16(17)-epdpa

EDHF (endothelium-derived hyperpolarizing factor) is an unidentified mediator released from vascular endothelial cells in response to acetylcholine and bradykinin which is distinct from the NOS- (nitric oxide) and COX-derived (prostacyclin) vasodilators.[1],[2]Cytochrome P450 (CYP450) metabolism of polyunsaturated fatty acids produces epoxides such as (±)14(15)-EET which are prime candidates for the actual active mediator.[3] However, the CYP450 metabolites of eicosapentaenoic acid and docosahexaenoic acid have been little studied relative to arachidonate epoxygenase metabolites. (±)16(17)-EpDPA is the DHA homolog of (±)14(15)-EpETrE, derived via epoxidation of the 16,17-double bond of DHA. The EDHF activity of (±)16(17)-EpDPA has not yet been determined. The epoxygenase metabolites of DHA have also been detected in a mouse inflammation model.[4]

15,16-Epoxy-12S-hydroxylabda-8(17),13(16),14-triene 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2632，CAS号为 216011-55-1。

15,16-Epoxy-12R-hydroxylabda-8(17),13(16),14-triene 是一种天然产物，可用于生命科学领域的相关研究。其产品编号为 TN2631，CAS号为 61597-55-5。

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17(13→14)-Abeo-ent-3S*,13S*,16-trihydroxystrob-8(15)-ene是一款具有抗炎特性的天然倍半萜内酯。

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16-Hydroxy-8(17),13-labdadien-15,16-olid-19-oic acid may show a strong algicidal activity against Raphidocelis subcapitata.