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Cat. No. | Product Name | ||
---|---|---|---|
L2510 | 脂代谢化合物库 | 492 compounds | |
492 个脂代谢相关的化合物集合,可用于高通量和高内涵筛选; | |||
L2501 | 人内源代谢化合物库 Plus | 1283 compounds | |
1283种内源性生物活性化合物的独特集合,用于高通量、高内涵筛选。 | |||
L2130 | 抗癌细胞代谢库 | 1268 compounds | |
1268 种癌细胞代谢相关的生物活性小分子化合物的特有集合,用于肿瘤相关的研究以及抗肿瘤药物的筛选,用于高通量、高内涵筛选; | |||
L2560 | 代谢化合物库 | 2320 compounds | |
2320 种代谢途径相关的化合物,可用于高通量和高内涵筛选。 | |||
L1510 | 核受体化合物库 | 531 compounds | |
531 个核受体作用化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2100 | 抗癌化合物库 | 7234 compounds | |
7234 种肿瘤相关的生物活性小分子化合物的特有集合,用于高通量、高内涵筛选; | |||
L1610 | FDA 上市激酶抑制剂库 | 263 compounds | |
263种靶向激酶的上市药物集合,用于特定靶向激酶,可用于高通量筛选和高内涵筛选; | |||
L2160 | 抗癌活性化合物库 | 3188 compounds | |
3188 种具有抗肿瘤活性的化合物的特有集合,用于高通量、高内涵筛选; | |||
L2150 | 抗癌药物库 | 3080 compounds | |
3080 个具有抗癌活性小分子的独特集合,生物活性已经临床前实验证实,可用于高通量、高内涵筛选; | |||
L7100 | 抗肥胖化合物库 | 2247 compounds | |
2247 个抗肥胖化合物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L2120 | 抗癌临床化合物库 | 2545 compounds | |
2545 个具有抗癌活性小分子的独特集合,可用于高通量高内涵筛选。 | |||
L2110 | 抗癌上市药物库 | 1779 compounds | |
1779 个具有抗癌活性小分子的独特集合,所有化合物都经过了严格的临床前研究和临床试验,由FDA、EMA 或NMPA 批准上市,可用于高通量、高内涵筛选。 | |||
L1120 | AMPK靶向分子库 | 80 compounds | |
80 个靶向AMPK 的分子集合,可用于高通量和高内涵筛选; | |||
L2550 | 谷氨酰胺代谢化合物库 | 565 compounds | |
565 种谷氨酰胺代谢相关的分子,可以用于高通量和高内涵筛选; | |||
L2180 | 抗肿瘤库Plus | 1468 compounds | |
1468 种抗肿瘤相关、结构新颖的化合物; | |||
L5300 | 线粒体靶向库 | 812 compounds | |
812 种具有潜在或确定线粒体靶向活性的化合物,以促进针对线粒体的药物研究; | |||
L6120 | 黄酮类天然产物库 | 514 compounds | |
514 种黄酮类天然产物的独特集合,可用于高通量筛选和高内涵筛选; | |||
L8500 | HIF-1化合物库 | 1336 compounds | |
1336 个HIF-1相关小分子的独特集合,可用于缺血性疾病、癌症等相关领域的药物开发和药理研究; |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T7093 |
Rafoxanide
碘醚柳胺,雷复尼特 |
CDK; Parasite | Cell Cycle/Checkpoint; Microbiology/Virology |
Rafoxanide 是口服活性水杨酰苯胺类驱虫剂。它作为抗寄生虫剂,可用于控制羊和牛的 Hemonchus 种和 Fasciola 种的感染。 | |||
T75325 |
ATP dimagnesium
|
Others | Others |
ATP dimagnesium 是体内能量储存和代谢的重要物质,参与机体的能量循环和代谢能量。ATP dimagnesium 可在细胞中充当辅酶,可被当做一种信号分子。 | |||
T1348 |
Diphenyl phosphate
磷酸二苯酯,Phenyl hydrogen phosphate |
Others | Others |
Diphenyl Phosphate 能够性别特异性的抑制斑马鱼的生长和能量代谢。 | |||
T22459 |
Xanthinol Nicotinate
Angioamin,烟酸占替诺,Complamin |
Others | Others |
Xanthinol Nicotinate (Complamin) 是血管扩张剂,可直接作用于小动脉和毛细血管的平滑肌,能够扩大血管,改善血液流变学并降低外周血管阻力。 | |||
T5882 |
3-Bromopyruvic acid
Hexokinase II Inhibitor II, 3-BP,3-溴丙酮酸,Bromopyruvic acid |
Apoptosis; Hexokinase; Autophagy | Apoptosis; Autophagy; Metabolism |
3-Bromopyruvic acid (Hexokinase II Inhibitor II, 3-BP) 是己糖激酶 II 抑制剂,是针对肝癌细胞的一种抗肿瘤剂。 | |||
T22317 |
DRB18
|
transporter | Metabolism |
DRB18 is a highly effective pan-class inhibitor of glucose transporter proteins (GLUT). It significantly modulates energy-related metabolism in A549 cells by inducing alterations in the abundance of metabolites associated with glucose-related pathways. DRB18 exerts its effects by promoting G1/S phase arrest, increasing oxidative stress, and prompting necrotic cell death, ultimately displaying notable anti-tumor activity [1]. | |||
T2585 |
Bedaquiline
R207910,TMC207,贝达喹啉 |
Antibacterial; Antibiotic | Microbiology/Virology |
Bedaquiline (R207910) 是一种二芳基喹啉药物,能同时靶向 c-亚基和 ε-亚基,抑制结核分枝杆菌 (Mtb) F1FO-ATP 合酶。它具有解偶联活性和有用于耐多药结核病的潜力。 | |||
T16342 |
KL1333
NQO1 activator 1 |
NADPH; Mitochondrial Metabolism | Metabolism |
KL1333 (NQO1 activator 1) 是口服NAD+调节剂,与 NAD(P)H: 醌氧化还原酶 1 作为底物反应。它改善线粒体脑肌病、乳酸酸中毒和中风样发作成纤维细胞的能量代谢和线粒体功能障碍。它对顺铂诱导的小鼠耳蜗培养耳毒性的保护作用。 | |||
T33511 |
ms2i6A
ms2i6-2-6,ms2i6 2 6 |
Others | Others |
ms2i6A is a mitochondrial tRNA-specific modification, which regulates efficient mitochondrial translation and energy metabolism in mammals. | |||
T13287 |
VBIT-4
|
VDAC | Membrane transporter/Ion channel |
VBIT-4 是一种电压依赖性阴离子通道 1 (VDAC1) 寡聚化抑制剂 (Kd=17 μM)。VBIT-4 可以预防线粒体功能障碍和细胞凋亡,并恢复细胞能量和代谢。VBIT-4 可用于治疗神经退行性疾病和心血管疾病。 | |||
T11965 |
MCHR1 antagonist 3
|
Others | Others |
MCHR1 antagonist 3, a potent antagonist of the melanin-concentrating hormone receptor-1 (MCHR1), is employed for the regulation of energy metabolism. | |||
T37802 |
Phospho-L-Arginine (lithium salt hydrate)
|
Others | Others |
Phospho-L-arginine is a phosphorylated form of L-arginine and a highly diffusible, high-energy metabolite and phosphagen involved in energy storage in invertebrates including crustaceans, insects, and Trypanosoma species. In the locust L. migratoria, phospho-L-arginine is found in the flight muscles, where it acts as both a buffer system and shuttle mechanism for high-energy phosphate. Measurement of phospho-L-arginine by 31P-NMR spectroscopy has been used to study invertebrate energy metabolism... | |||
T80144 |
Galanin-Like Peptide (human)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galanin-Like Peptide (human) 是由60个氨基酸组成的神经肽,在调节摄食、体重和能量代谢方面具有重要功能。 | |||
T80146 |
Galanin-Like Peptide (rat)
|
Neuropeptide Y Receptor | GPCR/G Protein; Neuroscience |
Galanin-Like Peptide (rat) 是含60个氨基酸的神经肽,主要功能是调节摄食、体重及能量代谢。 | |||
T35874 |
CC260
|
Others | Others |
CC260 is a selective PI5P4Kα and PI5P4Kβ inhibitor with Kis of 40 nM and 30 nM, respectively. CC260 does not inhibit or weakly inhibits other protein kinases, such as Plk1 and RSK2. CC260 can be used for cell energy metabolism, diabetes and cancer research[1]. In cultured C2C12 myotubes, CC260 (20 μM) enhances Insulin-induced Akt phosphorylation at both Thr-308 and Ser-473 but suppresses S6K phosphorylation (Thr-389) by mTORC1[1]. CC260 (2.5 μM, 5 μM, 10 μM, 20 μM) significantly increases phosph... | |||
T12003 |
Mensacarcin
|
Others; ADC Cytotoxin | Antibody-drug Conjugate/ADC Related; Others |
Mensacarcin, a highly complex polyketide compound, exhibits multifaceted effects on cellular processes. Specifically, it targets mitochondria, perturbs energy metabolism within these organelles, and activates caspase-dependent apoptotic pathways. Functionally, Mensacarcin can serve as a cytotoxic constituent in antibody-drug conjugates (ADCs). Furthermore, this antibiotic compound displays broad-spectrum inhibition of cell growth across various cancer cell lines and demonstrates potent induction... | |||
T34393 |
Rostaporfin
SnET2,tin etiopurpurin dichloride,tin ethyl etiopurpurin dichloride,Purlytin,Sn(IV) etiopurpurin |
Others | Others |
Rostaporfin (also known as REM-001, tin ethyl etiopurpurin, Sn(IV) etiopurpurin, Purlytin, SnET2), is a synthetic purpurin with photosensitizing activity. Rostaporfin preferentially accumulates in tumor cells due to an increased rate of metabolism. Upon e | |||
T83830 |
2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate sodium
2′-fluoro-2′-deoxy ATP,AfTP,2'-fluoro dATP |
Others | Others |
2'-Deoxy-2'-fluoroadenosine-5'-O-triphosphate是ATP的一种氟代衍生物,ATP是细胞代谢必需的能量底物。它抑制E. coli RNA聚合酶(Ki = 200 µM)。 | |||
T76655 |
Prokineticin 2 Isoform 2 (human)
|
||
Prokineticin 2 Isoform 2 (human) 为一下丘脑神经肽,能减少食物摄入,并在啮齿动物的体温调节与能量代谢中发挥作用。此外,Prokineticin 2 对高血糖、代谢综合征 (MetS) 及肥胖研究具有潜在价值。 | |||
T68511 |
KRH102140
|
Others | Others |
KRH102140 is a potent activator of PHD2. KRH102140, which has a structure similar to KRH102053. KRH102140 more efficiently suppressed HIF-1α than KRH102053 in human osteosarcoma cells under hypoxia. Furthermore, KRH102140 decreased the mRNA levels of HIF-regulated downstream target genes associated with angiogenesis and energy metabolism such as vascular endothelial growth factor, adrenomedullin, Glut1, aldolase A, enolase 1 and monocarboxylate transporter 4. KRH102140 also inhibited tube format... | |||
T77253 |
β-Nicotinamide adenine dinucleotide reduced dipotassium
|
Others | Others |
β-Nicotinamide adenine dinucleotide reduced dipotassium 作为一种口服有效的还原型辅酶,在ADP-核糖基转移酶反应中担任ADP-核糖单元的供体及环状ADP-核糖的前体。该化合物在细胞能量代谢,包含糖酵解、β-氧化及三羧酸(TCA)循环中,发挥重要的再生电子供体角色。 | |||
T81182 |
Secretin (swine)
|
||
Secretin (swine)为源自猪的神经内分泌激素,由十二指肠黏膜S细胞产生,具有27个氨基酸的多肽结构,并针对分泌素受体起作用。此激素在各类成熟肠内分泌细胞亚群中表达,受脂肪酸的促进。它主要激发胰腺释放水和碳酸氢盐,同时在消化系统、中枢神经系统和能量代谢方面具有广泛应用。 | |||
T35813 |
CAY10592
|
Others | Others |
Peroxisome proliferator-activated receptors (PPARs) α, δ, γ are ligand-activated nuclear transcription factors involved in the regulation of energy homeostasis as well as insulin sensitivity and glucose metabolism. Pharmacologies of PPARδ receptor agonists, though relatively obscure, have recently been reported to elevate high-density lipoprotein (HDL) cholesterol and lower plasma triglyceride (TG) levels in obese insulin resistant rhesus monkeys. CAY10592 is a full PPARδ agonist (EC50 = 30 nM) ... | |||
T76122 |
Phosphoglycerate kinase
|
Others | Others |
Phosphoglycerate kinase(PGK),即磷酸甘油酸激酶,是一种糖酵解酶,常用于生化研究。Phosphoglycerate kinase 可以催化磷酸基团从1,3-二磷酸甘油酸(1,3-BPG)到ADP 的可逆转移,从而产生 3-磷酸甘油酸(3-PG) 和 ATP。同时也可以参与糖异生,催化相反的反应产生 1,3BPGA 和ADP。Phosphoglycerate kinase 参与了能量代谢、与核酸的相互作用、肿瘤发生进展、细胞死亡和病毒复制等相关过程。 |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4766 |
3-Methylglutaric acid
|
Endogenous Metabolite | Metabolism |
3-Methylglutaric acid 是亮氨酸代谢物,是一种与两种亮氨酸途径 HMGCL、AUH 酶缺陷显著相关的 C6 二元羧酸有机酸。 | |||
T20089 |
ATP
Atipi,ATP disodium salt hydrate,Triphosphoric acid adenosine ester,Ara-ATP,Triphosphaden,Adenosine triphosphate;Ara-ATP,Adenosine triphosphate |
Endogenous Metabolite | Metabolism |
ATP (Adenosine triphosphate) 可为细胞提供能量,参与整体能量平衡,维持细胞内稳态。ATP 可以通过与特异性嘌呤能受体的相互作用充当细胞外信号分子,以介导神经传递、炎症、细胞凋亡和骨重塑等多种过程。 | |||
TN1353 |
N-Benzyllinoleamide
(9Z,12Z)-N-Benzyloctadeca-9,12-dienamide,N-苄基-(9Z,12Z)-十八碳二烯酰胺 |
Others | Others |
N-Benzyllinoleamide ((9Z,12Z)-N-Benzyloctadeca-9,12-dienamide) 是一种分离自 Lepidium meyeniiWalp,能够抗运动性疲劳的药物。 | |||
T2812 |
ATP disodium salt hydrate
ATP disodium,ATP disodium salt,Adenosine disodium triphosphate,三磷酸腺苷二钠盐 |
Others; Endogenous Metabolite | Metabolism; Others |
ATP disodium salt hydrate (Adenosine disodium triphosphate) 是体内能量储存和代谢的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。同时,它是也是免疫和炎症中重要的内源性信号分子。 | |||
T1352 |
ATP disodium salt
Adenosine 5'-triphosphate disodium salt,三磷酸腺苷二钠,ATP,ATP disodium,腺苷-5'-三磷酸二钠盐,Adetide,Adenosine-Triphosphate,Disodium adenosine triphosphate |
P2X Receptor; Endogenous Metabolite | Membrane transporter/Ion channel; Metabolism; Neuroscience |
ATP disodium salt (Adenosine-Triphosphate) 是体内能量储存的重要物质,为代谢提供能量,同时在细胞中作为辅酶发挥作用。Adenosine 5'-triphosphate disodium salt 也是免疫和炎症中重要的内源性信号分子。 | |||
T64980 |
ATP disodium trihydrate
Adenosine-5'-triphosphate disodium trihydrate |
Endogenous Metabolite | Metabolism |
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) 是体内能量储存和代谢的重要物质,是免疫和炎症中重要的内源性信号分子,可为机体代谢提供能量,同时在细胞中作为辅酶发挥作用。 | |||
T5242 |
Triarachidin
Triarachin,1,2,3-Trieicosanoyl Glycerol,Glycerol Trieicosanoate,三花生精 |
Others; Endogenous Metabolite | Metabolism; Others |
Triarachidin (1,2,3-Trieicosanoyl Glycerol) 是内源性代谢产物的一种。 | |||
T9719 |
3-Hydroxyoctanoic Acid
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
3-Hydroxyoctanoic Acid 是作为能量代谢中间体的羟基羧酸 (HCA) 之一。它是孤儿受体 GPR109B 的激动剂。 | |||
T6S1294 |
Nicotiflorin
Nictoflorin,Kaempferol-3-O-Rutinoside,山奈酚-3-O-芸香糖苷,Nicotifloroside |
Others | Others |
Nicotiflorin (Kaempferol-3-O-Rutinoside) 是一种黄酮苷,从传统中药Flos Carthami 中提取得到。它有抗糖化活性和神经保护作用。 | |||
TN1966 |
N-(3-Methoxybenzyl)Oleamide
N-Benzyloleamide,MAC 18:1 |
Antioxidant | oxidation-reduction |
N-(3-Methoxybenzyl)Oleamide (MAC 18:1) 是一种从 Lepidium meyenii 中分离出来的玛瑙酰胺,对运动引起的疲劳具有药理作用,可能与调节能量代谢和改善抗氧化状态有关。 | |||
T5300 |
Ammonium formate
甲酸铵,Formic acid ammonium salt |
Others | Others |
Ammonium formate (Formic acid ammonium salt) 是最简单的羧酸。它通过抑制细胞色素氧化酶活性(电子传递链的末端电子受体)来负责代谢性酸中毒和破坏线粒体电子传递和能量产生。 | |||
T0414 |
D-Mannitol
Mannite,Mannitol,D-甘露糖醇,Osmitrol |
Apoptosis; Dehydrogenase; Endogenous Metabolite | Apoptosis; Metabolism |
D-Mannitol (Mannitol) 是与山梨醇相关的利尿剂和肾脏诊断辅助剂,具有较弱的肾脏血管扩张活性。 | |||
T5079 |
Adenosine 5'-diphosphate sodium salt
腺苷-5‘-二磷酸钠盐,Adenosine-5'-diphosphate trisodium salt,ADP sodium salt |
Others; Endogenous Metabolite | Metabolism; Others |
Adenosine 5'-diphosphate sodium salt (ADP sodium salt) 是一种核苷二磷酸,是一种 ATP 酶对 ATP 去磷酸化的产物。它通过在 P2T-嘌呤受体上的作用诱导人血小板聚集并抑制刺激的腺苷酸环化酶。 | |||
T4776 |
Glycerol
Glycerin,甘油 |
Endogenous Metabolite | Metabolism |
Glycerol 是甘油三酯(即脂肪和油)和磷脂的重要成分。它在食品工业中被广泛用作甜味剂和保湿剂以及药物制剂。 | |||
T5S1632 |
Barlerin
8-O-乙酰山栀苷甲酯,8-O-Acetylshanzhiside methyl ester,ND01 |
VEGFR; TNF; NF-κB; Akt; Caspase | Angiogenesis; Apoptosis; Cytoskeletal Signaling; NF-κB; PI3K/Akt/mTOR signaling; Proteases/Proteasome; Tyrosine Kinase/Adaptors |
Barlerin (8-O-Acetylshanzhiside methyl ester) 是一种环孢菌素葡萄糖苷,从中国西藏民间药用植物中分离得到,能够抑制NF-κB 活性。 | |||
T4S2326 |
Cornuside
7-Galloylsecologanol,7-O-Galloylsecologanol,山茱萸新苷,Comuside |
ERK; p38 MAPK; NF-κB; JNK | MAPK; NF-κB |
Cornuside (Comuside) 是从山茱萸的果实中分离出的环烯醚萜苷,可用于炎症疾病的研究和促进血液循环。 它通过下调 MAPK 和 NF-κB 信号通路抑制肥大细胞介导的过敏反应,用于炎性过敏性疾病中的潜能。 | |||
T1331 |
Riboflavin phosphate sodium
Riboflavin 5'-phosphate sodium,核黄素磷酸钠(维生素B2),Vitamin B2 Phosphate Sodium Salt,Flavin mononucleotide,FMN,核黄素磷酸钠,FMN-Na,riboflavin-5'-phosphate |
Endogenous Metabolite | Metabolism |
Riboflavin phosphate sodium (FMN) 是 riboflavin 的磷酸钠盐形式,riboflavin 是一种水溶性和必需的微量营养素,是自然产生的维生素B复合物的主要生长促进因子。Riboflavin phosphate sodium 转化为2种辅酶,黄素单核苷酸(FMN)和黄素腺嘌呤二核苷酸(FAD),这两种辅酶通过帮助脂肪、碳水化合物和蛋白质的代谢来产生能量,并且是红细胞形成和呼吸、抗体产生以及调节人体生长和繁殖所必需的。 | |||
T37984 |
Fosfructose, sodium salt, hydrate (1:3:8)
D-Fructose-1,6-bisphosphate , sodium salt, hydrate (1:3:8) |
Others | Others |
D-Fructose-1,6-bisphosphate sodium salt hydrate 是碳水化合物代谢的中间体,包括糖酵解和糖异生。在糖酵解过程中,它是由磷酸果糖激酶磷酸化果糖-6-磷酸产生的。由果糖-1,6-二磷酸酶-1介导的逆反应是糖异生的限速步骤之一。同样的反应也发生在植物的叶绿体中,D-Fructose-1,6-bisphosphate sodium salt hydrate 作为还原性戊糖磷酸循环的一部分。由于癌细胞采用糖酵解作为代谢能量产生的主要来源,这一途径已成为癌症化疗的主要靶点。 | |||
T4947 |
3-Hydroxybutyric acid
Butanoic acid,3-羟基丁酸 |
Endogenous Metabolite | Metabolism |
3-Hydroxybutyric acid (Butanoic acid) 是一种人内源性代谢物,在 I 型糖尿病中升高。它能够调节膜脂的性质。 | |||
T40526 |
ATP dipotassium
腺苷三磷酸二钾盐,Adenosine5'-triphosphatedipotassium |
Others | Others |
ATP dipotassium (Adenosine 5'-triphosphate dipotassium) is a vital compound involved in energy storage and metabolism within living organisms. It plays a crucial role in supplying metabolic energy for driving pumps and acts as a coenzyme in cellular processes. Additionally, ATP dipotassium functions as a significant endogenous signaling molecule contributing to immunity and inflammation. | |||
T20123 |
L-Carnitine hydrochloride
L-Carnitine chloride,LC 80,Levocarnitine chloride,(R)-Carnitine hydrochloride,LC-80,LC80 |
Others | Others |
Carnitine is a quaternary amine that occurs naturally in most mammalian tissue. Carnitine is present in relatively high concentrations in skeletal muscle and heart where it is involved in regulating energy metabolism. It has also been used to allow the en |
Cat. No. | Product Name | Species | Expression System |
---|---|---|---|
TMPK-00050 |
Leptin Protein, Mouse, Recombinant (hFc)
LEP,Obesity factor,Leptin,LEPD,Obese protein,OBS,OB |
Mouse | HEK293 Cells |
Leptin has key roles in the regulation of energy balance, body weight, metabolism, and endocrine function. Leptin levels are undetectable or very low in patients with lipodystrophy, hypothalamic amenorrhea, and congenital leptin deficiency (CLD) due to mutations in the leptin gene. | |||
TMPH-03503 |
Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO)
ATP-AMP transphosphorylase,AK,Adenylate monophosphate kinase... |
Shigella flexneri | E. coli |
Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase Protein, Shigella flexneri, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 43.6 kDa and the accession number is Q83M40. | |||
TMPH-02142 |
ERR1 Protein, Human, Recombinant (GST)
Steroid hormone receptor ERR1,Estrogen receptor-like 1,Nucle... |
Human | E. coli |
Binds to an ERR-alpha response element (ERRE) containing a single consensus half-site, 5'-TNAAGGTCA-3'. Can bind to the medium-chain acyl coenzyme A dehydrogenase (MCAD) response element NRRE-1 and may act as an important regulator of MCAD promoter. Binds to the C1 region of the lactoferrin gene promoter. Requires dimerization and the coactivator, PGC-1A, for full activity. The ERRalpha/PGC1alpha complex is a regulator of energy metabolism. Induces the expression of PERM1 in the skeletal muscle. | |||
TMPK-00284 |
ANGPTL3 Protein, Human, Recombinant (His & Avi)
FHBL2,Angiopoietin-like Protein 3,ANG-5,ANGPTL3,ANGPT5,Angio... |
Human | HEK293 Cells |
ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C‑terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. ANGPTL3... | |||
TMPK-00285 |
ANGPTL3 Protein, Human, Recombinant (His & Avi), Biotinylated
ANGPTL3,FHBL2,ANGPT5,Angiopoietin-5,ANL3,ANG-5,Angiopoietin-... |
Human | HEK293 Cells |
ANGPTL3 is a secreted glycoprotein that is structurally related to the angiopoietins. Mature human ANGPTL3 contains an N-terminal coiled coil domain and a C‑terminal fibrinogen-like domain. ANGPTL3 is expressed in the liver from early in development through adulthood. Acts in part as a hepatokine that is involved in regulation of lipid and glucose metabolism. Proposed to play a role in the trafficking of energy substrates to either storage or oxidative tissues in response to food intake. ANGPTL3... | |||
TMPJ-01061 |
Nucleobindin-2 Protein, Human, Recombinant
NUCB2,NEFA,Gastric cancer antigen Zg4,Nesfatin-1,Prepronesfa... |
Human | E. coli |
Nesfatin-1 is a metabolic polypeptide encoded in the N-terminal region of the precursor protein, Nucleobindin2 (NUCB2). Nesfatin-1 is a neuropeptide produced in the hypothalamus of mammals. It participates in the regulation of hunger and fat storage. Nesfatin-1 is also expressed in other areas of the brain, and in pancreatic islets β-cells, gastric endocrine cells and adipocytes. Nesfatin-1 suppresses food intake and can regulate energy metabolism in a Leptin independent manner. Nesfatin-1 may ... | |||
TMPJ-00997 |
GALK1 Protein, Human, Recombinant (His)
Galactokinase,Galactose Kinase,GALK1,GALK |
Human | E. coli |
Galactokinase belongs to the GHMP kinase family and GalK subfamily. Galactokinase is more important to the galactose metabolism pathway. It modifies galactose to create a similar molecule called Galactose-1-Phosphate.Thus, a series of additional steps converts Galactose-1-Phosphate to another simple sugar Glucose, which is the main energy source for most cells. Galactokinase deficiency results in Galactosemia II, an autosomal recessive deficiency characterized by congenital cataracts during infa... | |||
TMPY-02421 |
PARP3 Protein, Human, Recombinant (His & GST)
ARTD3,IRT1,ADPRTL2,ADPRTL3,poly (ADP-ribose) polymerase fami... |
Human | Baculovirus Insect Cells |
Poly(ADP-ribose) polymerase 3 (PARP3) is an important member of the PARP family and shares high structural similarities with both PARP1 and PARP2. Poly(ADP-ribose) polymerase 3 (PARP3), a critical player in cellular response to DNA double-strand breaks (DSBs), plays an essential role in the maintenance of genome integrity. The ADP ribosyl transferase [poly(ADP-ribose) polymerase] ARTD3(PARP3) is a newly characterized member of the ARTD(PARP) family that catalyzes the reaction of ADP ribosylation... | |||
TMPJ-01450 |
SARS-CoV-2 Helicase Protein (His & MBP)
SARS-CoV 2 nsp13,SARS-CoV 2 Helicase |
SARS-CoV-2 | E. coli |
The non—structural protein 13 (nsp13) of SARS—CoV 2 is a helicase that separates double—stranded RNA or DNA with a 5'—3' polarity, using the energy of nucleotide hydrolysis. A basic biochemical characterization of nsp13 demonstrated that it can unwind both doublestranded DNA and RNA in a 5’-3’ direction, and it can hydrolyze all deoxyribonucleotide and ribonucleotide triphosphates. Helicases are motor proteins that utilize the energy derived from nucleotide hydrolysisto unwind double-stranded nu... | |||
TMPY-02051 |
FABP2 Protein, Human, Recombinant (His)
MGC133132,fatty acid binding protein 2,FABPI,I-FABP |
Human | E. coli |
Fatty acid binding protein (FABP) is one of the intracellular proteins, with a low molecular weight of approximately 15 kDa, that plays important roles in the transportation and metabolism of long-chain fatty acids. FABP family proteins could be used as tissue specific injury marker based on the following characteristics of FABP. The intestinal fatty acid binding protein (I-FABP), or fatty acid-binding protein 2 (FABP2), an intracellular protein expressed only in the intestine, involved in the a... | |||
TMPH-01664 |
OMA1 Protein, Human, Recombinant (His & SUMO)
Overlapping with the m-AAA protease 1 homolog,OMA1,Metallopr... |
Human | E. coli |
Metalloprotease that is part of the quality control system in the inner membrane of mitochondria. Activated in response to various mitochondrial stress, leading to the proteolytic cleavage of target proteins, such as OPA1, UQCC3 and DELE1. Following stress conditions that induce loss of mitochondrial membrane potential, mediates cleavage of OPA1 at S1 position, leading to OPA1 inactivation and negative regulation of mitochondrial fusion. Also acts as a regulator of apoptosis: upon BAK and BAX ag... |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T9087 |
Creatine-d3 hydrate
CREATINE-(METHYL-D3) MONOHYDRATE,肌氨酸酐-甲基-D3 一水合物 |
Endogenous Metabolite | Metabolism |
Creatine-d3 hydrate (CREATINE-(METHYL-D3) MONOHYDRATE) 是一种氘标记的肌酸水合物。其中肌酸水合物在肌肉和脑细胞的能量代谢中起着关键作用。 |