantly impeded erythroid maturation. EED depletion impaired the generation of hematopoietic stem cells. The function of EED within polycomb repressive complex 2 (PRC2) is mediated by a complex network of protein-protein interactions. The targeted disruption of EED's reader function can lead to allosteric inhibition of PRC2 catalyti... |
|
TMPY-03508
|
XTP3TPA Protein, Human, Recombinant (His)
XTP3TPA,dCTP pyrophosphatase 1,RS21C6,CDA03
|
Human
|
E. coli
|
|
DCTPP1 hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. It has a strong preference for modified dCTP. DCTPP1’s activity is highest with 5-iodo-dCTP, followed by 5-bromo-dCTP, unmodified dCTP, 5-methyl-dCTP and 5-chloro-dCTP. DCTPP1 also hydrolyzes 2-chloro-dATP and 2-hydroxy-dATP with lower efficiency, and has even lower activity with unmodified dATP, dTTP and dUTP (in vitro). DCTPP1 does not hydrolyze ATP, UTP, ITP, GTP, dADP, dCDP or dGTP.... |
|
TMPY-05693
|
SARS-CoV-2 Methyltransferase/ME Protein (His)
|
SARS-CoV-2
|
E. coli
|
|
Coronavirus encodes the 2’-O-MTase (2'O Methyltransferase) that is composed of the catalytic subunit nsp16 and the stimulatory subunit nsp10 and plays an important role in virus genome replication and evasion from innate immunity during viral infection. Nonstructural protein 16 (NSP16) / viral 2'O-methyltransferase (2'O-MTase) is highly conserved. The conserved 2'O-MTase activity is important for CoV pathogenesis and NSP16 is a conserved universal target for rapid live attenuated vaccine design ... |
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TMPY-01383
|
PRMT6 Protein, Human, Recombinant (His & Flag)
protein arginine methyltransferase 6,HRMT1L6
|
Human
|
HEK293 Cells
|
|
Protein arginine N-methyltransferase 6, also known as Histone-arginine N-methyltransferase PRMT6, PRMT6, and HRMT1L6, is a member of the protein arginine N-methyltransferase family and PRMT6 subfamily. PRMT6 is highly expressed in kidney and testes. PRMT6 is known to catalyze the generation of asymmetric dimethylarginine in polypeptides. It has been implicated in human immunodeficiency virus pathogenesis, DNA repair, and transcriptional regulation. PRMT6 is known to methylate histone H3 Arg-2 (H... |
|
TMPY-04403
|
NLK/Nemo Like Kinase Protein, Human, Recombinant (His & GST)
nemo-like kinase,LAK1
|
Human
|
Baculovirus Insect Cells
|
|
Nemo-like kinase contains 1 protein kinase domain and belongs to the protein kinase superfamily, CMGC Ser/Thr protein kinase family, and MAP kinase subfamily. It also contains a TQE activation loop motif in which autophosphorylation of the threonine residue (Thr-298) is sufficient for kinase activation. As a serine/threonine-protein kinase, Nemo-like kinase regulates some transcription factors with key roles in cell fate determination. It is a positive effector of the non-canonical Wnt signaling... |
|
TMPY-02384
|
MTSS1 Protein, Human, Recombinant (aa1-250, His & MBP)
metastasis suppressor 1,MIMB,MIM,MIMA
|
Human
|
E. coli
|
|
MTSS1 (Metastasis suppressor 1), also known as Missing in metastasis (MIM), is a tissue-specific regulator of plasma membrane dynamics. MTSS1 is well described for its function as a metastasis suppressor gene and is expressed in a variety of tissues. MTSS1 might be involved in shaping neuronal membranes in vivo. MTSS1 deforms phosphoinositide-rich membranes through its I-BAR domain and interacts with actin monomers through its WH2 domain. MTSS1/MIM was first identified as a metastasis suppressor... |
|
TMPH-00711
|
BioH Protein, E. coli, Recombinant (His & Myc)
bioB,Carboxylesterase BioH,Biotin synthesis protein BioH,Pim...
|
E. coli
|
E. coli
|
|
The physiological role of BioH is to remove the methyl group introduced by BioC when the pimeloyl moiety is complete. It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway through the hydrolysis of the ester bonds of pimeloyl-ACP esters. E.coli employs a methylation and demethylation strategy to allow elongation of a temporarily disguised malonate moiety to a pimelate moiety by the fatty acid synthetic enzymes. BioH shows a preference for short chain fatty acid esters (acyl c... |
|
TMPY-01270
|
PRMT3 Protein, Human, Recombinant (GST)
HRMT1L3,protein arginine methyltransferase 3
|
Human
|
E. coli
|
|
Protein arginine methyltransferase 3, also known as PRMT3, is one of four type I protein arginine methyltransferases (PRMT) that in humans is encoded by the PRMT3 gene. Methylation of arginine residues is a widespread post-translational modification of proteins catalyzed by a small family of PRMTs. The modification appears to regulate protein functions and interactions that affect gene regulation, signalling and subcellular localization of proteins and nucleic acids. In human cells, the PRMT fam... |
|
TMPY-01000
|
BVES Protein, Human, Recombinant (GST)
CARICK,LGMD2X,POP1,blood vessel epicardial substance,POPDC1,...
|
Human
|
E. coli
|
|
Blood vessel epicardial substance (BVES), or POPDC1, is a tight junction-associated transmembrane protein that modulates epithelial-to-mesenchymal transition (EMT) via junctional signaling pathways. BVES plays a protective role both in ulcerative and infectious colitis and identify BVES as a critical protector of colonic mucosal integrity. The Popeye domain containing1, also called Bves (Popdc1/Bves), is a transmembrane protein that functions in muscle regeneration, heart rate regulation, hypoxi... |
|
TMPY-02228
|
p53 Protein, Cynomolgus, Recombinant
tumor protein p53,p53,TP53
|
Cynomolgus
|
E. coli
|
|
p53, also known as Tp53, is a DNA-binding protein which belongs to the p53 family. It contains transcription activation, DNA-binding, and oligomerization domains. p53 protein is expressed at low level in normal cells and at a high level in a variety of transformed cell lines, where it's believed to contribute to transformation and malignancy. p53 (TP53) is a transcription factor whose protein levels and post-translational modification state alter in response to cellular stress (such as DNA damag... |
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