395
24
15
5
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T1696 |
2-(1-Piperazinyl)pyrimidine
|
Adrenergic Receptor | GPCR/G Protein; Neuroscience |
2-(1-Piperazinyl)pyrimidine 用作抗焦虑药。 | |||
T2075 |
Pyrazolo[1,5-a]pyrimidine 4h
|
Others | Others |
Pyrazolo[1,5-a]pyrimidine 4h 是一种吗啉衍生物,是腺苷 A2A 受体的选择性拮抗剂。在帕金森病和亨廷顿舞蹈症的动物模型中,它已被证明具有神经保护作用。 | |||
T7256 |
4-Chlorothieno[3,2-d]pyrimidine
|
Others | Others |
4-Chlorothieno[3,2-d]pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T7256,CAS号为 16269-66-2。 | |||
T50078 |
2-(pentylsulfanyl)pyrimidine-4,6-diol
|
GPR | Endocrinology/Hormones; GPCR/G Protein |
2-(pentylsulfanyl)pyrimidine-4,6-diol 是一种新型 GRP84 激动剂。 | |||
T9366 |
Pyrazoloadenine
4-Aminopyrazolo[3,4-d]pyrimidine |
ROS | Immunology/Inflammation |
Pyrazoloadenine (4-Aminopyrazolo[3,4-d]pyrimidine) 是人黄嘌呤氧化酶的抑制剂。 | |||
T8621 |
Ethyl 4-amino-2-(methylthio)pyrimidine-5-carboxylate
|
Others | Others |
ETHYL 4-AMINO-2-(METHYLTHIO)PYRIMIDINE-5-CARBOXYLATE 用于制备作为蛋白激酶抑制剂的嘧啶并嘧啶。 | |||
T7451 |
2-Cyanopyrimidine
2-氰基嘧啶,2-cyano-Pyrimidine |
Cysteine Protease | Proteases/Proteasome |
2-Cyanopyrimidine (m-Hydroxyphenylpropionic acid) 是半胱氨酸蛋白酶组织蛋白酶 K (cysteine protease cathepsin K) 的非选择性抑制剂(IC50:170 nM)。它能够用于骨质疏松症的研究。 | |||
T8613 |
1-Ethyl-6-aminouracil
6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE,1-乙基-6-氨基脲嘧啶 |
Adenosine Receptor | GPCR/G Protein; Neuroscience |
1-Ethyl-6-aminouracil (6-AMINO-1-ETHYL-1H-PYRIMIDINE-2,4-DIONE) 是合成一系列新的取代黄嘌呤的中间体,这些黄嘌呤对人腺苷 A2B 受体具有高亲和力和选择性。 | |||
T9945 |
MNK8
3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione |
STAT | JAK/STAT signaling; Stem Cells |
MNK8 (3-methyl-6-(naphthalen-1-yl)pyrimidine-2,4(1H,3H)-dione) 是一种有效的STAT3抑制剂,降低STAT3与DNA 结合的能力,对肝癌细胞也有良好的生长抑制作用。 | |||
T24639 |
PIH
pyrimidine-indole hybrid |
Others | Others |
PIH is a ciliogenesis inhibitor by microtubule destabilization that acts by antagonizing Hh signaling by repressing cilia biogenesis and disassembly of alpha-tubulin in its stabilized form. | |||
T16922 |
SPOP-IN-6b
2-Imino-10-methyl-N-(3-morpholinopropyl)-5-oxo-1-phenethyl-1,5-dihydro-2H-dipyrido[1,2-a:2',3'-d]pyrimidine-3-carboxamide |
Others | Others |
SPOP-IN-6b 是一种有效的斑点型 POZ 蛋白 (SPOP) 抑制剂,IC50 为 3.58 μM,可用于肾癌治疗的研究。 | |||
T13017 |
STL127705
Compound L,7-[[2-(3,4-Dimethoxyphenyl)ethyl]amino]-3-(3-fluorophenyl)pyrimido[4,5-d]pyrimidine-2,4(1H,3H)-dione |
DNA-PK; Others | DNA Damage/DNA Repair; Others; PI3K/Akt/mTOR signaling |
STL127705 (Compound L) 是一种有效的 Ku 70/80 异二聚体蛋白抑制剂,抑制 Ku70/80-DNA 相互作用,IC50 为 3.5 μM。 它抑制 Ku 依赖性 DNA-PKCS 激酶的激活,IC50 为 2.5 μM。 | |||
T2476 |
INCB032304
4-(1H-吡唑-4-基)-7-((2-(三甲基硅烷基)乙氧基)-甲基)-7H-吡咯并[2,3-D]嘧啶,4-(1H-Pyrazol-4-yl)-7-((2-(trimethylsilyl)ethoxy)-methyl)-7H-pyrrolo[2,3-d]pyrimidine |
Others | Others |
INCB032304是一种重要的医药中间体。可用于制备janus 激酶抑制剂Ruxolitinib phosphate(I008849),也可于制备Barretinib。 | |||
T67877 |
2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid
|
Others | Others |
2-(2-fluoro-6-methoxyphenyl)pyrimidine-4-carboxylic acid 常用来合成具有抗癌抗肿瘤作用的化合物。 | |||
T67762 |
2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid
|
Others | Others |
2-Oxo-6-phenyl-1,2,3,6-tetrahydro-pyrimidine-4-carboxylic acid 属于嘧啶家族,已被证明具有抗炎、抗惊厥和抗肿瘤的特性。 | |||
T9048 |
Ecamsule
|
Others | Others |
Ecamsule 是一种亚苄基樟脑衍生物,其中许多以其出色的光稳定性而闻名。 可添加到防晒霜中以过滤掉 UVA 射线。 | |||
T36870 |
5,6-dihydro-5-Fluorouracil
5-fluorodihydrouracil,5-Fluoro-dihydro-pyrimidine-2,4-dione |
Others | Others |
5,6-dihydro-5-Fluorouracil (5-FUH2)是 5-FU 的无活性代谢产物,可用于用于研究机体代谢。 | |||
T64428 |
4,6-Dichloro-2-(propylthio)pyrimidine
|
Others | Others |
4,6-Dichloro-2-(propylthio)pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64428,CAS号为 1401318-10-2。 | |||
T50079 |
Antitumor agent-152
|
Others | Others |
2-({[2-(4-ethoxy-3-methoxyphenyl)-1,3-thiazol-4-yl]methyl}sulfanyl)pyrimidine-4,6-diamine 可用于开发新的脱氧胞苷激酶(dCK)抑制剂。 | |||
T66446 |
2-(Propylthio)pyrimidine-4,6-diol
|
Others | Others |
2-(Propylthio)pyrimidine-4,6-diol 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66446,CAS号为 145783-12-6。 | |||
T4348 |
Syk Inhibitor II
|
5-HT Receptor; Syk | Angiogenesis; GPCR/G Protein; Neuroscience; Tyrosine Kinase/Adaptors |
Syk Inhibitor II 是一种可渗透细胞、具有 ATP 竞争性的嘧啶-甲酰胺化合物,可选择性且可逆地抑制 Syk,IC50为 41 nM。 | |||
T16911 |
Sorivudine
BV-araU,索立夫定 |
DNA/RNA Synthesis | Cell Cycle/Checkpoint; DNA Damage/DNA Repair |
Sorivudine (BV-araU) 是口服有效的,嘧啶核苷抗代谢药物。它的抗病毒活性来自某些 DNA 病毒中存在的特定胸苷激酶选择性转化为核苷酸,从而反过来会干扰病毒 DNA 合成。 | |||
T66602 |
4-Chloro-5H-pyrrolo[3,2-d] pyrimidine
|
Others | Others |
4-Chloro-5H-pyrrolo[3,2-d] pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66602,CAS号为 84905-80-6。 | |||
T64959 |
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate
|
Others | Others |
Ethyl 4-chloro-2-(methylthio)pyrimidine-5-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64959,CAS号为 5909-24-0。 | |||
T66222 |
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine
|
Others | Others |
4,6-Dichloro-5-nitro-2-(propylthio)pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66222,CAS号为 145783-14-8。 | |||
T66488 |
6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione
|
Others | Others |
6-(Chloromethyl)pyrimidine-2,4(1H,3H)-dione 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66488,CAS号为 18592-13-7。 | |||
TNU1019 |
6-Amino-4-methoxypyrazolo[3,4-d]pyrimidine
|
Others | Others |
6-Amino-4-methoxypyrazolo[3,4-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU1018 |
6-Amino-4-chloropyrazolo[3,4-d]pyrimidine
|
Others | Others |
6-Amino-4-chloropyrazolo[3,4-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU0659 |
4-Chloro-1H-pyrazolo[3,4-d]pyrimidine
|
Others | Others |
Heterocyclic compound-purine, intermediate and building block-electrophile, nucleoside base | |||
T66608 |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine
|
Others | Others |
2,4-Dichloro-7H-pyrrolo[2,3-d]pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66608,CAS号为 90213-66-4。 | |||
T5168 |
EGFR-IN-12
EGFR Inhibitor |
Apoptosis; EGFR | Angiogenesis; Apoptosis; JAK/STAT signaling; Tyrosine Kinase/Adaptors |
EGFR-IN-12 (EGFR Inhibitor) 是一种 4,6-二取代的嘧啶,可诱导细胞凋亡,具有抗肿瘤活性。它是ATP 竞争性,不可逆且高度选择性的EGFR 抑制剂,IC50为 21 nM。它对EGFR 的选择性高于 HER4 和 55种其他激酶。它还抑制突变型EGFRL858R 和EGFRL861Q,IC50分别为 63 nM 和 4 nM。 | |||
TNU0611 |
4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidine
|
Others | Others |
Heterocyclic compound –purines, intermediate and building block; Used for modified nucleosides and nucleic acids | |||
T65517 |
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine
|
Others | Others |
4-Chloro-7-tosyl-7H-pyrrolo[2,3-d]pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65517,CAS号为 479633-63-1。 | |||
T65530 |
4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine
|
Others | Others |
4-Chloro-6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T65530,CAS号为 16372-08-0。 | |||
T64808 |
5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine
|
Others | Others |
5-(3-Bromo-4,5-dimethoxybenzyl)pyrimidine-2,4-diamine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64808,CAS号为 16285-82-8。 | |||
TNU0717 |
4-Chloro-5-iodo-7H-pyrrol[2,3-d]pyrimidine
|
Others | Others |
Heterocyclic compound - purine; Intermediate and building blocks– electrophile and nucleophile; Nucleoside base | |||
T64531 |
2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine
|
Others | Others |
2-[4-(Pyrimidin-2-yl)piperazin-1-yl]pyrimidine 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T64531,CAS号为 84746-24-7。 | |||
T66943 |
5-Chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione
|
Others | Others |
5-Chloro-6-(chloromethyl)pyrimidine-2,4(1H,3H)-dione 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66943,CAS号为 73742-45-7。 | |||
T66583 |
Ethyl 4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
|
Others | Others |
Ethyl 4-((4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66583,CAS号为 211230-35-2。 | |||
TNU1015 |
4-Amino-6-bromo-5-cyano-7H-pyrrolo[2,3-d]pyrimidine
|
Others | Others |
4-Amino-6-bromo-5-cyano-7H-pyrrolo[2,3-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
TNU1032 |
7-(2-Deoxy-b-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine
|
Others | Others |
Nucleoside Derivatives - 7-Deaza-purine nucleosides; 6-De-aminopurine nucleosides | |||
T66523 |
4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid
|
Others | Others |
4-((3-Chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylic acid 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 T66523。 | |||
TNU1020 |
6-Amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine
|
Others | Others |
6-Amino-3-iodo-4-methoxy-1H-pyrazolo[3,4-d]pyrimidine bolongs toIntermediates and Building Blocks - Nucleoside Base; Multi-functional; Heterocyclic Compounds - Purine; Scaffold and Template. | |||
T9309 |
mTOR inhibitor 11
|
Others | Others |
mTOR inhibitor 11 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T9309,CAS号为 1195785-35-3。 | |||
TNU0323 |
4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
|
Others | Others |
4,6-Diamino-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine is a Nucleoside Derivative - 7-deaza-8-aza purine nucleoside. | |||
TNU0280 |
4,6-Diamino-1-(b-D-ribofuranosyl)-1H-pyrazolo[3,4-d]pyrimidine
|
Others | Others |
Nucleoside Derivatives - 8-Aza-7-deaza-purine nucleoside; 2-Modified purine nucleoside | |||
TNU1478 |
5-Carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine acetic acid
|
Others | Others |
5-Carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine acetic acid is a PNA-related Derivative; Heterocyclic Compound - Fused polyheterocycle. | |||
T66433 |
Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate
|
Others | Others |
Ethyl 4-((3-chloro-4-methoxybenzyl)amino)-2-(methylthio)pyrimidine-5-carboxylate 是一种有用的有机化合物,可用于生命科学领域的相关研究。其产品编号为 T66433,CAS号为 330785-81-4。 | |||
TNU1477 |
5-Carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine acetic acid benzyl ester
|
Others | Others |
5-Carboxy-3,4-dihydro-2,4-dioxo-1(2H)-pyrimidine acetic acid benzyl ester 是一种有用的有机化合物,可用于生命科学领域的相关研究,其产品编号为 TNU1477。 | |||
TNU0321 |
6-Amino-4-methoxy-2-(b-D-ribofuranosyl)-2H-pyrazolo[3,4-d]pyrimidine
|
Others | Others |
Nucleoside Derivatives - 7-deaza-8-aza purine nucleosides; 6-Modified purine nucleosides; Scaffolds and Templates |
Cat. No. | Product Name | Target | Signaling Pathways |
---|---|---|---|
T4809 |
Pyrimidine
嘧啶,Metadiazine |
Others; Endogenous Metabolite | Metabolism; Others |
Pyrimidine (Metadiazine) 是内源性代谢产物的一种。 | |||
T4746 |
Purine
7H-Imidazo(4,5-d)pyrimidine,嘌呤 |
Others; Endogenous Metabolite | Metabolism; Others |
Purine (7H-Imidazo(4,5-d)pyrimidine) 是内源性代谢产物的一种。 | |||
TN7191 |
4-Amino-5-Bromopyrrolo[2,3-D]Pyrimidine
4-氨基-5-溴吡咯并[2,3-D]嘧啶,5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-amine,5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-amine |
Others | Others |
4-Amino-5-Bromopyrrolo[2,3-D]Pyrimidine (5-bromo-1H-pyrrolo[2,3-d]pyrimidin-4-amine) 是一种海洋来源的天然产物,存在于Echinodictyum sp.。 | |||
T5078 |
Orotic acid monohydrate
2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate,Orotic Acid Monohydrate,2,6-Dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid hydrate,乳清酸一水合物 |
Others; Endogenous Metabolite | Metabolism; Others |
Orotic acid monohydrate (2,4-dioxo-1H-pyrimidine-6-carboxylic acid hydrate) 是内源性代谢产物的一种。 | |||
T7520 |
Deoxycytidine triphosphate
|
Nucleoside Antimetabolite/Analog; DNA/RNA Synthesis; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Deoxycytidine triphosphate 是一种核苷三磷酸,是合成 DNA 的原料,可用于实时荧光定量 PCR、cDNA 合成和 DNA 测序。 | |||
T0746 |
Orotic acid
乳清酸,Vitamin B13,6-Carboxyuracil |
Nucleoside Antimetabolite/Analog; Dehydrogenase; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Orotic acid (Vitamin B13) 是一种嘧啶核苷酸和 RNA 生物合成的前体,从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放,通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大,是尿素循环异常的常规新生儿筛查中的一种测量指标。 | |||
T3271 |
Orotic acid zinc
乳清酸锌二水合物,Orotic acid zinc salt dihydrate,Zinc Orotate |
Nucleoside Antimetabolite/Analog; Others; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism; Others |
Orotic acid zinc (Zinc Orotate) 是一种嘧啶核苷酸和 RNA 生物合成的前体,从线粒体二氢乳清酸脱氢酶 (DHODH) 中释放,通过细胞质 UMP 合酶转化为 UMP。它可引起大鼠肝脂肪变性和肝肿大,是尿素循环异常的常规新生儿筛查中的一种测量指标。 | |||
T4711 |
2,4-Dihydroxypyrimidine-5-carboxylic acid
脲嘧啶-5-羧酸,Isoorotic acid,Uracil-5-carboxylic acid |
Others; Endogenous Metabolite | Metabolism; Others |
2,4-Dihydroxypyrimidine-5-carboxylic acid (Isoorotic acid) 是内源性代谢产物的一种。 | |||
T5284 |
N-Carbamoyl-DL-aspartic acid
氨基甲酰-DL-天(门)冬氨酸,N-Carbamoyl-DL-aspartic acid,Ureidosuccinic acid,脲基琥珀酸 |
Others; Endogenous Metabolite | Metabolism; Others |
N-Carbamoyl-DL-aspartic acid (Ureidosuccinic acid) 是核酸嘧啶的前体之一。 | |||
T0986 |
Flucytosine
5-Fluorocytosine,Ro 2-9915,5-氟胞嘧啶,Fluorocytosine,NSC 103805 |
DNA/RNA Synthesis; Antibiotic; Antifungal | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Microbiology/Virology |
Flucytosine (NSC 103805) 是抗真菌化合物。 | |||
T4887 |
3-Amino-2-methylpropanoic acid
DL-3-AMINOISOBUTYRIC ACID,3-氨基异丁酸,α-Methyl-β-alanine |
Endogenous Metabolite | Metabolism |
3-Amino-2-methylpropanoic acid (α-Methyl-β-alanine) 是 N-carbamyl-beta-aminoisobutyric acid 经 enzyme Beta-ureidopropionase (EC 3.5.1.6)转化后的产物,是嘧啶降解的最后一步。-尿嘧啶丙酸酶缺乏症是一种与神经异常相关的嘧啶降解的先天性错误。 | |||
T7457 |
5-Methyl-2'-deoxycytidine
5-Methyldeoxycytidine,5-甲基-2'-脱氧胞苷,5MedCyd |
DNA Methyltransferase; Endogenous Metabolite | Chromatin/Epigenetic; Metabolism |
5-Methyl-2'-deoxycytidine (5MedCyd) 是嘧啶核苷,当掺入到单链 DNA 中时,可以顺式作用以从头发出信号。 | |||
T4831 |
α,α-Dimethylglycine
2-Aminoisobutyric acid,α-Aminoisobutanoic acid,2-甲基丙氨酸 |
Others; Endogenous Metabolite | Metabolism; Others |
NSC-16590 (2-Aminoisobutyric acid) 对苍耳子叶中内源性乙烯(ethylene)的产生具有抑制作用。 | |||
TMA2440 |
Uridine 5'-monophosphate disodium salt
尿苷-5'-单磷酸二钠盐,Disodium UMP,尿苷酸二钠盐,Disodium uridine-5'-monophosphate,5'-UMP disodium salt,Disodium 5'-Uridylate |
Others | Others |
Uridine 5'-monophosphate disodium salt (Disodium UMP) 是合成 RNA 的一种重要成分。 | |||
T1591L |
Cytidine
Cytosine-1-β-D-ribofuranoside,胞苷,Cytosine β-D-riboside |
Nucleoside Antimetabolite/Analog; Endogenous Metabolite | Cell Cycle/Checkpoint; DNA Damage/DNA Repair; Metabolism |
Cytidine (Cytosine-1-β-D-ribofuranoside) 是一种嘧啶核苷,由通过 β-N1-糖苷键与核糖结合的胞嘧啶组成。它是尿苷的前体,用于 RNA 合成。 | |||
T4832 |
Cytosine
6-Aminopyrimidin-2(1H)-one,4-Amino-2-hydroxypyrimidine,Cytosinimine,胞嘧啶 |
Endogenous Metabolite | Metabolism |
Cytosine (6-Aminopyrimidin-2(1H)-one) 是 DNA 和 RNA 中发现的四个主要碱基之一。它修饰表现出与表观遗传多样性和衰老有关的昼夜节律振荡。 | |||
T0069 |
Uracil
|
Others; Endogenous Metabolite | Metabolism; Others |
Uracil 是普遍存在的天然嘧啶衍生物,是 RNA 核酸中的四个碱基之一。 | |||
T8047 |
Menthyl acetate
乙酸-L-孟酯,(1R)-(-)-Menthyl acetate,(-)-Menthyl acetate,L-Menthyl acetate |
Others | Others |
Menthyl acetate 是一种可有效增强 5-氨基乙酰丙酸 (ALA) 皮肤渗透的 L-薄荷醇衍生物。 | |||
T4919 |
Ureidopropionic acid
Carbamoyl-b-alanine,3-酰脲丙酸,3-Ureidopropionic acid |
Endogenous Metabolite | Metabolism |
Ureidopropionic acid (3-Ureidopropionic acid) 是尿嘧啶代谢的中间体。更具体地说,它是二氢尿嘧啶的分解产物,由二氢嘧啶酶产生。它通过β -脲丙酸酶进一步分解为β -丙氨酸。尿素丙酸本质上是β -丙氨酸的尿素衍生物。高水平的尿丙酸存在于β -尿丙酸酶(UP)缺乏的个体中。嘧啶代谢中的酶缺乏与抗肿瘤药物5-氟尿嘧啶的严重毒性风险有关。 | |||
T4758 |
2'-Deoxycytidine
Cytosine deoxyribonucleoside,2'-Deoxycytidine monohydrate,2(1H)-Pyrimidinone,Cytosine deoxyriboside,Deoxyribose cytidine,Deoxycytidine,2'-脱氧胞嘧啶核苷一水合物 |
Endogenous Metabolite | Metabolism |
2'-Deoxycytidine 是由胞嘧啶和脱氧核糖组成的DNA的主要核苷之一,抑制溴脱氧尿苷 (Brdu) 的生物效应。核苷仅由与嘌呤或嘧啶碱相连的戊糖组成,没有磷酸基团。当N1与脱氧核糖的C1连接时,由胞嘧啶和脱氧核糖形成脱氧核苷和核苷酸;脱氧胞苷单磷酸(dCMP),脱氧胞苷二磷酸(dCDP),脱氧胞苷三磷酸(dCTP)。CTP是RNA(核糖核酸)中胞苷的来源,脱氧胞苷三磷酸(dCTP)是DNA(脱氧核糖核酸)中脱氧胞苷的来源。 | |||
T4880 |
L-Dihydroorotic acid
|
Others; Endogenous Metabolite | Metabolism; Others |
L-Dihydroorotic acid 是一种能够通过二氢乳清酶,能够逆水解产生的无环 L-脲基琥珀酸。 | |||
T39626 |
Orotidine 5′-monophosphate
Orotidine monophosphate,Orotidylicacid,Orotidine 5′-monophosphate |
Others | Others |
Orotidine 5′-monophosphate is a pyrimidine ribonucleoside and plays a role as an endogenous metabolite of human, E. coli or mouse. Orotidine 5′-monophosphate is an intermediate in the biosynthesis of uridine monophosphate (UMP). Orotidine 5′-monophosphate can be used for the study of mechanism of orotidine 5′-monophosphate decarboxylase. | |||
T82682 |
Convicine
|
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Convicine为一种嘧啶糖苷,其与Vicine共同作为糖苷配基Divicine和Isouramil的前体。该化合物是蚕豆病的关键因素——一种因蚕豆摄入而触发的严重溶血遗传性疾病。Convicine能够从蚕豆中提取分离。 | |||
T75676 |
Orotidine 5′-monophosphate trisodium
|
Others | Others |
Orotidine 5'-monophosphate trisodium 是一种嘧啶核苷酸。Orotidine 5'-monophosphate trisodium 是通过从头合成途径合成的,用于在大量微生物中合成 DNA,包括 M. tuberculosis、S. cerevisiae、S. typhimurium 和 P. falciparum 等等。乳清酸磷酸核糖基转移酶 (OPRT) 以磷酸核糖焦磷酸 (PRPP) 和乳清酸 (OA) 作为底物催化合成 Orotidine 5'-monophosphate trisodium[1] |
Cat. No. | Product Name | Species | Expression System |
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TMPH-00858 |
NT5C Protein, Human, Recombinant (His & Myc)
5'(3')-deoxyribonucleotidase, cytosolic type,NT5C,Cytosolic ... |
Human | E. coli |
Dephosphorylates the 5' and 2'(3')-phosphates of deoxyribonucleotides, with a preference for dUMP and dTMP, intermediate activity towards dGMP, and low activity towards dCMP and dAMP. NT5C Protein, Human, Recombinant (His & Myc) is expressed in E. coli expression system with N-10xHis and C-Myc tag. The predicted molecular weight is 28.4 kDa and the accession number is Q8TCD5. | |||
TMPY-03855 |
DNase I Protein, Human, Recombinant (His)
DRNI,DNL1,deoxyribonuclease I |
Human | HEK293 Cells |
DNase1, also known as deoxyribonuclease I and DNL1, is a member of the DNase family. DNaseI is a nuclease that cleaves DNA preferentially at phosphodiester linkages adjacent to a pyrimidine nucleotide, yielding 5'-phosphate-terminated polynucleotides with a free hydroxyl group on position 3', on average producing tetranucleotides. DNaseI binds to the cytoskeletal protein actin. It binds actin monomers with very high (sub-nanomolar) affinity and actin polymers with lower affinity. Mutations i... | |||
TMPY-04480 |
UMP-CMP kinase/CMPK1 Protein, Human, Recombinant (His)
CMPK,UMPK,UMK,CK,UMP-CMPK,CMK,cytidine monophosphate (UMP-CM... |
Human | Baculovirus Insect Cells |
CMPK1 plays a key role in the maintenance of pyrimidine nucleotide pool profile and for the metabolism of pyrimidine analogs in cells. It catalyzes the phosphoryl transfer from ATP to UMP, CMP, and deoxy-CMP (dCMP), resulting in the formation of ADP and the corresponding nucleoside diphosphate. CMPK1 also has a significant role in the activation of pyrimidine analogs, which are clinically useful anti-cancer and anti-viral drugs. In the meanwhile, CMPK1 functions in cellular nucleic acid bi... | |||
TMPH-02964 |
UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO)
Cmpk1,UMP-CMP kinase,Nucleoside-diphosphate kinase,Uridine m... |
Mouse | E. coli |
Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity. UMP-CMP kinase/CMPK1 Protein, Mouse, Recombinant (His & SUMO) is expressed in E. coli expression system with N-6xHis-SUMO tag. The predicted molecular weight is 38.2 kDa and the accession number is Q9DBP5. | |||
TMPJ-01374 |
UPB1 Protein, Human, Recombinant (His)
β-Ureidopropionase,Beta-Alanine Synthase,β-Alanine Synthase,... |
Human | E. coli |
β-Ureidopropionase is a cytoplasmic protein which belongs to the CN hydrolase family of BUP subfamily. β-Ureidopropionase binds one zinc ion per subunit, catalyzes the last step in the pyrimidine degradation pathway. β-Ureidopropionase can convert N-carbamyl-beta-aminoisobutyric acid and N-carbamyl-beta-alanine to beta-aminoisobutyric acid and beta-alanine, ammonia and carbon dioxide, respectively. The pyrimidine bases uracil and thymine are degraded via the consecutive action of dihydropyrimidi... | |||
TMPY-02893 |
NT5C3A/NT5C3 Protein, Human, Recombinant
P5N1,P5N-1,hUMP1,NT5C3,cN-III,PSN1,UMPH1,UMPH,POMP,5'-nucleo... |
Human | E. coli |
NT5C3A (5'-Nucleotidase, Cytosolic IIIA) is a Protein Coding gene. This gene encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. NT5C3A expression required both an intronic IFN-stimulated response element and the IFN-stimulated transcription factor IRF1. Overexpression of NT5C3A, but... | |||
TMPH-01779 |
RNASE2 Protein, Human, Recombinant (His)
Ribonuclease US,Eosinophil-derived neurotoxin,Non-secretory ... |
Human | E. coli |
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities. RNASE2 Protein, Human, Recombinant (His) is expressed in E. coli expression system with N-6xHis tag. The predicted molecular weight is 19.5 kDa and the accession number is P10153. | |||
TMPH-03614 |
DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO)
DNA photolyase,Deoxyribodipyrimidine photo-lyase,ph... |
Synechococcus | E. coli |
Involved in repair of UV radiation-induced DNA damage. Catalyzes the light-dependent monomerization (300-600 nm) of cyclobutyl pyrimidine dimers (in cis-syn configuration), which are formed between adjacent bases on the same DNA strand upon exposure to ultraviolet radiation. DNA photolyase Protein, Synechococcus sp., Recombinant (His & Myc & SUMO) is expressed in E. coli expression system with N-10xHis-SUMO and C-Myc tag. The predicted molecular weight is 74.3 kDa and the accession number is P05... | |||
TMPJ-01262 |
UPRT Protein, Human, Recombinant (His)
UPRT,UPP,FUR1,Uracil phosphoribosyltransferase homolog |
Human | E. coli |
UPRT is a cytoplasmic enzyme which belongs to the UPRTase family. UPRT is highly expressed in leukocytes, liver, spleen and thymus, with lower expression in brain, lung and skeletal muscle. UPRTcatalyzes the conversion of uracil and 5-phosphoribosyl-1-R-diphosphate to uridine monophosphate (UMP). This reaction is an important part of nucleotide metabolism, specifically the pyrimidine salvage pathway. UPRT is a potential target for rational design of drugs to treat parasitic infections and cancer | |||
TMPJ-00905 |
DTYMK Protein, Human, Recombinant (His)
DTYMK,TMPK,dTMP kinase,Thymidylate kinase,CDC8,TYMK |
Human | HEK293 Cells |
Thymidylate kinase (DTYMK) is a ubiquitous enzyme of about 25 kD which belongs to thymidylate kinase family. DTYMK is important in the dTTP synthesis pathway for DNA synthesis. It participated in the pyrimidine metabolism pathway and dTTP biosynthesis pathway. DTYMK catalyzes the conversion of dTMP to dTDP and catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) to form thymidine 5'-diphosphate (dTDP) in the presence of ATP and magnesium. Structural and functional analyses suggest ... | |||
TMPY-03332 |
PRTFDC1 Protein, Human, Recombinant (His)
HHGP,PRTFDC1,phosphoribosyl transferase domain containing 1 |
Human | E. coli |
PRTFDC1 is a member of the purine/pyrimidine phosphoribosyltransferase family. It can bind GMP, IMP and alpha-D-5-phosphoribosyl 1-pyrophosphate (PRPP). The epigenetic silencing of PRTFDC1 by hypermethylation of the CpG island leads to a loss of PRTFDC1 function, which might be involved in squamous cell oral carcinogenesis. PRTFDC1 is a genetic modifier of HPRT-deficiency in the mouse and has important implications for unraveling the molecular etiology of lesch-Nyhan disease(LND). LND is a sever... | |||
TMPJ-01207 |
UPP1 Protein, Human, Recombinant (His)
UPP1,Uridine Phosphorylase 1,UPP1 Protein |
Human | E. coli |
Uridinephosphorylase 1 (UPP1) is a member of the family of pentosyltransferase. UPP1 catalyses the reversible phosphorolysis of uridine to uracil. The expression levels and the enzymatic activity of UPP1 are higher in human solid tumors than in adjacent normal tissues. The high level of UPP1 expression in some tumors makes it a potential prognosticfactor for some cancers, such as oral squamous cell carcinoma. UPP1 is important for the homeostatic regulation of intracellular and plasma uridine c... | |||
TMPY-03180 |
Ribonuclease A Protein, Human, Recombinant (His)
RNS1,ribonuclease, RNase A family, 1 (pancreatic),RIB1,RAC1 |
Human | HEK293 Cells |
RNase A, also known as ribonuclease A and RNASE1, belongs to ribonuclease A superfamily. It is a pancreatic-type of secretory ribonuclease. RNase A is a basic protein and its many positive charges are consistent with its binding to RNA (a poly-anion). More generally, RNase A is unusually polar or, rather, unusually lacking in hydrophobic groups, especially aliphatic ones. As an endonuclease, RNase A cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) ... | |||
TMPY-03457 |
ERH Protein, Human, Recombinant (His)
DROER,enhancer of rudimentary homolog (Drosophila) |
Human | E. coli |
ERH(enhancer of rudimentary homolog) belongs to the E(R) family. It is expressed in all tissues examined. The monomeric structure of ERH comprises a single domain consisting of three α-helices and four β-strands, which is a novel fold. In the crystal structure, ERH assumes a dimeric structure, through interactions between the β-sheet regions. The formation of an ERH dimer is consistent with the results of analytical ultracentrifugation. ERH may have a role in the cell cycle. The Drosophil... | |||
TMPH-01239 |
XPC Protein, Human, Recombinant (His)
Xeroderma pigmentosum group C-complementing protein,p125,XPC... |
Human | E. coli |
Involved in global genome nucleotide excision repair (GG-NER) by acting as damage sensing and DNA-binding factor component of the XPC complex. Has only a low DNA repair activity by itself which is stimulated by RAD23B and RAD23A. Has a preference to bind DNA containing a short single-stranded segment but not to damaged oligonucleotides. This feature is proposed to be related to a dynamic sensor XPC can rapidly screen duplex DNA for non-hydrogen-bonded bases by forming a transient nucleoprotein i... |
Cat. No. | Product Name | Target | Signaling Pathways |
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T13026 |
Sulfadimethoxypyrimidine D4
|
Others | Others |
Sulfadimethoxypyrimidine D4, a deuterium-labeled version of Sulfadimethoxypyrimidine, is a sulfonamide antibiotic characterized by its broad-spectrum antibacterial effectiveness. | |||
TMID-0102 |
4,6-Dimethoxy-2-isothiocyanatopyrimidine-d6
DMPITC-d6 |
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4,6-Dimethoxy-2-isothiocyanatopyrimidine-d6 是 4,6-Dimethoxy-2-isothiocyanatopyrimidine 的氘代化合物。4,6-Dimethoxy-2-isothiocyanatopyrimidine 的 CAS 号为 110860-38-3。 | |||
TMIJ-0096 |
Buspirone EP Impurity A-d8
Buspirone USP Related Compound A-d8 |
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Buspirone EP Impurity A-d8 是 Buspirone EP Impurity A 的氘代化合物。Buspirone EP Impurity A 的 CAS 号为 20980-22-7。2-(1-Piperazinyl)pyrimidine 用作抗焦虑药。 | |||
TMID-0166 |
Thymine-d4
|
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Thymine-d4 是 Thymine 的氘代化合物。Thymine 的 CAS 号为 65-71-4。Thymine 是 DNA 的四个碱基之一,在动物癌症模型中,能够作为5-氟尿嘧啶的靶标,其 Km=2.3 μM。 | |||
T36895 |
5-Fluorouracil-13C,15N2
5-Fluorouracil-13C,15N2 |
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5-Fluorouracil-13C,15N2 is intended for use as an internal standard for the quantification of 5-flurouracil by GC- or LC-MS. 5-Fluorouracil is a pyrimidine analog that irreversibly inhibits thymidylate synthase, blocking the synthesis of thymidine which is required for DNA synthesis. Intracellular metabolites of 5-fluorouracil exert cytotoxic effects by either inhibiting thymidylate synthetase, or through incorporation into RNA and DNA, ultimately initiating apoptosis. |