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Search Results for " snare "

Targets Recommended: Autophagy

3

抑制剂 & 化合物

1

天然产物

15

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T11142	EACC	Autophagy	Autophagy
	EACC 是自噬的可逆抑制剂，可阻断自噬通量。它对自噬体特异性的 SNARE Stx17 易位具有选择性抑制作用，从而阻止自噬体与溶酶体的融合。
T76549	TAT-NSF700scr
	TAT-NSF700scr拥有完整的TAT结构域和甘氨酸连接肽，后接随机排列的NSF氨基酸序列，该化合物作为非抑制SNARE介导的胞吐作用的对照肽而被使用。
T6990	SNAP8 Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2,SNAP 8,SNAP-8	Others	Others
	SNAP8 (Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2) 是 SNAP-25 N 末端的模拟物，它与 SNAP-25 竞争 SNARE 复合物中的位置，从而调节其形成。

化合物

Cat.No: T11142

Target: Autophagy

Cat.No: T76549

Cat.No: T6990

Synonym: Ac-Glu-Glu-Met-Gln-Arg-Arg-Ala-Asp-Nh2,SNAP 8,SNAP-8

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T7846	Aegeline	Others; Antifungal	Microbiology/Virology; Others
	Aegeline 是从 Aegle marmelos 的叶子中分离出来的一种生物碱酰胺，有抗高血糖和抗血脂异常的活性。

天然产物

Cat.No: T7846

Target: Others, Antifungal

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-02306	VTI1B Protein, Human, Recombinant (His & SUMO) Vti1-rp1,VTI1B,Vesicle transport through interaction with t-...	Human	E. coli
	V-SNARE that mediates vesicle transport pathways through interactions with t-SNAREs on the target membrane. These interactions are proposed to mediate aspects of the specificity of vesicle trafficking and to promote fusion of the lipid bilayers. May be concerned with increased secretion of cytokines associated with cellular senescence.
TMPY-02245	SNAP-25 Protein, Human, Recombinant (His) synaptosomal-associated protein, 25kDa,SEC9,SNAP,RIC-4,dJ106...	Human	E. coli
	Synaptosomal-associated protein 25, also known as Super protein, Synaptosomal-associated 25 kDa protein, SNAP25 and SNAP, is a cytoplasm and cell membrane protein that belongs to the SNAP-25 family. SNAP25 / SUP contains 2 t-SNARE coiled-coil homology domains. SNAP25 / SUP is a membrane bound protein anchored to the cytosolic face of membranes via palmitoyl side chains in the middle of the molecule. SNAP25 / SUP protein is a component of the SNARE complex, which is proposed to account for the sp...
TMPY-03866	Syntaxin 3 Protein, Human, Recombinant (His) syntaxin 3,STX3A	Human	E. coli
	STX3, also known as syntaxin 3, belongs to the syntaxin family. STX3 is a target membrane protein (t-SNARE) that is needed for membrane fusion. Membrane fusion requires the formation of a complex between a vesicle protein (v-SNARE) and t-SNAREs. STX3, together with syntaxin 2, are predominantly localized at the plasma membrane. Syntaxin 2 cycles between the plasma membrane and the perinuclear compartment whereas syntaxin 3 cycles between the plasma membrane and the trans-Golgi network. It is pos...
TMPY-03981	CPLX3 Protein, Human, Recombinant (His) CPXIII,Nbla11589,CPX-III,complexin 3	Human	HEK293 Cells
	CPLX3, also known as complexin 3, belongs to the complexin/synaphin family. As a SNARE-binding protein, complexin (CPX), can act either as a facilitator or as an inhibitor of membrane fusion, constituting a controversial dilemma. CPX acts sequentially on assembling SNAREpins, first facilitating zippering by nearly doubling the distance at which v- and t-SNAREs can engage and then clamping them into a half-zippered fusion-incompetent state. Specifically, the central helix of CPX allows SNAREs to ...
TMPH-02164	Syntaxin-11 Protein, Human, Recombinant (GST) STX11,Syntaxin-11	Human	E. coli
	SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network.
TMPY-02025	CPLX2 Protein, Human, Recombinant (His) CPX-2,Hfb1,921-L,complexin 2,CPX2	Human	E. coli
	Complexin-2 (CPLX2), a member of the complexin/synaphin family, is a soluble pre-synaptic protein believed to regulate neurotransmitter release from pre-synaptic terminals. Complexins are soluble proteins that regulate the activity of soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complexes necessary for vesicle fusion. Complexins are unable to bind to monomeric SNARE proteins but bind with high affinity to ternary SNARE complexes and with lower affinity to target ...
TMPJ-00670	YKT6 Protein, Human, Recombinant (His) YKT6,Synaptobrevin homolog YKT6	Human	E. coli
	Synaptobrevin Homolog YKT6 (YKT6) is an enzyme that belongs to the Synaptobrevin family. YKT6 contains a longin domain and a v-SNARE coiled-coil homology domain. YKT6 is highly conserved from yeast to human and it can functionally complement the loss of the yeast homolog in the yeast secretory pathway. It is a membrane associated, isoprenylated protein that functions at the endoplasmic reticulum-Golgi transport step. YKT6 is considered as one of the SNARE recognition molecules implicated in vesi...
TMPY-03629	Syntaxin 8 Protein, Human, Recombinant (His) CARB,syntaxin 8	Human	HEK293 Cells
	STX8, also known as syntaxin 8, directly interacts with HECTd3. STX8 forms the SNARE complex with syntaxin 7, vti1b and endobrevin. STX8 belongs to the syntaxin family. Members of this family are key molecules implicated in diverse vesicle docking and membrane fusion events. STX8 physically interacts with cystic fibrosis transmembrane conductance regulator (CFTR): recombinant syntaxin 8 binds CFTR in vitro and both proteins co-immunoprecipitate in HT29 cells. Syntaxin 8 regulates CFTR-mediated c...
TMPJ-00678	STX6 Protein, Human, Recombinant STX6,Syntaxin-6	Human	E. coli
	Syntaxin-6 (STX6) is a single-pass type IV membrane protein, which belongs to the Syntaxin family. STX6 is mainly localized in the plasma membrane. STX6 contains one t-SNARE coiled-coil homology domain and involved in intracellular vesicle trafficking. When STX6 function is inhibited, internalization through caveolae is dramaticaliy reduced, whereas other endocytic mechanisms are unaffected. It is reported that STX6 is necessary for proper expression of focal adhesion kinase and integrin alpha5 ...
TMPH-02595	Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO) Cltrn,Collectrin,Tmem27,Nx17,Transmembrane protein 27	Mouse	E. coli
	Plays an important role in amino acid transport by acting as binding partner of amino acid transporters SLC6A18 and SLC6A19, regulating their trafficking on the cell surface and their activity. May also play a role in trafficking of amino acid transporters SLC3A1 and SLC7A9 to the renal cortical cell membrane. Regulator of SNARE complex function. Stimulator of beta cell replication.
TMPH-03399	VAMP2 Protein, Rat, Recombinant (His) Vesicle-associated membrane protein 2,Vamp2,Synaptobrevin-2	Rat	E. coli
	Involved in the targeting and/or fusion of transport vesicles to their target membrane. Major SNARE protein of synaptic vesicles which mediates fusion of synaptic vesicles to release neurotransmitters. Essential for fast vesicular exocytosis and activity-dependent neurotransmitter release as well as fast endocytosis that mediates rapid reuse of synaptic vesicles. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1. VAMP2 Protein, Rat, Recombina...
TMPH-01272	TRIM9 Protein, Human, Recombinant (His & SUMO) RING finger protein 91,RING-type E3 ubiquitin transferase TR...	Human	E. coli
	E3 ubiquitin-protein ligase which ubiquitinates itself in cooperation with an E2 enzyme UBE2D2/UBC4 and serves as a targeting signal for proteasomal degradation. May play a role in regulation of neuronal functions and may also participate in the formation or breakdown of abnormal inclusions in neurodegenerative disorders. May act as a regulator of synaptic vesicle exocytosis by controlling the availability of SNAP25 for the SNARE complex formation.
TMPJ-01388	STX8 Protein, Human, Recombinant STX8,Syntaxin-8	Human	E. coli
	Syntaxin-8 is a single-pass type IV membrane protein which belongs to the syntaxin family. It contains one t-SNARE coil homology domain. STX8 is highly expressed in heart, also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas. STX8 is involved in protein trafficking from early to late endosomes via vesicle fusion and exocytosis. It as a vesicle trafficking protein functions in the early secretory pathway, possibly mediating retrograde transport form cis-golgi m...
TMPJ-00951	TXLNA Protein, Human, Recombinant (His) α-Taxilin,Alpha-Taxilin,TXLN,TXLNA	Human	E. coli
	α-Taxilin belongs to the taxilin family. α-Taxilin exists in almost all tissues, with higher expression levels observed in the heart, kidney, liver, and pancreas. α-Taxilin binds to the C-terminal coiled coil region of syntaxin family members STX1A, STX3A, and STX4A, but not when these proteins are complexed with SNAP25, VAMP2 or STXBP1, suggesting that it interacts with syntaxins that do not form the SNARE complex. It is shown that α-Taxilin plays multiple roles in the generation and maintenanc...
TMPY-00151	Alpha SNAP Protein, Human, Recombinant (His) N-ethylmaleimide-sensitive factor attachment protein, alpha,...	Human	E. coli
	NAPA (NSF Attachment Protein Alpha) is a Protein Coding gene. This gene encodes a member of the soluble NSF attachment protein (SNAP) family. SNAP proteins play a critical role in the docking and fusion of vesicles to target membranes as part of the 20S NSF-SNAP-SNARE complex. NAPA represents an anti-apoptotic protein that promotes resistance to cisplatin in cancer cells by inducing the degradation of the tumor suppressor p53. NAPA overexpression decreased the ubiquitination and degradation of s...

重组蛋白

VTI1B Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-02306

Species: Human

Expression System: E. coli

SNAP-25 Protein, Human, Recombinant (His)

Cat.No: TMPY-02245

Species: Human

Expression System: E. coli

Syntaxin 3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03866

Species: Human

Expression System: E. coli

CPLX3 Protein, Human, Recombinant (His)

Cat.No: TMPY-03981

Species: Human

Expression System: HEK293 Cells

Syntaxin-11 Protein, Human, Recombinant (GST)

Cat.No: TMPH-02164

Species: Human

Expression System: E. coli

CPLX2 Protein, Human, Recombinant (His)

Cat.No: TMPY-02025

Species: Human

Expression System: E. coli

YKT6 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00670

Species: Human

Expression System: E. coli

Syntaxin 8 Protein, Human, Recombinant (His)

Cat.No: TMPY-03629

Species: Human

Expression System: HEK293 Cells

STX6 Protein, Human, Recombinant

Cat.No: TMPJ-00678

Species: Human

Expression System: E. coli

Collectrin Protein, Mouse, Recombinant (His & Myc & SUMO)

Cat.No: TMPH-02595

Species: Mouse

Expression System: E. coli

VAMP2 Protein, Rat, Recombinant (His)

Cat.No: TMPH-03399

Species: Rat

Expression System: E. coli

TRIM9 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01272

Species: Human

Expression System: E. coli

STX8 Protein, Human, Recombinant

Cat.No: TMPJ-01388

Species: Human

Expression System: E. coli

TXLNA Protein, Human, Recombinant (His)

Cat.No: TMPJ-00951

Species: Human

Expression System: E. coli

Alpha SNAP Protein, Human, Recombinant (His)

Cat.No: TMPY-00151

Species: Human

Expression System: E. coli

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