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Search Results for " recruitment "

Targets Recommended: Ligand for E3 Ligase

152

抑制剂 & 化合物

3

天然产物

1

化合物库

88

重组蛋白

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Cat. No.	Product Name
L9210	儿童药物库		972 compounds
	972 种儿童药物的独特集合，可用于高通量筛选和高内涵筛选

化合物库

儿童药物库

Cat.No: L9210

Compounds: 972

Cat. No.	Product Name	Target	Signaling Pathways
T18064	Lenalidomide-Br	Ligand for E3 Ligase	PROTAC
	Lenalidomide-Br 是一种用于 E3 泛素连接酶的 cereblon (CRBN) 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC，如 PROTAC STAT3 降解剂 SD-36。
T21938	AS-041164	PI3K	PI3K/Akt/mTOR signaling
	AS-041164 是选择性的，具有口服活性的PI3Kγ亚型抑制剂，IC50=70 nM。它对 PI3Kα (IC50:240 μM)，PI3Kβ (IC50:1.45 μM) 和 PI3Kδ (IC50:1.70 μM) 的活性较低。它具有抗炎活性。
T40548	NH-3	Thyroid hormone receptor(THR)	Endocrinology/Hormones
	NH-3是一种高效的口服活性甲状腺激素受体（THR）拮抗剂，具有可逆行为，其IC 50为55 nM。NH-3源自选择性甲状腺激素模拟物GC-1，有效地抑制甲状腺激素与相应受体的结合，从而阻碍辅因子的招募。
T26869	BMS-986122 BMS 986122	Opioid Receptor	Endocrinology/Hormones; GPCR/G Protein; Neuroscience
	BMS-986122 (BMS 986122) 是选择性 μ 阿片受体正变构调节剂，可增加 β-抑制蛋白募集、腺苷酸环化酶抑制和 G 蛋白活化的作用，还增强 DAMGO 介导的 [35S]GTPγS 在小鼠脑膜中的结合。
T8497	SX-682	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SX-682 是口服有效的 CXCR1和 CXCR2变构抑制剂，可以阻断肿瘤髓系抑制细胞募集并增强 T 细胞活化和抗肿瘤免疫，具有治疗去势抵抗性前列腺癌的潜力。
T16850	SB-265610 GSK-CXCR2	CXCR	Autophagy; GPCR/G Protein; Immunology/Inflammation
	SB-265610 (GSK-CXCR2) 是竞争性非肽变构CXCR2选择性拮抗剂，可阻断大鼠 CINC-1 诱导的钙动员和中性粒细胞趋化性，IC50分别为 3.7 和 70 nM。
T28073	MLS1547 MLS000051547,MLS 1547,MLS-1547	Dopamine Receptor	GPCR/G Protein; Neuroscience
	MLS1547 (MLS000051547) 是一种高效的 G 蛋白偏向多巴胺 D2 受体激动剂，Ki 为 1.2 μM。 MLS1547 在钙动员试验中刺激 D2R G 蛋白介导的信号传导，EC50 为 0.37 μM。
T4657	WHI-P97 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉	JAK	Angiogenesis; Chromatin/Epigenetic; JAK/STAT signaling; Stem Cells
	WHI-P97 是一种选择性 JAK-3抑制剂，可用于预防过敏性哮喘的研究。
T14667	BLT-1	Others; HCV Protease	Microbiology/Virology; Others; Proteases/Proteasome
	BLT-1 是一种氨基硫脲铜螯合剂，是一种选择性清除受体 B1 型 (SR-BI) 抑制剂，抑制高密度脂蛋白 (HDL) 和 SR-BI 介导的细胞之间的脂质转移。
T40028	(S,R,S)-AHPC	Ligand for E3 Ligase	PROTAC
	(S,R,S)-AHPC 是一种 VHL 配体，用于募集 VHL 蛋白。
T18831	Thalidomide-propargyl	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-propargyl 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到含 IMiD 的 PROTAC。
T40503	Thalidomide-5-methyl	Ligand for E3 Ligase	PROTAC
	Thalidomide-5-methyl 是基于 Thalidomide 的 CRBN 配体，可以用于CRBN 的招募。
T9029	STING-IN-3 C-171	STING	Immunology/Inflammation
	STING-IN-3 (C-171) 是干扰素基因刺激物 (STING) 的抑制剂。它与 STING 结合，抑制其棕榈酰化，并阻止 TBK1 的募集和磷酸化。
T7753	Thalidomide-O-COOH Cereblon ligand 3,E3 ligase Ligand 3,TCE35031	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-O-COOH (Cereblon ligand 3) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T22021	ACHP IKK-2 Inhibitor VIII	IκB/IKK	NF-κB
	ACHP(IKK-2 Inhibitor VIII) 是一种新型具有选择性和高效性的 IKK 抑制剂，对IKK-α和IKK-β 具有抑制作用。ACHP 具有抗 HIV-1 活性，通过抑制 NF-κB 激活来抑制 HIV-1 长末端重复序列（LTR）驱动的基因表达，抑制 TNF-α 诱导的 NF-κB （p65）募集到 HIV-1 LTR。
T7329	C-178	STING	Immunology/Inflammation
	C-178 是 STING 选择性共价抑制剂，与 Cys91 结合抑制小鼠中由不同的激活剂引起的 STING 反应。
TP1922L1	ELA-11 (human) acetate(1784687-32-6 free base)	Apelin receptor; Arrestin	GPCR/G Protein
	ELA-11 (human) acetate(1784687-32-6 free base)是亲和力 apelin 受体激动剂 (Ki = 14 nM)。 ELA-32 的生物活性片段。在体外抑制毛喉素诱导的 cAMP 产生并刺激 β-arrestin 募集。
T9291	Thalidomide-5-OH 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione	Others; Ligand for E3 Ligase	Others; PROTAC
	Thalidomide-5-OH (2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione) 是基于 Thalidomide 的的cereblon 配体，可用于募集CRBN 蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T18066	Lenalidomide-OH	Ligand for E3 Ligase	PROTAC
	Lenalidomide-OH 是一种用于 E3 泛素连接酶 (CRBN) 的 cereblon 配体 Lenalidomide 的类似物，用于 CRBN 蛋白的募集。它能够利用 linker 连接到蛋白质配体上形成 PROTAC。
T76882	Talquetamab JNJ-64407564,JNJ-7564	Dopamine Receptor	GPCR/G Protein; Neuroscience
	Talquetamab (JNJ-64407564）是一种用于多发性骨髓瘤的 T 细胞重定向 GPRC5D 双特异性抗体，具有抗肿瘤活性，通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab 可用于治疗多发性骨髓瘤 (MM）。
T39988	6'-GNTI dihydrochloride	Opioid Receptor; Akt	Cytoskeletal Signaling; Endocrinology/Hormones; GPCR/G Protein; Neuroscience; PI3K/Akt/mTOR signaling
	6'-GNTI dihydrochloride 是一种κ-阿片受体（KOR）激动剂，它偏向于激活 G 蛋白介导的信号传导，而不是β-阿司匹林2的募集。6'-GNTI dihydrochloride 只能激活纹状体神经元中的 Akt 通路。
T77673	7-FluorotryptaMine HCl	GPR; Arrestin	Endocrinology/Hormones; GPCR/G Protein
	7-FluorotryptaMine HCl 是一种有效的芳香单胺 GPRC5A 激动剂，可诱导 GPRC5A 介导的 β-arrestin 募集。7-FluorotryptaMine HCl 可用于研究与免疫和癌症相关的信号通路。
T8412	(S,R,S)-AHPC VH032-NH2,MDK7526,VHL ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC (VH032-NH2) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，得到 PROTAC 分子。
T13671	(S,R,S)-AHPC-Me hydrochloride VHL ligand 2 hydrochloride,E3 ligase Ligand 1	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC-Me hydrochloride (VHL ligand 2 hydrochloride) is a chemical compound utilized in the synthesis of ARV-771, an exceptionally potent BET protein degrader. This compound selectively degrades BET protein in cells resistant to castration, exhibiting a remarkable DC50 <1 nM. Recognized as VHL ligand 2 hydrochloride, (S,R,S)-AHPC-Me hydrochloride serves as the VHL ligand derived from (S,R,S)-AHPC for the recruitment of von Hippel-Lindau (VHL) protein.
T7755	Thalidomide 4-fluoride E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮	IRAK; Ligand for E3 Ligase	Immunology/Inflammation; NF-κB; PROTAC
	Thalidomide 4-fluoride (E3 ligase Ligand 4) 是一种基于 Thalidomide 的 Cereblon 配体，可用于募集 CRBN 蛋白。它能够利用 linker 与 IRAK4 靶蛋白配体连接，得到 PROTAC IRAK4 degrader-1。
T17927	(S,R,S)-AHPC TFA VH032-NH2 TFA,VHL ligand 1 TFA	Others; Ligand for E3 Ligase	Others; PROTAC
	(S,R,S)-AHPC TFA (VHL ligand 1 TFA) 是一种 VH032-based VHL ligand，可用于募集 von Hippel-Lindau (VHL)蛋白。它能够利用 linker 与靶蛋白配体连接，形成 PROTAC 分子。
T15611	JH-RE-06	DNA/RNA Synthesis	Cell Cycle/Checkpoint; DNA Damage/DNA Repair
	JH-RE-06是一种REV1-REV7互作抑制剂，IC50为0.78 μM，Kd 为0.42 μM。它靶向与 POLζ 的 REV7 亚基相互作用的 REV1，可改善化疗效果。它通过阻止诱变 POLζ 的募集来破坏诱变性跨损伤合成。
T73550	CUR5g	Others	Others
	CUR5g 是一种有效的自噬 (autophagy) 抑制剂。CUR5g 通过阻断自噬体-溶酶体融合选择性地抑制癌细胞中的自噬体降解。CUR5g 通过依赖 UVRAG 的机制阻止 STX17 募集到自噬体，导致自噬体无法与溶酶体融合。CUR5g 可提高顺铂 (Cisplatin) 在体外和体内对 A549 细胞的抗癌作用。
T17157	TRAF-STOP inhibitor 6877002 CD40-TRAF6 inhibitor	NF-κB	NF-κB
	TRAF-STOP inhibitor 6877002 (CD40-TRAF6 inhibitor)是一种 CD40-TRAF6 相互作用的选择性抑制剂，可以抑制 RAW 细胞中 NF-κB 活化。TRAF-STOP 6877002 可阻止小鼠动脉粥样硬化的恶化，减少白细胞募集和巨噬细胞的活化，减少动脉粥样硬化斑块中的巨噬细胞增殖。
T41231	GP 1a	Cannabinoid Receptor; PERK; Arrestin	Apoptosis; GPCR/G Protein
	GP 1a 是cannabinoid receptor 2（CB2）的强效激动剂（EC50=7.1),是在cAMP、GTPγS 和β-arrestin 招募试验中显示的。GP 1a 对CB2受体的选择性约为CB1受体的30倍，且在体外增加HL-60细胞的P-ERK1/2表达。GP 1a 对皮肤伤口愈合有益。GP 1a 可抑制炎症和纤维生成，同时促进上皮的重新形成。
T41068	P53R3	p53	Apoptosis
	P53R3是一种有效的 p53再激活剂。P53R3可恢复 p53热点突变体的序列特异性 DNA 结合，包括p53 R175H、p53 R248W 和p53 R273H。P53R3特异性诱导p53依赖性抗增殖作用，其特异性比PRIMA-1高得多的。P53R3增强野生型p53和p53 M237I 向靶基因启动子的募集。P53R3强烈增强死亡受体死亡受体5（DR5）的mRNA、总蛋白和细胞表面的水平。P53R3用于癌症研究。
T63790	Cbl-b-IN-3	E1/E2/E3 Enzyme	Ubiquitination
	Cbl-b-IN-3是一种有效的casitas b 系淋巴瘤原癌基因-b (Cbl-b)抑制剂（ic50 < 1 nM）。Cbl-b 是一种环型E3泛素蛋白连接酶，与T 淋巴细胞激活阈值的设定有关。Cbl-b 以不依赖于蛋白水解的方式负调控p85，通过其E3泛素连接酶活性，参与了p85向CD28和T 细胞抗原受体ζ的募集，抑制PI3K 抑制了Cblb-/- t 细胞活化的增强。
T77579	JC2-11	IL Receptor; Dehydrogenase; ROS; Caspase; NOD-like Receptor (NLR); AIM2	Apoptosis; Immunology/Inflammation; Metabolism; Proteases/Proteasome
	JC2-11 是一种对炎症有抑制作用的化合物。JC2-11 对含有募集结构域的蛋白质 NLRC 4、黑色素瘤 2 中缺失 (AIM 2) 和非典型 (NC) 炎症小体有抑制作用，通过破坏活性氧的产生和 caspase-1 的活性来抑制炎症小体的活化。JC2-11 减少了炎症小体中 caspase-1 (p20) 的分泌、gasdermin D (GSDMD) 的裂解、IL-1β 和乳酸脱氢酶 (LDH) 的释放。
T10926L	CYT-1010 hydrochloride	Others	Others
	CYT-1010 hydrochloride is an mu-opioid receptor agonist. The EC50 for β-arrestin recruitment and cAMP production inhibition were 13.1 nM and 0.0053 nM, respectively.
T39721	Thalidomide-5-PEG2-Cl Thalidomide-5-PEG2-Cl	Others	Others
	Thalidomide-5-PEG2-Cl, a Thalidomide-derived cereblon ligand, serves as the ligand for the recruitment of CRBN protein. It can be conjugated to the protein ligand via a linker to produce PROTACs.
T40283	Thalidomide-5,6-Cl	Others	Others
	Thalidomide-5,6-Cl, a derivative of Thalidomide, serves as a cereblon ligand for the recruitment of CRBN protein. It can be linked to a ligand for protein using a linker to form PROTACs.
T10926	CYT-1010	Others	Others
	CYT-1010 is an mu-opioid receptor agonist. The EC50 for the inhibition of β-arrestin recruitment and cAMP production is 13.1 nM and 0.0053 nM, respectively.
T70983	Zoledronate disodium	Others	Others
	Zoledronate disodium is an inhibitor of osteoclastogenesis and macrophage recruitment, decreasing bone turnover and stabilizing the bone matrix, exhibiting diverse anti-tumor effects in osteosarcoma.
T38457	Lenalidomide-4-OH	Others	Others
	Lenalidomide-4-OH is a cereblon (CRBN) ligand derived from Lenalidomide, utilized in the recruitment of the CRBN protein. It can be conjugated to the protein ligand via a linker, facilitating the formation of PROTAC.
T39699	Thalidomide-O-C8-Boc Thalidomide-O-C8-Boc	Others	Others
	Thalidomide-O-C8-Boc is a Cereblon ligand derived from Thalidomide, primarily employed in the recruitment of CRBN protein. This ligand can be linked to a protein ligand via a linker to create PROTACs.
T39894	Thalidomide-4-C3-NH2 hydrochloride Thalidomide-4-C3-NH2 hydrochloride	Others	Others
	Thalidomide-4-C3-NH2 hydrochloride is a Thalidomide-derived cereblon ligand utilized for the recruitment of CRBN protein. This compound can be linked to the ligand for protein using a linker to create PROTACs.
T77951	Thalidomide-5-O-C4-NH2 hydrochloride	Others	Others
	Thalidomide-5-O-C4-NH2 hydrochloride为一种Thalidomide衍生的cereblon配体，能够招募CRBN蛋白。它能通过linker与目标蛋白配体结合，进而构建PROTAC分子，如THAL-SNS-032。
T77960	Thalidomide-5-O-C13-NH2 hydrochloride	Others	Others
	Thalidomide-5-O-C13-NH2 hydrochloride 是一款Thalidomide衍生的cereblon配体，能够招募CRBN蛋白。该化合物能通过linker与特定的靶蛋白配体结合，进而构建PROTAC分子，如THAL-SNS-032。
T14777	BRD5529	Others	Others
	BRD5529 is a selective inhibitor of CARD9-E3 ubiquitin ligase TRIM62 protein-protein interaction (IC50: 8.6 μM). BRD5529 directly and selectively binds CARD9, disrupts TRIM62 recruitment, inhibits TRIM62-mediated ubiquitinylation, and activation of CARD9.
T39032	Pomalidomide-5-O-CH3 Pomalidomide-5-O-CH3	Others	Others
	Pomalidomide-5-O-CH3, a derivative of Pomalidomide, serves as a specific ligand for cereblon (CRBN) protein recruitment. It can be linked to the protein ligand to create a PROTAC.
T61371	CB1R Allosteric modulator 4	Others	Others
	CB1R Allosteric modulator 4 is an effective and positive modulator of cannabinoid type-1 (CB1R), exhibiting significant biological activity. This compound inhibits the production of cAMP and demonstrates strong β-arrestin-2 recruitment [1].
T35884	Sialyl-Lewis X	Others	Others
	Sialyl-Lewis X (sLeX), a sialylated fucosylated tetrasaccharide and endogenous antigen, serves as a high-affinity ligand for selectins (E-, P-, and L-selectin)[1]. It interacts with ELAM-1 and CD62, consequently inhibiting CD62-mediated neutrophil recruitment to inflammation sites[2].
T71869	IMB-10	Others	Others
	IMB-10 is an alphaMbeta2 integrin modulator, inhibiting leukocyte migration and recruitment in vitro and in vivo.
T80972	TNH TMP-NVOC linker-Halo	Others	Others
	TNH为一种二聚体，能够渗透活细胞并招募蛋白质至细胞结构。
T39599	Lenalidomide-C5-amido-Boc Lenalidomide-C5-amido-Boc	Others	Others
	Lenalidomide-C5-amido-Boc is a Cereblon ligand derived from Lenalidomide, and serves in the recruitment of CRBN protein. It can be effectively linked to the protein ligand through a linker, resulting in the formation of PROTAC.

化合物

Lenalidomide-Br

Cat.No: T18064

Target: Ligand for E3 Ligase

Cat.No: T21938

Target: PI3K

Cat.No: T40548

Target: Thyroid hormone receptor(THR)

Cat.No: T26869

Synonym: BMS 986122

Target: Opioid Receptor

Cat.No: T8497

Target: CXCR

Cat.No: T16850

Synonym: GSK-CXCR2

Target: CXCR

Cat.No: T28073

Synonym: MLS000051547,MLS 1547,MLS-1547

Target: Dopamine Receptor

Cat.No: T4657

Synonym: 4-(3',5'-二溴-4-羟基苯基)氨基-6,7-二甲氧基喹唑啉

Target: JAK

Cat.No: T14667

Target: Others, HCV Protease

Cat.No: T40028

Target: Ligand for E3 Ligase

Thalidomide-propargyl

Cat.No: T18831

Target: Others, Ligand for E3 Ligase

Thalidomide-5-methyl

Cat.No: T40503

Target: Ligand for E3 Ligase

Cat.No: T9029

Synonym: C-171

Target: STING

Thalidomide-O-COOH

Cat.No: T7753

Synonym: Cereblon ligand 3,E3 ligase Ligand 3,TCE35031

Target: Others, Ligand for E3 Ligase

Cat.No: T22021

Synonym: IKK-2 Inhibitor VIII

Target: IκB/IKK

Cat.No: T7329

Target: STING

ELA-11 (human) acetate(1784687-32-6 free base)

Cat.No: TP1922L1

Target: Apelin receptor, Arrestin

Thalidomide-5-OH

Cat.No: T9291

Synonym: 4 - 羟基沙利度胺,2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione

Target: Others, Ligand for E3 Ligase

Lenalidomide-OH

Cat.No: T18066

Target: Ligand for E3 Ligase

Cat.No: T76882

Synonym: JNJ-64407564,JNJ-7564

Target: Dopamine Receptor

6'-GNTI dihydrochloride

Cat.No: T39988

Target: Opioid Receptor, Akt

7-FluorotryptaMine HCl

Cat.No: T77673

Target: GPR, Arrestin

Cat.No: T8412

Synonym: VH032-NH2,MDK7526,VHL ligand 1

Target: Others, Ligand for E3 Ligase

(S,R,S)-AHPC-Me hydrochloride

Cat.No: T13671

Synonym: VHL ligand 2 hydrochloride,E3 ligase Ligand 1

Target: Others, Ligand for E3 Ligase

Thalidomide 4-fluoride

Cat.No: T7755

Synonym: E3 ligase Ligand 4,2-(2,6-二氧代-哌啶-3-基)-4-氟基-异吲哚-1,3-二酮

Target: IRAK, Ligand for E3 Ligase

(S,R,S)-AHPC TFA

Cat.No: T17927

Synonym: VH032-NH2 TFA,VHL ligand 1 TFA

Target: Others, Ligand for E3 Ligase

Cat.No: T15611

Target: DNA/RNA Synthesis

Cat.No: T73550

Target: Others

TRAF-STOP inhibitor 6877002

Cat.No: T17157

Synonym: CD40-TRAF6 inhibitor

Target: NF-κB

Cat.No: T41231

Target: Cannabinoid Receptor, PERK, Arrestin

Cat.No: T41068

Target: p53

Cat.No: T63790

Target: E1/E2/E3 Enzyme

Cat.No: T77579

Target: IL Receptor, Dehydrogenase, ROS, Caspase, NOD-like Receptor (NLR), AIM2

CYT-1010 hydrochloride

Cat.No: T10926L

Target: Others

Thalidomide-5-PEG2-Cl

Cat.No: T39721

Synonym: Thalidomide-5-PEG2-Cl

Target: Others

Thalidomide-5,6-Cl

Cat.No: T40283

Target: Others

Cat.No: T10926

Target: Others

Zoledronate disodium

Cat.No: T70983

Target: Others

Lenalidomide-4-OH

Cat.No: T38457

Target: Others

Thalidomide-O-C8-Boc

Cat.No: T39699

Synonym: Thalidomide-O-C8-Boc

Target: Others

Thalidomide-4-C3-NH2 hydrochloride

Cat.No: T39894

Synonym: Thalidomide-4-C3-NH2 hydrochloride

Target: Others

Thalidomide-5-O-C4-NH2 hydrochloride

Cat.No: T77951

Target: Others

Thalidomide-5-O-C13-NH2 hydrochloride

Cat.No: T77960

Target: Others

Cat.No: T14777

Target: Others

Pomalidomide-5-O-CH3

Cat.No: T39032

Synonym: Pomalidomide-5-O-CH3

Target: Others

CB1R Allosteric modulator 4

Cat.No: T61371

Target: Others

Cat.No: T35884

Target: Others

Cat.No: T71869

Target: Others

Cat.No: T80972

Synonym: TMP-NVOC linker-Halo

Target: Others

Lenalidomide-C5-amido-Boc

Cat.No: T39599

Synonym: Lenalidomide-C5-amido-Boc

Target: Others

Cat. No.	Product Name	Target	Signaling Pathways
T4953	Neotuberostemonine	NOS	Immunology/Inflammation
	Neotuberostemonine 是一种结核分枝杆菌根中主要的止咳生物碱，能够阻碍巨噬细胞的募集和活化，从而减轻博来霉素 (Bleomycin) 诱导的肺纤维化。
T25687	Leukotriene C4 LTC4,Leukotriene C	Endogenous Metabolite	Metabolism
	Leukotriene C4 (LTC4) 是一种类花生酸脂质介质，可调节炎症部位白细胞的募集和功能。Leukotriene C4 是支气管收缩、粘液分泌过多和嗜酸性粒细胞增多的介质，在荨麻疹中具有介导作用。
TN6458	Acetylshikonin
	Acetylshikonin can effectively inhibit tumor cells, it can be used to treat hepatocellular carcinoma cells expressing hepatitis B virus X protein (HBX) by inducing ER stress , an oncoprotein from hepatitis B virus. Acetylshikonin inhibits the production of eicosanoid, is due to the attenuation of cytosolic phospholipase A(2) membrane recruitment via the decrease in [Ca(2+)](i) and to the blockade of cyclooxygenase and 5-lipoxygenase activity.

天然产物

Neotuberostemonine

Cat.No: T4953

Target: NOS

Cat.No: T25687

Synonym: LTC4,Leukotriene C

Target: Endogenous Metabolite

Cat.No: TN6458

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPH-01738	NLRP1 Protein, Human, Recombinant (GST) Caspase recruitment domain-containing protein 7,Nuc...	Human	E. coli
	NLRP1 Protein, Human, Recombinant (GST) is expressed in E. coli expression system with N-GST tag. The predicted molecular weight is 42.9 kDa and the accession number is Q9C000.
TMPH-00289	NOD2 Protein, Bovine, Recombinant (His & KSI) Caspase recruitment domain-containing protein 15,Nu...	Bovine	E. coli
	NOD2 Protein, Bovine, Recombinant (His & KSI) is expressed in E. coli expression system with N-6xHis-KSI tag. The predicted molecular weight is 36.8 kDa and the accession number is Q6E804.
TMPH-00951	PYCARD Protein, Human, Recombinant (His & Myc) Caspase recruitment domain-containing protein 5,PYD...	Human	HEK293 Cells
	PYCARD Protein, Human, Recombinant (His & Myc) is expressed in HEK293 mammalian cells with N-10xHis and C-Myc tag. The predicted molecular weight is 26.7 kDa and the accession number is Q9ULZ3.
TMPH-00950	PYCARD Protein, Human, Recombinant (E. coli, His & Myc) Target of methylation-induced silencing 1,PYCARD,Caspase	Human	E. coli
	PYCARD Protein, Human, Recombinant (E. coli, His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 29.1 kDa and the accession number is Q9ULZ3.
TMPJ-00562	PDGF-BB Protein, Mouse, Recombinant (His) PDGFBB,PDGF-BB,血小板源生长因子	Mouse	E. coli
	Platelet-Derived Growth Factor Subunit B (PDGFB) belongs to the PDGF/VEGF growth factor family. Platelet-derived growth factor is a potent mitogen for cells of mesenchymal origin. PDGFB can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha polypeptide (PDGF-AB), where the dimers are connected by disulfide bonds. As growth factor，it plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival...
TMPY-02953	TEM8/ANTXR1 Protein, Human, Recombinant (hFc) ATR,TEM8,anthrax toxin receptor 1,GAPO	Human	HEK293 Cells
	ANTXR1 contains 1 VWFA domain and belongs to the ATR family. ATR (Ataxia telangiectasia and Rad3 related) and ATM (Ataxia telangiectasia mutated) are closely related kinases that are activated by DNA damage. They are serine-threonine protein kinases and belongs to the phosphatidylinositol 3' kinase-like kinase (PIKK) family. Upon recruitment by the DNA damage binding proteins/complexes (ATRIP for ATR; MRN for ATM), ATM/ATR initiate the DNA damage checkpoint by phosphorylating a number of key pro...
TMPY-05176	AMH Protein, Human, Recombinant (His) MIS,anti-Mullerian hormone,MIF	Human	HEK293 Cells
	Anti-Mullerian hormone (AMH), a member of the TGF-beta superfamily, is produced by granulosa cells (GCs) of preantral and small antral follicles and plays a role in regulating the recruitment of primordial follicles and the FSH-dependent development of follicles. BMP15 up-regulates the transcription of AMH and that the inhibition of p38 MAPK decreases the BMP15-induced expression of AMH and SOX9, suggesting that BMP15 up-regulates the expression of AMH via the p38 MAPK signaling pathway, and thi...
TMPY-04483	IRAK4 Protein, Human, Recombinant (His) IPD1,NY-REN-64,REN64,interleukin-1 receptor-associated kinas...	Human	Baculovirus Insect Cells
	Interleukin-1 receptor-associated kinase 4, also known as Renal carcinoma antigen NY-REN-64, IRAK-4, and IRAK4, is a member of the protein kinase superfamily, TKL Ser/Thr protein kinase family, and Pelle subfamily. IRAK4 contains one death domain and one protein kinase domain. IRAK4 is required for the efficient recruitment of IRAK1 to the IL-1 receptor complex following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization. ...
TMPK-00876	G-CSFR/CD114 Protein, Mouse, Recombinant (His) CD114,G CSF R,G-CSF-R,G-CSF R,CSF3R,GCSFR,Csfgr	Mouse	HEK293 Cells
	The Granulocyte Colony-Stimulating Factor (G-CSF) receptor, a member of the hematopoietin cytokine receptor superfamily, functions as a homodimer and requires the recruitment of cytosolic protein tyrosine kinases (PTKs) to transduce its signal.
TMPH-02227	ERG Protein, Human, Recombinant (His) Transcriptional regulator ERG,Transforming protein ERG,ERG	Human	P. pastoris (Yeast)
	Transcriptional regulator. May participate in transcriptional regulation through the recruitment of SETDB1 histone methyltransferase and subsequent modification of local chromatin structure. ERG Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 56.6 kDa and the accession number is P11308.
TMPJ-01213	ASXL1 Protein, Human, Recombinant (GST) Putative Polycomb group protein ASXL1,Additional sex combs-l...	Human	E. coli
	Putative Polycomb group protein ASXL1 involved in transcriptional regulation mediated by ligand-bound nuclear hormone receptors, such as retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). It acts as coactivator of RARA and RXRA through association with NCOA1. ASXL1 also acts as corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 t...
TMPH-01106	CD300LB Protein, Human, Recombinant (His) CMRF35-like molecule 7,CD300LB,CMRF35A2,CD300b,TREM-5,Leukoc...	Human	E. coli
	Acts as an activating immune receptor through its interaction with ITAM-bearing adapter TYROBP, and also independently by recruitment of GRB2. CD300LB Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 18.8 kDa and the accession number is A8K4G0.
TMPH-01313	EIF4G1 Protein, Human, Recombinant (His) EIF4G,eIF-4-gamma 1,Eukaryotic translation initiation factor...	Human	P. pastoris (Yeast)
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (His) is expressed in yeast with N-6xHis tag. The predicted molecular weight is 41.6 kDa and the accession number is Q04637.
TMPJ-01328	ZBP1 Protein, Human, Recombinant (His) Tumor Stroma and Activated Macrophage Protein DLM,DLM1,Z-DNA...	Human	E. coli
	Z-DNA Binding Protein 1 (ZBP1) is a protein with 2 DRADA repeats. ZBP1 is highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow, and spleen. ZBP1 participates in the detection of viral and bacterial DNA from by the host's innate immune system. It plays a role in host defense against tumors and pathogens. ZBP1 Acts as a cytoplasmic DNA sensor which, when activated, induces the recruitment of TBK1 and IRF3 to its C-terminal region and activates the downstream ...
TMPH-03289	EIF3I Protein, Rat, Recombinant (E. coli, His) eIF3 p36,eIF3i,eIF-3-beta,Eukaryotic translation initiation ...	Rat	E. coli
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPK-01031	MAdCAM-1 Protein, Mouse, Recombinant (His) MACAM1,MADCAM1,MAdCAM-1	Mouse	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with C-His tag. The pred...
TMPH-03526	Cap8A Protein, S. aureus, Recombinant (His) MAGEB2,MAGE XP-2 antigen,DAM6,MAGE-B2 antigen,Melanoma-assoc...	Staphylococcus aureus	E. coli
	May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. Cap8A Protein, S. aureus, Recombinant (His) is expressed in E. coli expression system with N-10xHis tag. The predicted molecular weight is 26.4 kDa and the accession number is O15479.
TMPH-01079	CLN5 Protein, Human, Recombinant (His) CLN5,BMPS,Bis(monoacylglycero)phosphate synthase CLN5,S-depa...	Human	E. coli
	Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane. CLN5 Protein, Human, Recombinant (His) is expressed in E. coli expression system with C-6xHis tag. The predicted molecular weight is 43.5 kDa and ...
TMPH-03634	GRA3 Protein, Toxoplasma gondii, Recombinant (His) P30,GRA3,Dense granule protein 3	Toxoplasma gondii	E. coli
	Direct host-parasite interaction occurs at the cytoplasmic faces of the parasitophorous vacuole membrane (PVM) and the host endoplasmic reticulum (ER) membrane via GRA3 and host CAMLG association. Direct insertion of GRA3 ER retrieval motif into the host ER membrane contributes to the host ER recruitment to the PVM. GRA3 Protein, Toxoplasma gondii, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 10.8 kDa and the accession number is ...
TMPK-00177	LAIR1 Protein, Human, Recombinant (His & Avi) CD305,LAIR1,LAIR-1,HLAIR1	Human	HEK293 Cells
	LAIR1 (leukocyte-associated Ig-like receptor-1, designated CD305) is an approximately 40 kDa type I transmembrane inhibitory glycoprotein belonging to the Ig superfamily.LAIR1 functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium ...
TMPY-03343	EIF3K Protein, Human, Recombinant (His & GST) PRO1474,eukaryotic translation initiation factor 3, subunit ...	Human	Baculovirus Insect Cells
	EIF3K is a member of the eIF3 subunit K family. It is a component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 4S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). It stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. EIF3K i...
TMPK-00965	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) MADCAM1,MACAM1,MAdCAM-1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc) is expressed in HEK293 mammalian cells with C-hFc ta...
TMPH-01312	EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) eIF-4G 1,EIF4G,Eukaryotic translation initiation factor 4 ga...	Human	E. coli
	Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome. As a member of the eIF4F complex, required for endoplasmic reticulum stress-induced ATF4 mRNA translation. EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc) is expressed in E. coli expression system with N-10xHis-B2M-JD and C-Myc tag. The predicted molecular weight is 46.6 kDa and the accession nu...
TMPH-02835	PDGFD Protein, Mouse, Recombinant (His & SUMO) Platelet-derived growth factor D,Pdgfd,Spinal cord-derived g...	Mouse	E. coli
	Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Plays an important role in wound healing. Has oncogenic potential and can induce tumor formation. Induces macrophage recruitment, increased interstitial pressure, and blood vessel maturation during angiogenesis. Can initiate events that lead to a mesangial proliferative glomerulonephritis, including inf...
TMPH-02175	TAF5L Protein, Human, Recombinant (GST) TAF5L,TAF5-like RNA polymerase II p300/CBP-associated factor...	Human	E. coli
	Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. With TAF6L, acts as an epigenetic regulator essential for somatic reprogramming. Regulates target genes through H3K9ac deposition and MYC recruitment which trigger MYC regulatory network to orchestrate gene expression programs to control embryonic stem cell state.
TMPY-00518	SBDS Protein, Human, Recombinant (His) CGI-97,Shwachman-Bodian-Diamond syndrome,SDS,SWDS	Human	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Human, Recombinant (His) is expressed in E. coli expression system with His ta...
TMPH-02055	RBPMS Protein, Human, Recombinant (His & Myc) RBPMS,Heart and RRM expressed sequence,RNA-binding protein w...	Human	E. coli
	Acts as a coactivator of transcriptional activity. Required to increase TGFB1/Smad-mediated transactivation. Acts through SMAD2, SMAD3 and SMAD4 to increase transcriptional activity. Increases phosphorylation of SMAD2 and SMAD3 on their C-terminal SSXS motif, possibly through recruitment of TGFBR1. Promotes the nuclear accumulation of SMAD2, SMAD3 and SMAD4 proteins. Binds to poly(A) RNA. RBPMS Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-...
TMPK-00966	MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) MACAM1,MADCAM1,MAdCAM-1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His) is expressed in HEK293 mammalian cells with C-His ta...
TMPJ-01133	NEDD8 Protein, Human, Recombinant (His & SUMO) Neddylin,Ubiquitin-like protein Nedd8,NEDD8,Neural precursor...	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHi...
TMPY-03341	ASF1B Protein, Human, Recombinant (His) anti-silencing function 1B histone chaperone,CIA-II	Human	Baculovirus Insect Cells
	The histone chaperone anti-silencing factor 1a (ASF1a) interacts with MDC1 and is recruited to sites of DSBs to facilitate the interaction of phospho-ATM with MDC1 and phosphorylation of MDC1, which are required for the recruitment of RNF8/RNF168 histone ubiquitin ligases. Thus, ASF1a deficiency reduces histone ubiquitination at DSBs, decreasing the recruitment of 53BP1, and decreases NHEJ, rendering cells more sensitive to DSBs. This role of ASF1a in DSB repair cannot be provided by the closely...
TMPH-02217	SMARCA4 Protein, Human, Recombinant (His) Transcription activator BRG1,Protein brahma homolog 1,SWI/SN...	Human	P. pastoris (Yeast)
	Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating the calcium-dependent release of a repressor compl...
TMPJ-01132	NEDD8 Protein, Human, Recombinant Ubiquitin-like protein Nedd8,NEDD8,Neddylin,Neural precursor...	Human	E. coli
	Human NEDD8 shares 60% amino acid sequence identity to ubiquitin. The only known substrates of NEDD8 modification are the cullin subunits of SCF ubiquitin E3 ligases. The NEDDylation of cullins is critical for the recruitment of E2 to the ligase complex, thus facilitating ubiquitin conjugation. NEDD8 modification has therefore been implicated in cell cycle progression and cytoskeletal regulation. NEDD8 Protein, Human, Recombinant is expressed in E. coli expression system. The predicted molecular...
TMPH-03288	EIF3I Protein, Rat, Recombinant (His) eIF3i,Eif3s2,eIF-3-beta,Eukaryotic translation initiation fa...	Rat	Baculovirus Insect Cells
	Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly an...
TMPY-00564	MCP-4 Protein, Human, Recombinant (His) MCP-4,CCL13,SCYL1,NCC-1,MCP4,NCC1,CKb10,SCYA13,chemokine (C-...	Human	P. pastoris (Yeast)
	Monocyte Chemoattractant Proteins 4 (MCP-4/CCL13) is a member of a distinct, structurally-related subclass of CC chemokines mainly involved in recruitment of eosinphils to inflammatory sites. CCL13/MCP-4, is a CC family chemokine that is chemoattractant for eosinophils, basophils, monocytes, macrophages, immature dendritic cells, and T cells, and its capable of inducing crucial immuno-modulatory responses through its effects on epithelial, muscular and endothelial cells. Similar to other CC chem...
TMPJ-00252	SIRP beta 1 Protein, Human, Recombinant (His) CD172b,CD172 antigen-like family member B,Signal-regulatory ...	Human	HEK293 Cells
	Signal-regulatory protein beta-1 (SIRPB1, CD172b) is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate...
TMPJ-00612	PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc) CLA,PSGL1,CD162,PSGL-1	Mouse	HEK293 Cells
	P-selectin glycoprotein ligand 1 is the high affinitycounter-receptor for P-selectin on expressed on activated endothelial cells and platelets. As such, it plays a critical role in the tethering of these cells to activated platelets or endothelia expressing P-selectin. As cell adhesion molecules, multiple studies have shown that PSGL-1/ P-selectin interaction is required for the normal recruitment of leukocytes during inflammatory reactions, and also participates in hemostatic responses. PSGL-1 ...
TMPY-00452	SBDS Protein, Mouse, Recombinant (His) 4733401P19Rik,AI836084,CGI-97,SDS,Shwachman-Bodian-Diamond s...	Mouse	E. coli
	The mutation of Shwachman-Bodian-Diamond syndrome (SBDS) gene has been proposed to be a major causative reason for SDS. Shwachman-Diamond syndrome (SDS) is a rare pediatric disease characterized by various systemic disorders, including hematopoietic dysfunction. SBDS deficiency leads to telomere shortening, that SBDS is a telomere-protecting protein that participates in regulating telomerase recruitment. SBDS Protein, Mouse, Recombinant (His) is expressed in E. coli expression system with His ta...
TMPH-01267	RNF13 Protein, Human, Recombinant (His & Myc) RING finger protein 8,RNF8,E3 ubiquitin-protein ligase RNF8,...	Human	E. coli
	E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of hist...
TMPH-02180	TTBK2 Protein, Human, Recombinant (His & Myc) Tau-tubulin kinase 2,TTBK2	Human	E. coli
	Serine/threonine kinase that acts as a key regulator of ciliogenesis: controls the initiation of ciliogenesis by binding to the distal end of the basal body and promoting the removal of CCP110, which caps the mother centriole, leading to the recruitment of IFT proteins, which build the ciliary axoneme. Has some substrate preference for proteins that are already phosphorylated on a Tyr residue at the +2 position relative to the phosphorylation site. Able to phosphorylate tau on serines in vitro.
TMPK-00964	MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated MADCAM1,MAdCAM-1,MACAM1	Human	HEK293 Cells
	Mucosal addressin cell adhesion molecule-1 (MAdCAM-1) contributes to the recruitment of donor T cells into the mucosal tissues of the recipient after allogeneic hematopoietic stem cell transplantation (aHSCT). The aim of our study was to determine whether selected single nucleotide polymorphisms (SNPs) of the MADCAM1 gene are associated with development of serious complications after aHSCT. MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian cells with...
TMPJ-00914	YY1 Protein, Human, Recombinant (His) NF-E1,Transcriptional repressor protein YY1,Yin and yang 1,I...	Human	E. coli
	Transcriptional repressor protein YY1（YY1）contains 4 C2H2-type zinc fingers and belongs to the YY transcription factor family. Multifunctional transcription factor exhibits positive and negative control on a large number of cellular and viral genes by binding to sites overlapping the transcription start site. The effect on transcription regulation of the protein is depending upon the context in which it binds and diverse mechanisms of action include direct activation or repression, indirect acti...
TMPH-02301	VPS35 Protein, Human, Recombinant (His & Myc) VPS35,Vacuolar protein sorting-associated protein 35,Vesicle...	Human	E. coli
	Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The CSC seems to associate with the cytoplasmic domain of cargo proteins predominantly via VPS35; however, these interactions seem to be of...
TMPH-01388	GCKR Protein, Human, Recombinant (His & SUMO) GCKR,Glucokinase regulatory protein	Human	E. coli
	Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. GCKR Protein, Human, R...
TMPH-01387	GCKR Protein, Human, Recombinant (His) Glucokinase regulatory protein,GCKR	Human	P. pastoris (Yeast)
	Regulates glucokinase (GCK) by forming an inactive complex with this enzyme. Acts by promoting GCK recruitment to the nucleus, possibly to provide a reserve of GCK that can be quickly released in the cytoplasm after a meal. The affinity of GCKR for GCK is modulated by fructose metabolites: GCKR with bound fructose 6-phosphate has increased affinity for GCK, while GCKR with bound fructose 1-phosphate has strongly decreased affinity for GCK and does not inhibit GCK activity. GCKR Protein, Human, R...
TMPH-02212	TLR8 Protein, Human, Recombinant (His) TLR8,Toll-like receptor 8	Human	P. pastoris (Yeast)
	Endosomal receptor that plays a key role in innate and adaptive immunity. Controls host immune response against pathogens through recognition of RNA degradation products specific to microorganisms that are initially processed by RNASET2. Recognizes GU-rich single-stranded RNA (GU-rich RNA) derived from SARS-CoV-2, SARS-CoV-1 and HIV-1 viruses. Upon binding to agonists, undergoes dimerization that brings TIR domains from the two molecules into direct contact, leading to the recruitment of TIR-con...
TMPJ-00467	Mindin Protein, Human, Recombinant (His) Spondin-2,Differentially expressed in cancerous and non-canc...	Human	HEK293 Cells
	Spondin-2, also referred to as mindin, belongs to the F-spondin family of secreted extracellular matrix proteins. Spondins are characterised by the presence of F-spondin domains 1 and 2 (FS1 and FS2) at the N-terminus and a thrombospondin-type 1 repeat (TSR1) domain at the C-terminus. Spondin-2 functions as a pattern-recognition molecule for bacterial and viral pathogens and as an integrin ligand for inflammatory cell recruitment and T cell priming. In addition to its roles in promoting neuron o...
TMPJ-01040	MAX Protein, Human, Recombinant (His) Protein Max,MAX,bHLHd4,Myc-Associated Factor X,Class D Basic...	Human	E. coli
	Myc-Associated Factor X (MAX) is a member of the basic helix-loop-helix leucine zipper (bHLHZ) family of transcription factors. It contains 1 basic helix-loop-helix (bHLH) domain. It is found in the brain, heart, and lung at high levels while lower levels are seen in the liver, kidney, and skeletal muscle. MAX forms a sequence-specific DNA-binding protein complex with MYC or MAD which recognizes the core sequence 5'-CAC[GA]TG-3'. The MYC-MAX complex is a transcriptional activator, whereas the MA...
TMPH-00533	T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc) T7 RNA polymerase,DNA-directed RNA polymerase	Escherichia phage T7	E. coli
	Highly processive DNA-dependent RNA polymerase that catalyzes the transcription of class II and class III viral genes. Recognizes a specific promoter sequence and enters first into an 'abortive phase' where very short transcripts are synthesized and released before proceeding to the processive transcription of long RNA chains. Unwinds the double-stranded DNA to expose the coding strand for templating. Participates in the initiation of viral DNA replication presumably by making primers accessible...
TMPJ-01323	NTAL Protein, Human, Recombinant (His) Williams-Beuren Syndrome Chromosomal Region 5 P,Membrane-Ass...	Human	HEK293 Cells
	Linker for Activation of T-Cells Family Member 2 (LAT2) is a single-pass type III membrane protein. LAT2 is highly expressed in the spleen, peripheral blood lymphocytes, and germinal centers of lymph nodes. LAT2 is involved in FCER1 (high affinity immunoglobulin epsilon receptor)-mediated signaling in mast cells. It may also be involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and FCGR1 (high affinity immunoglobulin gamma Fc receptor I)-mediated signaling in myeloid cells. ...
TMPJ-00419	CD16b Protein, Human, Recombinant (hFc & His) Fc-γ RIII-beta,FCG3,FcR-10,Fc-gamma RIII-β,FCGR3,FCGR3B,Low ...	Human	HEK293 Cells
	Low affinity immunoglobulin gamma Fc region receptor III-B, also known as Fc-gamma RIII-beta, FcR-10, IgG Fc receptor III-1, FCG3, FCGR3, CD16b and FCGR3B. FCGR3B is a GPI-anchor membrane protein and contains two Ig-like C2 type domains. FCGR3B can be expressed in orphonuclear leukocytes and stimulated eosinophils. FCGR3B can interact with INPP5D/SHIP1. FCGR3B localizes in the FCGR gene cluster is a CN polymorphic gene involved in the recruitment of polymorphonuclear neutrophils to sites of infl...
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重组蛋白

NLRP1 Protein, Human, Recombinant (GST)

Cat.No: TMPH-01738

Species: Human

Expression System: E. coli

NOD2 Protein, Bovine, Recombinant (His & KSI)

Cat.No: TMPH-00289

Species: Bovine

Expression System: E. coli

PYCARD Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-00951

Species: Human

Expression System: HEK293 Cells

PYCARD Protein, Human, Recombinant (E. coli, His & Myc)

Cat.No: TMPH-00950

Species: Human

Expression System: E. coli

PDGF-BB Protein, Mouse, Recombinant (His)

Cat.No: TMPJ-00562

Species: Mouse

Expression System: E. coli

TEM8/ANTXR1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-02953

Species: Human

Expression System: HEK293 Cells

AMH Protein, Human, Recombinant (His)

Cat.No: TMPY-05176

Species: Human

Expression System: HEK293 Cells

IRAK4 Protein, Human, Recombinant (His)

Cat.No: TMPY-04483

Species: Human

Expression System: Baculovirus Insect Cells

G-CSFR/CD114 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-00876

Species: Mouse

Expression System: HEK293 Cells

ERG Protein, Human, Recombinant (His)

Cat.No: TMPH-02227

Species: Human

Expression System: P. pastoris (Yeast)

ASXL1 Protein, Human, Recombinant (GST)

Cat.No: TMPJ-01213

Species: Human

Expression System: E. coli

CD300LB Protein, Human, Recombinant (His)

Cat.No: TMPH-01106

Species: Human

Expression System: E. coli

EIF4G1 Protein, Human, Recombinant (His)

Cat.No: TMPH-01313

Species: Human

Expression System: P. pastoris (Yeast)

ZBP1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-01328

Species: Human

Expression System: E. coli

EIF3I Protein, Rat, Recombinant (E. coli, His)

Cat.No: TMPH-03289

Species: Rat

Expression System: E. coli

MAdCAM-1 Protein, Mouse, Recombinant (His)

Cat.No: TMPK-01031

Species: Mouse

Expression System: HEK293 Cells

Cap8A Protein, S. aureus, Recombinant (His)

Cat.No: TMPH-03526

Species: Staphylococcus aureus

Expression System: E. coli

CLN5 Protein, Human, Recombinant (His)

Cat.No: TMPH-01079

Species: Human

Expression System: E. coli

GRA3 Protein, Toxoplasma gondii, Recombinant (His)

Cat.No: TMPH-03634

Species: Toxoplasma gondii

Expression System: E. coli

LAIR1 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-00177

Species: Human

Expression System: HEK293 Cells

EIF3K Protein, Human, Recombinant (His & GST)

Cat.No: TMPY-03343

Species: Human

Expression System: Baculovirus Insect Cells

MAdCAM-1 Protein, Human, Recombinant (aa 19-317, hFc)

Cat.No: TMPK-00965

Species: Human

Expression System: HEK293 Cells

EIF4G1 Protein, Human, Recombinant (B2M & His & JD & Myc)

Cat.No: TMPH-01312

Species: Human

Expression System: E. coli

PDGFD Protein, Mouse, Recombinant (His & SUMO)

Cat.No: TMPH-02835

Species: Mouse

Expression System: E. coli

TAF5L Protein, Human, Recombinant (GST)

Cat.No: TMPH-02175

Species: Human

Expression System: E. coli

SBDS Protein, Human, Recombinant (His)

Cat.No: TMPY-00518

Species: Human

Expression System: E. coli

RBPMS Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02055

Species: Human

Expression System: E. coli

MAdCAM-1 Protein, Human, Recombinant (aa 19-317, His)

Cat.No: TMPK-00966

Species: Human

Expression System: HEK293 Cells

NEDD8 Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPJ-01133

Species: Human

Expression System: E. coli

ASF1B Protein, Human, Recombinant (His)

Cat.No: TMPY-03341

Species: Human

Expression System: Baculovirus Insect Cells

SMARCA4 Protein, Human, Recombinant (His)

Cat.No: TMPH-02217

Species: Human

Expression System: P. pastoris (Yeast)

NEDD8 Protein, Human, Recombinant

Cat.No: TMPJ-01132

Species: Human

Expression System: E. coli

EIF3I Protein, Rat, Recombinant (His)

Cat.No: TMPH-03288

Species: Rat

Expression System: Baculovirus Insect Cells

MCP-4 Protein, Human, Recombinant (His)

Cat.No: TMPY-00564

Species: Human

Expression System: P. pastoris (Yeast)

SIRP beta 1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00252

Species: Human

Expression System: HEK293 Cells

PSGL-1/CD162 Protein, Mouse, Recombinant (aa 42-307, hFc)

Cat.No: TMPJ-00612

Species: Mouse

Expression System: HEK293 Cells

SBDS Protein, Mouse, Recombinant (His)

Cat.No: TMPY-00452

Species: Mouse

Expression System: E. coli

RNF13 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-01267

Species: Human

Expression System: E. coli

TTBK2 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02180

Species: Human

Expression System: E. coli

MAdCAM-1 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-00964

Species: Human

Expression System: HEK293 Cells

YY1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00914

Species: Human

Expression System: E. coli

VPS35 Protein, Human, Recombinant (His & Myc)

Cat.No: TMPH-02301

Species: Human

Expression System: E. coli

GCKR Protein, Human, Recombinant (His & SUMO)

Cat.No: TMPH-01388

Species: Human

Expression System: E. coli

GCKR Protein, Human, Recombinant (His)

Cat.No: TMPH-01387

Species: Human

Expression System: P. pastoris (Yeast)

TLR8 Protein, Human, Recombinant (His)

Cat.No: TMPH-02212

Species: Human

Expression System: P. pastoris (Yeast)

Mindin Protein, Human, Recombinant (His)

Cat.No: TMPJ-00467

Species: Human

Expression System: HEK293 Cells

MAX Protein, Human, Recombinant (His)

Cat.No: TMPJ-01040

Species: Human

Expression System: E. coli

T7 RNA polymerase Protein, Enterobacteria phage T7, Recombinant (His & Myc)

Cat.No: TMPH-00533

Species: Escherichia phage T7

Expression System: E. coli

NTAL Protein, Human, Recombinant (His)

Cat.No: TMPJ-01323

Species: Human

Expression System: HEK293 Cells

CD16b Protein, Human, Recombinant (hFc & His)

Cat.No: TMPJ-00419

Species: Human

Expression System: HEK293 Cells

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