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Search Results for " lymphocytic "

Targets Recommended: Others

40

抑制剂 & 化合物

2

天然产物

26

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T9925	Ofatumumab	Others	Others
	Ofatumumab 是一种人源化靶向抗 CD20单克隆抗体。它作用于表达 CD20 的 B 淋巴细胞，能够诱导产生抗体依赖性细胞介导的细胞毒性和补体依赖性细胞毒性的作用。
T9744	MP07-66	Phosphatase	Metabolism
	MP07-66 是 FTY720 的一种类似物，没有免疫抑制作用。MP07-66通过破坏 SET-PP2A 复合物导致PP2A 重新激活。MP07-66在慢性淋巴细胞白血病中显示出良好的抗肿瘤作用。
T12317	Orelabrutinib ICP-022	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Orelabrutinib (ICP-022) 是一种口服活性的、强效的、不可逆的 Bruton 酪氨酸激酶(BTK)抑制剂，具有潜在的抗肿瘤作用。它能够阻止 B 细胞抗原受体 (BCR) 信号通路的激活和 BTK 介导的下游生存通路的激活，抑制过度表达 BTK 的恶性 B 细胞的生长。
T3626	Acalabrutinib ACP-196,阿可替尼	BTK	Angiogenesis; Tyrosine Kinase/Adaptors
	Acalabrutinib (ACP-196) 是一种不可逆的、高效的、具有口服活性、选择性的第二代BTK 抑制剂。它与 BTK 的 ATP 结合口袋中的 Cys481 共价结合。它在慢性淋巴细胞性白血病 (CLL) 小鼠模型中显示出强大的靶向作用和功效。
T2558	Cladribine 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA	Apoptosis; Adenosine deaminase	Apoptosis; Metabolism
	Cladribine (2CdA) 是一种嘌呤核苷类似物，是具有口服活性的腺苷脱氨酶抑制剂。它能作为 DNA 合成的抑制剂，可阻断受损 DNA 的修复。它可抑制 DNA 甲基化，具有抗淋巴瘤活性，可研究血液恶性肿瘤和多发性硬化。
T4976	Umbralisib TGR-1202,RP5264,TGR 1202,TGR1202	PI3K	PI3K/Akt/mTOR signaling
	Umbralisib (TGR 1202) 是一种PI3Kδ抑制剂，IC50=22.2 nM，EC50=24.3 nM。它同时可抑制CK1ε，EC50=6.0 μM。
TP1758L	LCMV gp33-41 acetate LCMV gp33-41 acetate（151705-84-9 Free base）	Others	Others
	LCMV gp33-41 acetate 是淋巴细胞性脉络丛脑膜炎病毒的序列，受主要组织相容性复合体 I 类 H-2Db 限制，呈递给细胞毒性 T 淋巴细胞。
T3099	Pinometostat EPZ-5676	Histone Methyltransferase	Chromatin/Epigenetic
	Pinometostat (EPZ-5676) 是有效的DOT1L 组蛋白甲基转移酶抑制剂，Ki 为 80 pM。它可用于研究多种白血病治疗的实验。
T16157	MT-802	BTK; PROTACs	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	MT-802 是一种基于Cereblon 配体的、BTK 的降解剂，其 DC50=1 nM。它具有研究 C481S 突变型慢性淋巴细胞白血病的潜力。
T15420	GS-9901	PI3K	PI3K/Akt/mTOR signaling
	GS-9901 是一种具有选择性、口服活性和高效性的 PI3Kδ 抑制剂（IC50：1 nM），可用于研究非霍奇金淋巴瘤和慢性淋巴细胞白血病。
T8380	Bendamustine SDX105,宾达氮芥	Apoptosis; Others; DNA Alkylator/Crosslinker	Apoptosis; DNA Damage/DNA Repair; Others
	Bendamustine (SDX105) 是一种嘌呤类似物，是一种 DNA 交联剂，具有烷基化、抗癌和抗代谢作用。它可激活 DNA 损伤反应和细胞凋亡。
T76794	Ulocuplumab BMS 936564,MDX 1338	Apoptosis; CXCR	Apoptosis; Autophagy; GPCR/G Protein; Immunology/Inflammation
	Ulocuplumab (BMS-936564) 是一种完全人抗 CXCR4 的 IgG4 抗体。Ulocplumab 在急性髓系白血病 (AML)，非霍奇金淋巴瘤 (NHL) 和多发性骨髓瘤移植模型中展现出抗肿瘤活性。Ulocplumab 对 CXCL12 介导的慢性淋巴细胞白血病 (CLL) 细胞在 CXCR4 激活下的迁移有抑制作用，诱导癌细胞凋亡 (apoptosis)，。
T10483	Lisaftoclax Bcl-2/Bcl-xl inhibitor 1,APG-2575	BCL	Apoptosis
	Lisaftoclax (Bcl-2/Bcl-xl inhibitor 1) 是一种双重 Bcl-2 和 Bcl-xl 抑制剂(IC50：2 nM 和 5.9 nM)，具有抗肿瘤活性。
T77093	Theralizumab TGN1412,TAB-08,TABO8	Others	Others
	Theralizumab (TGN1412) 是一种抗靶向 CD28 的单克隆抗体，可直接刺激 T 细胞。Theralizumab 具有抗肿瘤活性，用于治疗 B 细胞慢性淋巴细胞白血病和类风湿性关节炎。
T4564	Ethacrynic acid Edecrin,利尿酸,Etacrynic Acid,Hydromedin	Others; Calcium Channel; NF-κB; GST	Membrane transporter/Ion channel; Metabolism; NF-κB; Others; oxidation-reduction
	Ethacrynic acid (Edecrin) 是谷胱甘肽 S-转移酶抑制剂，也是NF-κB 信号传导途径的有效抑制剂，并且还调节白三烯的形成。它还可抑制 L 型电压依赖性和储存操作的钙通道，从而导致气道平滑肌细胞松弛。它是利尿剂，具有抗炎特性，可减轻类维生素 A 诱导的小鼠耳部水肿。
T38622	Bcl-xL antagonist 2	BCL	Apoptosis
	Bcl-xL antagonist 2 是一种有效的选择性 Bcl-xL 拮抗剂，IC50 为 91 nM，Ki 为 65 nM。 Bcl-xL antagonist 2 可诱导癌细胞凋亡，可用于慢性淋巴细胞白血病和非霍奇金淋巴瘤的研究。
T19661	8-Chloroadenosine NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷	AMPK	Chromatin/Epigenetic; PI3K/Akt/mTOR signaling
	8-Chloroadenosine (NSC-354258) 是一种 5' AMP 激活的蛋白激酶激动剂，可能用于治疗慢性淋巴细胞白血病。它的活性与 mTOR 通路的抑制有关。它是一种核苷类似物。在体内代谢为 8-氯-ATP。在转录过程中掺入 RNA 并抑制 RNA 合成。在 MM.1S、RPMI-8226 和 U266 癌细胞系中表现出细胞毒性；在 A549 和 H1299 细胞中诱导 G2/M 细胞周期停滞和有丝分裂灾难。它已被证明可消耗 ATP 并抑制血液恶性肿瘤以及肺癌和乳腺癌细胞系中的肿瘤生长。
T1835	Ibrutinib 伊布替尼,依鲁替尼,PCI-32765	Tyrosine Kinases; Src; BTK; Ligands for Target Protein for PROTAC	Angiogenesis; PROTAC; Tyrosine Kinase/Adaptors
	Ibrutinib (PCI-32765) 是一种布鲁顿酪氨酸激酶 (BTK) 抑制剂 (IC50=0.5 nM)，具有不可逆性和选择性。Ibrutinib 可以阻断 BTK 抑制 B 细胞的增殖和存活，具有抗肿瘤活性，可以用于治疗慢性淋巴细胞白血病等。
T71996	VU0621623	Others	Others
	VU0621623 is an arenavirus multiplication inhibitor which blocks lymphocytic choriomeningitis virus (LCMV) cell entry.
T70107	Olcorolimus	Others	Others
	Olcorolimus inhibits single allergen-induced allergic inflammation such as eosinophilic and lymphocytic infiltration and mRNA expression for interleukin (IL)-4 and IL-5
T37602	GSK 143	Others	Others
	Spleen tyrosine kinase (Syk) inhibitor (pIC50 = 7.5). Also inhibits phosphorylated Erk (pIC50 = 7.1). Decreases cell number and viability in chronic lymphocytic leukemia (CCL) cell lines. Liddle et al (2011) Discovery of GSK143, a highly potent, selective and orally efficacious spleen tyrosine kinase inhibitor. Bioorg.Med.Chem.Lett. 21 6188 PMID:21903390 \|Varghese et al (2018) Highly selective SYK inhibitor, GSK143, abrogates survival signals in chronic lymphocytic leukaemia. Br.J.Haematol 182 9...
TP1640	Glycoprotein (276-286) Glycoprotein 276-286
	Known Db-restricted peptide of lymphocytic choriomeningitis virus (LCMV).
TP1758	LCMV gp33-41
	LCMV gp33-41, the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes.This is the H-2Db restricted epitope derived from the lymphocytic
T36890	A 410099.1	Others	Others
	High affinity XIAP antagonist (Kd = 16 nM for the BIR3 domain of XIAP). Exhibits cytotoxicity in a wide range of cancer cell lines in vitro (EC50 = 13 nM in MDA-MB-231 cells). Also displays antitumor activity in a mouse breast cancer xenograft model. Enhances TRAIL-induced apoptosis in chronic lymphocytic leukemia (CLL) cells. Oost et al (2004) Discovery of potent antagonists of the antiapoptotic protein XIAP for the treatment of cancer. J.Med.Chem. 47 4417 PMID:15317454 \|Loeder et al (2009) A n...
T64152	Purinostat mesylate	Others	Others
	Purinostat mesylate 是一种选择性的 HDAC 抑制剂。Purinostat mesylate 能够抑制 I 型和 IIb 型 HDACs (IC50: 0.81-11.5 nM)。Purinostat mesylate 能够影响LAMA84 和 188 BL-2 细胞的细胞周期，并诱导其凋亡，在体内显示出较强的抗白血病效果。Purinostat mesylate 能够用于研究淋巴细胞白血病。
TP2150	Nucleoprotein (396-404) (TFA) NP 396 TFA	Others	Others
	Nucleoprotein (396-404) TFA is the 396 to 404 fragment of the lymphocytic choriomeningitis virus (LCMV). It is the H-2D(b)-restricted immunodominant epitope used as a molecular model of viral antigen.
TP1629	LCMV gp33-41 (TFA) (151705-84-9 free base) LCMV gp33-41 (TFA)
	LCMV gp33-41 (TFA), the carboxyl-extended 11-aa-long peptide, is an lymphocytic choriomeningitis virus sequence restricted by MHC class I H-2Db molecules and presented to cytotoxic T lymphocytes[1].
TP1752	GP(33-41)
	GP(33-41), a 9-aa-long peptide, is the optimal sequence of the GP1 epitope of lymphocytic choriomeningitis virus, and can upregulate H-2Db molecules at the RMA-S (Db Kb) cell surface with a SC50 of 344 nM. GP33-41 Epitopeis a strong agonist of CD8 T cells
TP1078	Nucleoprotein (396-404) Nucleoprotein 396-404,NP 396
	Nucleoprotein (396-404) refers to a specific fragment within the lymphocytic choriomeningitis virus (LCMV). This fragment, also known as the H-2D(b)-restricted immunodominant epitope, has been identified as a significant component of the viral antigen. It can be utilized as a valuable molecular model for studying viral antigens.
T75982	LCMV gp33-41 TFA
	LCMV gp33-41 (TFA)是一种带有羧基延伸的11-aa长肽，作为淋巴细胞脉络丛脑膜炎病毒序列，在MHC I类H-2Db分子的限制下，能够被呈递给细胞毒性T淋巴细胞。
T70304	CI-898 HCl	Others	Others
	CI-898 HCl is a lipophilic antifolate inhibitor of dihydrofolate reductase (DHFR). It has enhanced binding to DHFR in the presence of the cofactor NADPH. Cl-898 HCl inhibits cell growth and halts the cell cycle at the G1/S phase in L1210 mouse lymphocytic leukemia cells and is active against methotrexate-resistant cancer cell lines. It also enhances the activity of doxorubicin, cyclophosphamide, and 6-thioguanine (6-TG) in mice with advanced stage P338 leukemia.
T76909	Apolizumab
	Apolizumab (Hu1D10)为人源化单克隆抗体，针对人类白细胞抗原-DR β链。该抗体能够介导慢性淋巴细胞白血病(CLL)细胞在体外的凋亡。
T78295	Samalizumab ALXN 6000
	Samalizumab（ALXN 6000）是一种针对CD200具有特异性结合并能阻断CD200与CD200R（CD200受体）相互作用的人源化单克隆抗体。它目前被用于多发性骨髓瘤和B细胞慢性淋巴细胞白血病的研究中。
T75766	GP(33-41) TFA
	GP(33-41) TFA 是一种由 9 个氨基酸残基组成的多肽，它是淋巴细胞性脉络丛脑膜炎病毒 GP1 抗原决定基中的序列。GP(33-41) TFA 能够上调 RMA-S (Db Kb) 细胞表面 H-2Db 分子，SC50值为 344 nM。
T38383	Altemicidin	Others	Others
	Altemicidin is a monoterpene alkaloid originally isolated fromS. sioyaensiswith acaricidal and anticancer activities.1It is acaricidal to two-spotted spider mites (T. urticae) in a greenhouse pot test at concentrations of 10 and 100 ppm. Altemicidin inhibits the growth of murine L1210 lymphocytic leukemia and IMC carcinoma cells (IC50s = 0.84 and 0.82 μg/ml, respectively). It is toxic to mice with an LD50value of 0.3 mg/kg. 1.Takahashi, A., Kurasawa, S., Ikeda, D., et al.Altemicidin, a new acari...
T36397	TAN 420E	Others	Others
	TAN 420E is a bacterial metabolite originally isolated from Streptomyces. It scavenges 2,2-diphenyl-1-picrylhydrazyl radicals in a cell-free assay (IC50 = 1.3 μM) and reduces thiobarbituric acid reactive substances (TBARS) in rat liver microsomes by 72% when used at a concentration of 100 μg/ml. TAN 420E is active against B. brevis, B. cereus, M. flavus, and S. aureus (MICs = 50-100 μg/ml). It is cytotoxic to P388 and KB lymphocytic leukemia cells (EC50s = 0.022 and 0.3 μg/ml, respectively).
T68667	Oxanosine	Others	Others
	Oxanosine is an analog of guanosine that has been found in S. capreolus and has diverse biological activities, including antibacterial, antiviral, and anticancer properties. It is active against a variety of bacteria, including S. flexneri, P. mirabilis, and E. coli (MICs = 6.25, 12.5, 25 µg/ml, respectively, on peptone, but not nutrient, agar). Oxanosine inhibits replication of the HIV-1 strain IIIb in infected CEM and U937, but not H9, cells (EC50s = 7, 27, and >500 µg/ml, respectively). It al...
T70856	3-Oxobetulin Acetate	Others	Others
	3-Oxobetulin acetate is a derivative of the cholesterol biosynthesis inhibitor betulin. It inhibits the growth of P388 murine lymphocytic leukemia cells (EC50 = 0.12 µg/ml), as well as human MCF-7 breast, SF-268 CNS, H460 lung, and KM20L2 colon cancer cells (GI50s = 8, 10.6, 5.2, and 12.7 µg/ml, respectively), but not BxPC-3 pancreas or DU145 prostate cancer cells (GI50s = >10 µg/ml for both). 3-Oxobetulin acetate inhibits replication of X4 tropic recombinant HIV (NL4.3-Ren) in MT-2 lymphoblasto...
T72527	Umbralisib sulfate TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate	Others	Others
	Umbralisib (TGR-1202) sulfate 是一种口服有效、选择性的 PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双抑制剂，其 EC50分别为 22.2 nM 和 6.0 μM。 Umbralisib sulfate 显示出对慢性淋巴细胞白血病 (CLL) T 细胞独特的免疫调节作用。Umbralisib sulfate 可用于血液系统恶性肿瘤的研究。
T72465	Umbralisib tosylate RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate	Others	Others
	Umbralisib (TGR-1202) tosylate是一种口服有效、具有选择性的PI3Kδ和酪蛋白激酶-1-ε (CK1ε) 双重抑制剂，EC50值分别为22.2 nM和6.0 μM。该化合物针对慢性淋巴细胞白血病 (CLL) 中的T细胞显示出独特的免疫调节作用，适用于血液系统恶性肿瘤的研究。

化合物

Cat.No: T9925

Target: Others

Cat.No: T9744

Target: Phosphatase

Cat.No: T12317

Synonym: ICP-022

Target: BTK

Cat.No: T3626

Synonym: ACP-196,阿可替尼

Target: BTK

Cat.No: T2558

Synonym: 2-chlorodeoxyadenosine,克拉屈滨,2-Chloro-2′-deoxyadenosine,CldAdo,2CdA

Target: Apoptosis, Adenosine deaminase

Cat.No: T4976

Synonym: TGR-1202,RP5264,TGR 1202,TGR1202

Target: PI3K

LCMV gp33-41 acetate

Cat.No: TP1758L

Synonym: LCMV gp33-41 acetate（151705-84-9 Free base）

Target: Others

Cat.No: T3099

Synonym: EPZ-5676

Target: Histone Methyltransferase

Cat.No: T16157

Target: BTK, PROTACs

Cat.No: T15420

Target: PI3K

Cat.No: T8380

Synonym: SDX105,宾达氮芥

Target: Apoptosis, Others, DNA Alkylator/Crosslinker

Cat.No: T76794

Synonym: BMS 936564,MDX 1338

Target: Apoptosis, CXCR

Cat.No: T10483

Synonym: Bcl-2/Bcl-xl inhibitor 1,APG-2575

Target: BCL

Cat.No: T77093

Synonym: TGN1412,TAB-08,TABO8

Target: Others

Ethacrynic acid

Cat.No: T4564

Synonym: Edecrin,利尿酸,Etacrynic Acid,Hydromedin

Target: Others, Calcium Channel, NF-κB, GST

Bcl-xL antagonist 2

Cat.No: T38622

Target: BCL

8-Chloroadenosine

Cat.No: T19661

Synonym: NSC 354258,8-Cl-Ado,NSC354258,NSC-354258,8-氯腺嘌呤核苷

Target: AMPK

Cat.No: T1835

Synonym: 伊布替尼,依鲁替尼,PCI-32765

Target: Tyrosine Kinases, Src, BTK, Ligands for Target Protein for PROTAC

Cat.No: T71996

Target: Others

Cat.No: T70107

Target: Others

Cat.No: T37602

Target: Others

Glycoprotein (276-286)

Cat.No: TP1640

Synonym: Glycoprotein 276-286

Cat.No: TP1758

Cat.No: T36890

Target: Others

Purinostat mesylate

Cat.No: T64152

Target: Others

Nucleoprotein (396-404) (TFA)

Cat.No: TP2150

Synonym: NP 396 TFA

Target: Others

LCMV gp33-41 (TFA) (151705-84-9 free base)

Cat.No: TP1629

Synonym: LCMV gp33-41 (TFA)

Cat.No: TP1752

Nucleoprotein (396-404)

Cat.No: TP1078

Synonym: Nucleoprotein 396-404,NP 396

LCMV gp33-41 TFA

Cat.No: T75982

Cat.No: T70304

Target: Others

Cat.No: T76909

Cat.No: T78295

Synonym: ALXN 6000

Cat.No: T75766

Cat.No: T38383

Target: Others

Cat.No: T36397

Target: Others

Cat.No: T68667

Target: Others

3-Oxobetulin Acetate

Cat.No: T70856

Target: Others

Umbralisib sulfate

Cat.No: T72527

Synonym: TGR-1202 sulfate ; RP-5264 sulfate,TGR-1202 sulfate,RP-5264 sulfate

Target: Others

Umbralisib tosylate

Cat.No: T72465

Synonym: RP5264 tosylate,TGR-1202 tosylate ; RP5264 tosylate,TGR-1202 tosylate

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
TN1564	Delphinidin 3-glucoside chloride Delphinidin-3-O-glucoside chloride	Apoptosis; EGFR	Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	Delphinidin 3-glucoside chloride (Delphinidin-3-O-glucoside chloride) 是从 Hibiscus sabdariffa 提取物中发现的膳食酚类物质。Delphinidin 3-glucoside chloride 具有抗氧化活性，可诱导 B 细胞慢性淋巴细胞性白血病 (B CLL) 的促凋亡作用，抑制 EGFR，抑制血小板聚集。Delphinidin 3-glucoside chloride 具有抗肿瘤活性，通过调节 pAKT/IRF1/HOTAIR 通路发挥作用。
T68865	Amoorastatin	Others	Others
	Amoorastatin is a natural product that has been studied in cancer research. Its derivative was found to significantly inhibit growth of the murine P388 lymphocytic leukemia cell lines.

天然产物

Delphinidin 3-glucoside chloride

Cat.No: TN1564

Synonym: Delphinidin-3-O-glucoside chloride

Target: Apoptosis, EGFR

Cat.No: T68865

Target: Others

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-03667	SLAM/CD150 Protein, Rat, Recombinant (His) signaling lymphocytic activation molecule family me...	Rat	HEK293 Cells
	SLAM/CD150 Protein, Rat, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 17.4 kDa and the accession number is D3ZAD7.
TMPY-00627	SLAM/CD150 Protein, Rat, Recombinant (hFc) signaling lymphocytic activation molecule family me...	Rat	HEK293 Cells
	SLAM/CD150 Protein, Rat, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 51.3 kDa and the accession number is A6JG08.
TMPY-01016	SLAM/CD150 Protein, Human, Recombinant (His) CDw150,CD150,signaling lymphocytic activation molec...	Human	HEK293 Cells
	SLAM/CD150 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 25.8 kDa and the accession number is Q13291-1.
TMPJ-00226	SLAMF1 Protein, Mouse, Recombinant (His) signaling lymphocytic activation molecule,SLAM fami...	Mouse	HEK293 Cells
	Signaling lymphocyte activation molecule (SLAM), is a self-ligand glycoprotein which exists not only found on the surface of activated and memory T cells, but also on the surface of activated B cells, dendritic cells, and macrophages. SLAM consists of a extracellular domain (ECD) with two Ig-like domains,transmembrane segment, and cytoplasmic domain with three immunoreceptor tyrosine switch motifs (ITSM). SLAM is thought to play an important role in adhesion between T cells and APCs and has been...
TMPJ-00223	SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated CDw150,CD150,SLAM,IPO-3,SLAMF1,Signaling Lymphocytic	Human	HEK293 Cells
	SLAM-induced signal-transduction events in T-lymphocytes are different from those in B-cells. Two modes of SLAM signaling are likely to exist: one in which the inhibitor SH2D1A acts as a negative regulator and another in which protein-tyrosine phosphatase 2C (PTPN11)-dependent signal transduction operates.
TMPH-02413	Lymphocytic choriomeningitis virus (LCMV) (strain Armstrong) GPC Protein (His & SUMO) GPC,Pre-glycoprotein polyprotein GP complex	LCMV	E. coli
	Lymphocytic choriomeningitis virus (LCMV) (strain Armstrong) GPC Protein (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 42.4 kDa and the accession number is P09991.
TMPH-02412	Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc) Pre-glycoprotein polyprotein GP complex,GPC	LCMV	E. coli
	Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc) is expressed in E. coli expression system with N-6xHis and C-Myc tag. The predicted molecular weight is 30.9 kDa and the accession number is P07399.
TMPJ-00455	SLAMF5 Protein, Mouse, Recombinant (His) CD84 molecule,SLAM family member 5,Leukocyte differentiation...	Mouse	HEK293 Cells
	CD84, also called SLAMF5, is a member of the CD2 subgroup of the immunoglobulin receptor superfamily. Members of this CD2 subgroup mediate signal transduction through the interaction of its immunoreceptor tyrosine-based switch motifs (ITSM) in the intracellular region and the SH2 domain of adaptor molecules SAP (SLAM-associated protein) and EAT-2 (EWS-activated transcript 2), and accordingly modulate both adaptive and innate immune responses. CD84 expression has been documented on several hemato...
TMPJ-00228	SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated Cell surface antigen MAX.3,SLAMF5,SLAM family member 5,Signa...	Human	HEK293 Cells
	SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-6xHis-Avi tag. The predicted molecular weight is 40-50 KDa and the accession number is Q9UIB8.
TMPJ-01086	CD244 Protein, Mouse, Recombinant (His) NK cell type I receptor protein 2B4,Natural killer cell rece...	Mouse	HEK293 Cells
	Natural killer cell receptor 2B4 (2B4/CD244)is a 66 kDa type I transmembrane glycoprotein in the SLAM subgroup of the CD2 protein family. SLAM family proteins have an extracellular domain (ECD) with two or four Ig-like domains and at least two cytoplasmic immunoreceptor tyrosine-based switch motifs (ITSMs). 2B4 interacts with CD48, while other SLAM family proteins interact in a homophilic manner. The mouse 2B4 cDNA encodes a 397 amino acid (aa) precursor that includes a 19 aa signal sequence, a ...
TMPJ-00229	SLAMF5 Protein, Human, Recombinant (His) SLAMF5,Signaling lymphocytic activation molecule 5,...	Human	HEK293 Cells
	SLAMF5 Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with C-6xHis tag. The predicted molecular weight is 35-43 KDa and the accession number is Q9UIB8.
TMPJ-00359	SLAMF3 Protein, Human, Recombinant (His) Signaling lymphocytic activation molecule 3,CD229,C...	Human	HEK293 Cells
	SLAMF3 (CD229) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature human SLAMF3 consists of a 407 amino acid (aa) extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains. The ECD of human SLAMF3 shares 57% - 59% aa sequence identity with mouse and rat SLAMF3. Within the first two Ig-like domains that are common to all SLAM proteins, human SLAMF3 shares 24% - 39% aa sequence identity with human 2B4, BLAME, CD2F-10, CD84, CRACC, ...
TMPJ-01154	SLAMF3 Protein, Mouse, Recombinant (His) SLAM family member 3,T-lymphocyte surface antigen Ly-9,Ly-9,...	Mouse	HEK293 Cells
	CD229(SLAMF3) is a type I transmembrane glycoprotein in the SLAM subgroup of the CD2 family. Mature mouse CD229 consists of a 406 aa extracellular domain (ECD) with two Ig-like V-set and two Ig-like truncated C2-set domains, a 21 aa transmembrane segment, and a 180 aa cytoplasmic domain with two immunoreceptor tyrosinebased switch motifs ITSMs. Within the first two Ig-like domains that are common to all SLAM proteins, mouse CD229 shares 22%-36% aa sequence identity with mouse 2B4, BLAME, CD2F10,...
TMPY-04272	FcRH2/FCRL2 Protein, Human, Recombinant (His) IFGP4,FCRH2,CD307b,SPAP1,SPAP1B,Fc receptor like 2,SPAP1C,FC...	Human	HEK293 Cells
	Fc receptor-like 2 (FCRL2) is highly expressed on B-cell chronic lymphocytic leukemia (B-CLL) cells and could possibly influence disease pathogenesis. FCRL2 has robust predictive value for determining IGHV gene mutation status and clinical progression and thus may further improve prognostic definition in CLL (B-cell chronic lymphocytic leukemia).
TMPK-00234	CD84 Protein, Human, Recombinant (His & Avi) CD84,DKFZp781E2378,Hly9-beta,Hly9-β,CD84 molecule,SLAMF5,LY9...	Human	HEK293 Cells
	Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of CD5 B lymphocytes in peripheral blood, lymphoid organs and bone marrow. The main feature of the disease is accumulation of the malignant cells due to decreased apoptosis. CD84 belongs to the signaling lymphocyte activating molecule family of immunoreceptors, and has an unknown function in CLL cells.
TMPK-00300	CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated T1,CD5,LEU1,CD5 antigen,CD5 molecule	Mouse	HEK293 Cells
	CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated is expressed in HEK293 mammalian cells with C-His tag. The predicted molecular weight is 38.9 kDa and the accession number is P13379.
TMPK-00302	CD5 Protein, Human, Recombinant (hFc & Avi), Biotinylated T1,LEU1,CD5 molecule,CD5 antigen,CD5	Human	HEK293 Cells
	CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein, Human, Recombinant (hFc & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 67.1 kDa and the accession number is P06127.
TMPK-00301	CD5 Protein, Human, Recombinant (hFc & Avi) CD5 molecule,CD5,LEU1,CD5 antigen,T1	Human	HEK293 Cells
	CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein, Human, Recombinant (hFc & Avi) is expressed in HEK293 mammalian cells with C-hFc-Avi tag. The predicted molecular weight is 67.1 kDa and the accession number is P06127.
TMPK-00642	CD5 Protein, Rhesus macaque, Recombinant (His & Avi) LEU1,T1,CD5,CD5 antigen,CD5 molecule	Rhesus	HEK293 Cells
	CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein, Rhesus macaque, Recombinant (His & Avi) is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.7 kDa and the accession number is F6V5Q9.
TMPK-00643	CD5 Protein, Rhesus macaque, Recombinant (His & Avi), Biotinylated T1,LEU1,CD5,CD5 antigen,CD5 molecule	Rhesus	HEK293 Cells
	CD5: a type I transmembrane protein found on T cells, thymocytes, and some B cells that is a ligand for CD72 and is involved in cellular activation or adhesion; expressed in B-cell chronic lymphocytic leukemia and T-cell lymphoma. CD5 Protein, Rhesus macaque, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with C-His-Avi tag. The predicted molecular weight is 41.7 kDa and the accession number is F6V5Q9.
TMPY-03959	CHST11 Protein, Human, Recombinant (His) carbohydrate (chondroitin 4) sulfotransferase 11,HSA269537,C...	Human	Baculovirus Insect Cells
	CHST11, also known as C4ST-1, belongs to the sulfotransferase 2 family. CHST11 localizes to the golgi membrane, and catalyzes the transfer of sulfate to position 4 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Chondroitin sulfate constitutes the predominant proteoglycan present in cartilage, and is distributed on the surfaces of many cells and extracellular matrices. A chromosomal translocation involving CHST11 gene and IgH, t(12;14)(q23;q32), has been reported in a patient with ...
TMPJ-00608	SLAMF9 Protein, Mouse, Recombinant (His) Slamf9,SLAM family member 9	Mouse	HEK293 Cells
	Mouse SLAM family member 9(Slamf9) is a single-pass type I membrane protein. The SLAMF9 gene encodes a member of the signaling lymphocytic activation molecule family. The encoded protein is a cell surface molecule that consists of two extracellular immunoglobulin domains, a transmembrane domain and a short cytoplasmic tail that lacks the signal transduction motifs found in other family members. The slamf9 protein may play a role in the immune response.
TMPY-03748	BCL2L12 Protein, Human, Recombinant (GST) BCL2-like 12 (proline rich)	Human	E. coli
	BCL2-like 12 (BCL2L12 ) is a new member of the apoptosis-related BCL2 gene family, members of which are implicated in various malignancies. The mRNA expression of BCL2L12 may constitute a novel biomarker for the prediction of short-term relapse in nasopharyngeal carcinoma. BCL2L12 is a recently identified gene belonging to the BCL2 family, members of which are implicated in hematologic malignancies, including chronic lymphocytic leukemia (CLL). BCL2L12 can be considered as a new independent prog...
TMPY-02440	SAP/SH2D1A Protein, Human, Recombinant (His) XLPD,EBVS,DSHP,SAP,MTCP1,IMD5,SH2 domain containing 1A,LYP,S...	Human	E. coli
	SH2domain-containing protein 1A (SH2D1A / SAP) is a 128 amino acid protein, containing a single Src homology 2 (SH2) domain, flanked by 5 amino acids at the N-terminus and 25 amino acids at the C-terminus. The absence of a catalytic domain and the presence of an SH2domain suggest that SH2D1A regulates one or more signal transduction pathways. SH2D1A interacts with signaling lymphocytic activation molecule (SLAM), which is a transmembrane protein expressed on the surface of activated T and B cell...
TMPH-01258	DAG1 Protein, Human, Recombinant (His & Myc) Dystrophin-associated glycoprotein 1,Dystroglycan,Dystroglyc...	Human	Baculovirus Insect Cells
	The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.; Extracellular peripheral glycoprotein that acts as a receptor for extracellular matrix proteins containing laminin-G domains. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for laminin LAMA5.; Transmembra...
TMPH-02855	PML Protein, Mouse, Recombinant (His & Myc) Protein PML,Pml	Mouse	E. coli
	Functions via its association with PML-nuclear bodies (PML-NBs) in a wide range of important cellular processes, including tumor suppression, transcriptional regulation, apoptosis, senescence, DNA damage response, and viral defense mechanisms. Acts as the scaffold of PML-NBs allowing other proteins to shuttle in and out, a process which is regulated by SUMO-mediated modifications and interactions. Positively regulates p53/TP53 by acting at different levels (by promoting its acetylation and phosp...

重组蛋白

SLAM/CD150 Protein, Rat, Recombinant (His)

Cat.No: TMPY-03667

Species: Rat

Expression System: HEK293 Cells

SLAM/CD150 Protein, Rat, Recombinant (hFc)

Cat.No: TMPY-00627

Species: Rat

Expression System: HEK293 Cells

SLAM/CD150 Protein, Human, Recombinant (His)

Cat.No: TMPY-01016

Species: Human

Expression System: HEK293 Cells

SLAMF1 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00226

Species: Mouse

Expression System: HEK293 Cells

SLAMF1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00223

Species: Human

Expression System: HEK293 Cells

Lymphocytic choriomeningitis virus (LCMV) (strain Armstrong) GPC Protein (His & SUMO)

Cat.No: TMPH-02413

Species: LCMV

Expression System: E. coli

Lymphocytic choriomeningitis virus (LCMV) (strain WE) GPC Protein (His & Myc)

Cat.No: TMPH-02412

Species: LCMV

Expression System: E. coli

SLAMF5 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00455

Species: Mouse

Expression System: HEK293 Cells

SLAMF5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPJ-00228

Species: Human

Expression System: HEK293 Cells

CD244 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01086

Species: Mouse

Expression System: HEK293 Cells

SLAMF5 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00229

Species: Human

Expression System: HEK293 Cells

SLAMF3 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00359

Species: Human

Expression System: HEK293 Cells

SLAMF3 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01154

Species: Mouse

Expression System: HEK293 Cells

FcRH2/FCRL2 Protein, Human, Recombinant (His)

Cat.No: TMPY-04272

Species: Human

Expression System: HEK293 Cells

CD84 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00234

Species: Human

Expression System: HEK293 Cells

CD5 Protein (Primary Amine Labeling), Mouse, Recombinant (His), Biotinylated

Cat.No: TMPK-00300

Species: Mouse

Expression System: HEK293 Cells

CD5 Protein, Human, Recombinant (hFc & Avi), Biotinylated

Cat.No: TMPK-00302

Species: Human

Expression System: HEK293 Cells

CD5 Protein, Human, Recombinant (hFc & Avi)

Cat.No: TMPK-00301

Species: Human

Expression System: HEK293 Cells

CD5 Protein, Rhesus macaque, Recombinant (His & Avi)

Cat.No: TMPK-00642

Species: Rhesus

Expression System: HEK293 Cells

CD5 Protein, Rhesus macaque, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00643

Species: Rhesus

Expression System: HEK293 Cells

CHST11 Protein, Human, Recombinant (His)

Cat.No: TMPY-03959

Species: Human

Expression System: Baculovirus Insect Cells

SLAMF9 Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00608

Species: Mouse

Expression System: HEK293 Cells

BCL2L12 Protein, Human, Recombinant (GST)

Cat.No: TMPY-03748

Species: Human

Expression System: E. coli

SAP/SH2D1A Protein, Human, Recombinant (His)

Cat.No: TMPY-02440

Species: Human

Expression System: E. coli

DAG1 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01258

Species: Human

Expression System: Baculovirus Insect Cells

PML Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02855

Species: Mouse

Expression System: E. coli

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