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Search Results for " dioxygenase "

Targets Recommended: Indoleamine 2,3-Dioxygenase (IDO) IDO Indoleamine 2,3-Dioxygenase (IDO)

60

抑制剂 & 化合物

12

天然产物

28

重组蛋白

1

同位素标记化合物

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Cat. No.	Product Name	Target	Signaling Pathways
T11615	IDO-IN-12	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-12 是吲哚胺 2,3-双加氧酶抑制剂。
T39598	4-Chlorocatechol	Others	Others
	4-Chlorocatechol, a significant degradation product of 4-chloro-2-aminophenol (4C2AP), serves as a substrate for both catechol 1,2-dioxygenases and chlorocatechol dioxygenase [1] [2].
T11901	IDO1-IN-5	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-5 是可透过血脑屏障的、选择性的IDO1抑制剂，能够与缺乏血红素的 apo-IDO1 结合，但无法与成熟血红素的 IDO1 结合。
T11616	IDO-IN-13 GS-4361	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-13 (GS-4361) 是 indoleamine 2,3-dioxygenase 1 抑制剂，EC50=17 nM。
T10199	GNF-PF-3777 8-Nitrotryptanthrin	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	GNF-PF-3777 (8-Nitrotryptanthrin) 是人吲哚胺2，3-双加氧酶 2 (hIDO2) 抑制剂，能够降低IDO2活性，Ki=为 0.97 μM。
T9164	BMS-986242 BMS986242	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	BMS-986242 是具有口服具有活力、强效的、选择性的 indoleamine-2,3-dioxygenase 1 抑制剂，可用于研究癌症。
T2647	IDO5L INCB024360 analogue,INCB14943	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO5L (INCB024360 analogue) 是一种有效的吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，IC50=67 nM。
T4532	Linrodostat BMS-986205	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Linrodostat (BMS-986205) 是选择性的、不可逆的吲哚胺 2,3-双加氧酶 1(IDO1) 抑制剂，能够有效抑制 IDO1-HEK293 细胞，其IC50=1.1 nM。它在晚期癌症中具有良好的药理特性。
T4307	PF-06840003 EOS200271,PF 06840003	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PF-06840003 (EOS200271) 是口服具有活力的、选择性的IDO-1抑制剂，抑制 hIDO-1， dIDO-1和 mIDO-1 的IC50分别为 0.41 μM， 0.59 μM，和 1.5 μM。
TQ0071	Navoximod GDC-0919,NLG-919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Navoximod (GDC-0919) 是 IDO(indoleamine-(2,3)-dioxygenase) 抑制剂，Ki=7 nM/，EC50=75 nM。
T3548	Epacadostat INCB 024360,艾卡哚司他,IDO Inhibitor 1	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Epacadostat (INCB 024360) 是选择性的IDO1抑制剂，IC50=71.8 nM。
T7181	IDO-IN-1 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-1 是吲哚胺-2,3-双加氧酶抑制剂，IC50=59 nM。
T1847	Necrostatin-1 Nec-1,Necrostatin 1	Indoleamine 2,3-Dioxygenase (IDO); Ferroptosis; Autophagy; RIP kinase	Apoptosis; Autophagy; Metabolism; NF-κB
	Necrostatin-1 (Nec-1) 是一种坏死性凋亡抑制剂和 RIP1 抑制剂，具有特异性。Necrostatin-1 抑制 TNF-α 诱导的坏死性凋亡。Necrostatin-1 也可以抑制 IDO。
T1806	IDO-IN-7 NLG919,Navoximod,NLG-919 analogue,GDC-0919	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO-IN-7 (NLG-919 analogue) 是 IDO1 抑制剂，IC50=38 nM。
T4142	PCC0208009 IDO inhibitor 1,DO-IN-2,IDO-IN-2	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	PCC0208009 (IDO-IN-2) 是一种有效的 IDO 抑制剂，其在 HeLa 细胞中的 IC50=4.52 nM。它调节 ACC 和杏仁核的突触可塑性，减少神经性疼痛和合并症。
T6543	Indoximod NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan,吲哚莫德	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Indoximod (Indoximod (NLG-8189)) 是一种具有口服具有活力的吲哚胺2,3-双加氧酶(IDO) 途径抑制剂。它在调节 mTOR 中充当 Trp 模拟物。它是一种可用于癌症研究的免疫代谢佐剂。
T40421	4,5-Dichlorocatechol	Others	Others
	4,5-Dichlorocatechol 是广谱的pseudomonas chlororaphisRW71 氯邻苯二酚 1,2-二加氧酶的底物。对于Pseudomonas putidaAC27 菌株双加氧酶和AcidovoraxPS14 菌株双加氧酶的Ki 都为 30 nM。
T1684	Nitisinone 尼替西农,NTBC,SC0735,Nitisone	Others; Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB; Others
	Nitisinone (SC0735) 是一种 4-羟基苯丙酮酸双加氧酶抑制剂。
T20513	IDO1-IN-1 IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1	IDO	Metabolism
	IDO1-IN-1 (2 HzBTZ) 是一种吲哚胺 2,3-双加氧酶 1 (IDO1) 抑制剂。
T7660	IDO inhibitor 1 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO inhibitor 1 是一种有效的吲哚胺-2,3 双加氧酶 (IDO) 抑制剂 (IC50 <100 nM)。具有潜在的免疫调节和抗肿瘤活性。
T16951	Sulcotrione	Reactive Oxygen Species	Immunology/Inflammation; Metabolism; NF-κB
	Sulcotrione 属于β-三酮类除草剂，对羟基苯基丙酮酸双加氧酶有抑制作用。
T39476	NLG802	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	NLG802 是 indoximod 的前药，indoximod 是一种口服活性的吲哚胺2,3-双加氧酶（IDO）抑制剂。
T20318	Benzylideneaniline N-苄叉苯胺,N-Benzylideneaniline	Others	Others
	Benzylideneaniline (N-Benzylideneaniline) 是一种有效的木质芪-α,β-双加氧酶抑制剂，它是氧化裂解木质芪中心双键的关键酶。
T36624L	α-Hydroxyglutaric Acid Lithium α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)	Decarboxylase; Endogenous Metabolite; mTOR	Metabolism; Others; PI3K/Akt/mTOR signaling
	α-Hydroxyglutaric Acid Lithium 在微生物和动物体内有谷氨酸转化而来，是 α-酮戊二酸依赖性双加氧酶和 5-甲基胞嘧啶羟化酶抑制剂，对 ATP 合酶和 mTOR 信号传导有抑制作用。
T4410	LM10	Others	Others
	LM10 是有效的色氨酸 2,3-双加氧酶的抑制剂。色氨酸 2,3-双加氧酶是一种无关的肝酶，它可通过犬尿氨酸途径降解色氨酸。它对研究癌症疾病具有潜在的研究价值。
T61202	TDO-IN-1	Others	Others
	TDO-IN-1 是一种具有口服活性、有效性和选择性的色氨酸 2,3-双加氧酶 (TDO)抑制剂，对吲哚胺-2,3-双加氧酶具有抑制作用。TDO-IN-1 具有抗肿瘤活性，能够通过逆转肿瘤组织的局部免疫耐受来发挥作用。
T6820	D-α-Hydroxyglutaric acid disodium D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate	ATPase; Others; Reactive Oxygen Species; Endogenous Metabolite; mTOR	Immunology/Inflammation; Membrane transporter/Ion channel; Metabolism; NF-κB; Others; PI3K/Akt/mTOR signaling
	D-α-Hydroxyglutaric acid disodium (Disodium (R)-2-Hydroxyglutarate) 是神经代谢疾病 D-2-羟基戊二酸尿症中积累的主要代谢产物，可增加活性氧的产生。它是 α-酮戊二酸 (α-KG) 的弱竞争拮抗剂，可抑制多种α-KG 依赖性双加氧酶，Ki 为 10.87 mM。
T11623	IDO/TDO-IN-1	Others	Others
	IDO/TDO-IN-1 is an orally active dual indoleamine-2,3-dioxygenase (IDO) and tryptophan 2,3-dioxygenase (TDO) inhibitor (IC50s: 9.7 and 47 nM).
T11618	IDO-IN-4	Others	Others
	IDO-IN-4 is an indoleamine 2,3-dioxygenase 1 (IDO-1) inhibitor.
T11620	IDO-IN-6 NLG-1486	IDO	Metabolism
	IDO-IN-6 is an indoleamine 2,3-dioxygenase (IDO) inhibitor.
T74992	NU223612	Others	Others
	NU223612 是一种有效的PROTAC(PROTACs)，可降解吲哚胺 2,3-双加氧酶 1 (IDO1) (Indoleamine 2,3-Dioxygenase (IDO))，Kd 为 640 nM。NU223612 通过CRBN 介导的蛋白酶体降解有效降解IDO1蛋白。NU223612 以 290 nM 的亲和力与 CRBN 结合。NU223612 可以穿过血脑屏障 (BBB)。
T11619	IDO-IN-5 NLG-1489	IDO	Metabolism
	IDO-IN-5 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T11617	IDO-IN-3	IDO	Metabolism
	IDO-IN-3 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 290 nM).
T11621	IDO-IN-8 NLG-1487	IDO	Metabolism
	IDO-IN-8 is an indoleamine 2,3-dioxygenase (IDO) inhibitor (IC50: 1-10 μM).
T70189	Navoximod phosphate	Others	Others
	Navoximod phosphate is an indoleamine 2,3-dioxygenase (IDO) inhibitor, immunomodulator and antineoplastic.
T11622	IDO-IN-9	IDO	Metabolism
	IDO-IN-9 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.011 μM (Kinase) and 0.0018 μM (Hela Cell).
T40493	3,6-Dichlorocatechol	Others	Others
	3,6-Dichlorocatechol serves as a substrate for the broad-spectrum chlorocatechol 1,2-dioxygenase found in pseudomonas chlororaphis RW71.
T40497	3,4-Dichlorocatechol	Others	Others
	3,4-Dichlorocatechol serves as a substrate for the broad-spectrum chlorocatechol 1,2-dioxygenase enzyme found in pseudomonas chlororaphis RW71.
T11614	IDO-IN-11	IDO	Metabolism
	IDO-IN-11 is an indoleamine-2,3-dioxygenase (IDO) inhibitor with IC50s of 0.18 μM (Kinase) and 0.014 μM (Hela Cell).
T38781	3,5-Dichlorocatechol	Others	Others
	3,5-Dichlorocatechol serves as a substrate for the broad-spectrum chlorocatechol 1,2-dioxygenase found in pseudomonas chlororaphis RW71.
T14531	Benzobicyclon	Others	Others
	Benzobicyclon is a pro-herbicide and it acts as an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (4-HPPD) in plant, and leads to bleaching and death[1].
T68792	Abamine	Others	Others
	Abamine is an inhibitor of 9-Cis-Epoxycarotenoid dioxygenase (NCED), the key regulatory enzyme in the plant hormone abscisic acid (ABA) biosynthesis pathway.
T73437	DP00477	Others	Others
	DP00477，一种高效IDO1(indoleamine 2,3-dioxygenase 1)抑制剂，IC50为7.0 µM，展现在癌症研究中的潜力。
T60698	Roxyl-9	Others	Others
	Roxyl-9 是一种 IDO1 (吲哚胺2,3-双加氧酶1) 抑制剂。
T12668	(Rac)-IDO1-IN-5	Others	Others
	(Rac)-IDO1-IN-5 is a racemate of IDO1-IN-5, a potent, selective, and brain-penetrating inhibitor of Indoleamine 2,3-Dioxygenase 1 (IDO1) activity. It specifically binds to apo-IDO1, which lacks heme, instead of mature heme-bound IDO1.
T37329	PROTAC IDO1 Degrader-1 PROTAC IDO1 Degrader-1	PROTACs	PROTAC
	PROTAC IDO1 Degrader-1 is the first potent IDO1 (indoleamine 2,3-dioxygenase 1) degrader that hijacks IDO1 to CRBN E3 ligase to introduce IDO1 into UPS and eventually achieve ubiquitination and degradation (DC50=2.84 μM). PROTAC IDO1 Degrader-1 moderately improves the tumor-killing activity of H ER2 CAR-T cells[1]. PROTAC IDO1 Degrader-1 (compound 2c) (10 μM; 24 hours) notably decreases IDO1 level induced by IFN-γ[1].PROTAC IDO1 Degrader-1 and IFN-γ (5 ng/mL) are incubated with HeLa cells for 24...
T82082	IDO1-IN-23	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	IDO1-IN-23（化合物41）是一种有效的人类IDO1抑制剂，具备13 μM的IC50值。
T39888	IDO1-IN-7 IDO1-IN-7	Others	Others
	IDO1-IN-7, a potent and selective indoleamine-2,3-dioxygenase-1 (IDO1) inhibitor, exhibits high potency with an IC 50 of 6.1 nM in the cellular assay (SKOV3). Apart from its inhibitory properties, IDO1-IN-7 also demonstrates immunomodulatory effects, contributing to its potential applications in cancer research.
T60266	(Rac)-Indoximod	Others	Others
	(Rac)-Indoximod (1-Methyl-DL-tryptophan) is a potent inhibitor of indoleamine 2,3-dioxygenase (IDO). Combined treatment with IFN-γ and (Rac)-Indoximod significantly suppresses the activity of α-SMA-expressing human cardiac myofibroblasts (hCMs) and promotes apoptosis by up-regulating the genes IRF-1, Fas, and FasL. Moreover, this co-treatment effectively improves cardiac fibrosis[1].
T74369	Topramezone	Others	Others
	Topramezone为高效的4-羟基苯基丙酮酸双加氧酶(4-HPPD)抑制剂，作为除草剂(herbicide)，适用于防治玉米中的阔叶杂草和禾本科杂草出苗后。

化合物

Cat.No: T11615

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

4-Chlorocatechol

Cat.No: T39598

Target: Others

Cat.No: T11901

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T11616

Synonym: GS-4361

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T10199

Synonym: 8-Nitrotryptanthrin

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T9164

Synonym: BMS986242

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T2647

Synonym: INCB024360 analogue,INCB14943

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4532

Synonym: BMS-986205

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4307

Synonym: EOS200271,PF 06840003

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: TQ0071

Synonym: GDC-0919,NLG-919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3548

Synonym: INCB 024360,艾卡哚司他,IDO Inhibitor 1

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T7181

Synonym: 4-氨基-N-(3-溴-4-氟苯基)-N'-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T1847

Synonym: Nec-1,Necrostatin 1

Target: Indoleamine 2,3-Dioxygenase (IDO), Ferroptosis, Autophagy, RIP kinase

Cat.No: T1806

Synonym: NLG919,Navoximod,NLG-919 analogue,GDC-0919

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T4142

Synonym: IDO inhibitor 1,DO-IN-2,IDO-IN-2

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T6543

Synonym: NLG-8189,Indoximod (NLG-8189）,1-Methyl-D-tryptophan,吲哚莫德

Target: Indoleamine 2,3-Dioxygenase (IDO)

4,5-Dichlorocatechol

Cat.No: T40421

Target: Others

Cat.No: T1684

Synonym: 尼替西农,NTBC,SC0735,Nitisone

Target: Others, Reactive Oxygen Species

Cat.No: T20513

Synonym: IDO1 inhibitor 1,2 HzBTZ,2-肼基苯并噻唑,IDO1IN1,2-HzBTZ,IDO1-inhibitor-1

Target: IDO

IDO inhibitor 1

Cat.No: T7660

Synonym: 4-[[2-[(氨基磺酰基)氨基]乙基]氨基]-N'-(3-溴-4-氟苯基)-N-羟基-1,2,5-恶二唑-3-甲脒

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T16951

Target: Reactive Oxygen Species

Cat.No: T39476

Target: Indoleamine 2,3-Dioxygenase (IDO)

Benzylideneaniline

Cat.No: T20318

Synonym: N-苄叉苯胺,N-Benzylideneaniline

Target: Others

α-Hydroxyglutaric Acid Lithium

Cat.No: T36624L

Synonym: α-Hydroxyglutaric Acid Lithium(2889-31-8 Free base)

Target: Decarboxylase, Endogenous Metabolite, mTOR

Cat.No: T4410

Target: Others

Cat.No: T61202

Target: Others

D-α-Hydroxyglutaric acid disodium

Cat.No: T6820

Synonym: D-alpha-Hydroxyglutaric acid disodium salt,(R)-2-羟基戊二酸二钠盐,Disodium (R)-2-Hydroxyglutarate

Target: ATPase, Others, Reactive Oxygen Species, Endogenous Metabolite, mTOR

Cat.No: T11623

Target: Others

Cat.No: T11618

Target: Others

Cat.No: T11620

Synonym: NLG-1486

Target: IDO

Cat.No: T74992

Target: Others

Cat.No: T11619

Synonym: NLG-1489

Target: IDO

Cat.No: T11617

Target: IDO

Cat.No: T11621

Synonym: NLG-1487

Target: IDO

Navoximod phosphate

Cat.No: T70189

Target: Others

Cat.No: T11622

Target: IDO

3,6-Dichlorocatechol

Cat.No: T40493

Target: Others

3,4-Dichlorocatechol

Cat.No: T40497

Target: Others

Cat.No: T11614

Target: IDO

3,5-Dichlorocatechol

Cat.No: T38781

Target: Others

Cat.No: T14531

Target: Others

Cat.No: T68792

Target: Others

Cat.No: T73437

Target: Others

Cat.No: T60698

Target: Others

(Rac)-IDO1-IN-5

Cat.No: T12668

Target: Others

PROTAC IDO1 Degrader-1

Cat.No: T37329

Synonym: PROTAC IDO1 Degrader-1

Target: PROTACs

Cat.No: T82082

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T39888

Synonym: IDO1-IN-7

Target: Others

(Rac)-Indoximod

Cat.No: T60266

Target: Others

Cat.No: T74369

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4S0051	Coptisine sulfate	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine Sulfate 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T3S1967	(S)-Indoximod N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine	Others; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism; Others
	(S)-Indoximod (L-Abrine) 是一种吲哚胺-2,3-双加氧酶 (IDO) 抑制剂，可用于研究癌症。
T5S0053	Coptisine 黄连碱,Coptisin	Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Coptisine (Coptisin) 是一种从黄连中分离到的生物碱，是非竞争性的IDO 抑制剂，Ki=为 5.8 μM，IC50=6.3 μM。
T2718	Palmatine chloride	Others; Indoleamine 2,3-Dioxygenase (IDO); Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Others
	Palmatine chloride 是口服具有活力的不可逆 IDO-1抑制剂。它能够减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，并改善 DSS 诱发的结肠炎。
T5S0056	Coptisine chloride 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754	Indoleamine 2,3-Dioxygenase (IDO); Influenza Virus; Antibacterial	Metabolism; Microbiology/Virology
	Coptisine chloride (NSC-119754) 是从黄连中分离到的一种生物碱，是一种非竞争性 IDO 抑制剂，Ki 值为 5.8 μM，IC50值为 6.3 μM。它是一种 H1N1 神经氨酸酶抑制剂，可用于甲型流感病毒感染，IC50为 104.6 μg/mL。
T5S0802	Palmatine 巴马汀,Berbericinine,Burasaine	Indoleamine 2,3-Dioxygenase (IDO); AChR; AChE; Aurora Kinase	Cell Cycle/Checkpoint; Chromatin/Epigenetic; Metabolism; Neuroscience
	Palmatine (Burasaine) 是口服具有活力的、不可逆IDO-1抑制剂。它可以减轻结肠损伤，预防肠道菌群失调和调节色氨酸分解代谢，从而改善DSS (Dextran Sulphate Sodium Salt) 诱发的结肠炎。它有用于结肠炎的研究潜力。
T8214	Kushenol E 苦参醇E,Flemiphilippinin D	IDO; Indoleamine 2,3-Dioxygenase (IDO)	Metabolism
	Kushenol E (Flemiphilippinin D) 是一种分离自Sophora flavescens 中的类黄酮，是一种IDO1的非竞争性抑制剂，其IC50=7.7 µM，Ki=为 9.5 µM，具有抗肿瘤特性。
T4779	4-Methylcatechol p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene	Others; Endogenous Metabolite	Metabolism; Others
	4-Methylcatechol (3,4-Dihydroxytoluene) 是 p-toluate 的代谢物，它是 Catechol 2,3-Dioxygenase 的自杀性底物抑制剂。
T5066	Nε,Nε,Nε-Trimethyllysine chloride Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride	Others; Endogenous Metabolite	Metabolism; Others
	Nε,Nε,Nε-Trimethyllysine chloride (Lys(Me)3-OH Chloride) 是肠道菌群依赖性形成 N,N,N-trimethyl-5-aminovaleric acid (TMAVA) 的前体。
T4858	4-Hydroxyphenylpyruvic acid 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid	Endogenous Metabolite	Metabolism
	4-Hydroxyphenylpyruvic acid 是一种苯丙氨酸代谢的中间产物，是一种酶抑制剂。
T72508	Palmatine hydroxide	Others	Others
	Palmatine hydroxide 是不可逆的口服活性IDO-1抑制剂，其对HEK 293-hIDO-1 和 rhIDO-1的IC50值分别为3 μM和157 μM。该化合物还能非竞争性抑制(WNV)NS2B-NS3蛋白酶，IC50值为96 μM。Palmatine hydroxide展现了抗癌、抗炎、神经保护、抗细菌和抗病毒的活性。
T82822	Brassicanate A sulfoxide
	Brassicanate A sulfoxide 表现出除草效果，它能抑制植物中必需氨基酸的生物合成路径。该化合物通过结合并抑制多种酶的活性来发挥其作用，包括二羟酸脱水酶 (DHAD)、羟甲基丙酮酸双加氧酶 (HPPD)、乙酰乳酸合酶 (ALS)、PYL家族蛋白及转运抑制剂响应 1 (TIR1)。Brassicanate A sulfoxide 可以从甘蓝 (Brassica oleracea) 中提取获得。

天然产物

Coptisine sulfate

Cat.No: T4S0051

Target: Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T3S1967

Synonym: N-ME-Tryptophan,Abrine,相思豆碱,L-Abrine

Target: Others, Indoleamine 2,3-Dioxygenase (IDO)

Cat.No: T5S0053

Synonym: 黄连碱,Coptisin

Target: Indoleamine 2,3-Dioxygenase (IDO)

Palmatine chloride

Cat.No: T2718

Target: Others, Indoleamine 2,3-Dioxygenase (IDO), Aurora Kinase

Coptisine chloride

Cat.No: T5S0056

Synonym: 盐酸黄连碱,氯化黄连碱,Q-100696,NSC-119754

Target: Indoleamine 2,3-Dioxygenase (IDO), Influenza Virus, Antibacterial

Cat.No: T5S0802

Synonym: 巴马汀,Berbericinine,Burasaine

Target: Indoleamine 2,3-Dioxygenase (IDO), AChR, AChE, Aurora Kinase

Cat.No: T8214

Synonym: 苦参醇E,Flemiphilippinin D

Target: IDO, Indoleamine 2,3-Dioxygenase (IDO)

4-Methylcatechol

Cat.No: T4779

Synonym: p-Methylcatechol,3,4-二羟基甲苯,Homocatechol,4-methylbenzene-1,2-diol,3,4-Dihydroxytoluene

Target: Others, Endogenous Metabolite

Nε,Nε,Nε-Trimethyllysine chloride

Cat.No: T5066

Synonym: Lys(Me)3-OH Chloride,Nε,Nε,Nε-Trimethyllysine hydrochloride

Target: Others, Endogenous Metabolite

4-Hydroxyphenylpyruvic acid

Cat.No: T4858

Synonym: 4-羟苯基丙酮酸,4-Hydroxyphenylpyruvic acid

Target: Endogenous Metabolite

Palmatine hydroxide

Cat.No: T72508

Target: Others

Brassicanate A sulfoxide

Cat.No: T82822

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-02928	IDO Protein, Human, Recombinant IDO-1,Indoleamine 2,3‑dioxygenase,indoleamine 2,3-<...	Human	E. coli
	IDO Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular weight is 45.2 kDa and the accession number is A0A348GSI3.
TMPY-01821	IDO Protein, Human, Recombinant (His) IDO,indoleamine 2,3-dioxygenase 1,Indoleamine 2,3‑<...	Human	E. coli
	IDO Protein, Human, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46 kDa and the accession number is P14902-1.
TMPY-04176	HAAO Protein, Rat, Recombinant (His) 3-hydroxyanthranilate 3,4-dioxygenase	Rat	E. coli
	HAAO Protein, Rat, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 34.8 kDa and the accession number is P46953.
TMPY-02803	IDO2 Protein, Human, Recombinant (His) indoleamine 2,3-dioxygenase 2,INDOL1	Human	E. coli
	IDO2 belongs to the indoleamine 2,3-dioxygenase family. Indoleamine 2,3-dioxgyenase (IDO), is a cytosolic haem protein which, together with the hepatic enzyme tryptophan 2,3-dioxygenase, catalyzes the conversion of tryptophan and other indole derivatives to kynurenines. In addition to classic IDO (IDO1), a new variant, IDO2, has recently been described. IDO2 is expressed in the liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon. IDO is widely distributed in human ti...
TMPH-00047	DODA Protein, Amanita muscaria, Recombinant (His & Myc) DOPA 4,5-dioxygenase,DODA	Amanita muscaria	E. coli
	Extradiol dioxygenase that opens up the cyclic ring of DOPA between carbons 4 and 5 thus producing an unstable seco-DOPA that rearranges non-enzymatically to betalamic acid. Can also catalyze the formation of muscaflavin (a pigment found in the hygrocybe mushrooms family and of some amanita species only) by a 2,3-extradiol cleavage of DOPA. DODA Protein, Amanita muscaria, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight...
TMPJ-01142	CDO1 Protein, Human, Recombinant (His) CDO-I,CDO,Cysteine Dioxygenase Type I,CDO1,Cysteine...	Human	E. coli
	Cysteine Dioxygenase Type 1 (CDO1) is a mammalian non-heme iron enzyme that belongs to the cysteine dioxygenase family. CDO1 is highly expressed in the liver and placenta, and has a low expression in heart, brain and pancreas. CDO1 can also be detected in hepatoblastoma HepG2 cells. CDO1 catalyzes the conversion of L-cysteine to cysteine sulfinic acid by incorporation of dioxygen. CDO1 is a vital regulator of cellular cysteine concentrations and has an essential role in maintaining the hepatic c...
TMPY-06772	IDO Protein, Mouse, Recombinant (His) Indo,indoleamine 2,3-dioxygenase 1,Ido	Mouse	E. coli
	IDO Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His tag. The predicted molecular weight is 46.47 kDa and the accession number is P28776.
TMPH-03159	DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO) DOPA 4,5-dioxygenase,DODA	Portulaca grandiflora	E. coli
	Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid. DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 49.9 kDa and the accession number is Q7XA48.
TMPY-04909	HAAO Protein, Human, Recombinant (His & GST) 3-hydroxyanthranilate 3,4-dioxygenase,3-HAO,HAO	Human	Baculovirus Insect Cells
	HAAO Protein, Human, Recombinant (His & GST) is expressed in Baculovirus insect cells with His and GST tag. The predicted molecular weight is 60.4 kDa and the accession number is P46952-1.
TMPH-03187	PHT3 Protein, Pseudomonas putida, Recombinant (His & Myc) pht3,Phthalate 4,5-dioxygenase oxygenase subunit	Pseudomonas putida	E. coli
	N/A. PHT3 Protein, Pseudomonas putida, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 56.7 kDa and the accession number is Q05183.
TMPH-00025	DELTA-actitoxin-Aeq1a Protein, Acinetobacter baumannii, Recombinant (His & SUMO) 1,2-CTD,catA,Catechol 1,2-dioxygenase	Acinetobacter baylyi	E. coli
	DELTA-actitoxin-Aeq1a Protein, Acinetobacter baumannii, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 50.3 kDa and the accession number is P07773.
TMPH-03186	Metapyrocatechase Protein, Pseudomonas putida, Recombinant (His & Myc & SUMO) Catechol 2,3-dioxygenase,xylE,CatO2ase,Metapyrocate...	Pseudomonas putida	E. coli
	N/A. Metapyrocatechase Protein, Pseudomonas putida, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 55.2 kDa and the accession number is P06622.
TMPY-03756	BBOX1 Protein, Human, Recombinant (His & GST) butyrobetaine (γ), 2-oxoglutarate dioxygenase (γ-bu...	Human	Baculovirus Insect Cells
	BBOX1, also known as gamma-BBH, belongs to thegamma-BBH/TMLD family. It is highly expressed in kidney and moderately expressed in liver. BBOX1 catalyzes the formation of L-carnitine from gamma-butyrobetaine, the last step in the L-carnitine biosynthetic pathway. Carnitine is essential for the transport of activated fatty acids across the mitochondrial membrane during mitochondrial beta-oxidation. BBOX1 is an inhibition target for mildronate which can be used to treatanginaandmyocardial infarctio...
TMPH-00026	Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) Equinatoxin-2,EqTII,DELTA-AITX-Aeq1a,Equinatoxin II,DELTA-ac...	Actinia equina	E. coli
	Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 23.9 kDa and the accession number is P61914.
TMPH-00577	AlkB Protein, E. coli, Recombinant (His & Myc & SUMO) Alpha-ketoglutarate-dependent dioxygenase AlkB homo...	E. coli	E. coli
	AlkB Protein, E. coli, Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 44.1 kDa and the accession number is P05050.
TMPJ-00938	4HPPD Protein, Human, Recombinant (His) PPD,4HPPD,HPD,4-Hydroxyphenylpyruvate Dioxygenase,H...	Human	E. coli
	4-Hydroxyphenylpyruvate Dioxygenase (4HPPD) belongs to the 4HPPD family. 4HPPD is a key enzyme in the degradation of tyrosine, which catalyzes the second reaction in the catabolism of tyrosine the conversation of 4-hydroxyphenylpyruvate to homogentisate. 4HPPD exists in homodimer forms, which uses zinc as a cofactor to catalyze the third step in the conversion of L-phenylalanine to fumarate and acetoacetic acid. When the active 4HPPD enzyme concentration is low in the human body, it results in h...
TMPH-02839	PLOD2 Protein, Mouse, Recombinant (His & Myc) Procollagen-lysine,2-oxoglutarate 5-dioxygenase 2,L...	Mouse	Baculovirus Insect Cells
	Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links. PLOD2 Protein, Mouse, Recombinant (His & Myc) is expressed in Baculovirus insect cells with C-6xHis-Myc tag. The predicted molecular weight is 85.2 kDa and the accession number is Q9R0B9.
TMPH-02403	JBP1 Protein, Leishmania infantum, Recombinant (His & V5) J-binding protein 1,Thymine dioxygenase JBP1,Thymid...	Leishmania infantum	E. coli
	JBP1 Protein, Leishmania infantum, Recombinant (His & V5) is expressed in E. coli expression system with N-10xHis-V5 tag. The predicted molecular weight is 53.4 kDa and the accession number is A4HU70.
TMPH-01501	HGD Protein, Human, Recombinant (His) Homogentisicase,Homogentisic acid oxidase,Homogentisate 1,2-...	Human	E. coli
	HGD Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 54.0 kDa and the accession number is Q93099.
TMPH-00359	AlkB Protein, Caulobacter vibrioides, Recombinant (His & Myc) Alpha-ketoglutarate-dependent dioxygenase AlkB homo...	Caulobacter vibrioides	E. coli
	AlkB Protein, Caulobacter vibrioides, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 31.2 kDa and the accession number is B8GWW6.
TMPH-02840	PLOD2 Protein, Mouse, Recombinant (E. coli, His & Myc) Lysyl hydroxylase 2,Plod2,Procollagen-lysine,2-oxoglutarate ...	Mouse	E. coli
	Forms hydroxylysine residues in -Xaa-Lys-Gly- sequences in collagens. These hydroxylysines serve as sites of attachment for carbohydrate units and are essential for the stability of the intermolecular collagen cross-links.
TMPH-01920	P4HA3 Protein, Human, Recombinant (His & SUMO) Prolyl 4-hydroxylase subunit alpha-3,Procollagen-proline,2-o...	Human	E. coli
	P4HA3 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli.
TMPH-01919	P4HA1 Protein, Human, Recombinant (His) P4HA1,Prolyl 4-hydroxylase subunit alpha-1,Procollagen-proli...	Human	E. coli
	P4HA1 Protein, Human, Recombinant (His) is expressed in E. coli.
TMPH-01899	ALKBH5 Protein, Human, Recombinant (His) ABH5,Alkylated DNA repair protein alkB homolog 5,RNA demethy...	Human	E. coli
	ALKBH5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 48.2 kDa and the accession number is Q6P6C2.
TMPH-00920	FTO Protein, Human, Recombinant (His & Myc) U6 small nuclear RNA (2'-O-methyladenosine-N(6)-)-demethylas...	Human	E. coli
	FTO Protein, Human, Recombinant (His & Myc) is expressed in E. coli.
TMPY-01736	COX-2 Protein, Human, Recombinant (His) GRIPGHS,PHS-2,hCox-2,COX-2,PGHS-2,prostaglandin-endoperoxide...	Human	Baculovirus Insect Cells
	PTGS2, also known as COX-2, is s component of Prostaglandin-endoperoxide synthase (PTGS). PTGS, also known as cyclooxygenase, is the key enzyme in prostaglandin biosynthesis, and acts both as a dioxygenase and as a peroxidase. There are two isozymes of PTGS: a constitutive PTGS1 and an inducible PTGS2, which differ in their regulation of expression and tissue distribution. PTGS2 is overexpressed in many cancers. The overexpression of PTGS2 along with increased angiogenesis and GLUT-1 expression ...
TMPH-03606	P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc) Proline 3-hydroxylase type I,L-proline cis-3-hydroxylase 1,P...	Streptomyces	E. coli
	Dioxygenase that catalyzes the 2-oxoglutarate-dependent selective hydroxylation of free L-proline to cis-3-hydroxy-L-proline (cis-3-Hyp). D-proline, trans-4-hydroxy-L-proline, cis-4-hydroxy-L-proline, cis-4-hydroxy-D-proline, and 3,4-dehydro-DL-proline are not substrates. P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 44.0 kDa and the accession number is P96010.
TMPY-03658	ETHE1 Protein, Human, Recombinant (His) YF13H12,HSCO,ethylmalonic encephalopathy 1	Human	E. coli
	ETHE1, also known as HSCO, is a sulfur dioxygenase that localizes within the mitochondrial matrix. ETHE1 probably plays an important role in metabolic homeostasis in mitochondria. It may also function as a nuclear-cytoplasmic shuttling protein that binds transcription factor RELA/NFKB3 in the nucleus and exports it to the cytoplasm. ETHE1 can suppresses p53-induced apoptosis by preventing nuclear localization of RELA. Mutations in ETHE1 gene result in ethylmalonic encephalopathy. Ethylmalonic en...

重组蛋白

IDO Protein, Human, Recombinant

Cat.No: TMPY-02928

Species: Human

Expression System: E. coli

IDO Protein, Human, Recombinant (His)

Cat.No: TMPY-01821

Species: Human

Expression System: E. coli

HAAO Protein, Rat, Recombinant (His)

Cat.No: TMPY-04176

Species: Rat

Expression System: E. coli

IDO2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02803

Species: Human

Expression System: E. coli

DODA Protein, Amanita muscaria, Recombinant (His & Myc)

Cat.No: TMPH-00047

Species: Amanita muscaria

Expression System: E. coli

CDO1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01142

Species: Human

Expression System: E. coli

IDO Protein, Mouse, Recombinant (His)

Cat.No: TMPY-06772

Species: Mouse

Expression System: E. coli

DODA Protein, Portulaca grandiflora, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03159

Species: Portulaca grandiflora

Expression System: E. coli

HAAO Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-04909

Species: Human

Expression System: Baculovirus Insect Cells

PHT3 Protein, Pseudomonas putida, Recombinant (His & Myc)

Cat.No: TMPH-03187

Species: Pseudomonas putida

Expression System: E. coli

DELTA-actitoxin-Aeq1a Protein, Acinetobacter baumannii, Recombinant (His & SUMO)

Cat.No: TMPH-00025

Species: Acinetobacter baylyi

Expression System: E. coli

Metapyrocatechase Protein, Pseudomonas putida, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-03186

Species: Pseudomonas putida

Expression System: E. coli

BBOX1 Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03756

Species: Human

Expression System: Baculovirus Insect Cells

Catechol 1,2-dioxygenase Protein, Acinetobacter baylyi, Recombinant (His)

Cat.No: TMPH-00026

Species: Actinia equina

Expression System: E. coli

AlkB Protein, E. coli, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-00577

Species: E. coli

Expression System: E. coli

4HPPD Protein, Human, Recombinant (His)

Cat.No: TMPJ-00938

Species: Human

Expression System: E. coli

PLOD2 Protein, Mouse, Recombinant (His & Myc)

Cat.No: TMPH-02839

Species: Mouse

Expression System: Baculovirus Insect Cells

JBP1 Protein, Leishmania infantum, Recombinant (His & V5)

Cat.No: TMPH-02403

Species: Leishmania infantum

Expression System: E. coli

HGD Protein, Human, Recombinant (His)

Cat.No: TMPH-01501

Species: Human

Expression System: E. coli

AlkB Protein, Caulobacter vibrioides, Recombinant (His & Myc)

Cat.No: TMPH-00359

Species: Caulobacter vibrioides

Expression System: E. coli

PLOD2 Protein, Mouse, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-02840

Species: Mouse

Expression System: E. coli

P4HA3 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01920

Species: Human

Expression System: E. coli

P4HA1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01919

Species: Human

Expression System: E. coli

ALKBH5 Protein, Human, Recombinant (His)

Cat.No: TMPH-01899

Species: Human

Expression System: E. coli

FTO Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00920

Species: Human

Expression System: E. coli

COX-2 Protein, Human, Recombinant (His)

Cat.No: TMPY-01736

Species: Human

Expression System: Baculovirus Insect Cells

P3H 1 Protein, Streptomyces sp., Recombinant (His & Myc)

Cat.No: TMPH-03606

Species: Streptomyces

Expression System: E. coli

ETHE1 Protein, Human, Recombinant (His)

Cat.No: TMPY-03658

Species: Human

Expression System: E. coli

Cat. No.	Product Name	Target	Signaling Pathways
T36055	Nitisinone-13C6 Nitisinone-13C6
	Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (F...

同位素标记化合物

Nitisinone-13C6

Cat.No: T36055

Synonym: Nitisinone-13C6

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