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Search Results for " emphysema "

Targets Recommended: Others

14

抑制剂 & 化合物

1

天然产物

3

重组蛋白

2

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T40495	Elastase from porcine pancreas 弹性蛋白酶,EC 3.2.1.35	Others	Others
	Elastase from porcine pancreas 由 240 个氨基酸残基组成，是一种丝氨酸蛋白酶，可以水解蛋白质和多肽。它可诱发仓鼠气肿。
T4983	Isoetharine mesylate salt Isoetarine mesilate,异丙肾上腺素甲磺酸盐	Others; Adrenergic Receptor	GPCR/G Protein; Neuroscience; Others
	Isoetharine mesylate salt (Isoetarine mesilate) 是一种 β-肾上腺素能受体激动剂。它还是能够上调 CYP450 表达的孕烷 X 受体(PXR) 激活剂。
T15543	IA-Alkyne N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne	TRP/TRPV Channel	Membrane transporter/Ion channel
	IA-Alkyne (Iodoacetamide-alkyne) 是TRP 通道 (TRPC) 的激动剂，有用于呼吸道感染相关疾病研究的潜力。IA-Alkyne 可以用于开发同位素标记的探针，在定量的半胱氨酸反应分析 (cysteine-reactivity)有应用的价值。
T6547	Ipratropium Bromide Sch 1000,异丙托溴铵,Itrop,Atrovent	AChR	Neuroscience
	Ipratropium Bromide (Sch 1000) 是毒蕈碱的受体的拮抗剂，可用于 COPD 和哮喘等研究，对 M1、M2 和 M3 受体的结合的IC50值分别为 2.9、2 和 1.7 nM。
T2555	Aclidinium bromide LAS 34273,LAS-W 330,阿地溴铵	AChR	Neuroscience
	Aclidinium bromide (LAS-W 330) 是长效可吸入型的毒蕈碱拮抗剂，有用于慢性阻塞性肺病 (COPD) 的研究潜力。
T68179	Neltenexine	Others	Others
	Neltenexine is an elastase inhibitor that may be useful for preventing pulmonary emphysema.
T13899	Spirofylline	Others	Others
	Spirofylline is an agent of bronchodilator, has the potential for asthma and bronchitis and emphysema treatment.
T4983L	Isoetharine Isoetarine,Bronkosol,Bronkometer,Etyprenalinum	Others	Others
	Isoetharine is a selective agonist of β2-adrenergic receptor used as a bronchodilator for emphysema, bronchitis, and asthma.
T68178	Neltenexine HCl	Others	Others
	Neltenexine HCl is the salt form of Neltenexine free base, an elastase inhibitor that may be useful for preventing pulmonary emphysema.
T60071	PF 00356231	MMP	Proteases/Proteasome
	PF 00356231 是一种特异性抑制剂 MMP-12，可用于治疗肺气肿和慢性阻塞性肺病 (COPD) 的研究。
T75330	Lysozyme chloride	Others	Others
	Lysozyme chloride 是一种杀菌酶，它能裂解革兰氏阳性细菌 (bacteria)。Lysozyme chloride 还可用于HIV 感染和肺气肿的研究。
T27540	Hexoprenaline Sulfate ST-1512,Argocian,Gynipral	Others	Others
	Hexoprenaline Sulfate is a selective beta2-adrenoreceptor agonist. Hexoprenaline Sulfate is active in man as a bronchodilator by the oral or intravenous routes and by inhalation. Hexoprenaline Sulfate is indicated for use in the treatment of bronchospasm
T70097	Acefylline piperazine	Others	Others
	Acefylline piperazine is a stimulant drug of the xanthine chemical class. It acts as an adenosine receptor antagonist. Acephylline piperazine is a theophylline derivative with a direct bronchodilator action. It has the advantages over theophylline in being far less toxic and producing minimal gastric irritation. It is indicated for the treatment of asthma, emphysema, acute and chronic bronchitis associated with bronchospasm.Acefylline relaxes smooth muscles, relieves bronchospasm & has a stimula...
T21989	SSR 69071	Others	Others
	SSR69071 是一种有效的，具有口服活性的选择性中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂。SSR69071 对人弹性蛋白酶 (Ki=0.0168 nM) 的亲和力高于对大鼠 (Ki=3 nM)、小鼠 (Ki=1.8 nM) 和兔 (Ki=58 nM) 弹性蛋白酶。SSR69071 减少缺血再灌注损伤后的心肌梗死面积。SSR69071 还具有治疗慢性阻塞性肺病、哮喘、肺气肿、囊性纤维化和多种炎症性疾病的潜力。

化合物

Elastase from porcine pancreas

Cat.No: T40495

Synonym: 弹性蛋白酶,EC 3.2.1.35

Target: Others

Isoetharine mesylate salt

Cat.No: T4983

Synonym: Isoetarine mesilate,异丙肾上腺素甲磺酸盐

Target: Others, Adrenergic Receptor

Cat.No: T15543

Synonym: N-Hex-5-ynyl-2-iodo-acetamide,Iodoacetamide-alkyne

Target: TRP/TRPV Channel

Ipratropium Bromide

Cat.No: T6547

Synonym: Sch 1000,异丙托溴铵,Itrop,Atrovent

Target: AChR

Aclidinium bromide

Cat.No: T2555

Synonym: LAS 34273,LAS-W 330,阿地溴铵

Target: AChR

Cat.No: T68179

Target: Others

Cat.No: T13899

Target: Others

Cat.No: T4983L

Synonym: Isoetarine,Bronkosol,Bronkometer,Etyprenalinum

Target: Others

Neltenexine HCl

Cat.No: T68178

Target: Others

Cat.No: T60071

Target: MMP

Lysozyme chloride

Cat.No: T75330

Target: Others

Hexoprenaline Sulfate

Cat.No: T27540

Synonym: ST-1512,Argocian,Gynipral

Target: Others

Acefylline piperazine

Cat.No: T70097

Target: Others

Cat.No: T21989

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T0892	Diphylline 二羟丙茶碱,Dyphylline,Diprophylline	PDE; Adenosine Receptor	GPCR/G Protein; Metabolism; Neuroscience
	Diphylline (Diprophylline) 是一种A1/A2腺苷受体拮抗剂，也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物，具有支气管扩张和血管扩张作用，有用于治疗慢性支气管炎和肺气肿的潜力。

天然产物

Cat.No: T0892

Synonym: 二羟丙茶碱,Dyphylline,Diprophylline

Target: PDE, Adenosine Receptor

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02869	MMP-12 Protein, Human, Recombinant (catalytic domain) HME,ME,MMP-12,MME,matrix metallopeptidase 12	Human	E. coli
	Matrix metalloproteinases (MMPs) are a family of zinc-dependent endopeptidases that degrade components of the extracellular matrix (ECM) and play essential roles in various physiological processes such as morphogenesis, differentiation, angiogenesis, and tissue remodeling, as well as pathological processes including inflammation, arthritis, cardiovascular diseases, pulmonary diseases, and tumor invasion. Macrophage Metalloelastase, also known as Matrix metalloproteinase-12, Macrophage elastase, ...
TMPJ-00505	Serpin A1 Protein, Human, Recombinant (aa 25-418, His) Alpha-1-Antiproteinase,α-1-Antiproteinase,SERPINA1,Serpin A1...	Human	HEK293 Cells
	Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants re...
TMPJ-01069	Serpin A1e Protein, Mouse, Recombinant (His) Dom5,α-1-antitrypsin 1-5,Serpina1e,Spi1-5,Serine protease in...	Mouse	HEK293 Cells
	Alpha-1-antitrypsin 1-5(SERPIN A1) is a secreted protein and belongs to the serpin family. Serpins bind the protease active site resulting in a major conformational rearrangement that traps the enzyme in a covalent acyl-enzyme intermediate. Mouse SERPIN A1 is a serine protease inhibitor whose targets include elastase,plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Defects in this gene can cause emphysema orliver disease. Several transcript variants encoding the same protein ...

重组蛋白

MMP-12 Protein, Human, Recombinant (catalytic domain)

Cat.No: TMPY-02869

Species: Human

Expression System: E. coli

Serpin A1 Protein, Human, Recombinant (aa 25-418, His)

Cat.No: TMPJ-00505

Species: Human

Expression System: HEK293 Cells

Serpin A1e Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-01069

Species: Mouse

Expression System: HEK293 Cells

Cat. No.	Product Name	Target	Signaling Pathways
TMIH-0283	Ipratropium-d3 Bromide
	Ipratropium-d3 Bromide 是 Ipratropium Bromide 的氘代化合物。Ipratropium Bromide 的 CAS 号为 22254-24-6。Ipratropium bromide 是毒蕈碱的受体的拮抗剂，可用于 COPD 和哮喘等研究，对 M1、M2 和 M3 受体的结合的IC50值分别为 2.9、2 和 1.7 nM。
TMID-0119	Diprophylline-d6
	Diprophylline-d6 是 Diprophylline 的氘代化合物。Diprophylline 的 CAS 号为 479-18-5。Diphylline 是一种A1/A2腺苷受体拮抗剂，也是环状核苷酸磷酸二酯酶抑制剂。它是一种黄嘌呤衍生物，具有支气管扩张和血管扩张作用，有用于治疗慢性支气管炎和肺气肿的潜力。

同位素标记化合物

Ipratropium-d3 Bromide

Cat.No: TMIH-0283

Diprophylline-d6

Cat.No: TMID-0119

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