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Search Results for " macrolide "

Targets Recommended: Antibacterial Antibiotic

73

抑制剂 & 化合物

33

天然产物

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化合物库

5

同位素标记化合物

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Cat. No.	Product Name
L4700	免疫/炎症分子化合物库		4720 compounds
	4720 种具有抗炎症活性的化合物的特有集合，可用于高通量筛选和高内涵筛选；

化合物库

免疫/炎症分子化合物库

Cat.No: L4700

Compounds: 4720

Cat. No.	Product Name	Target	Signaling Pathways
T22228	Tylvalosin tartrate 酒石酸乙酰异戊酰泰乐菌素,Acetylisovaleryltylosin Tartrate	Antibacterial; Antibiotic	Microbiology/Virology
	Tylvalosin tartrate (Acetylisovaleryltylosin Tartrate) 是一种对革兰氏阳性细菌具有抗性的大环内酯类抗生素。
T21572	Erythromycin A enol ether	Others	Others
	Erythromycin A enol ether 是大环内酯类抗生素红霉素A 的降解产物。
T0777	Tilmicosin LY-177370,替米考星,EL-870	Antibacterial; Antibiotic	Microbiology/Virology
	Tilmicosin (EL-870) 是一种抗生素，可研究曼氏杆菌和巴氏杆菌相关的牛羊呼吸系统疾病。
T68163	Timcodar	Antibacterial	Microbiology/Virology
	timcodar 是一种非 FKBP12 结合大环内酯衍生物，是外排泵抑制剂，具有抗菌活性，抑制脂质积累，抑制结核杆菌，可用于研究肥胖。
T22439	Tilmicosin phosphate 磷酸替米考星,替米考星磷酸盐	Antibacterial; Antibiotic	Microbiology/Virology
	Tilmicosin phosphate 是一种抗生素，可研究曼氏杆菌和巴氏杆菌相关的牛羊呼吸系统疾病。
T21148	Troleandomycin AI3-50166,Triacetyloleandomycin,Aovine,Micotil,Matromycin T,Cyclamycin	P450; Antibiotic	Metabolism; Microbiology/Virology
	Troleandomycin (Triacetyloleandomycin) 是一种大环内酯类抗生素，是具有口服活性和特异性的 CYP3A 抑制剂，可诱发记性感言，诱导长期胆汁淤积，可用于研究哮喘疾病。
T7096	Tildipirosin	Antibacterial; Antibiotic	Microbiology/Virology
	Tildipirosin 是一种具有长效抗菌作用的大环内酯抗生素。
T4267	Tulathromycin A CP 472295,Draxxin,Tulathromycin,托拉菌素 A	Antibacterial; Antibiotic	Microbiology/Virology
	Tulathromycin A (CP 472295) 是一种大环内酯类抗生素，靶向细菌核糖体抑制蛋白质合成 (IC50=0.26 µM)，具有免疫调节作用。它可研究牛和猪的呼吸道疾病。
T9950	ElteN378	mTOR	PI3K/Akt/mTOR signaling
	Elte N378 是一种高效的合成 FKBP12 抑制剂，Ki 为 0.5 nM，是一种低原子量配体，其亲和力与大环内酯类雷帕霉素相当。
T12607	Quinupristin	Antibacterial; Antibiotic	Microbiology/Virology
	Quinupristin 是一种链球菌素类抗生素，可阻断细菌核糖体亚基中的肽键合成，阻止多肽链的延伸，促进不完全蛋白链的分离。
T1434	Clarithromycin A-56268,克拉霉素	P450; ribosome; MRP; Antibacterial; Antibiotic; Autophagy	Autophagy; Immunology/Inflammation; Metabolism; Microbiology/Virology
	Clarithromycin (A-56268) 具有广谱的抗菌活性。它抑制 CYP3A4催化的三唑仑 α-羟基化，IC50(Ki) 值为 56 (43) μM。它抑制 HERG 钾电流。它可削弱连接 hERG1 和 PI3K 的信号通路影响自噬流。
T0580	4-Pentynoic acid Propargylacetic acid,戊炔酸	Others	Others
	4-Pentynoic acid (Propargylacetic acid) 已用于与 1-溴-1-炔烃在 Pd 催化剂存在下的反应，产生具有生物活性的烯醇内酯。它还用于通过双乙炔的闭环复分解合成具有细胞毒性的大环内酯。
T16551	Pladienolide B	Apoptosis	Apoptosis
	Pladienolide B 是一种有效的剪接体抑制剂，是从钝顶链霉菌 Mer-12 中分离出的大环内酯类化合物，其作用靶向剪接体的 SF3B1 亚单位。Pladienolide B 通过抑制前 mRNA 剪接发挥抗肿瘤作用，诱导调亡。Pladienolide B 具有抗肿瘤活性，可用于研究白血病和淋巴肿瘤。
T6334	Ridaforolimus AP23573,Deforolimus,MK-8669	mTOR; Autophagy	Autophagy; PI3K/Akt/mTOR signaling
	Ridaforolimus (AP23573) 是亲脂性大环内酯类抗生素雷帕霉素的小分子非前药类似物，具有潜在的抗肿瘤活性。它是一种有效和选择性的 mTOR 抑制剂，在 HT-1080 细胞中抑制 S6 磷酸化的 IC50值为 0.2 nM。
T25303	Deltamycin A1	Others	Others
	Deltamycin A1 is a novel macrolide antibiotic.
T20686	RK 397 RK397,RK-397	Others	Others
	RK 397 is an antibiotic of oxopentaene macrolide.
T25039	Aldgamycin G 8-Deoxyaldgamycin F	Others	Others
	Aldgamycin G is a Macrolide antibiotic against Gram-positive bacteria isolated from Streptomyces avidinii.
T30038	Amphidinolide F	Others	Others
	Amphidinolide F is a new cytotoxic macrolide
T26057	Relomycin Relomycinum,Dihydrotylosin,Relomicina	Others	Others
	Relomycin is a macrolide antibiotic.
T25778	Maridomycin Turimycin EP(sub 3),Maridomycin III	Others	Others
	Maridomycin is a macrolide antibiotic.
T26116	Rokitamycin	Others	Others
	Rokitamycin is a macrolide antibiotic produced from strains of Streptomyces kitasatoensis.
T26410	A 26771B A-26771B,A26771B	Others	Others
	A 26771B is an antibiotic in the class of macrolide lactone.
T23140	PF-945863	Others	Others
	PF-945863 is a macrolide antibiotic.
T7148L2	Josamycin propionate BRN 1677122,BRN-1677122,BRN1677122	Others	Others
	Josamycin propionate is a macrolide antibiotic.
T25868	Niddamycin F-3463,F 3463,F3463	Others	Others
	Niddamycin is a new macrolide antibiotic.
T28121	Mycinamicin I Antibiotic A 11725 I,Mycinomycin I,A 11725 I	Others	Others
	Mycinamicin I is a macrolide antibiotic.
T26211	Sporeamicin A SRM A,L-53-18 A,L53-18 A,L 53-18 A,SRM-A	Others	Others
	Sporeamicin A is a new macrolide antibiotic from Saccaropolyspora.
T25038	Aldgamycin E	Others	Others
	Aldgamycin E is a neutral macrolide antibiotic agent from culture filtrates of Streptomyces lavendulae. Methanolysis produces methyl algarosides A & B.
T25762	Lucimycin FI1163,Antibiotic 1163 F.I.,FI 1163,FI-1163,NSC 143257	Others	Others
	Lucimycin is a macrolide antibiotic from cultures of Streptomyces lucensis.
T26088	Rimocidin Rimocidine	Others	Others
	Rimocidin is a macrolide antifungal compound isolated from Streptomyces rimosus.
T24777	Sedecamycin T-2636A,T-2636,Ro 23-0731/000,NSC 145117	Others	Others
	Sedecamycin is a 17-membered macrolide antibiotic. It is used for treating swine dysentery.
T25621	Lankacidinol A Lankacidinol 14-acetate,Antibiotic T-2636D,P 2636 D,P2636 D,P-2636 D	Others	Others
	Lankacidinol A is a metabolite of macrolide antibiotic.
T25992	Propionylmaridomycin Propionylmaridomycin I	Others	Others
	Propionylmaridomycin is a macrolide antibiotic.
T30037	Amphidinolide C	Others	Others
	Amphidinolide C is a potent cytotoxic 25-membered macrolide from marine dinoflagellate Amphidinium sp.
T25643	Lavendofuseomycin	Others	Others
	Lavendofuseomycin is a macrolide pentaene antibiotic.
T7148L1	Josamycin HCl Josamycin hydrochloride,Leucomycin A3 hydrochloride	Others	Others
	Josamycin HCl is a macrolide antibiotic.
T26124	Roseofungin	Others	Others
	Roseofungin is a polyenic macrolide antibiotic with the subgroup of carbonyl conjugated pentaenes.
T36183	Neospiramycin I	Others	Others
	Neospiramycin I is a macrolide antibiotic and derivative of spiramycin I.1It is active against the macrolide-sensitive KB210, but not the macrolide-resistant KB224, strain ofS. aureus(MICs = 3.12 and >100 μg/ml, respectively), as well asB. cereus,B. subtilis,M. luteus,E. coli, andK. pneumoniae(MICs = 1.56, 3.12, 3.12, 0.2, 50, and 12.5 μg/ml, respectively). Neospiramycin I binds toE. coliribosomes with an IC50value of 1.2 μM. It protects against mortality in a mouse model ofS. pneumoniaetype III...
T25027	Albocycline TA-2407,Ingramycin	Others	Others
	Albocycline is a Macrolide antibiotic from Streptomyces bruneogriseus nov. sp. MCRL-0129; specifically anti-staphylococcal, including antibiotic-resistant strains.
T25587	Kujimycin A Desacetyllankamycin	Others	Others
	Kujimycin A is a macrolide antibiotics agent from various strains of Streptomyces. It has great activity against some Gram-positive bacteria.
T26344	Yl 704 A1 Yl-704 A1,Yl704 A1	Others	Others
	Yl 704 A1 is a primary component of macrolide antibiotic YL-704 from Streptomyces platensis subsp. malvinus.
T25955	Picromycin Antibiotic B 62169A,Amaromycin,Albomycetin,Pikromycin	Others	Others
	Picromycin is a 14-membered macrolide antibiotic and Prolyl endopeptidase (PREP) inhibitor. Pikromycin shows activity against gram-positive bacteria including mycobacteria.
T28046	Mirosamicin A 11725 II,Antibiotic AR 5-2	Others	Others
	Mirosamicin is a macrolide antibiotic, it has antimicrobial effect against gram-positive bacteria, some gram-negative bacteria and mycoplasma.
T85067	Berkeleylactone E	Others	Others
	Berkeleylactone E为一种大环内酯类抗生素。
T36533	SCH 725674	Others	Others
	SCH 725674 is an antifungal macrolide originally isolated from Aspergillus. It inhibits the growth of S. cerevisiae and C. albicans in vitro (MICs = 8 and 32 μg/ml, respectively).
T28626	Rutamycin Oligomycin D,A272,A 272,A-272	Others	Others
	Rutamycin is a macrolide antibiotic of the oligomycin group obtained from Streptomyces rutgersensis. It inhibits various ATPases and uncouples oxidative phosphorylation from electron transport.
T32624	Leinamycin DC107,(+)-Leinamycin,DC 107,DC-107,Antibiotic DC 107	Others	Others
	Leinamycin is a thiazole containing macrolide that is extracted from Streptomyces possibly used as a DNA alkylator.
T16382	Oleandomycin	Others	Others
	Oleandomycin is similar to Erythromycin has antimicrobial activity. Oleandomycin is a macrolide antibiotic structurally closely related to Erythromycin.
T71647	Rustmicin	Others	Others
	Rustmicin is a 14-membered macrolide identified as an inhibitor of plant pathogenic fungi.
T25721	Lienomycin	Others	Others
	Lienomycin is a pentaene macrolide antitumor antibiotic generated by Actinomyces vendargensis Struyk et Stheeman. It has inonphore-like action.

化合物

Tylvalosin tartrate

Cat.No: T22228

Synonym: 酒石酸乙酰异戊酰泰乐菌素,Acetylisovaleryltylosin Tartrate

Target: Antibacterial, Antibiotic

Erythromycin A enol ether

Cat.No: T21572

Target: Others

Cat.No: T0777

Synonym: LY-177370,替米考星,EL-870

Target: Antibacterial, Antibiotic

Cat.No: T68163

Target: Antibacterial

Tilmicosin phosphate

Cat.No: T22439

Synonym: 磷酸替米考星,替米考星磷酸盐

Target: Antibacterial, Antibiotic

Cat.No: T21148

Synonym: AI3-50166,Triacetyloleandomycin,Aovine,Micotil,Matromycin T,Cyclamycin

Target: P450, Antibiotic

Cat.No: T7096

Target: Antibacterial, Antibiotic

Tulathromycin A

Cat.No: T4267

Synonym: CP 472295,Draxxin,Tulathromycin,托拉菌素 A

Target: Antibacterial, Antibiotic

Cat.No: T9950

Target: mTOR

Cat.No: T12607

Target: Antibacterial, Antibiotic

Cat.No: T1434

Synonym: A-56268,克拉霉素

Target: P450, ribosome, MRP, Antibacterial, Antibiotic, Autophagy

4-Pentynoic acid

Cat.No: T0580

Synonym: Propargylacetic acid,戊炔酸

Target: Others

Cat.No: T16551

Target: Apoptosis

Cat.No: T6334

Synonym: AP23573,Deforolimus,MK-8669

Target: mTOR, Autophagy

Cat.No: T25303

Target: Others

Cat.No: T20686

Synonym: RK397,RK-397

Target: Others

Cat.No: T25039

Synonym: 8-Deoxyaldgamycin F

Target: Others

Amphidinolide F

Cat.No: T30038

Target: Others

Cat.No: T26057

Synonym: Relomycinum,Dihydrotylosin,Relomicina

Target: Others

Cat.No: T25778

Synonym: Turimycin EP(sub 3),Maridomycin III

Target: Others

Cat.No: T26116

Target: Others

Cat.No: T26410

Synonym: A-26771B,A26771B

Target: Others

Cat.No: T23140

Target: Others

Josamycin propionate

Cat.No: T7148L2

Synonym: BRN 1677122,BRN-1677122,BRN1677122

Target: Others

Cat.No: T25868

Synonym: F-3463,F 3463,F3463

Target: Others

Cat.No: T28121

Synonym: Antibiotic A 11725 I,Mycinomycin I,A 11725 I

Target: Others

Cat.No: T26211

Synonym: SRM A,L-53-18 A,L53-18 A,L 53-18 A,SRM-A

Target: Others

Cat.No: T25038

Target: Others

Cat.No: T25762

Synonym: FI1163,Antibiotic 1163 F.I.,FI 1163,FI-1163,NSC 143257

Target: Others

Cat.No: T26088

Synonym: Rimocidine

Target: Others

Cat.No: T24777

Synonym: T-2636A,T-2636,Ro 23-0731/000,NSC 145117

Target: Others

Cat.No: T25621

Synonym: Lankacidinol 14-acetate,Antibiotic T-2636D,P 2636 D,P2636 D,P-2636 D

Target: Others

Propionylmaridomycin

Cat.No: T25992

Synonym: Propionylmaridomycin I

Target: Others

Amphidinolide C

Cat.No: T30037

Target: Others

Lavendofuseomycin

Cat.No: T25643

Target: Others

Cat.No: T7148L1

Synonym: Josamycin hydrochloride,Leucomycin A3 hydrochloride

Target: Others

Cat.No: T26124

Target: Others

Neospiramycin I

Cat.No: T36183

Target: Others

Cat.No: T25027

Synonym: TA-2407,Ingramycin

Target: Others

Cat.No: T25587

Synonym: Desacetyllankamycin

Target: Others

Cat.No: T26344

Synonym: Yl-704 A1,Yl704 A1

Target: Others

Cat.No: T25955

Synonym: Antibiotic B 62169A,Amaromycin,Albomycetin,Pikromycin

Target: Others

Cat.No: T28046

Synonym: A 11725 II,Antibiotic AR 5-2

Target: Others

Berkeleylactone E

Cat.No: T85067

Target: Others

Cat.No: T36533

Target: Others

Cat.No: T28626

Synonym: Oligomycin D,A272,A 272,A-272

Target: Others

Cat.No: T32624

Synonym: DC107,(+)-Leinamycin,DC 107,DC-107,Antibiotic DC 107

Target: Others

Cat.No: T16382

Target: Others

Cat.No: T71647

Target: Others

Cat.No: T25721

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0971	Dirithromycin Dirithromycinum,地红霉素,ASE 136,LY237216,Diritromicina,Dirithromycine	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Dirithromycin (LY237216) 是一种红霉素衍生物，是一种具有口服活性的半合成大环内酯类抗生素。它用于治疗许多不同类型的细菌感染。
T2481	Ascomycin FK520,Immunomycin,子囊霉素,FR-900520	Phosphatase; Others; Antibiotic; Parasite; Antifungal	Metabolism; Microbiology/Virology; Others
	Ascomycin (Immunomycin) 是 Tacrolimus 的乙基类似物，具有免疫抑制特性。它也是一种大环聚酮类抗生素，具有抗疟疾、抗真菌和抗痉挛等多种生物活性。它可防止移植排斥，并具有用于各种皮肤病研究的潜力。
T3607	Leucomycin 吉他霉素,Kitasamycin,Leucomycin V,Turimycin	Antibacterial; Antibiotic	Microbiology/Virology
	Leucomycin (Turimycin) 是一种由 Streptomyces kitasatoensis 产生的大环内酯类抗生素。
T1032	Erythromycin 红霉素,E-Mycin	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Erythromycin (E-Mycin) 是由放线菌产生的大环内酯类抗生素。它结合细菌的 50S 核糖体亚基，通过阻断转肽和易位反应来抑制 RNA 依赖性蛋白的合成。
T1151	Roxithromycin Roxl-150,罗红霉素,RU-28965	ribosome; Antibacterial; Antibiotic	Microbiology/Virology
	Roxithromycin (RU-28965) 是半合成的大环内酯类抗生素。
T3629	Gamithromycin ML-1709460,加米霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Gamithromycin (ML-1709460) 是一种可抑制 MmmSC 菌株 B237 和 Tan8 生长的大环内酯类抗菌剂，MIC 值分别为 0.00012 和 0.00006 μg/mL。
T0474	Erythromycin ethylsuccinate EES,琥乙红霉素	ribosome; HIV Protease; Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology; Proteases/Proteasome
	Erythromycin ethylsuccinate (EES) 是一种由红链霉菌产生的大环内酯类抗生素，有潜力用于多种细菌感染。它具有抗 HIV-1病毒活性。
T5037	Midecamycin Antibiotic SF-837,Turimycin P3,Medecamycin A1,Rubimycin,麦迪霉素,Platenomycin B1,Espinomycin A	Antibacterial; Antibiotic	Microbiology/Virology
	Midecamycin (Medecamycin A1) 是乙酰氧基取代的大环内酯类抗生素，对革兰氏阳性和阴性菌有效。
T21495	Spinosyn A	Others	Others
	Spinosyn A 是聚酮化合物衍生的大环内酯，来自多刺甘蔗多孢菌。Spinosyn A 是有效的杀虫剂。
T1419	Azithromycin hydrate CP-62993 dihydrate,阿奇霉素二水物,Azithromycin dihydrate,阿奇霉素二水合物	ribosome; Antibacterial; Antibiotic; Autophagy	Autophagy; Microbiology/Virology
	Azithromycin hydrate (CP-62993 dihydrate) 是一种大环内酯抗生素，可研究细菌感染。
T67867	Mycaminosyltylonolide	Antibacterial	Microbiology/Virology
	Mycaminosyltylonolide 是一种大环内酯类抗生素，它是 tyololide 在位置5上具有β - d -mycaminosyl 残基。Mycaminosyltylonolide 是一种有效的抗生素，具有抗菌活性和抑制荧光素酶的合成。
T0861	Tylosin tartrate 酒石酸泰洛星,酒石酸泰乐菌素	Antibacterial; Antibiotic	Microbiology/Virology
	Tylosin tartrate 是一种大环内酯类抗生素，是 Streptomyces fradiae 的产物。它对革兰氏阳性菌具有高效的抗菌活性。它作为饲料添加剂可促进动物生长。它被用于治疗家禽、猪和牛的细菌性痢疾和呼吸道疾病。
T11287	Filipin complex	Antifungal	Microbiology/Virology
	Filipin complex 是一种 28 元环戊烯大环内酯类抗真菌抗生素，由 S. filipinensis、S. avermitilis 和 S. miharaensis 产生的混合物，抑制 PRRSV 病毒进入细胞，通过与膜固醇相互作用发挥作用。
T7148	JOSAMYCIN EN-141,交沙霉素	Antibacterial; Antibiotic	Microbiology/Virology
	Josamycin (EN-141) 是一种大环内酯类抗生素，对多种病原体有抗菌活性。它对核糖体的解离常数Kd 为 5.5 nM。
T1003	Tylosin Fradizine,Tylosin A,泰乐菌素,Tylosine,Tylocine	Antibacterial; Antibiotic	Microbiology/Virology
	Tylosin (Tylosine) 是一种兽医用大环内酯类抗生素，是 Streptomyces fradiae 的产物。它对革兰氏阳性菌具有高抗菌活性。它是饲料添加剂用于促进动物生长。它被用于治疗家禽、猪和牛的细菌性痢疾和呼吸道疾病。
T6194	Fidaxomicin 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101	Apoptosis; DNA/RNA Synthesis; Antibacterial; Antibiotic	Apoptosis; Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology
	Fidaxomicin (Tiacumicin B) 是一种大环RNA 聚合酶抑制剂，具有窄谱活性。它选择性地根除致病性艰难梭菌，对构成正常健康肠道菌群的多种细菌影响很小。
T6062	Brefeldin A BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin	ATPase; Mitophagy; Antibiotic; Autophagy; HSV; CRISPR/Cas9	Autophagy; DNA Damage/DNA Repair; Membrane transporter/Ion channel; Microbiology/Virology
	Brefeldin A (Cyanein) 属于大环内酯类抗生素，是一种 ATPase 抑制剂 (IC50=0.2 μM)。Brefeldin A 可以诱导肿瘤细胞分化和凋亡，也具有抑制自噬的活性。
T15245	Erythromycin estolate Phtalic anhydride,ilosone	Antibacterial	Microbiology/Virology
	Erythromycin estolate 是红霉素的衍生物，属于大环内酯类抗生素，常用于研究多种细菌感染。酯酸红霉素对胆汁酸转运有抑制作用，可引起肝损伤，主要是胆汁淤积性肝炎。
T6740	Bafilomycin A1 巴佛洛霉素A1,巴佛洛霉素 A1	Apoptosis; Proton pump; Antibacterial; Antibiotic; Autophagy	Apoptosis; Autophagy; Membrane transporter/Ion channel; Microbiology/Virology
	Bafilomycin A1 属于大环内酯类抗生素，是一种 V-ATPase 抑制剂 (IC50=0.44 nM)，具有特异性和可逆性。Bafilomycin A1 是自噬晚期阶段抑制剂，阻断自噬体与溶酶体的融合。Bafilomycin A1 也诱导凋亡。
T0819	Spiramycin Espiramicin,螺旋霉素,Sequamycin,Rovamycin,Provamycin,Formacidine	Antibacterial; Antibiotic; Parasite	Microbiology/Virology
	Spiramycin (Rovamycin) 是一种由安博链霉菌产生的大环内酯类抗生素，具有抗细菌和弓形虫活性，并具有抗寄生虫作用。它由 16 个内酯环组成，其上附着 mycaminose，forosamine 和 mycarose 三种糖。
T20879	Tacrolimus monohydrate FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506	Phosphatase; Others; Antibacterial; Antibiotic; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others
	Tacrolimus monohydrate (LCP-Tacro) 是大环内酯类化合物，它与 FK506 结合蛋白 (FKBP) 结合形成复合物并抑制钙调神经磷酸酶，从而抑制 T 淋巴细胞信号转导和 IL-2 转录。具有强免疫抑制特性。
T2144	Tacrolimus 他克莫司,Fujimycin,FK506,FR900506	Phosphatase; Others; Antibacterial; Antibiotic; mTOR; Autophagy	Autophagy; Metabolism; Microbiology/Virology; Others; PI3K/Akt/mTOR signaling
	Tacrolimus (Fujimycin) 属于大环内酯类抗生素，可以与 FKBP12 结合形成高亲和力复合物 (Ki=0.2 nM)，抑制钙/钙调蛋白依赖性蛋白磷酸酶的活性。Tacrolimus 是一种免疫抑制剂，通过抑制 IL-2 的释放，全面抑制 T 淋巴细胞的作用。
T23505	Venturicidin A	Others	Others
	Venturicidin A is a macrolide antibiotic.
T20779	Kitasamycin tartrate Leucomycin tartrate	Others	Others
	Kitasamycin tartrate, a macrolide antibiotic produced by Streptomyces kitasatoensis, has a wide spectrum of antimicrobial activity.
T25622	Lankacidins Bundlin A,Lankacidin C,Antibiotic T-2636 C,NSC 145118,Lankacidin	Others	Others
	Lankacidins is an antitumor antibiotic of the macrolide tetraenes family from Streptomyces.
T10582	Borrelidin Treponemycin	Others	Others
	Borrelidin (Treponemycin) is a bacterial and eukaryal threonyl-tRNA synthetase inhibitor. It is a macrolide antibiotic isolated from Streptomyces rochei.
T10455	Bafilomycin B1 巴佛洛霉素 B1	Others	Others
	Bafilomycin B1, a macrolide antibiotic isolated from Streptomyces sp, acts as an inhibitor of K+-dependent ATPase of E. coli. It also inhibits Gram-positive bacteria and fungi.
T36044	17-hydroxy Venturicidin A	Others	Others
	17-hydroxy Venturicidin A is a macrolide fungal metabolite originally isolated from Streptomyces. It has antibiotic activity against M. luteus, B. subtilis, and S. aureus and antifungal activity against V. dahlia, Fusarium, and C. tropicalis in a disc assay.
T14831	Bryostatin 1	HIV Protease; PKC	Chromatin/Epigenetic; Cytoskeletal Signaling; Microbiology/Virology; Proteases/Proteasome
	Bryostatin 1 is a natural macrolide isolated from the bryozoan Bugula neritina and is a CNS)permeable PKC modulator. Bryostatin 1 binds to the isolated C1 domain of Munc13-1 and the full-length Munc13-1 protein (Kis: 8.07 nM and 0.45 nM).
TN7259	Concanamycin C 4'-O-de(aminocarbonyl)-Concanamycin A	Others	Others
	Concanamycin C, a natural macrolide antibiotic, was initially isolated from Streptomyces and identified as an inhibitor of T-cell proliferation in response to concanavalin A (1,2). It exhibits cytotoxicity to fungi, including yeasts, by inhibiting vacuolar-type ATPases (3,4).
T11233	Erythromycin thiocyanate	Antibacterial	Microbiology/Virology
	Erythromycin thiocyanate acts by binding to bacterial 50S ribosomal subunits and inhibits RNA-dependent protein synthesis by blockage of transpeptidation and/or translocation reactions, without affecting synthesis of nucleic acid .Erythromycin thiocyanate
T38258	Phanerosporic Acid	Others	Others
	Phanerosporic acid is a fungal secondary metabolite originally isolated from P. chrysosporum that has antibacterial activity against B. cereus, B. subtilis, and E. coli and antifungal activity against S. cerevisiae, A. niger, O. ulmi, U. maydis, C. cucmerinum, C. cladosporioides, and B. cinerea.1 It has been used in the synthesis of macrolide derivatives.References1. Arnone, A., Assante, G., Nasini, G., et al. Phanerosporic acid, a β-resorcylate obtained from Phanerochaete chrysosporium. Phytoch...
T36417	Nargenicin Antibiotic 47444	Others	Others
	Nargenicin is a macrolide antibiotic that selectively inhibits the growth of S. aureus, methicilin resistant S. aureus (MRSA), and M. luteus (MICs = 0.6, 0.3, and 2.5 μg/ml, respectively) over a panel of 11 Gram-positive and Gram-negative bacteria (MICs = >80 μg/ml). [1] It dose-dependently inhibits S. aureus DnaE in the presence of DNase I-activated DNA and E. coli DnaE when used at concentrations of 0.00001-0.1 and 0.01-100 μg/mL, respectively. [2] In murine BV-2 microglial cells, nargenicin (...

天然产物

Cat.No: T0971

Synonym: Dirithromycinum,地红霉素,ASE 136,LY237216,Diritromicina,Dirithromycine

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T2481

Synonym: FK520,Immunomycin,子囊霉素,FR-900520

Target: Phosphatase, Others, Antibiotic, Parasite, Antifungal

Cat.No: T3607

Synonym: 吉他霉素,Kitasamycin,Leucomycin V,Turimycin

Target: Antibacterial, Antibiotic

Cat.No: T1032

Synonym: 红霉素,E-Mycin

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T1151

Synonym: Roxl-150,罗红霉素,RU-28965

Target: ribosome, Antibacterial, Antibiotic

Cat.No: T3629

Synonym: ML-1709460,加米霉素

Target: Antibacterial, Antibiotic

Erythromycin ethylsuccinate

Cat.No: T0474

Synonym: EES,琥乙红霉素

Target: ribosome, HIV Protease, Antibacterial, Antibiotic, Autophagy

Cat.No: T5037

Synonym: Antibiotic SF-837,Turimycin P3,Medecamycin A1,Rubimycin,麦迪霉素,Platenomycin B1,Espinomycin A

Target: Antibacterial, Antibiotic

Cat.No: T21495

Target: Others

Azithromycin hydrate

Cat.No: T1419

Synonym: CP-62993 dihydrate,阿奇霉素二水物,Azithromycin dihydrate,阿奇霉素二水合物

Target: ribosome, Antibacterial, Antibiotic, Autophagy

Mycaminosyltylonolide

Cat.No: T67867

Target: Antibacterial

Tylosin tartrate

Cat.No: T0861

Synonym: 酒石酸泰洛星,酒石酸泰乐菌素

Target: Antibacterial, Antibiotic

Filipin complex

Cat.No: T11287

Target: Antifungal

Cat.No: T7148

Synonym: EN-141,交沙霉素

Target: Antibacterial, Antibiotic

Cat.No: T1003

Synonym: Fradizine,Tylosin A,泰乐菌素,Tylosine,Tylocine

Target: Antibacterial, Antibiotic

Cat.No: T6194

Synonym: 非达米星,Tiacumicin B,OPT-80,Clostomicin B1,PAR-101

Target: Apoptosis, DNA/RNA Synthesis, Antibacterial, Antibiotic

Cat.No: T6062

Synonym: BFA,布雷非德菌素 A,Ascotoxin,Cyanein,Decumbin

Target: ATPase, Mitophagy, Antibiotic, Autophagy, HSV, CRISPR/Cas9

Erythromycin estolate

Cat.No: T15245

Synonym: Phtalic anhydride,ilosone

Target: Antibacterial

Cat.No: T6740

Synonym: 巴佛洛霉素A1,巴佛洛霉素 A1

Target: Apoptosis, Proton pump, Antibacterial, Antibiotic, Autophagy

Cat.No: T0819

Synonym: Espiramicin,螺旋霉素,Sequamycin,Rovamycin,Provamycin,Formacidine

Target: Antibacterial, Antibiotic, Parasite

Tacrolimus monohydrate

Cat.No: T20879

Synonym: FK-506,FR 900506,Prograf,FR900506,Tacrolimus hydrate,LCP-Tacro,他克莫司一水合物,FK 506

Target: Phosphatase, Others, Antibacterial, Antibiotic, Autophagy

Cat.No: T2144

Synonym: 他克莫司,Fujimycin,FK506,FR900506

Target: Phosphatase, Others, Antibacterial, Antibiotic, mTOR, Autophagy

Cat.No: T23505

Target: Others

Kitasamycin tartrate

Cat.No: T20779

Synonym: Leucomycin tartrate

Target: Others

Cat.No: T25622

Synonym: Bundlin A,Lankacidin C,Antibiotic T-2636 C,NSC 145118,Lankacidin

Target: Others

Cat.No: T10582

Synonym: Treponemycin

Target: Others

Cat.No: T10455

Synonym: 巴佛洛霉素 B1

Target: Others

17-hydroxy Venturicidin A

Cat.No: T36044

Target: Others

Cat.No: T14831

Target: HIV Protease, PKC

Cat.No: TN7259

Synonym: 4'-O-de(aminocarbonyl)-Concanamycin A

Target: Others

Erythromycin thiocyanate

Cat.No: T11233

Target: Antibacterial

Phanerosporic Acid

Cat.No: T38258

Target: Others

Cat.No: T36417

Synonym: Antibiotic 47444

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TMID-0293	Acetylisovaleryltylosin-d3 Tartrate
	Acetylisovaleryltylosin-d3 Tartrate 是 Acetylisovaleryltylosin Tartrate 的氘代化合物。Acetylisovaleryltylosin Tartrate 的 CAS 号为 63428-13-7。Tylvalosin tartrate是一种对革兰氏阳性细菌具有抗性的大环内酯类抗生素。
TMIJ-0109	Erythromycin Ethylsuccinate-13C-d3
	Erythromycin Ethylsuccinate-13C-d3 是 Erythromycin Ethylsuccinate 的 13C 和氘代化合物。Erythromycin Ethylsuccinate 的 CAS 号为 1264-62-6。Erythromycin Ethylsuccinate是一种由红链霉菌产生的大环内酯类抗生素，有潜力用于多种细菌感染。它具有抗HIV-1病毒活性。
TMIJ-0520	(1E,13E) Tilmicosin-d3
	(1E,13E) Tilmicosin-d3 是 Tilmicosin 的氘代化合物。Tilmicosin 的 CAS 号为 108050-54-0。Tilmicosin是一种抗生素，可研究曼氏杆菌和巴氏杆菌相关的牛羊呼吸系统疾病。
TMIJ-0110	Clarithromycin-13C-d3
	Clarithromycin-13C-d3 是 Clarithromycin 的 13C 和氘代化合物。Clarithromycin 的 CAS 号为 81103-11-9。Clarithromycin 具有广谱的抗菌活性。它抑制CYP3A4催化的三唑仑 α-羟基化，IC50(Ki) 值为 56 (43) μM。它抑制 HERG 钾电流。它可削弱连接 hERG1 和 PI3K 的信号通路影响自噬流。
TMID-0292	Tylosin-d3
	Tylosin-d3 是 Tylosin 的氘代化合物。Tylosin 的 CAS 号为 1401-69-0。Tylosin 是一种兽医用大环内酯类抗生素，是Streptomyces fradiae的产物。它对革兰氏阳性菌具有高抗菌活性。它是饲料添加剂用于促进动物生长。它被用于治疗家禽、猪和牛的细菌性痢疾和呼吸道疾病。

同位素标记化合物

Acetylisovaleryltylosin-d3 Tartrate

Cat.No: TMID-0293

Erythromycin Ethylsuccinate-13C-d3

Cat.No: TMIJ-0109

(1E,13E) Tilmicosin-d3

Cat.No: TMIJ-0520

Clarithromycin-13C-d3

Cat.No: TMIJ-0110

Cat.No: TMID-0292

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